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  1. Article ; Online: ON AN ERROR TERM RELATED TO THE GREATEST DIVISOR OF n, WHICH IS PRIME TO k

    S. D. ADHIKARI,A. SANKARANARAYANAN, R. BALASUBRAMANIAN

    Proceedings of Indian National Science Academy, Vol 19, Iss

    2015  Volume 9

    Abstract: ON AN ERROR TERM RELATED TO THE GREATEST DIVISOR OF n, WHICH IS PRIME TO k ...

    Abstract ON AN ERROR TERM RELATED TO THE GREATEST DIVISOR OF n, WHICH IS PRIME TO k
    Keywords Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Computer-assisted multistep chemoenzymatic retrosynthesis using a chemical synthesis planner.

    Sankaranarayanan, Karthik / Jensen, Klavs F

    Chemical science

    2023  Volume 14, Issue 23, Page(s) 6467–6475

    Abstract: Chemoenzymatic synthesis methods use organic and enzyme chemistry to synthesize a desired small molecule. Complementing organic synthesis with enzyme-catalyzed selective transformations under mild conditions enables more sustainable and synthetically ... ...

    Abstract Chemoenzymatic synthesis methods use organic and enzyme chemistry to synthesize a desired small molecule. Complementing organic synthesis with enzyme-catalyzed selective transformations under mild conditions enables more sustainable and synthetically efficient chemical manufacturing. Here, we present a multistep retrosynthesis search algorithm to facilitate chemoenzymatic synthesis of pharmaceutical compounds, specialty chemicals, commodity chemicals, and monomers. First, we employ the synthesis planner ASKCOS to plan multistep syntheses starting from commercially available materials. Then, we identify transformations that can be catalyzed by enzymes using a small database of biocatalytic reaction rules previously curated for RetroBioCat, a computer-aided synthesis planning tool for biocatalytic cascades. Enzymatic suggestions captured by the approach include ones capable of reducing the number of synthetic steps. We successfully plan chemoenzymatic routes for active pharmaceutical ingredients or their intermediates (
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01355c
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  3. Article: Perceived Value of the Daily Safety Briefing.

    Sankaranarayanan, Krishnan

    Journal of healthcare management / American College of Healthcare Executives

    2019  Volume 64, Issue 1, Page(s) 52–53

    MeSH term(s) Communication ; Patient Care Team ; Patient Safety
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1418083-2
    ISSN 1944-7396 ; 1096-9012
    ISSN (online) 1944-7396
    ISSN 1096-9012
    DOI 10.1097/JHM-D-18-00253
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  4. Article ; Online: Targeted gene manipulation of Leloir pathway genes for the constitutive expression of β-galactosidase and its transgalactosylation product galacto-oligosaccharides from Kluyveromyces lactis GG799 and knockout strains.

    Ponnusamy, Vimalraj / Sankaranarayanan, Meenakshisundaram

    Enzyme and microbial technology

    2023  Volume 169, Page(s) 110263

    Abstract: ... for the production of galacto-oligosaccharides (GOS) in Kluyveromyces lactis (K. Lactis) by applying a knockout based ... transformation into its genome. The k.lactis strain subjected to Leloir pathway genes knockout, resulted ...

    Abstract Galacto-oligosaccharides (GOS) are used as prebiotic ingredients in various food and pharmaceutical industry. At present, production of GOS involves the enzymatic transformation of lactose by transgalactosylation using β-galactosidase. The yeast Kluyveromyces lactis can utilize lactose as its carbon and energy source. In this species lactose is hydrolyzed by an intracellular β-galactosidase (EC 3.2.1.23) which is induced by its substrate and related compounds like galactose. The molecular details of gene regulation in kluyveromyces lactis, we have used multiple knockout approaches to study the constitutive expression by which galactose induces β-galactosidase. The present study involved carrying out to a method of enhancing the constitutive expression of β-galactosidase through galactose induction and its trans-galactosylation reaction for the production of galacto-oligosaccharides (GOS) in Kluyveromyces lactis (K. Lactis) by applying a knockout based approach on Leloir pathway genes based on fusion-overlap extension polymerase chain reaction and transformation into its genome. The k.lactis strain subjected to Leloir pathway genes knockout, resulted in the accumulation of galactose intracellularly and this internal galactose acts as an inducer of galactose regulon for constitutive expression of β-galactosidase at early stationary phase was due to the positive regulatory function of mutant gal1p, gal7p and both. These resulted strains used for trans-galactosylation of lactose by β - galactosidase is characterized for the production of galacto-oligosaccharides. Galactose-induced constitutive expression of β-galactosidase during the early stationary phase of knockout strains was analysed qualitatively & quantitatively. The activity of β-galactosidase of wild type, gal1z, gal7k and gal1z & gal7k strains were 7, 8, 9 and 11 U/ml respectively using high cell density cultivation medium. Based on these expression differences in β-galactosidase, the trans-galactosylation reaction for GOS production and percentage yield of GOS were compared at 25% w/v of lactose. The percentage yield of GOS production of wild type, Δgal1z Lac4+, Δgal7k Lac4++ and Δgal1z Δgal7k Lac4+++mutants strains were 6.3, 13, 17 and 22 U/ml, respectively. Therefore, we propose that the availability of galactose can be used for constitutive over expression of β - galactosidase in Leloir pathway engineering applications and also for GOS production. Further, increased expression of β - galactosidases can be used in dairy industry by-products like whey to produce added value products such as galacto-oligosaccharides.
    MeSH term(s) Lactose/metabolism ; Galactose/metabolism ; Oligosaccharides/metabolism ; Kluyveromyces/genetics ; Kluyveromyces/metabolism ; beta-Galactosidase/metabolism
    Chemical Substances Lactose (J2B2A4N98G) ; Galactose (X2RN3Q8DNE) ; Oligosaccharides ; beta-Galactosidase (EC 3.2.1.23)
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2023.110263
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  5. Article: Evolutionary Search and Theoretical Study of Silicene Grain Boundaries' Mechanical Properties.

    Zhang, Jianan / Koneru, Aditya / Sankaranarayanan, Subramanian K R S / Lilley, Carmen M

    The journal of physical chemistry. C, Nanomaterials and interfaces

    2024  Volume 128, Issue 14, Page(s) 6019–6030

    Abstract: Defects such as grain boundaries (GBs) are almost inevitable during the synthesis process of 2D materials. To take advantage of the fascinating properties of 2D materials, understanding the nature and impact of various GB structures on pristine 2D sheets ...

    Abstract Defects such as grain boundaries (GBs) are almost inevitable during the synthesis process of 2D materials. To take advantage of the fascinating properties of 2D materials, understanding the nature and impact of various GB structures on pristine 2D sheets is crucial. In this work, using an evolutionary algorithm search, we predict a wide variety of silicene GB structures with very different atomic structures compared with those found in graphene or hexagonal boron-nitride. Twenty-one GBs with the lowest energy were validated by density functional theory (DFT), a majority of which were previously unreported to our best knowledge. Based on the diversity of the GB predictions, we found that the formation energy and mechanical properties can be dramatically altered by adatom positions within a GB and certain types of atomic structures, such as four-atom rings. To study the mechanical behavior of these GBs, we apply strain to the GB structures stepwise and use DFT calculations to investigate the mechanical properties of 9 representative structures. It is observed that GB structures based on pentagon-heptagon pairs are likely to have similar or higher in-plane stiffness and strength compared to the zigzag orientation of pristine silicene. However, an adatom located at the hollow site of a heptagon ring can significantly deteriorate the mechanical strength. For all of the structures, the in-plane stiffness and strength were found to decrease with increasing formation energy. For the failure behavior of GB structures, it was found that GB structures based on pentagon-heptagon pairs have failure behavior similar to that of graphene. We also found that the GB structures with atoms positioned outside of the 2D plane tend to experience phase transitions before failure. Utilizing the evolutionary algorithm, we locate diverse silicene GBs and obtain useful information about their mechanical properties.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 1932-7447
    ISSN 1932-7447
    DOI 10.1021/acs.jpcc.3c07294
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  6. Article ; Online: Polyoxometalates Mediated Amyloid Fibrillation Dynamics and Restoration of Enzyme Activity of Hen Egg White Lysozyme Treated under Cold Atmospheric Pressure Plasma.

    Kalita, Kaberi / Phukan, Shankab J / Garai, Somenath / Sankaranarayanan, Kamatchi

    ACS omega

    2024  Volume 9, Issue 3, Page(s) 3423–3429

    Abstract: Neurodegenerative disorders are one of the most devastating disorders worldwide. Although a definite mechanistic pathway of neurodegenerative disorders is still not clear, it is almost clear that these diseases are initiated by protein misfolding. Hen ... ...

    Abstract Neurodegenerative disorders are one of the most devastating disorders worldwide. Although a definite mechanistic pathway of neurodegenerative disorders is still not clear, it is almost clear that these diseases are initiated by protein misfolding. Hen Egg White Lysozyme (Lyz) can be converted to highly arranged amyloid fibrils and is therefore considered a good model protein for studying protein aggregation in connection to neurodegeneration. In this study, Lyz has been converted to fibrils using He-air gas fed single jet cold atmospheric plasma (CAP). The reactive oxygen species and the reactive nitrogen species produced by the plasma jet interact with the protein molecules and enhance the fibril formation. We monitored the fibrillation kinetics with the Thioflavin T (ThT) assay and observed that fibrils are formed when the samples are treated for 10 min with He-air gas fed CAP. Further, we studied the role of a special class of inorganic nanomaterials called polyoxometalates (POMs) in the process of the Lyz fibrillation using various biophysical techniques. The Keggin POMs used in this study are phosphomolybdic acid (PMA) and silico molybdic acid (SMA). Keggin POMs bring in structural self-assembly of the protein and disrupt the fibrils as evidenced in the ThT assay and TEM analysis. Molecular docking studies together with electrokinetic potential studies show the interactions between POMs and Lyz dominated via hydrogen bonding and electrostatic interactions. The enzyme activity of Lyz was assessed using the substrate
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06921
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  7. Article ; Online: Correction: Accelerating copolymer inverse design using monte carlo tree search.

    Patra, Tarak K / Loeffler, Troy D / Sankaranarayanan, Subramanian K R S

    Nanoscale

    2023  Volume 15, Issue 39, Page(s) 16227

    Abstract: Correction for 'Accelerating copolymer inverse design using monte carlo tree search' by Tarak K ...

    Abstract Correction for 'Accelerating copolymer inverse design using monte carlo tree search' by Tarak K. Patra
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr90182c
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  8. Article: Is sarcopenia an associated factor of increased administration of specific medications in patients with heart failure? A systematic review and meta-analysis.

    Saied, Schabnam / Prokopidis, Konstantinos / Adenaya, Adeoye / Isanejad, Masoud / Sankaranarayanan, Rajiv

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1293537

    Abstract: Background: There is controversy in relation to commonly used drugs in heart failure (HF) and their impact on muscle function. The aim of this study was to evaluate the odds of receiving specific medications often used in clinical practice by patients ... ...

    Abstract Background: There is controversy in relation to commonly used drugs in heart failure (HF) and their impact on muscle function. The aim of this study was to evaluate the odds of receiving specific medications often used in clinical practice by patients with HF and sarcopenia vs. without sarcopenia.
    Methods: A systematic literature search of cohort studies via databases (PubMed, Web of Science, Scopus, and Cochrane Library) was conducted from inception until March 2023. To determine if sarcopenia is linked to a higher number of specific HF-related medications, a meta-analysis using a random-effects model was used to calculate the pooled effects.
    Results: Our main analyses showed no significant association of sarcopenia with administration of higher HF-related medication count vs. those without sarcopenia. Those with lower appendicular lean mass (ALM) had significantly lower odds of receiving angiotensin converting enzyme inhibitors (ACE-Is)/angiotensin receptor blockers (ARBs) (OR: 0.68, 95%CI 0.50-0.90,
    Conclusion: This systematic review and meta-analysis did not find a relationship of specific medication count in sarcopenia vs. without sarcopenia in patients with HF, although increased odds of ACE-I/ARB was shown in those with higher ALM.
    Systematic review registration: PROSPERO (CRD42023411137).
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1293537
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  9. Article ; Online: The RNA world of fungal pathogens.

    Sankaranarayanan, Srimeenakshi / Kwon, Seomun / Heimel, Kai / Feldbrügge, Michael

    PLoS pathogens

    2023  Volume 19, Issue 11, Page(s) e1011762

    MeSH term(s) RNA ; Fungi/genetics ; Fungi/pathogenicity
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011762
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  10. Article ; Online: Reclassification of

    Lawson, Paul A / Saavedra Perez, Liz / Sankaranarayanan, Krithivasan

    International journal of systematic and evolutionary microbiology

    2023  Volume 73, Issue 1

    Abstract: ... The ... ...

    Abstract The genus
    MeSH term(s) Male ; Humans ; Fatty Acids/chemistry ; RNA, Ribosomal, 16S/genetics ; Phylogeny ; Sequence Analysis, DNA ; Bacterial Typing Techniques ; Base Composition ; DNA, Bacterial/genetics ; Clostridium/genetics
    Chemical Substances Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005694
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