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  1. Article: An Extensive Case of Merkel Cell Carcinoma due to Fright of COVID-19.

    Danielsen, Maria / Høgsberg, Trine / Lorentzen, Henrik Frank / Rossau, Ann-Kathrine Rahr German

    Case reports in dermatology

    2021  Volume 13, Issue 3, Page(s) 525–529

    Abstract: Merkel cell carcinoma (MCC) is a subtype of nonmelanoma skin cancer (NMSC) with increasing incidence. Clinically, MCC resembles other far less-aggressive NMSCs, and the pathogenesis is still not understood completely. Rapid diagnosis and treatment are ... ...

    Abstract Merkel cell carcinoma (MCC) is a subtype of nonmelanoma skin cancer (NMSC) with increasing incidence. Clinically, MCC resembles other far less-aggressive NMSCs, and the pathogenesis is still not understood completely. Rapid diagnosis and treatment are essential to improve overall survival. We present a case report of a 74-year-old female, who had noticed a rapidly growing, oozing tumor on her right flank. She was hesitant to contact the dermatology ward where she had regular checkups as she was afraid of contracting COVID-19. This was in the beginning of the COVID-19 pandemic. At presentation, she had a large exophytic MCC on her right flank and multiple metastases. The disease was at a late stage, and palliative care was the only treatment option left. With this case, we wish to report a rather uncharacteristic location and size of an MCC tumor and suggest that fear of the pandemic and the COVID-19 lockdown has impacted dramatically on attendance of symptomatic patients.
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505300-0
    ISSN 1662-6567
    ISSN 1662-6567
    DOI 10.1159/000519649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TINF2

    Jensen, Marlene Richter / Jelsig, Anne Marie / Gerdes, Anne-Marie / Hölmich, Lisbet Rosenkrantz / Kainu, Kati Hannele / Lorentzen, Henrik Frank / Hansen, Mary Højgaard / Bak, Mads / Johansson, Peter A / Hayward, Nicholas K / Van Overeem Hansen, Thomas / Wadt, Karin A W

    HGG advances

    2023  Volume 4, Issue 4, Page(s) 100225

    Abstract: ... ...

    Abstract TINF2
    MeSH term(s) Humans ; Melanoma/genetics ; Thyroid Neoplasms ; Sarcoma ; Syndrome ; Neoplasms, Multiple Primary ; Denmark/epidemiology ; Telomere-Binding Proteins/genetics
    Chemical Substances TINF2 protein, human ; Telomere-Binding Proteins
    Language English
    Publishing date 2023-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-2477
    ISSN (online) 2666-2477
    DOI 10.1016/j.xhgg.2023.100225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data.

    Lorentzen, Henrik Frank / Schmidt, Sigrun Aj / Sandholdt, Håkon / Benfield, Thomas

    Danish medical journal

    2020  Volume 67, Issue 9

    Abstract: Introduction: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the ... ...

    Abstract Introduction: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the gold standard has yet to be defined.
    Methods: We reanalysed published data on real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) of severe acute respiratory syndrome coronavirus-2 to illustrate how predictive values vary with disease prevalence, sensitivity (set to values between 30% and 95%) and specificity (set to 99% or 99.98%). We used published data on chest CT and RT-qPCR to examine the potential of latent class analysis to estimate the sensitivity and specificity of RT-qPCR when no single gold standard exists.
    Results: For the various sensitivity values, the negative predictive value of a RT-qPCR test remained above 92% until a COVID-19 prevalence of > 10%. The positive predictive value (PPV) was more variable. For a sensitivity of 95% and a specificity of 99%, the PPV was less-than 10% at a prevalence of 0.1%, increasing to about 90% at a prevalence of 10%. This improved to a PPV of 85% and almost 100%, respectively, when specificity increased to 99.98%. In a restricted latent class analysis, the sensitivity was 97.1% and the specificity was 99.9%, which is similar to figures from the Danish Health Authority. However, derived predictive values depended on model specification.
    Conclusions: A high risk of false-positives should be considered when extending the testing strategy, whereas false-negatives may occur during local outbreaks. This may have consequences for, e.g., containment strategies and research. A confirmatory test (e.g., demonstrating seroconversion or repeated RT-qPCR) may be warranted.
    Funding: none.
    Trial registration: not relevant.
    MeSH term(s) Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; DNA, Viral/analysis ; False Negative Reactions ; Humans ; Pandemics ; Periodicals as Topic ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2
    Chemical Substances DNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 2648771-8
    ISSN 2245-1919 ; 2245-1919
    ISSN (online) 2245-1919
    ISSN 2245-1919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Martorells sår.

    Andersen, Stine Maria / Diernæs, Jon Erik Fraes / Lorentzen, Henrik Frank

    Ugeskrift for laeger

    2017  Volume 179, Issue 37

    Title translation Martorell ulcer.
    MeSH term(s) Aged ; Humans ; Leg Ulcer/complications ; Leg Ulcer/pathology ; Leg Ulcer/surgery ; Male ; Pain/etiology ; Skin Transplantation
    Language Danish
    Publishing date 2017-09-15
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Melanoma associated with the use of melanotan-II.

    Hjuler, Kasper Fjellhaugen / Lorentzen, Henrik Frank

    Dermatology (Basel, Switzerland)

    2014  Volume 228, Issue 1, Page(s) 34–36

    Abstract: Background: Unlicensed use of melanotan-II (MT-II) to promote skin pigmentation has become prevalent amongst young people attending fitness centres. We present a case where the melanocyte stimulation of MT-II in combination with the use of sun tanning ... ...

    Abstract Background: Unlicensed use of melanotan-II (MT-II) to promote skin pigmentation has become prevalent amongst young people attending fitness centres. We present a case where the melanocyte stimulation of MT-II in combination with the use of sun tanning beds coincided with cutaneous melanoma.
    Observation: A 20-year-old woman with Fitzpatrick skin type II was referred to a dermatology clinic. Clinical examination revealed a suspicious black melanocytic lesion in her left gluteal region. Furthermore, her skin was universally intensely pigmented. The melanocytic lesion was excised, and histology confirmed the diagnosis of melanoma. Three months prior to the excision the patient had conducted a 3- to 4-week course of self-injections with MT-II, intending an augmentation of sunbed tanning.
    Conclusions and relevance: This observation brings attention to the potential risks related to the use of the cyclic α-melanocyte-stimulating hormone analogue MT-II. There are several hazardous aspects of the possible widespread use of MT-II. As the drug is unlicensed and incompletely tested, the extent and types of adverse effects are unknown. Clinicians are advised to be aware of the problem, and counsel their at-risk patients regarding the potential hazards related to the use of MT-II.
    MeSH term(s) Female ; Humans ; Melanoma/etiology ; Melanoma/pathology ; Peptides, Cyclic/administration & dosage ; Skin Neoplasms/etiology ; Skin Neoplasms/pathology ; Sunbathing ; Young Adult ; alpha-MSH/administration & dosage ; alpha-MSH/analogs & derivatives
    Chemical Substances Peptides, Cyclic ; melanotan-II (121062-08-6) ; alpha-MSH (581-05-5)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000356389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data

    Lorentzen, Henrik Frank / Schmidt, Sigrun Aj / Sandholdt, Håkon Benfield / Thomas,

    Danish medical journal

    Abstract: INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential The challenge of any novel disease is that the ... ...

    Abstract INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential The challenge of any novel disease is that the gold standard has yet to be defined METHODS: We reanalysed published data on real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) of severe acute respiratory syndrome coronavirus-2 to illustrate how predictive values vary with disease prevalence, sensitivity (set to values between 30% and 95%) and specificity (set to 99% or 99 98%) We used published data on chest CT and RT-qPCR to examine the potential of latent class analysis to estimate the sensitivity and specificity of RT-qPCR when no single gold standard exists RESULTS: For the various sensitivity values, the negative predictive value of a RT-qPCR test remained above 92% until a COVID-19 prevalence of > 10% The positive predictive value (PPV) was more variable For a sensitivity of 95% and a specificity of 99%, the PPV was less-than 10% at a prevalence of 0 1%, increasing to about 90% at a prevalence of 10% This improved to a PPV of 85% and almost 100%, respectively, when specificity increased to 99 98% In a restricted latent class analysis, the sensitivity was 97 1% and the specificity was 99 9%, which is similar to figures from the Danish Health Authority However, derived predictive values depended on model specification CONCLUSIONS: A high risk of false-positives should be considered when extending the testing strategy, whereas false-negatives may occur during local outbreaks This may have consequences for, e g , containment strategies and research A confirmatory test (e g , demonstrating seroconversion or repeated RT-qPCR) may be warranted FUNDING: none TRIAL REGISTRATION: not relevant
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720284
    Database COVID19

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  7. Article ; Online: Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data

    Lorentzen, Henrik Frank / Schmidt, Sigrun A.J. / Sandholdt, Håkon / Benfield, Thomas

    Lorentzen , H F , Schmidt , S A J , Sandholdt , H & Benfield , T 2020 , ' Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data ' , Danish Medical Journal , vol. 67 , no. 9 , A04200237 .

    2020  

    Abstract: INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the ... ...

    Abstract INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the gold standard has yet to be defined. METHODS: We reanalysed published data on real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) of severe acute respiratory syndrome coronavirus-2 to illustrate how predictive values vary with disease prevalence, sensitivity (set to values between 30% and 95%) and specificity (set to 99% or 99.98%). We used published data on chest CT and RT-qPCR to examine the potential of latent class analysis to estimate the sensitivity and specificity of RT-qPCR when no single gold standard exists. RESULTS: For the various sensitivity values, the negative predictive value of a RT-qPCR test remained above 92% until a COVID-19 prevalence of > 10%. The positive predictive value (PPV) was more variable. For a sensitivity of 95% and a specificity of 99%, the PPV was < 10% at a prevalence of 0.1%, increasing to about 90% at a prevalence of 10%. This improved to a PPV of 85% and almost 100%, respectively, when specificity increased to 99.98%. In a restricted latent class analysis, the sensitivity was 97.1% and the specificity was 99.9%, which is similar to figures from the Danish Health Authority. However, derived predictive values depended on model specification. CONCLUSIONS: A high risk of false-positives should be considered when extending the testing strategy, whereas false-negatives may occur during local outbreaks. This may have consequences for, e.g., containment strategies and research. A confirmatory test (e.g., demonstrating seroconversion or repeated RT-qPCR) may be warranted.
    Keywords covid19
    Subject code 310
    Language English
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data

    Lorentzen, Henrik Frank / Schmidt, Sigrun A.J. / Sandholdt, Håkon / Benfield, Thomas

    Lorentzen , H F , Schmidt , S A J , Sandholdt , H & Benfield , T 2020 , ' Estimation of the diagnostic accuracy of real-time reverse transcription quantitative polymerase chain reaction for SARS-CoV-2 using re-analysis of published data ' , Danish Medical Journal , vol. 67 , no. 9 , A04200237 , pp. 1-11 .

    2020  

    Abstract: INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the ... ...

    Abstract INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the gold standard has yet to be defined. METHODS: We reanalysed published data on real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) of severe acute respiratory syndrome coronavirus-2 to illustrate how predictive values vary with disease prevalence, sensitivity (set to values between 30% and 95%) and specificity (set to 99% or 99.98%). We used published data on chest CT and RT-qPCR to examine the potential of latent class analysis to estimate the sensitivity and specificity of RT-qPCR when no single gold standard exists. RESULTS: For the various sensitivity values, the negative predictive value of a RT-qPCR test remained above 92% until a COVID-19 prevalence of > 10%. The positive predictive value (PPV) was more variable. For a sensitivity of 95% and a specificity of 99%, the PPV was < 10% at a prevalence of 0.1%, increasing to about 90% at a prevalence of 10%. This improved to a PPV of 85% and almost 100%, respectively, when specificity increased to 99.98%. In a restricted latent class analysis, the sensitivity was 97.1% and the specificity was 99.9%, which is similar to figures from the Danish Health Authority. However, derived predictive values depended on model specification. CONCLUSIONS: A high risk of false-positives should be considered when extending the testing strategy, whereas false-negatives may occur during local outbreaks. This may have consequences for, e.g., containment strategies and research. A confirmatory test (e.g., demonstrating seroconversion or repeated RT-qPCR) may be warranted.
    Keywords covid19
    Subject code 310
    Language English
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Melanoma Associated with the Use of Melanotan-II

    Hjuler, Kasper Fjellhaugen / Lorentzen, Henrik Frank

    Dermatology

    2013  Volume 228, Issue 1, Page(s) 34–36

    Abstract: Background: Unlicensed use of melanotan-II (MT-II) to promote skin pigmentation has become prevalent amongst young people attending fitness centres. We present a case where the melanocyte stimulation of MT-II in combination with the use of sun tanning ... ...

    Institution Department of Dermatology, Aarhus University Hospital, Aarhus, and Hudklinikken i Herning, Herning, Denmark
    Abstract Background: Unlicensed use of melanotan-II (MT-II) to promote skin pigmentation has become prevalent amongst young people attending fitness centres. We present a case where the melanocyte stimulation of MT-II in combination with the use of sun tanning beds coincided with cutaneous melanoma. Observation: A 20-year-old woman with Fitzpatrick skin type II was referred to a dermatology clinic. Clinical examination revealed a suspicious black melanocytic lesion in her left gluteal region. Furthermore, her skin was universally intensely pigmented. The melanocytic lesion was excised, and histology confirmed the diagnosis of melanoma. Three months prior to the excision the patient had conducted a 3- to 4-week course of self-injections with MT-II, intending an augmentation of sunbed tanning. Conclusions and Relevance: This observation brings attention to the potential risks related to the use of the cyclic α-melanocyte-stimulating hormone analogue MT-II. There are several hazardous aspects of the possible widespread use of MT-II. As the drug is unlicensed and incompletely tested, the extent and types of adverse effects are unknown. Clinicians are advised to be aware of the problem, and counsel their at-risk patients regarding the potential hazards related to the use of MT-II.
    Keywords Skin pigmentation ; Melanoma ; Melanotan-II
    Language English
    Publishing date 2013-12-18
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Case Report
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000356389
    Database Karger publisher's database

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  10. Article: The Danish Melanoma Database.

    Hölmich, Lisbet Rosenkrantz / Klausen, Siri / Spaun, Eva / Schmidt, Grethe / Gad, Dorte / Svane, Inge Marie / Schmidt, Henrik / Lorentzen, Henrik Frank / Ibfelt, Else Helene

    Clinical epidemiology

    2016  Volume 8, Page(s) 543–548

    Abstract: Aim of database: The aim of the database is to monitor and improve the treatment and survival of melanoma patients.: Study population: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma ... ...

    Abstract Aim of database: The aim of the database is to monitor and improve the treatment and survival of melanoma patients.
    Study population: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD). In 2014, 2,525 patients with invasive melanoma and 780 with in situ tumors were registered. The coverage is currently 93% compared with the Danish Pathology Register.
    Main variables: The main variables include demographic, clinical, and pathological characteristics, including Breslow's tumor thickness, ± ulceration, mitoses, and tumor-node-metastasis stage. Information about the date of diagnosis, treatment, type of surgery, including safety margins, results of lymphoscintigraphy in patients for whom this was indicated (tumors > T1a), results of sentinel node biopsy, pathological evaluation hereof, and follow-up information, including recurrence, nature, and treatment hereof is registered. In case of death, the cause and date are included. Currently, all data are entered manually; however, data catchment from the existing registries is planned to be included shortly.
    Descriptive data: The DMD is an old research database, but new as a clinical quality register. The coverage is high, and the performance in the five Danish regions is quite similar due to strong adherence to guidelines provided by the Danish Melanoma Group. The list of monitored indicators is constantly expanding, and annual quality reports are issued. Several important scientific studies are based on DMD data.
    Conclusion: DMD holds unique detailed information about tumor characteristics, the surgical treatment, and follow-up of Danish melanoma patients. Registration and monitoring is currently expanding to encompass even more clinical parameters to benefit both patient treatment and research.
    Language English
    Publishing date 2016-10-25
    Publishing country New Zealand
    Document type Review ; Journal Article
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S99484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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