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Article ; Online: Effects of Estrogens on Osteoimmunology: A Role in Bone Metastasis.

Marie, Julien C / Bonnelye, Edith

2022 Volume 13, Page(s) 899104

Abstract: Bone loss associated with estrogen deficiency indicates a fundamental role of these hormones in skeletal growth and bone remodeling. In the last decades, growing recent evidence demonstrated that estrogens can also affect the immune compartment of the ... ...

Abstract	Bone loss associated with estrogen deficiency indicates a fundamental role of these hormones in skeletal growth and bone remodeling. In the last decades, growing recent evidence demonstrated that estrogens can also affect the immune compartment of the bone. In this review, we summarize the impacts of estrogens on bone immune cells and their consequences on bone homeostasis, metastasis settlement into the bone and tumor progression. We also addressed the role of an orphan nuclear receptor ERRalpha ("Estrogen-receptor Related Receptor alpha") on macrophages and T lymphocytes, and as an immunomodulator in bone metastases. Hence, this review links estrogens to bone immune cells in osteo-oncology.
MeSH term(s)	Bone Neoplasms ; Bone Remodeling ; Bone and Bones ; Estrogens ; Humans ; Immunologic Factors
Chemical Substances	Estrogens ; Immunologic Factors
Language	English
Publishing date	2022-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.899104
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Article ; Online: Deformation Behavior and Seismic Characteristics of Sandy Facies Opalinus Clay During Triaxial Deformation Under Dry and Wet Conditions

Schuster, V. / Rybacki, E. / Bonnelye, A. / Dresen, G.

Rock Mechanics and Rock Engineering

2024

Abstract: ... in an anisotropic stress field, e.g., adjacent to fault zones or tunnel excavations. Changes in elastic anisotropy ...

Abstract	Unconsolidated, undrained triaxial deformation tests were performed on sandy facies Opalinus Clay at 50 MPa confining pressure to characterize the effect of water and microfabric orientation on the deformation behavior, mechanical properties, and P-wave velocity evolution. Dry and wet (≈ 8 and > 95% initial water saturation, respectively) samples with 12.6 ± 0.4 vol% porosity were deformed parallel and perpendicular to the bedding direction at a constant strain rate of 5 × 10–6 s−1. Dry samples revealed semi-brittle behavior and exhibited strain localization at failure, while deformation was more ductile at saturated conditions, promoting stable, slow faulting. Peak strength, Young’s modulus, and number of cumulative acoustic emissions decreased significantly for wet samples compared to dry samples; the opposite was observed for Poisson’s ratio. P-wave velocity anisotropy was significantly altered by differential stress, primarily due to the interplay between pore and fracture closure and stress-induced microcrack formation. For samples that were deformed perpendicular to bedding, we observed a reduction and reversal of P-wave velocity anisotropy with increasing differential stress, whereas anisotropy of parallel samples increased. The results suggest that water saturation reduces the pressure at the brittle-ductile transition and that the elastic properties and anisotropy of sandy facies Opalinus Clay can be significantly altered in an anisotropic stress field, e.g., adjacent to fault zones or tunnel excavations. Changes in elastic anisotropy are primarily controlled by the orientation between the pre-existing microfabric and the maximum principal stress direction, stress magnitude, and the degree of water saturation.
Subject code	669
Publishing country	de
Document type	Article ; Online
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Article ; Online: Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes.

Bonnelye, Edith / Reboul, Pascal / Duval, Nicolas / Cardelli, Marco / Aubin, Jane E

Arthritis and rheumatism

2011 Volume 63, Issue 8, Page(s) 2374–2384

Abstract: ... regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and ...

Abstract	Objective: We reported previously that the orphan nuclear receptor, estrogen receptor-related receptor α (ERRα), is expressed in articular chondrocytes and is dysregulated in a mouse model of inflammatory arthritis. The aim of this study, therefore, was to determine whether ERRα is also dysregulated in patients with osteoarthritis (OA). Methods: ERRα messenger RNA (mRNA) and protein were quantified in normal and OA cartilage samples and in OA chondrocytes in vitro, with and without short-term treatment with a variety of OA-associated factors and signaling pathway agonists and inhibitors. Results: ERRα expression was lower in OA than in normal articular cartilage. Interleukin-1β (IL-1β) markedly up-regulated ERRα expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720). Treatment with the ERRα inverse agonist XCT790 decreased the expression of SOX9 and the up-regulation of ERRα by IL-1β, suggesting autoregulation of ERRα in the IL-1β pathway. Matrix metalloproteinase 13 (MMP-13) expression was also decreased by treatment with XCT790 plus IL-1β versus IL-1β alone, and the down-regulation of MMP-13 mRNA and protein observed with XCT790 alone suggests that the up-regulation of MMP-13 by IL-1β is ERRα-dependent. Conclusion: We report the first evidence that ERRα expression is regulated by IL-1β in COX-2-, cAMP-, and PKA-dependent pathways in OA chondrocytes. We confirmed that SOX9 is an ERRα target gene in human, as in rodent, chondrocytes and identified MMP-13 as a potential new target gene, which suggests that ERRα may both respond to the healing signal and contribute to extracellular degradation in OA cartilage.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cartilage, Articular/metabolism ; Cells, Cultured ; Chondrocytes/metabolism ; Cyclic AMP/genetics ; Cyclic AMP/metabolism ; Female ; Humans ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Male ; Middle Aged ; Osteoarthritis/genetics ; Osteoarthritis/metabolism ; Prostaglandins E/genetics ; Prostaglandins E/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Signal Transduction/physiology ; ERRalpha Estrogen-Related Receptor
Chemical Substances	Interleukin-1beta ; Prostaglandins E ; RNA, Messenger ; Receptors, Estrogen ; SOX9 Transcription Factor ; SOX9 protein, human ; Cyclic AMP (E0399OZS9N)
Language	English
Publishing date	2011-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.30398
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Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Targeting Bone Metastasis in Cancers.

Bonnelye, Edith / Juárez, Patricia

Cancers

2021 Volume 13, Issue 17

Abstract: This Special Issue ... ...

Abstract	This Special Issue of
Language	English
Publishing date	2021-09-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13174490
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Article ; Online: Long-term benefits of a therapeutic make-up consultation for patients with various facial dermatoses.

Bonnelye, Julia / Lancien, Ugo / Poinas, Alexandra / Vibet, Marie-Anne / Dreno, Brigitte

European journal of dermatology : EJD

2023 Volume 33, Issue 4, Page(s) 419–425

Abstract: ... of therapeutic make-up on patients' quality of life persists in the longer term, i.e., after one year ...

Abstract	Background: Therapeutic make-up has previously been proven to be efficacious in improving the quality of life of patients with facial dermatoses, but its efficacy has only been assessed in the short term (less than one month). Objectives: This study aimed to determine whether the effect of therapeutic make-up on patients' quality of life persists in the longer term, i.e., after one year. Materials & methods: This study included 53 patients who benefited from a therapeutic make-up consultation in the context of various facial dermatoses (pigmentation disorders, scars, acne, rosacea, eczema, adverse events of chemotherapy, etc.). Patients were asked to complete a quality-of-life questionnaire to obtain the Skindex score at baseline, and one month (M1) and one year (M12) after the first consultation. The difference in scores between baseline and M12 was calculated and Student's t-test was used to assess the significance of the values. Results: Our results showed a significant difference (p<0.001) with an improvement in quality-of-life score by more than 10% between baseline and M12, for all the dimensions of the score (Emotion, Symptoms and Functioning). Based on the subgroup analysis, this score particularly improved for patients suffering with acne or rosacea (p=0.009) and scars (p=0.43), as well as for younger patients (<30 years old) (p=0.009). Conclusion: This is the first study to demonstrate a persistent long-term effect of therapeutic make-up on the quality of life of patients with facial dermatoses.
MeSH term(s)	Humans ; Adult ; Cicatrix/pathology ; Quality of Life ; Acne Vulgaris/drug therapy ; Rosacea/drug therapy ; Facial Dermatoses/drug therapy
Language	English
Publishing date	2023-10-12
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2023.4534
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Zs.A 3484: Show issues

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Article ; Online: Authors’ Reply to the Discussion by Crisci et al. on “Experimental Deformation of Opalinus Clay at Elevated Temperature and Pressure Conditions Mechanical Properties and the Influence of Rock Fabric”

Schuster, V. / Rybacki, E. / Bonnelye, A. / Dresen, G.

Rock Mechanics and Rock Engineering

2021

Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experimental investigation on static and dynamic bulk moduli of dry and fluid-saturated porous sandstones

Wang, L. / Rybacki, E. / Bonnelye, A. / Bohnhoff, M. / Dresen, G.

Rock Mechanics and Rock Engineering

2021

Abstract: Knowledge of pressure-dependent static and dynamic moduli of porous reservoir rocks is of key importance for evaluating geological setting of a reservoir in geo-energy applications. We examined experimentally the evolution of static and dynamic bulk ... ...

Abstract	Knowledge of pressure-dependent static and dynamic moduli of porous reservoir rocks is of key importance for evaluating geological setting of a reservoir in geo-energy applications. We examined experimentally the evolution of static and dynamic bulk moduli for porous Bentheim sandstone with increasing confining pressure up to about 190 MPa under dry and water-saturated conditions. The static bulk moduli (Ks) were estimated from stress–volumetric strain curves while dynamic bulk moduli (Kd) were derived from the changes in ultrasonic P- and S- wave velocities (~ 1 MHz) along different traces, which were monitored simultaneously during the entire deformation. In conjunction with published data of other porous sandstones (Berea, Navajo and Weber sandstones), our results reveal that the ratio between dynamic and static bulk moduli (Kd/Ks) reduces rapidly from about 1.5 − 2.0 at ambient pressure to about 1.1 at high pressure under dry conditions and from about 2.0 − 4.0 to about 1.5 under water-saturated conditions, respectively. We interpret such a pressure-dependent reduction by closure of narrow (compliant) cracks, highlighting that Kd/Ks is positively correlated with the amount of narrow cracks. Above the crack closure pressure, where equant (stiff) pores dominate the void space, Kd/Ks is almost constant. The enhanced difference between dynamic and static bulk moduli under water saturation compared to dry conditions is possibly caused by high pore pressure that is locally maintained if measured using high-frequency ultrasonic wave velocities. In our experiments, the pressure dependence of dynamic bulk modulus of water-saturated Bentheim sandstone at effective pressures above 5 MPa can be roughly predicted by both the effective medium theory (Mori–Tanaka scheme) and the squirt-flow model. Static bulk moduli are found to be more sensitive to narrow cracks than dynamic bulk moduli for porous sandstones under dry and water-saturated conditions.
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Strain Partitioning and Frictional Behavior of Opalinus Clay During Fault Reactivation

Schuster, V. / Rybacki, E. / Bonnelye, A. / Kwiatek, G. / Schleicher, A. / Dresen, G.

Rock Mechanics and Rock Engineering

2022

Abstract: The Opalinus Clay (OPA) formation is considered a suitable host rock candidate for nuclear waste storage. However, the sealing integrity and long-term safety of OPA are potentially compromised by pre-existing natural or artificially induced faults. ... ...

Abstract	The Opalinus Clay (OPA) formation is considered a suitable host rock candidate for nuclear waste storage. However, the sealing integrity and long-term safety of OPA are potentially compromised by pre-existing natural or artificially induced faults. Therefore, characterizing the mechanical behavior and microscale deformation mechanisms of faults and the surrounding rock is relevant for predicting repository damage evolution. In this study, we performed triaxial tests using saw-cut samples of the shaly and sandy facies of OPA to investigate the influence of pressure and mineral composition on the deformation behavior during fault reactivation. Dried samples were hydrostatically pre-compacted at 50 MPa and then deformed at constant strain rate, drained conditions and confining pressures (pc) of 5–35 MPa. Mechanical data from triaxial tests was complemented by local strain measurements to determine the relative contribution of bulk deformation and fault slip, as well as by acoustic emission (AE) monitoring, and elastic P-wave velocity measurements using ultrasonic transmissions. With increasing pc, we observe a transition from brittle deformation behavior with highly localized fault slip to semi-brittle behavior characterized by non-linear strain hardening with increasing delocalization of deformation. We find that brittle localization behavior is limited by pc at which fault strength exceeds matrix yield strength. AEs were only detected in tests performed on sandy facies samples, and activity decreased with increasing pc. Microstructural analysis of deformed samples revealed a positive correlation between increasing pc and gouge layer thickness. This goes along with a change from brittle fragmentation and frictional sliding to the development of shear zones with a higher contribution of cataclastic and granular flow. Friction coefficient at fault reactivation is only slightly higher for the sandy (µ ~ 0.48) compared to the shaly facies (µ ~ 0.4). Slide-hold-slide tests performed after ~ 6 mm axial shortening ...
Subject code	669
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An energetic orphan in an endocrine tissue: a revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage.

Bonnelye, Edith / Aubin, Jane E

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2013 Volume 28, Issue 2, Page(s) 225–233

Abstract: Estrogen receptor-related receptor alpha (ERRα) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERα/β, but it does not bind estrogen. ERRα not only plays a functional role in osteoblasts but also in osteoclasts and ... ...

Abstract	Estrogen receptor-related receptor alpha (ERRα) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERα/β, but it does not bind estrogen. ERRα not only plays a functional role in osteoblasts but also in osteoclasts and chondrocytes. In addition, the ERRs, including ERRα, can be activated by coactivators such as peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC1α and β) and are implicated in adipogenesis, fatty acid oxidation, and oxidative stress defense, suggesting that ERRα-through its activity in bone resorption and adipogenesis--may regulate the insulin and leptin pathways and contribute to aging-related changes in bone and cartilage. In this review, we discuss data on ERRα and its cellular and molecular modes of action, which have broad implications for considering the potential role of this orphan receptor in cartilage and bone endocrine function, on whole-organism physiology, and in the bone aging process.
MeSH term(s)	Adipogenesis ; Animals ; Bone and Bones/metabolism ; Cartilage/metabolism ; Endocrine System/metabolism ; Glucose/metabolism ; Humans ; Receptors, Estrogen/metabolism ; ERRalpha Estrogen-Related Receptor
Chemical Substances	Receptors, Estrogen ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2013-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.1836
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Article ; Online: Pressure-dependent bulk compressibility of a porous granular material modelled by improved contact mechanics and micromechanical approaches

Wang, L. / Dresen, G. / Rybacki, E. / Bonnelye, A. / Bohnhoff, M.

Acta Materialia

effects of surface roughness of grains

2020

Abstract: ... i.e., Ceff ∝Pe−1/2), but deviates at intermediate pressures. At elevated pressures beyond full contact ...

Abstract	The change of the mechanical properties of granular materials with pressure is an important topic associated with many industrial applications. In this paper we investigate the influence of hydrostatic pressure (Pe) on the effective bulk compressibility (Ceff) of a granular material by applying two modified theoretical approaches that are based on contact mechanics and micromechanics, respectively. For a granular material composed of rough grains, an extended contact model is developed to elucidate the effect of roughness of grain surfaces on bulk compressibility. At relatively low pressures, the model predicts that the decrease of bulk compressibility with pressure may be described by a power law with an exponent of -1/2 (i.e., Ceff ∝Pe−1/2), but deviates at intermediate pressures. At elevated pressures beyond full contact, bulk compressibility remains almost unchanged, which may be roughly evaluated by continuum contact mechanics. As an alternative explanation of pressure-dependent bulk compressibility, we suggest a micromechanical model that accounts for effects of different types of pore space present in granular materials. Narrow and compliant inter-granular cracks are approximated by three-dimensional oblate spheroidal cracks with rough surfaces, whereas the equant and stiff pores surrounded by three and four neighboring grains are modeled as tubular pores with cross sections of three and four cusp-like corners, respectively. In this model, bulk compressibility is strongly reduced with increasing pressure by progressive closure of rough-walled cracks. At pressures exceeding crack closure pressure, deformation of the remaining equant pores is largely insensitive to pressure, with almost no further change in bulk compressibility. To validate these models, we performed hydrostatic compression tests on Bentheim sandstone (a granular rock consisting of quartz with high porosity) under a wide range of pressure. The relation between observed microstructures and measured pressure-dependent bulk compressibility is well explained by both suggested models.
Subject code	660
Publishing country	de
Document type	Article ; Online
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