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Article ; Online: Mapping the subcortical connectome using in vivo diffusion MRI: Feasibility and reliability.

Kai, Jason / Khan, Ali R / Haast, Roy Am / Lau, Jonathan C

2022 Volume 262, Page(s) 119553

Abstract: Tractography combined with regions of interest (ROIs) has been used to non-invasively study the structural connectivity of the cortex as well as to assess the reliability of these connections. However, the subcortical connectome (subcortex to subcortex) ... ...

Abstract	Tractography combined with regions of interest (ROIs) has been used to non-invasively study the structural connectivity of the cortex as well as to assess the reliability of these connections. However, the subcortical connectome (subcortex to subcortex) has not been comprehensively examined, in part due to the difficulty of performing tractography in this complex and compact region. In this study, we performed an in vivo investigation using tractography to assess the feasibility and reliability of mapping known connections between structures of the subcortex using the test-retest dataset from the Human Connectome Project (HCP). We further validated our observations using a separate unrelated subjects dataset from the HCP. Quantitative assessment was performed by computing tract densities and spatial overlap of identified connections between subcortical ROIs. Further, known connections between structures of the basal ganglia and thalamus were identified and visually inspected, comparing tractography reconstructed trajectories with descriptions from tract-tracing studies. Our observations demonstrate both the feasibility and reliability of using a data-driven tractography-based approach to map the subcortical connectome in vivo.
MeSH term(s)	Cerebral Cortex ; Connectome ; Diffusion Magnetic Resonance Imaging ; Feasibility Studies ; Humans ; Reproducibility of Results
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2022.119553
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Article: Adoption and Utilization of Social Media Among Adult and Pediatric Infectious Diseases Divisions and Fellowship Programs in the United States.

Ryder, Jonathan H / Mowrer, Clayton / Van Roy, Zachary / Lyden, Elizabeth / Cawcutt, Kelly A / Marcelin, Jasmine R

Open forum infectious diseases

2023 Volume 10, Issue 3, Page(s) ofad065

Abstract: Background: Social media (SoMe) is ubiquitous, but its adoption and utilization by infectious diseases (ID) divisions are poorly characterized in the United States.: Methods: A systematic search of US ID fellowship/division Twitter, Facebook, and ... ...

Abstract	Background: Social media (SoMe) is ubiquitous, but its adoption and utilization by infectious diseases (ID) divisions are poorly characterized in the United States. Methods: A systematic search of US ID fellowship/division Twitter, Facebook, and Instagram accounts occurred in November-December 2021. Social media account and program characteristics, post frequency and content, and other measures of SoMe adoption and utilization were recorded and compared between adult and pediatric programs. Posts were thematically categorized as social, promotional, educational, recruitment, or other. Results: Of 222 ID programs identified, 158 (71.2%) were adult and 64 (28.8%) pediatric. Seventy (31.5%) Twitter, 14 (6.3%) Facebook, and 14 (6.3%) Instagram accounts were identified from US programs. Twitter accounts were associated with larger programs and higher match rates. More adult than pediatric programs had Twitter accounts (37.3% vs 17.2%, Conclusions: Social media remains underutilized across ID divisions, but COVID-19 and virtual recruiting may have influenced recent account creation. Twitter was the most frequently used ID program SoMe platform. Social media may benefit ID programs in recruitment and amplification of their trainees, faculty, and specialty.
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad065
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Article ; Online: Adjuvanted nanoliposomes displaying six hemagglutinins and neuraminidases as an influenza virus vaccine.

Sia, Zachary R / Roy, Jayishnu / Huang, Wei-Chiao / Song, Yiting / Zhou, Shiqi / Luo, Yuan / Li, Qinzhe / Arpin, Dominic / Kutscher, Hilliard L / Ortega, Joaquin / Davidson, Bruce A / Lovell, Jonathan F

Cell reports. Medicine

2024 Volume 5, Issue 3, Page(s) 101433

Abstract: Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, ... ...

Abstract	Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, H1N1, H3N2, and type B, are surface displayed on nanoliposomes co-loaded with immunostimulatory adjuvants, generating "hexaplex" particles that are used to immunize mice. Protective immune responses to hexaplex liposomes involve functional antibody elicitation against each included antigen, comparable to vaccination with monovalent antigen particles. When compared to contemporary recombinant or adjuvanted influenza virus vaccines, hexaplex liposomes perform favorably in many areas, including antibody production, T cell activation, protection from lethal virus challenge, and protection following passive sera transfer. Based on these results, hexaplex liposomes warrant further investigation as an adjuvanted recombinant influenza vaccine formulation.
MeSH term(s)	Mice ; Animals ; Humans ; Influenza Vaccines ; Hemagglutinins ; Neuraminidase/genetics ; Orthomyxoviridae Infections ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Liposomes ; Influenza, Human ; Adjuvants, Immunologic ; Vaccines, Synthetic
Chemical Substances	Influenza Vaccines ; Hemagglutinins ; Neuraminidase (EC 3.2.1.18) ; Liposomes ; Adjuvants, Immunologic ; Vaccines, Synthetic
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2024.101433
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Article ; Online: Intracardiac vs Transesophageal Echocardiography for Left Atrial Appendage Occlusion With Watchman FLX in the U.S.

Ferro, Enrico G / Alkhouli, Mohamad / Nair, Devi G / Kapadia, Samir R / Hsu, Jonathan C / Gibson, Douglas N / Freeman, James V / Price, Matthew J / Roy, Kristine / Allocco, Dominic J / Yeh, Robert W / Piccini, Jonathan P

JACC. Clinical electrophysiology

2023 Volume 9, Issue 12, Page(s) 2587–2599

Abstract: Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac ... ...

Abstract	Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) is an emerging imaging modality. Objectives: This study compared outcomes after ICE- and TEE-guided Watchman FLX implantation in the SURPASS (SURveillance Post Approval AnalySiS Plan) nationwide LAAO registry. Methods: Baseline characteristics were compared using chi-square and t-tests. Outcomes were reported in unadjusted and adjusted comparisons via propensity weighting. Results: Between August 2020 and September 2021, LAAO was attempted in 39,759 patients at 698 sites, including 2,272 cases (5.7%) with ICE and 31,835 (80.0%) with TEE. ICE and TEE patients had similar baseline characteristics and mean procedural times (ICE 82 minutes vs TEE 78 minutes). ICE patients were less likely to receive general anesthesia (54% vs 98%, P < 0.01). Successful device implantation (98.3% vs 97.6%) and complete seal rates at 45 days were similar (n = 25,280; 83% vs 82%). Most adverse event rates were similar; unadjusted mortality rates at 45 days were 1.1% for ICE vs 0.8% for TEE (P = 0.14), and 1.0% vs 0.7% (P = 0.27) in adjusted analyses. Even after adjustment, pericardial effusion rates requiring intervention were significantly higher with ICE at 45 days (1.0% vs 0.5%; P = 0.02). This rate decreased as operators performed more ICE-guided procedures, although 82% of operators had performed <10 ICE-guided procedures overall. Conclusions: In the largest comparison to date, ICE use was infrequent. ICE and TEE both achieved high rates of complete LAAO. ICE was associated with significantly higher rates of pericardial effusion requiring intervention.
MeSH term(s)	Humans ; Echocardiography, Transesophageal ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Pericardial Effusion/etiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Cardiac Catheterization/methods
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.08.004
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Article ; Online: The relationship between sleep, perfectionistic strivings, perfectionistic concerns, and academic and sports performance in young athletes.

Roy, Jonathan / Godin, Roxanne / Gaudreault, Pascale / Forest, Geneviève

Chronobiology international

2023 Volume 40, Issue 11, Page(s) 1500–1514

Abstract: Perfectionism is associated with sleep as well as with academic and sports performance. Given the importance of sleep for performance and the sleep changes that occur during adolescence, the present study aimed to explore the relationship between sleep, ... ...

Abstract	Perfectionism is associated with sleep as well as with academic and sports performance. Given the importance of sleep for performance and the sleep changes that occur during adolescence, the present study aimed to explore the relationship between sleep, two dimensions of perfectionism (perfectionistic strivings and perfectionistic concerns), with academic and sports performance in young athletes. The occurrence of perfectionistic strivings was identified as a tendency to set high personal standards for oneself, while the occurrence of perfectionistic concerns was identified as a tendency to feel pressure to be perfect and have concerns about imperfections. A total of 32 athletes aged 13 to 16 years old participated in this study. Perfectionism, sleep, and course grades were measured at the end of the school year. Sleep was measured by actigraphy, and sports performance improvement was obtained by comparing individual performance at the beginning and the end of the school year. The moderating effect of both dimensions of perfectionism on the relationships between sleep and academic and sports performance improvement was measured. First, results showed no significant relationship between sleep and academic/sports performance. Further analyses revealed that perfectionistic strivings moderated the relationship between certain aspects of sleep with academic and sports performance improvement. Delayed and suboptimal sleep habits were associated with lower academic and sports performance improvement when low levels of perfectionistic strivings were present. Results with perfectionistic concerns showed that this dimension did not moderate the relationship between sleep and academic and sports performance improvement. This study supports the notion that high levels of perfectionistic strivings in young athletes may mitigate the adverse effects of poor sleep habits in young athletes.
MeSH term(s)	Adolescent ; Humans ; Perfectionism ; Circadian Rhythm ; Athletes ; Athletic Performance ; Sleep
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2023.2273828
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Article: Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients.

Guda, Poornachander R / Sharma, Anu / Anthony, Adam J / ElMasry, Mohamed S / Couse, Andrew D / Ghatak, Piya Das / Das, Amitava / Timsina, Lava / Trinidad, Jonathan C / Roy, Sashwati / Clemmer, David E / Sen, Chandan K / Ghatak, Subhadip

Nano today

2023 Volume 52

Abstract: Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell ... ...

Abstract	Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in paracrine signaling for successful cell-cell crosstalk
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2224882-1
ISSN	1878-044X ; 1748-0132
ISSN (online)	1878-044X
ISSN	1748-0132
DOI	10.1016/j.nantod.2023.101954
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Article ; Online: Draft Whole-Genome Sequences of 10

Gray, Katie / Green, Luke R / Chaudhuri, Roy R / Shaw, Jonathan G

Microbiology resource announcements

2019 Volume 8, Issue 30

Abstract: ... ...

Abstract	Aeromonas
Language	English
Publishing date	2019-07-25
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00170-19
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Article ; Online: Metal and Organic Templates Together Control the Size of Covalent Macrocycles and Cages.

Lavendomme, Roy / Ronson, Tanya K / Nitschke, Jonathan R

Journal of the American Chemical Society

2019 Volume 141, Issue 30, Page(s) 12147–12158

Abstract: Covalent macrocycles and three-dimensional cages were prepared by the self-assembly of di- or tritopic anilines and 2,6-diformylpyridine subcomponents around palladium(II) templates. The resulting 2,6-bis(imino)pyridyl- ... ...

Abstract	Covalent macrocycles and three-dimensional cages were prepared by the self-assembly of di- or tritopic anilines and 2,6-diformylpyridine subcomponents around palladium(II) templates. The resulting 2,6-bis(imino)pyridyl-Pd
Language	English
Publishing date	2019-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b06182
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Article ; Online: A Zn

Lu, Zhenpin / Lavendomme, Roy / Burghaus, Olaf / Nitschke, Jonathan R

Angewandte Chemie (International ed. in English)

2019 Volume 58, Issue 27, Page(s) 9073–9077

Abstract: A redox-switchable self-assembled ... ...

Abstract	A redox-switchable self-assembled Zn
Language	English
Publishing date	2019-05-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201903286
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Article ; Online: High-Grade, Nonsarcomatoid Chromophobe Renal Cell Carcinoma: A Series of 22 Cases With Novel Molecular Features on a Subset.

Baraban, Ezra G / Elias, Roy / Lin, Ming-Tseh / Ged, Yasser / Zhu, Jing / Pallavajjala, Aparna / Singla, Nirmish / Lotan, Tamara L / Argani, Pedram / Eshleman, James R / Epstein, Jonathan I

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2024 Volume 37, Issue 5, Page(s) 100472

Abstract: Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of renal cell carcinoma and typically exhibits indolent behavior, though a rare subset can exhibit high-grade morphologic features and is associated with a poor prognosis. Although ...

Abstract	Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of renal cell carcinoma and typically exhibits indolent behavior, though a rare subset can exhibit high-grade morphologic features and is associated with a poor prognosis. Although there are limited data on the molecular characteristics of metastatic and sarcomatoid ChRCC, the molecular features of high-grade, nonsarcomatoid ChRCC remain unexplored. Herein, we characterize 22 cases of ChRCC with high-grade, nonsarcomatoid components. High-grade ChRCC frequently demonstrated advanced stage at diagnosis (64% ≥pT3a or N1), with regions of extrarenal extension, nodal metastases, and vascular invasion consisting solely of high-grade ChRCC morphologically. We performed spatially guided panel-based DNA sequencing on 11 cases comparing high-grade and low-grade regions (n = 22 samples). We identified recurring somatic alterations emblematic of ChRCC, including deletions of chromosomes 1, 2, 6, 10, 13, 17, and 21 in 91% (10/11) of cases and recurring mutations in TP53 (81.8%, n = 9/11) and PTEN (36.4%, n = 4/11). Notably, although PTEN and TP53 alterations were found in both high-grade and low-grade regions, private mutations were identified in 3 cases, indicating convergent evolution. Finally, we identified recurring RB1 mutations in 27% (n = 3) of high-grade regions leading to selective protein loss by immunohistochemistry not observed in adjacent low-grade regions. This finding was confirmed in The Cancer Genome Atlas cohort where 2 of 66 cases contained RB1 mutations and demonstrated unequivocal high-grade, nonsarcomatoid morphology. We also detected multiple chromosomal gains confined to the high-grade regions, consistent with imbalanced chromosome duplication. These findings broaden our understanding of the molecular pathogenesis of ChRCC and suggest that subclonal RB1 mutations can drive the evolution to high-grade, nonsarcomatoid ChRCC.
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2024.100472
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