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  1. Article ; Online: The challenge hypothesis: Triumphs and caveats.

    Maney, Donna L

    Hormones and behavior

    2020  Volume 123, Page(s) 104663

    Language English
    Publishing date 2020-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2019.104663
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 693: Show issues Location:
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  2. Article ; Online: Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses.

    Gompers, Annika / Olivier, Madeline T / Maney, Donna L

    Biology of sex differences

    2024  Volume 15, Issue 1, Page(s) 32

    Abstract: Background: Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effective training in how to account for sex, and in some cases gender, in biomedical studies.: Methods: Here, we ... ...

    Abstract Background: Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effective training in how to account for sex, and in some cases gender, in biomedical studies.
    Methods: Here, we evaluated three sets of publicly available online training materials on this topic: (1) Integrating Sex & Gender in Health Research from the Canadian Institutes of Health Research (CIHR); (2) Sex as a Biological Variable: A Primer from the United States National Institutes of Health (NIH); and (3) The Sex and Gender Dimension in Biomedical Research, developed as part of "Leading Innovative measures to reach gender Balance in Research Activities" (LIBRA) from the European Commission. We reviewed each course with respect to their coverage of (1) What is required by the policy; (2) Rationale for the policy; (3) Handling of the concepts "sex" and "gender;" (4) Research design and analysis; and (5) Interpreting and reporting data.
    Results: All three courses discussed the importance of including males and females to better generalize results, discover potential sex differences, and tailor treatments to men and women. The entangled nature of sex and gender, operationalization of sex, and potential downsides of focusing on sex more than other sources of variation were minimally discussed. Notably, all three courses explicitly endorsed invalid analytical approaches that produce bias toward false positive discoveries of difference.
    Conclusions: Our analysis suggests a need for revised or new training materials that incorporate four major topics: precise operationalization of sex, potential risks of over-emphasis on sex as a category, recognition of gender and sex as complex and entangled, and rigorous study design and data analysis.
    MeSH term(s) Humans ; Female ; Male ; Sex Factors ; Canada ; Biomedical Research ; Policy ; Sex Characteristics
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2587352-0
    ISSN 2042-6410 ; 2042-6410
    ISSN (online) 2042-6410
    ISSN 2042-6410
    DOI 10.1186/s13293-024-00610-6
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  3. Article ; Online: Supergenes on steroids.

    Maney, Donna L / Küpper, Clemens

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2022  Volume 377, Issue 1855, Page(s) 20200507

    Abstract: At the birth of supergenes, the genomic landscape is dramatically re-organized leading to pronounced differences in phenotypes and increased intrasexual diversity. Two of the best-studied supergenes in vertebrates are arguably the inversion polymorphisms ...

    Abstract At the birth of supergenes, the genomic landscape is dramatically re-organized leading to pronounced differences in phenotypes and increased intrasexual diversity. Two of the best-studied supergenes in vertebrates are arguably the inversion polymorphisms on chromosomes 2 and 11 in the white-throated sparrow (
    MeSH term(s) Animals ; Chromosome Inversion ; Genome ; Social Behavior ; Sparrows/genetics ; Steroids
    Chemical Substances Steroids
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2020.0507
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    In stock of ZB MED Cologne/Königswinter

    Einzelsignatur: Show issues

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  4. Article ; Online: Sex-Inclusive Biomedicine: Are New Policies Increasing Rigor and Reproducibility?

    Maney, Donna L / Rich-Edwards, Janet W

    Women's health issues : official publication of the Jacobs Institute of Women's Health

    2023  Volume 33, Issue 5, Page(s) 461–464

    MeSH term(s) Humans ; Reproducibility of Results ; Policy
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085396-0
    ISSN 1878-4321 ; 1049-3867
    ISSN (online) 1878-4321
    ISSN 1049-3867
    DOI 10.1016/j.whi.2023.03.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3298: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Best practices to promote rigor and reproducibility in the era of sex-inclusive research.

    Rich-Edwards, Janet W / Maney, Donna L

    eLife

    2023  Volume 12

    Abstract: To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex ... ...

    Abstract To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex differences. However, education in sound methods to consider sex as a subgroup category has lagged behind, resulting in a problematic literature in which study designs, analyses, and interpretations of results are often flawed. Here, we outline best practices for complying with sex-inclusive mandates, both for studies in which sex differences are a primary focus and for those in which they are not. Our recommendations are organized within the "4 Cs of Studying Sex to Strengthen Science: Consideration, Collection, Characterization and Communication," a framework developed by the Office of Research on Women's Health at the National Institutes of Health in the United States. Following these guidelines should help researchers include females and males in their studies while at the same time upholding high standards of rigor.
    MeSH term(s) United States ; Humans ; Female ; Male ; Reproducibility of Results ; Communication ; Educational Status ; National Institutes of Health (U.S.) ; Research Design
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.90623
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  6. Article ; Online: Considering Sex as a Variable at a Research University: Knowledge, Attitudes, and Practices.

    Maney, Donna L / Karkazis, Katrina / Hagen, Kimberly B Sessions

    Journal of women's health (2002)

    2023  Volume 32, Issue 8, Page(s) 843–851

    Abstract: Biomedical research has a history of excluding females as research subjects, which threatens rigor, reproducibility, and inclusivity. In 2016, to redress this bias, the U.S. National Institutes of Health (NIH) implemented a policy requiring the ... ...

    Abstract Biomedical research has a history of excluding females as research subjects, which threatens rigor, reproducibility, and inclusivity. In 2016, to redress this bias, the U.S. National Institutes of Health (NIH) implemented a policy requiring the consideration of sex as a biological variable (SABV) in all studies involving vertebrate animals, including humans. Unless strongly justified, females and males must be included in all studies and results reported disaggregated by sex. Recent evidence indicates, however, that misunderstandings of the policy and other significant barriers impede its implementation. To shed light on those barriers at our home institution, we conducted a study funded by the Emory University Specialized Center of Research Excellence on Sex Differences (SCORE). In semistructured interviews of Emory principal investigators in the biological sciences, we noted their knowledge of what the policy entails and why it was implemented, their attitudes toward it, and the extent to which it has or has not changed their research practices. Although attitudes toward SABV were generally positive, most researchers face challenges with respect to its implementation. We suggest interventions that can be mounted at the level of home institutions, such as raising awareness of locally available core facilities, to help address these challenges. More training is needed on what the policy asks of researchers, how sex is defined, the nonhormonal ways that sex differences can manifest, and best practices for statistical analysis of sex-based data. Home institutions may also want to explore ways to lessen the stress associated with rollout of SABV policy.
    MeSH term(s) Animals ; Humans ; Male ; Female ; Health Knowledge, Attitudes, Practice ; Reproducibility of Results ; Universities ; Biomedical Research ; Sexual Behavior
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2022.0522
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables.

    Pape, Madeleine / Miyagi, Miriam / Ritz, Stacey A / Boulicault, Marion / Richardson, Sarah S / Maney, Donna L

    Cell

    2024  Volume 187, Issue 6, Page(s) 1316–1326

    Abstract: Understanding sex-related variation in health and illness requires rigorous and precise approaches to revealing underlying mechanisms. A first step is to recognize that sex is not in and of itself a causal mechanism; rather, it is a classification system ...

    Abstract Understanding sex-related variation in health and illness requires rigorous and precise approaches to revealing underlying mechanisms. A first step is to recognize that sex is not in and of itself a causal mechanism; rather, it is a classification system comprising a set of categories, usually assigned according to a range of varying traits. Moving beyond sex as a system of classification to working with concrete and measurable sex-related variables is necessary for precision. Whether and how these sex-related variables matter-and what patterns of difference they contribute to-will vary in context-specific ways. Second, when researchers incorporate these sex-related variables into research designs, rigorous analytical methods are needed to allow strongly supported conclusions. Third, the interpretation and reporting of sex-related variation require care to ensure that basic and preclinical research advance health equity for all.
    MeSH term(s) Humans ; Health Equity ; Sex ; Biomedical Research
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.02.008
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    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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  8. Article ; Online: Best practices to promote rigor and reproducibility in the era of sex-inclusive research

    Janet W Rich-Edwards / Donna L Maney

    eLife, Vol

    2023  Volume 12

    Abstract: To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex ... ...

    Abstract To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex differences. Education in sound methods to consider sex as a subgroup category has lagged behind, however, resulting in a problematic literature in which study designs, analyses, and interpretations of results are often flawed. Here, we outline best practices for complying with sex-inclusive mandates, both for studies in which sex differences are a primary focus and for those in which they are not. Our recommendations are organized within the “4 Cs of Studying Sex to Strengthen Science: Consideration, Collection, Characterization and Communication,” a framework developed by the Office of Research on Women’s Health at the National Institutes of Health in the United States. Following these guidelines should help researchers include females and males in their studies while at the same time upholding high standards of rigor.
    Keywords science forum ; sex differences ; sex as a biological variable ; statistics ; data analysis ; NIH policy ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 360
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Polymorphisms in sex steroid receptors: From gene sequence to behavior.

    Maney, Donna L

    Frontiers in neuroendocrinology

    2017  Volume 47, Page(s) 47–65

    Abstract: Sex steroid receptors have received much interest as potential mediators of human behaviors and mental disorders. Candidate gene association studies have identified about 50 genetic variants of androgen and estrogen receptors that correlate with human ... ...

    Abstract Sex steroid receptors have received much interest as potential mediators of human behaviors and mental disorders. Candidate gene association studies have identified about 50 genetic variants of androgen and estrogen receptors that correlate with human behavioral phenotypes. Because most of these polymorphisms lie outside coding regions, discerning their effect on receptor function is not straightforward. Thus, although discoveries of associations improve our ability to predict risk, they have not greatly advanced our understanding of underlying mechanisms. This article is intended to serve as a starting point for psychologists and other behavioral biologists to consider potential mechanisms. Here, I review associations between polymorphisms in sex steroid receptors and human behavioral phenotypes. I then consider ways in which genetic variation can affect processes such as mRNA transcription, splicing, and stability. Finally, I suggest ways that hypotheses about mechanism can be tested, for example using in vitro assays and/or animal models.
    MeSH term(s) Endophenotypes ; Gene Expression Regulation ; Humans ; Polymorphism, Genetic ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism
    Chemical Substances Receptors, Androgen ; Receptors, Estrogen
    Language English
    Publishing date 2017-07-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 390985-2
    ISSN 1095-6808 ; 0532-7466 ; 0091-3022
    ISSN (online) 1095-6808
    ISSN 0532-7466 ; 0091-3022
    DOI 10.1016/j.yfrne.2017.07.003
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    Zs.A 3423: Show issues Location:
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    Zs.MO 443: Show issues

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  10. Article ; Online: Determination of sex differences requires formal test for differences: Comment on "lipoprotein-subclass particle numbers in children with abdominal obesity".

    Vorland, Colby J / Golzarri-Arroyo, Lilian / Maney, Donna L / Brown, Andrew W

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15489

    MeSH term(s) Humans ; Male ; Female ; Child ; Obesity, Abdominal ; Sex Characteristics ; Obesity ; Lipoproteins ; Lipoproteins, LDL
    Chemical Substances Lipoproteins ; Lipoproteins, LDL
    Language English
    Publishing date 2023-01-31
    Publishing country Australia
    Document type Letter
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15489
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