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Article ; Online: Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications.

Feng, Fuhai / He, Shasha / Li, Xiaoling / He, Jiake / Luo, Lianxiang

2024 Volume 15, Issue 2, Page(s) 714–738

Abstract: Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be closely associated with the development of many diseases. Mitochondria are vital components of eukaryotic cells, serving important functions in energy ... ...

Abstract	Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be closely associated with the development of many diseases. Mitochondria are vital components of eukaryotic cells, serving important functions in energy production, cellular metabolism, and apoptosis regulation. Presently, the precise relationship between mitochondria and ferroptosis remains unclear. In this study, we aim to systematically elucidate the mechanisms via which mitochondria regulate ferroptosis from multiple perspectives to provide novel insights into mitochondrial functions in ferroptosis. Additionally, we present a comprehensive overview of how mitochondria contribute to ferroptosis in different conditions, including cancer, cardiovascular disease, inflammatory disease, mitochondrial DNA depletion syndrome, and novel coronavirus pneumonia. Gaining a comprehensive understanding of the involvement of mitochondria in ferroptosis could lead to more effective approaches for both basic cell biology studies and medical treatments.
MeSH term(s)	Humans ; Ferroptosis ; Apoptosis ; Cardiovascular Diseases ; Cell Death ; Mitochondria
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0717
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The advancement of polysaccharides in disease modulation: Multifaceted regulation of programmed cell death.

Luo, Lianxiang / Feng, Fuhai / Zhong, Ai / Guo, Nuoqing / He, Jiake / Li, Chenying

International journal of biological macromolecules

2024 Volume 261, Issue Pt 1, Page(s) 129669

Abstract: Programmed cell death (PCD), also known as regulatory cell death (RCD), is a process that occurs in all organisms and is closely linked to both normal physiological processes and disease states. Various signaling pathways, such as TP53, KRAS, NOTCH, ... ...

Abstract	Programmed cell death (PCD), also known as regulatory cell death (RCD), is a process that occurs in all organisms and is closely linked to both normal physiological processes and disease states. Various signaling pathways, such as TP53, KRAS, NOTCH, hypoxia, and metabolic reprogramming, have been found to regulate RCD. Polysaccharides, which are essential natural products, have been the subject of extensive research in the fields of food, nutrition, and medicine due to their wide range of pharmacological effects. Studies have shown that polysaccharides have biological activities and the potential to target signal transduction pathways for the treatment of diseases. This paper provides a review of the mechanisms through which polysaccharides exert their therapeutic effects at different levels and explores the relationship between different types of RCD and human diseases. The aim of this review is to provide a theoretical basis for the further clinical use and application of polysaccharide bioactivities.
MeSH term(s)	Humans ; Apoptosis/physiology ; Cell Death ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Signal Transduction ; Biological Products/pharmacology
Chemical Substances	Polysaccharides ; Biological Products
Language	English
Publishing date	2024-01-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129669
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Article ; Online: Extraordinary Polarization and Thickness Dependences of Photocarrier Dynamics in PdSe

Yang, Jin / Xie, Jiafeng / Jiang, Shaolong / Zhang, Kai / Li, Qi / Wang, Yunfeng / Wang, Tianwu / Su, Fuhai

The journal of physical chemistry letters

2024 Volume 15, Issue 16, Page(s) 4276–4285

Abstract: Pentagonal palladium diselenide ( ... ...

Abstract	Pentagonal palladium diselenide (PdSe
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.4c00765
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: PathFinder: a novel graph transformer model to infer multi-cell intra- and inter-cellular signaling pathways and communications.

Feng, Jiarui / Province, Michael / Li, Guangfu / Payne, Philip R O / Chen, Yixin / Li, Fuhai

bioRxiv : the preprint server for biology

2024

Abstract: Recently, large-scale scRNA-seq datasets have been generated to understand the complex and poorly understood signaling mechanisms within microenvironment of Alzheimer's Disease (AD), which are critical for identifying novel therapeutic targets and ... ...

Abstract	Recently, large-scale scRNA-seq datasets have been generated to understand the complex and poorly understood signaling mechanisms within microenvironment of Alzheimer's Disease (AD), which are critical for identifying novel therapeutic targets and precision medicine. Though a set of targets have been identified, however, it remains a challenging to infer the core intra- and inter-multi-cell signaling communication networks using the scRNA-seq data, considering the complex and highly interactive background signaling network. Herein, we introduced a novel graph transformer model, PathFinder, to infer multi-cell intra- and inter-cellular signaling pathways and signaling communications among multi-cell types. Compared with existing models, the novel and unique design of PathFinder is based on the divide-and-conquer strategy, which divides the complex signaling networks into signaling paths, and then score and rank them using a novel graph transformer architecture to infer the intra- and inter-cell signaling communications. We evaluated PathFinder using scRNA-seq data of APOE4-genotype specific AD mice models and identified novel APOE4 altered intra- and inter-cell interaction networks among neurons, astrocytes, and microglia. PathFinder is a general signaling network inference model and can be applied to other omics data-driven signaling network inference.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.13.575534
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Article ; Online: High-Performance Flexible Broadband Photothermoelectric Photodetectors Based on Tellurium Films.

Zhang, Mingcong / Liu, Yunjie / Guo, Fuhai / Zhang, Bo / Hu, Bing / Li, Siqi / Yu, Weizhuo / Hao, Lanzhong

ACS applied materials & interfaces

2024 Volume 16, Issue 5, Page(s) 6152–6161

Abstract: Mid- and far-infrared photodetectors that can operate at room temperature are essential for both civil and military applications. However, the widespread use of mid-to-far-infrared photonic technology faces challenges due to the need for low-temperature ... ...

Abstract	Mid- and far-infrared photodetectors that can operate at room temperature are essential for both civil and military applications. However, the widespread use of mid-to-far-infrared photonic technology faces challenges due to the need for low-temperature cooling of existing commercial semiconductors and the limited optical absorption efficiency of two-dimensional materials. We have utilized the photothermoelectric effect to fabricate a self-powered, broadband, and high-performance photodetector based on a one-dimensional tellurium nanorod array film. The device surpasses energy band gap limitations, functioning even at wavelengths up to approximately 10,600 nm. In particular, the detectivity of the device can reach 4.8 × 10
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c17933
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum for "LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2" [eBioMedicine 41 (2019) 200-213].

Liao, Meijian / Liao, Weijie / Xu, Naihan / Li, Bing / Liu, Fuhai / Zhang, Shikuan / Wang, Yanzhi / Wang, Songmao / Zhu, Yuanchang / Chen, Deheng / Xie, Weidong / Jiang, Yuyang / Cao, Liu / Yang, Burton B / Zhang, Yaou

EBioMedicine

2024 Volume 102, Page(s) 105084

Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.105084
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Article ; Online: A high-sensitivity SnSe/Si heterojunction position-sensitive detector for ultra-low power detection.

Hu, Bing / Liu, Yunjie / Zhang, Bo / Guo, Fuhai / Zhang, Mingcong / Yu, Weizhuo / Li, Siqi / Hao, Lanzhong

Nanoscale

2024 Volume 16, Issue 8, Page(s) 4170–4175

Abstract: Position-sensitive detectors (PSDs) based on the lateral photovoltaic effect are crucial components in non-contact distance measurement, process control, guidance systems, and other related applications. However, PSDs are challenging due to the narrow ... ...

Abstract	Position-sensitive detectors (PSDs) based on the lateral photovoltaic effect are crucial components in non-contact distance measurement, process control, guidance systems, and other related applications. However, PSDs are challenging due to the narrow spectral range and low sensitivity, limiting further practical application. Here, we present an ultra-sensitive SnSe/Si PSD device. A large-area uniform SnSe nanorod (NR) array film was grown on Si using a glancing-angle magnetron sputtering deposition technique and a SnSe/Si heterojunction PSD device was fabricated. PSDs exhibit an excellent photoresponse in a wide spectral range of 405-980 nm, showing an ultrahigh position sensitivity of 1517.4 mV mm
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr05906e
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Article ; Online: VO

Guo, Fuhai / Liu, Yunjie / Zhang, Mingcong / Yu, Weizhuo / Li, Siqi / Zhang, Bo / Hu, Bing / Li, Shuangshuang / Sun, Ankai / Jiang, Jianyu / Hao, Lanzhong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310767

Abstract: Artificial optoelectronic synapses (OES) have attracted extensive attention in brain-inspired information processing and neuromorphic computing. However, OES at near-infrared wavelengths have rarely been reported, seriously limiting the application in ... ...

Abstract	Artificial optoelectronic synapses (OES) have attracted extensive attention in brain-inspired information processing and neuromorphic computing. However, OES at near-infrared wavelengths have rarely been reported, seriously limiting the application in modern optical communication. Herein, high-performance near-infrared OES devices based on VO
Language	English
Publishing date	2024-03-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310767
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Article: Bibliometric and visual analysis of RAN methylation in cardiovascular disease.

Song, Boce / Xie, Beili / Liu, Mingwang / Li, Haohao / Shi, Dazhuo / Zhao, Fuhai

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1110718

Abstract: Background: RNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD.: Methods: Articles and reviews ... ...

Abstract	Background: RNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD. Methods: Articles and reviews on RNA methylation in CVD published before 6 November 2022 were searched in the Web of Science Core Collection. Visual and statistical analysis was performed using CiteSpace 1.6.R4 advanced and VOSviewer 1.6.18. Results: There were 847 papers from 1,188 institutions and 63 countries/regions. Over approximately 30 years, there was a gradual increase in publications and citations on RNA methylation in CVD. America and China had the highest output (284 and 259 papers, respectively). Nine of the top 20 institutions that published articles were from China, among which Fudan University represented the most. The Conclusions: A bibliometric analysis reveals research hotspots and trends of RNA methylation in CVD. The regulatory mechanisms of RNA methylation related to CVD and the clinical application of their results, especially m
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1110718
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quality assessment and quality control of deep soil mixing columns based on a cement-content controlled method

Jinyu Zuo / Baotian Wang / Wenwei Li / Shaoyang Han / Jiahui Wang / Fuhai Zhang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract This paper presents a cement-content controlled method for quality assessment and quality control of the deep soil mixing (DSM) columns in slope reinforcement. The ethylene diamine tetraacetic acid (EDTA) titration method was modified and used ... ...

Abstract	Abstract This paper presents a cement-content controlled method for quality assessment and quality control of the deep soil mixing (DSM) columns in slope reinforcement. The ethylene diamine tetraacetic acid (EDTA) titration method was modified and used for the cement content measurement of core samples, and the effects of curing conditions and curing period on the titration results were investigated. 35 DSM columns with different construction parameters were installed in the test section, and cement content and unconfined compression tests of field core samples were conducted. The relationship between the unconfined compressive strength (UCS) and cement content of DSM columns was formulated, and the quality of DSM columns with different construction parameters was assessed. The test results suggested that the failure strength of the field cores was approximately 15–55% lower than that of laboratory samples with the same cement content. In single columns, the coefficient of variation (CV) of cement content had a negative correlation with the average failure strength and a positive correlation with the coefficient of variation of failure strength. Bidirectional mixing method, lower penetration and withdrawal velocity, more mixing blades and larger number of mixings could improve the uniformity of the DSM columns.
Keywords	Medicine ; R ; Science ; Q
Subject code	690
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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