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Book ; Online ; E-Book: Harrison's Principles of Internal Medicine

Loscalzo, Joseph / Fauci, Anthony / Kasper, Dennis / Hauser, Stephen / Longo, Dan / Jameson, J. Larry

2021

Abstract: This book presents a sharp focus on the clinical presentation of disease, expert in-depth summaries of pathophysiology and treatment, and includes highlights of emerging frontiers of science and medicine. ...

Title translation	Principles of internal medicine
Title variant	Principles of internal medicine ; Harrison's online
Abstract	This book presents a sharp focus on the clinical presentation of disease, expert in-depth summaries of pathophysiology and treatment, and includes highlights of emerging frontiers of science and medicine.
MeSH term(s)	Internal Medicine
Keywords	Internal medicine
Subject code	616
Language	English
Size	1 online resource
Edition	21st edition /
Publisher	McGraw-Hill Education LLC
Publishing place	New York, N.Y
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-264-26851-3 ; 1-264-28584-1 ; 978-1-264-26851-1 ; 978-1-264-28584-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Harrison's principles of internal medicine

Fauci, Anthony S. / Hauser, Stephen L. / Jameson, J. Larry / Kasper, Dennis L. / Longo, Dan L. / Loscalzo, Joseph

(McGraw-Hill's AccessMedicine)

2018

Abstract: Harrison's is intended for learners throughout their careers. For students, Part 1, Chapter 1 begins with an overview of "The Practice of Medicine". In this introductory chapter, the editors continue the tradition of orienting clinicians to the science ... ...

Title translation	Principles of internal medicine
Title variant	Principles of internal medicine ; Harrison's online
Series title	McGraw-Hill's AccessMedicine
Abstract	"Harrison's is intended for learners throughout their careers. For students, Part 1, Chapter 1 begins with an overview of "The Practice of Medicine". In this introductory chapter, the editors continue the tradition of orienting clinicians to the science and the art of medicine, emphasizing the values of our profession while incorporating new advances in technology, science, and clinical care. Part 2, "Cardinal Manifestations and Presentation of Diseases" is a signature feature of Harrison's. These chapters eloquently describe how patients present with common clinical conditions, such as headache, fever, cough, palpitations, or anemia, and provide an overview of typical symptoms, physical findings, and differential diagnosis. Mastery of these topics prepares students for subsequent chapters on specific diseases they will encounter in courses on pathophysiology and in clinical clerkships"--
MeSH term(s)	Internal Medicine
Keywords	Internal medicine
Subject code	616
Language	English
Size	1 online resource :, illustrations.
Edition	20th ed. /
Publisher	McGraw-Hill Education LLC
Publishing place	New York, N.Y
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-259-64402-2 ; 1-259-64404-9 ; 9781259644030 ; 9781259644016 ; 978-1-259-64402-3 ; 978-1-259-64404-7 ; 1259644030 ; 1259644014
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Nutrition-An Evidence-Based, Practical Approach to Chronic Disease Prevention and Treatment.

Hauser, Michelle E / McMacken, Michelle / Lim, Anthony / Shetty, Paulina

The Journal of family practice

2022 Volume 71, Issue Suppl 1 Lifestyle, Page(s) S5–S16

MeSH term(s)	Chronic Disease ; Diabetes Mellitus, Type 2/prevention & control ; Humans
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197883-4
ISSN	1533-7294 ; 0094-3509
ISSN (online)	1533-7294
ISSN	0094-3509
DOI	10.12788/jfp.0292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1274: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 444: Show issues

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Article ; Online: Bayesian workflow for time-varying transmission in stratified compartmental infectious disease transmission models.

Bouman, Judith A / Hauser, Anthony / Grimm, Simon L / Wohlfender, Martin / Bhatt, Samir / Semenova, Elizaveta / Gelman, Andrew / Althaus, Christian L / Riou, Julien

PLoS computational biology

2024 Volume 20, Issue 4, Page(s) e1011575

Abstract: Compartmental models that describe infectious disease transmission across subpopulations are central for assessing the impact of non-pharmaceutical interventions, behavioral changes and seasonal effects on the spread of respiratory infections. We present ...

Abstract	Compartmental models that describe infectious disease transmission across subpopulations are central for assessing the impact of non-pharmaceutical interventions, behavioral changes and seasonal effects on the spread of respiratory infections. We present a Bayesian workflow for such models, including four features: (1) an adjustment for incomplete case ascertainment, (2) an adequate sampling distribution of laboratory-confirmed cases, (3) a flexible, time-varying transmission rate, and (4) a stratification by age group. Within the workflow, we benchmarked the performance of various implementations of two of these features (2 and 3). For the second feature, we used SARS-CoV-2 data from the canton of Geneva (Switzerland) and found that a quasi-Poisson distribution is the most suitable sampling distribution for describing the overdispersion in the observed laboratory-confirmed cases. For the third feature, we implemented three methods: Brownian motion, B-splines, and approximate Gaussian processes (aGP). We compared their performance in terms of the number of effective samples per second, and the error and sharpness in estimating the time-varying transmission rate over a selection of ordinary differential equation solvers and tuning parameters, using simulated seroprevalence and laboratory-confirmed case data. Even though all methods could recover the time-varying dynamics in the transmission rate accurately, we found that B-splines perform up to four and ten times faster than Brownian motion and aGPs, respectively. We validated the B-spline model with simulated age-stratified data. We applied this model to 2020 laboratory-confirmed SARS-CoV-2 cases and two seroprevalence studies from the canton of Geneva. This resulted in detailed estimates of the transmission rate over time and the case ascertainment. Our results illustrate the potential of the presented workflow including stratified transmission to estimate age-specific epidemiological parameters. The workflow is freely available in the R package HETTMO, and can be easily adapted and applied to other infectious diseases.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Direct and indirect effects of the COVID-19 pandemic on mortality in Switzerland.

Riou, Julien / Hauser, Anthony / Fesser, Anna / Althaus, Christian L / Egger, Matthias / Konstantinoudis, Garyfallos

Nature communications

2023 Volume 14, Issue 1, Page(s) 90

Abstract: The direct and indirect impact of the COVID-19 pandemic on population-level mortality is of concern to public health but challenging to quantify. Using data for 2011-2019, we applied Bayesian models to predict the expected number of deaths in Switzerland ...

Abstract	The direct and indirect impact of the COVID-19 pandemic on population-level mortality is of concern to public health but challenging to quantify. Using data for 2011-2019, we applied Bayesian models to predict the expected number of deaths in Switzerland and compared them with laboratory-confirmed COVID-19 deaths from February 2020 to April 2022 (study period). We estimated that COVID-19-related mortality was underestimated by a factor of 0.72 (95% credible interval [CrI]: 0.46-0.78). After accounting for COVID-19 deaths, the observed mortality was -4% (95% CrI: -8 to 0) lower than expected. The deficit in mortality was concentrated in age groups 40-59 (-12%, 95%CrI: -19 to -5) and 60-69 (-8%, 95%CrI: -15 to -2). Although COVID-19 control measures may have negative effects, after subtracting COVID-19 deaths, there were fewer deaths in Switzerland during the pandemic than expected, suggesting that any negative effects of control measures were offset by the positive effects. These results have important implications for the ongoing debate about the appropriateness of COVID-19 control measures.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Switzerland/epidemiology ; Bayes Theorem ; Mortality
Language	English
Publishing date	2023-01-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-35770-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis.

Roodselaar, Jay / Zhou, Yifan / Leppert, David / Hauser, Anja E / Urich, Eduard / Anthony, Daniel C

Neurology(R) neuroimmunology & neuroinflammation

2021 Volume 8, Issue 3

Abstract: Objective: Therapies targeting B cells have been used in the clinic for multiple sclerosis (MS). In patients with relapsing MS, anti-CD20 therapy often suppresses relapse activity; yet, their effect on disease progression has been disappointing. Most ... ...

Abstract	Objective: Therapies targeting B cells have been used in the clinic for multiple sclerosis (MS). In patients with relapsing MS, anti-CD20 therapy often suppresses relapse activity; yet, their effect on disease progression has been disappointing. Most anti-CD20 therapeutic antibodies are type I, but within the unique microenvironment of the brain, type II antibodies may be more beneficial, as type II antibodies exhibit reduced complement-dependent cytotoxicity and they have an increased capacity to induce direct cell death that is independent of the host immune response. Methods: We compared the effect of type I with type II anti-CD20 therapy in a new rodent model of secondary progressive MS (SPMS), which recapitulates the principal histopathologic features of MS including meningeal B-cell aggregates. Focal MS-like lesions were induced by injecting heat-killed Results: Anti-CD20 therapy decreased the extent of glial activation, significantly decreased the number of B and T lymphocytes in the lesion, and resulted in disruption of the meningeal aggregates. Moreover, at the given dose, the type II anti-CD20 therapy was more efficacious than the type I and also protected against neuronal death. Conclusions: These results indicate that anti-CD20 may be an effective therapy for SPMS with B-cell aggregates and that the elimination of CD20
MeSH term(s)	Animals ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/pharmacology ; Antigens, CD20 ; Astrocytes/drug effects ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Brain/pathology ; Disease Models, Animal ; Humans ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Rituximab/pharmacology
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antigens, CD20 ; Rituximab (4F4X42SYQ6) ; obinutuzumab (O43472U9X8)
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000000975
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Data-Driven Modelling and Control for Robot Needle Insertion in Deep Anterior Lamellar Keratoplasty.

Edwards, William / Tang, Gao / Tian, Yuan / Draelos, Mark / Izatt, Joseph / Kuo, Anthony / Hauser, Kris

IEEE robotics and automation letters

2022 Volume 7, Issue 2, Page(s) 1526–1533

Abstract: Deep anterior lamellar keratoplasty (DALK) is a technique for cornea transplantation which is associated with reduced patient morbidity. DALK has been explored as a potential application of robot microsurgery because the small scales, fine control ... ...

Abstract	Deep anterior lamellar keratoplasty (DALK) is a technique for cornea transplantation which is associated with reduced patient morbidity. DALK has been explored as a potential application of robot microsurgery because the small scales, fine control requirements, and difficulty of visualization make it very challenging for human surgeons to perform. We address the problem of modelling the small scale interactions between the surgical tool and the cornea tissue to improve the accuracy of needle insertion, since accurate placement within 5% of target depth has been associated with more reliable clinical outcomes. We develop a data-driven autoregressive dynamic model of the tool-tissue interaction and a model predictive controller to guide robot needle insertion. In an
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ISSN	2377-3766
ISSN	2377-3766
DOI	10.1109/lra.2022.3140458
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A scientific note on a black soldier fly (Stratiomyidae: Hermetia illucens) infestation within a western honey bee (Apis mellifera) colony

Auth, Connor Anthony / Hauser, Martin / Hopkins, Brandon Kingsley

Apidologie. 2021 June, v. 52, no. 3

2021

Abstract: Black soldier fly larvae (Hermetia illucens) were discovered in a weak honey bee colony in Hailey, Idaho. The larvae were localized to the brood area and caused the affected comb to putrefy. Further communication with the beekeeper revealed that the ... ...

Abstract	Black soldier fly larvae (Hermetia illucens) were discovered in a weak honey bee colony in Hailey, Idaho. The larvae were localized to the brood area and caused the affected comb to putrefy. Further communication with the beekeeper revealed that the colony recently returned from California and that the larvae likely originated there as well. In California, H. illucens are common and exist sympatrically with honey bees, yet there have been very few reports of damage. We therefore believe H. illucens are unlikely to cause damage to healthy colonies or significantly impact the apiculture industry. This report is the first published observation of H. illucens in Idaho and shows conclusively for the first time that H. illucens associates with honey bee colonies in North America.
Keywords	Apis mellifera ; Hermetia illucens ; apiculture ; beekeepers ; honey ; honey bee colonies ; honey bees ; industry ; California ; Idaho
Language	English
Dates of publication	2021-06
Size	p. 576-579.
Publishing place	Springer Paris
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	280429-3
ISSN	1297-9678 ; 0044-8435 ; 0365-5407
ISSN (online)	1297-9678
ISSN	0044-8435 ; 0365-5407
DOI	10.1007/s13592-021-00844-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Socio-demographic characteristics associated with COVID-19 vaccination uptake in Switzerland: longitudinal analysis of the CoMix study.

Reichmuth, Martina L / Heron, Leonie / Riou, Julien / Moser, André / Hauser, Anthony / Low, Nicola / Althaus, Christian L

BMC public health

2023 Volume 23, Issue 1, Page(s) 1523

Abstract: Background: Vaccination is an effective strategy to reduce morbidity and mortality from coronavirus disease 2019 (COVID-19). However, the uptake of COVID-19 vaccination has varied across and within countries. Switzerland has had lower levels of COVID-19 ...

Abstract	Background: Vaccination is an effective strategy to reduce morbidity and mortality from coronavirus disease 2019 (COVID-19). However, the uptake of COVID-19 vaccination has varied across and within countries. Switzerland has had lower levels of COVID-19 vaccination uptake in the general population than many other high-income countries. Understanding the socio-demographic factors associated with vaccination uptake can help to inform future vaccination strategies to increase uptake. Methods: We conducted a longitudinal online survey in the Swiss population, consisting of six survey waves from June to September 2021. Participants provided information on socio-demographic characteristics, history of testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), social contacts, willingness to be vaccinated, and vaccination status. We used a multivariable Poisson regression model to estimate the adjusted rate ratio (aRR) and 95% confidence intervals (CI) of COVID-19 vaccine uptake. Results: We recorded 6,758 observations from 1,884 adults. For the regression analysis, we included 3,513 observations from 1,883 participants. By September 2021, 600 (75%) of 806 study participants had received at least one vaccine dose. Participants who were older, male, and students, had a higher educational level, household income, and number of social contacts, and lived in a household with a medically vulnerable person were more likely to have received at least one vaccine dose. Female participants, those who lived in rural areas and smaller households, and people who perceived COVID-19 measures as being too strict were less likely to be vaccinated. We found no significant association between previous SARS-CoV-2 infections and vaccination uptake. Conclusions: Our results suggest that socio-demographic factors as well as individual behaviours and attitudes played an important role in COVID-19 vaccination uptake in Switzerland. Therefore, appropriate communication with the public is needed to ensure that public health interventions are accepted and implemented by the population. Tailored COVID-19 vaccination strategies in Switzerland that aim to improve uptake should target specific subgroups such as women, people from rural areas or people with lower socio-demographic status.
MeSH term(s)	Adult ; Female ; Humans ; Male ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Switzerland/epidemiology ; SARS-CoV-2 ; Vaccination ; Ethnicity
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16405-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Socio-demographic characteristics associated with COVID-19 vaccination uptake in Switzerland

Martina L Reichmuth / Leonie Heron / Julien Riou / André Moser / Anthony Hauser / Nicola Low / Christian L Althaus

BMC Public Health, Vol 23, Iss 1, Pp 1-

longitudinal analysis of the CoMix study

2023 Volume 11

Abstract: Abstract Background Vaccination is an effective strategy to reduce morbidity and mortality from coronavirus disease 2019 (COVID-19). However, the uptake of COVID-19 vaccination has varied across and within countries. Switzerland has had lower levels of ... ...

Abstract	Abstract Background Vaccination is an effective strategy to reduce morbidity and mortality from coronavirus disease 2019 (COVID-19). However, the uptake of COVID-19 vaccination has varied across and within countries. Switzerland has had lower levels of COVID-19 vaccination uptake in the general population than many other high-income countries. Understanding the socio-demographic factors associated with vaccination uptake can help to inform future vaccination strategies to increase uptake. Methods We conducted a longitudinal online survey in the Swiss population, consisting of six survey waves from June to September 2021. Participants provided information on socio-demographic characteristics, history of testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), social contacts, willingness to be vaccinated, and vaccination status. We used a multivariable Poisson regression model to estimate the adjusted rate ratio (aRR) and 95% confidence intervals (CI) of COVID-19 vaccine uptake. Results We recorded 6,758 observations from 1,884 adults. For the regression analysis, we included 3,513 observations from 1,883 participants. By September 2021, 600 (75%) of 806 study participants had received at least one vaccine dose. Participants who were older, male, and students, had a higher educational level, household income, and number of social contacts, and lived in a household with a medically vulnerable person were more likely to have received at least one vaccine dose. Female participants, those who lived in rural areas and smaller households, and people who perceived COVID-19 measures as being too strict were less likely to be vaccinated. We found no significant association between previous SARS-CoV-2 infections and vaccination uptake. Conclusions Our results suggest that socio-demographic factors as well as individual behaviours and attitudes played an important role in COVID-19 vaccination uptake in Switzerland. Therefore, appropriate communication with the public is needed to ensure that public health ...
Keywords	Vaccine ; COVID-19 ; Contact survey ; Social contact ; Socio-demographic characteristics ; Switzerland ; Public aspects of medicine ; RA1-1270
Subject code	300
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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