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Article ; Online: El refuerzo de la naturaleza reglamentaria de los instrumentos de ordenación urbanística bajo la perspectiva del Desarrollo Urbano Sostenible e Integrado

Álvaro Cerezo Ibarrondo

Revista de Estudios de la Administración Local y Autonómica, Iss prepublicación (2023)

2023

Abstract: Adicionalmente a las distintas posiciones de la doctrina y al criterio jurisprudencial sobre la naturaleza reglamentaria de los instrumentos de ordenación urbanística, la incorporación a los mismos del principio del Desarrollo Urbano Sostenible e ... ...

Abstract	Adicionalmente a las distintas posiciones de la doctrina y al criterio jurisprudencial sobre la naturaleza reglamentaria de los instrumentos de ordenación urbanística, la incorporación a los mismos del principio del Desarrollo Urbano Sostenible e Integrado (DUSI) hace necesario reevaluar dicha naturaleza, permite ampliar la justificación del concepto y constatar la proporcionalidad de la declaración de nulidad de pleno derecho cuando las nuevas determinaciones, contenidos y exigencias legales no se cumplen
Keywords	Instrumento ; reglamento ; urbanístico ; nulidad ; DUSI ; Political science ; J ; Political institutions and public administration (General) ; JF20-2112
Language	Spanish
Publishing date	2023-02-01T00:00:00Z
Publisher	Instituto Nacional de Administración Pública (INAP)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19 (vol 383, pg 1085, 2020)

Ibarrondo, F. J.

New England Journal of Medicine

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #838447
Database	COVID19

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Article ; Online: Using Age-Specific Rates for Parametric Survival Function Estimation in Simulation Models.

Arrospide, Arantzazu / Ibarrondo, Oliver / Blasco-Aguado, Rubén / Larrañaga, Igor / Alarid-Escudero, Fernando / Mar, Javier

Medical decision making : an international journal of the Society for Medical Decision Making

2024 , Page(s) 272989X241232967

Abstract: Purpose: To describe a procedure for incorporating parametric functions into individual-level simulation models to sample time to event when age-specific rates are available but not the individual data.: Methods: Using age-specific event rates, ... ...

Abstract	Purpose: To describe a procedure for incorporating parametric functions into individual-level simulation models to sample time to event when age-specific rates are available but not the individual data. Methods: Using age-specific event rates, regression analysis was used to parametrize parametric survival distributions (Weibull, Gompertz, log-normal, and log-logistic), select the best fit using the Results: The 3 selected survival functions (Gompertz, Weibull, and log-normal) had a good fit to the data up to 85 y of age. We selected Gompertz distribution as the best-fitting distribution due to its goodness of fit. Conclusions: Our work provides a simple procedure for incorporating parametric risk functions into simulation models without individual-level data. Highlights: We describe the procedure for sampling times to event for individual-level simulation models as a function of age from parametric survival functions when age-specific rates are available but not the individual dataWe used linear regression to estimate age-specific hazard functions, obtaining estimates of parameter uncertainty.Our approach allows incorporating parameter (second-order) uncertainty in individual-level simulation models needed for probabilistic sensitivity analysis in the absence of individual-level survival data.
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	604497-9
ISSN	1552-681X ; 0272-989X
ISSN (online)	1552-681X
ISSN	0272-989X
DOI	10.1177/0272989X241232967
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Article ; Online: Comorbidity and household income as mediators of gender inequalities in dementia risk: a real-world data population study.

Zubiagirre, Uxue / Ibarrondo, Oliver / Larrañaga, Igor / Soto-Gordoa, Myriam / Mar-Barrutia, Lorea / Mar, Javier

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 209

Abstract: Background: Low household income (HI), comorbidities and female sex are associated with an increased risk of dementia. The aim of this study was to measure the mediating effect of comorbidity and HI on the excess risk due to gender in relation to the ... ...

Abstract	Background: Low household income (HI), comorbidities and female sex are associated with an increased risk of dementia. The aim of this study was to measure the mediating effect of comorbidity and HI on the excess risk due to gender in relation to the incidence and prevalence of dementia in the general population. Methods: A retrospective and observational study using real-world data analysed all people over 60 who were registered with the Basque Health Service in Gipuzkoa. The study measured HI level, the Charlson comorbidity index (CCI), age and sex. The prevalence and incidence of dementia were analysed using logistic regression and Poisson regression models, respectively, adjusted by HI, sex, comorbidity and age. We estimated the combined mediation effect of HI and comorbidity on the prevalence of dementia associated with gender. Results: Of the 221,777 individuals, 3.85% (8,549) had a diagnosis of dementia as of 31 December 2021. Classification by the CCI showed a gradient with 2.90% in CCI 0-1, 10.60% in CCI 2-3 and 18.01% in CCI > 3. Both low HI and gender were associated with a higher crude prevalence of dementia. However, in the CCI-adjusted model, women had an increased risk of dementia, while HI was no longer statistically significant. The incidence analysis produced similar results, although HI was not significant in any model. The CCI was significantly higher for men and for people with low HI. The mediation was statistically significant, and the CCI and HI explained 79% of the gender effect. Conclusions: Comorbidity and low HI act as mediators in the increased risk of dementia associated with female sex. Given the difference in the prevalence of comorbidities by HI, individual interventions to control comorbidities could not only prevent dementia but also reduce inequalities, as the risk is greater in the most disadvantaged population.
MeSH term(s)	Male ; Humans ; Female ; Retrospective Studies ; Gender Equity ; Comorbidity ; Research Design ; Dementia/diagnosis ; Dementia/epidemiology
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04770-3
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Article: Excess healthcare costs of mental disorders in children, adolescents and young adults in the Basque population registry adjusted for socioeconomic status and sex.

Larrañaga, Igor / Ibarrondo, Oliver / Mar-Barrutia, Lorea / Soto-Gordoa, Myriam / Mar, Javier

Cost effectiveness and resource allocation : C/E

2023 Volume 21, Issue 1, Page(s) 18

Abstract: Background: Mental illnesses account for a considerable proportion of the global burden of disease. Economic evaluation of public policies and interventions aimed at mental health is crucial to inform decisions and improve the provision of healthcare ... ...

Abstract	Background: Mental illnesses account for a considerable proportion of the global burden of disease. Economic evaluation of public policies and interventions aimed at mental health is crucial to inform decisions and improve the provision of healthcare services, but experts highlight that nowadays the cost implications of mental illness are not properly quantified. The objective was to measure the costs of excess use of all healthcare services by 1- to 30-year-olds in the Basque population as a function of whether or not they had a mental disorder diagnosis. Methods: A real-world data study was used to identify diagnoses of mental disorders and to measure resource use in the Basque Health Service Registry in 2018. Diagnoses were aggregated into eight diagnostic clusters: anxiety, attention deficit hyperactivity disorder, conduct disorders, mood disorders, substance use, psychosis and personality disorders, eating disorders, and self-harm. We calculated the costs incurred by each individual by multiplying the resource use by the unit costs. Annual costs for each cluster were compared with those for individuals with no diagnosed mental disorders through entropy balancing and two-part models which adjusted for socioeconomic status (SES). Results: Of the 609,381 individuals included, 96,671 (15.9%) had ≥ 1 mental disorder diagnosis. The annual cost per person was two-fold higher in the group diagnosed with mental disorders (€699.7) than that with no diagnoses (€274.6). For all clusters, annual excess costs associated with mental disorders were significant. The adjustment also evidenced a social gradient in healthcare costs, individuals with lower SES consuming more resources than those with medium and higher SES across all clusters. Nonetheless, the effect of being diagnosed with a mental disorder had a greater impact on the mean and excess costs than SES. Conclusions: Results were consistent in showing that young people with mental disorders place a greater burden on healthcare services. Excess costs were higher for severe mental disorders like self-harm and psychoses, and lower SES individuals incurred, overall, more than twice the costs per person with no diagnoses. A socioeconomic gradient was notable, excess costs being higher in low SES individuals than those with a high-to-medium SES. Differences by sex were also statistically significant but their sizes were smaller than those related to SES.
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2119372-1
ISSN	1478-7547
ISSN	1478-7547
DOI	10.1186/s12962-023-00428-w
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Article ; Online: Health-related quality of life in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis treated with certolizumab pegol.

Sarobe, Maite / Arrondo, Amaya / Ibarrondo, Oliver / Mar, Javier

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

2021 Volume 46, Issue 1, Page(s) 27–30

Abstract: Objective: Inflammatory joint diseases cause pain and disability. The objective of this study was to measure the quality of life of patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis treated with certolizumab pegol and ... ...

Title translation	Calidad de vida relacionada con la salud en pacientes con artritis reumatoide, artritis psoriásica y espondilitis anquilosante tratados con certolizumab pegol.
Abstract	Objective: Inflammatory joint diseases cause pain and disability. The objective of this study was to measure the quality of life of patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis treated with certolizumab pegol and compare the results with those of the general population. Method: Using a cross-sectional design and sociodemographic and clinical variables, adherence to treatment and quality of life data were collected using the Euroqol-5d-5L (EQ-5D) questionnaire. The quality of life of the general population was obtained from the Spanish National Health Survey. Answers to the EQ-5D questionnaire were analyzed in both groups using two-part models, which measure the probability of having perfect health as well as the disutility caused by the disease. Results: The sample included 59 patients with high adherence (92.3%). The mean utility value was 0.78 and pain was the most affected dimen sion. The reduction in utility (EQ-5D index) of patients with inflammatory joint disease as compared to the general population was 0.127. Conclusions: The subjects of the study showed a significantly lower quality of life than the general population despite effective control of the disease. Two- part models facilitate the interpretation of quality-of-life studies using the EQ- 5D.
MeSH term(s)	Arthritis, Psoriatic/drug therapy ; Certolizumab Pegol/therapeutic use ; Cross-Sectional Studies ; Humans ; Quality of Life ; Spondylitis, Ankylosing/drug therapy
Chemical Substances	Certolizumab Pegol (UMD07X179E)
Language	English
Publishing date	2021-12-11
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1122680-8
ISSN	2171-8695 ; 1130-6343
ISSN (online)	2171-8695
ISSN	1130-6343
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Article ; Online: Development and Validation of a Discrete Event Simulation Model to Evaluate the Cardiovascular Impact of Population Policies for Obesity.

Arrospide, Arantzazu / Ibarrondo, Oliver / Castilla, Iván / Larrañaga, Igor / Mar, Javier

Medical decision making : an international journal of the Society for Medical Decision Making

2021 Volume 42, Issue 2, Page(s) 241–254

Abstract: Introduction: Our aim was to describe the development and validation of an obesity model representing the cardiovascular risks associated with different body mass index (BMI) categories, through simulation, designed to evaluate the epidemiological and ... ...

Abstract	Introduction: Our aim was to describe the development and validation of an obesity model representing the cardiovascular risks associated with different body mass index (BMI) categories, through simulation, designed to evaluate the epidemiological and economic impact of population policies for obesity. Methods: A discrete event simulation model was built in R considering the risk of cardiovascular events (heart failure, stroke, coronary heart disease, and diabetes) associated with BMI categories in the Spanish population. The main parameters included in the model were estimated from Spanish hospital discharge records and the Spanish Health Survey and allowed both first-order and second-order (probabilistic sensitivity analysis) uncertainty to be programmed into the model. The simulation yielded the incidence and prevalence of cardiovascular events as validation outputs. To illustrate the capacity of the model, we estimated the reduction in cardiovascular events and cost-utility (incremental cost/incremental quality-adjusted life-years [QALYs]) of a hypothetical intervention that fully eliminated the cardiovascular risks associated with obesity and overweight. Results: The Validation Status of Health-Economic decision models (AdViSHE) tool was applied. Internal validation plots showed adequate goodness of fit for the Spanish population. External validation was achieved by comparing the simulated and real incidence by age group for stroke, acute myocardial infarction, and heart failure. The intervention reduced the population hazard ratios of stroke, acute myocardial infarction, and heart failure to 0.81, 0.74, and 0.78, respectively, and added 0.74 QALYs to the whole population. Conclusions: This obesity simulation model evidenced good properties for estimating the long-term epidemiological and economic impact of policies to tackle obesity in Spain. The conceptual model could be implemented for other counties using country-specific input data.
MeSH term(s)	Cost-Benefit Analysis ; Humans ; Models, Economic ; Obesity/epidemiology ; Public Policy ; Quality-Adjusted Life Years ; Stroke
Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604497-9
ISSN	1552-681X ; 0272-989X
ISSN (online)	1552-681X
ISSN	0272-989X
DOI	10.1177/0272989X211032964
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Article: Loss of Anti-SARS-CoV-2 Antibodies in Mild Covid-19. Reply

Yang, Otto O / Ibarrondo, F Javier

N Engl J Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #786738
Database	COVID19

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Article ; Online: Budget impact analysis of the use of Souvenaid in patients with prodromal Alzheimer's Disease in Spain.

Mar, Javier / Ibarrondo, Oliver / Larrañaga, Igor / Mar-Barrutia, Lorea / Soto-Gordoa, Myriam

Alzheimer's research & therapy

2022 Volume 14, Issue 1, Page(s) 171

Abstract: Introduction: The effectiveness, safety, and cost-effectiveness of the use of Souvenaid for Alzheimer's disease (AD) have been previously evidenced. To complete the economic analysis, there is a need to assess whether society can afford it. The ... ...

Abstract	Introduction: The effectiveness, safety, and cost-effectiveness of the use of Souvenaid for Alzheimer's disease (AD) have been previously evidenced. To complete the economic analysis, there is a need to assess whether society can afford it. The objective of this study was to carry out a budget impact analysis of the use of Souvenaid in Spain under the conditions of the LipiDidiet clinical trial from a societal perspective. Methods: We built a population model that took into account all the cohorts of individuals with AD, their individual progression, and the potential impact of Souvenaid treatment on their trajectories. Patient progression data were obtained from mixed models. The target population was estimated based on the population forecast for 2020-2035 and the incidence of dementia. Individual progression to dementia measured by the Clinical Dementia Rating-Sum of Boxes was reproduced using mixed models. Besides the costs of treatment and diagnosis, direct costs of medical and non-medical care and indirect costs were included. Results: The epidemiological indicators and the distribution of life expectancy by stages validated the model. From the third year (2022), the differences in the cost of dementia offset the incremental cost of diagnosis and treatment. The costs of dependency reached €500 million/year while those of the intervention were limited to €40 million. Conclusions: Souvenaid, with modest effectiveness in delaying dementia associated with AD, achieved a positive economic balance between costs and savings. Its use in the treatment of prodromal AD would imply an initial cost that would be ongoing, but this would be offset by savings in the care system for dependency associated with dementia from the third year. These results were based on adopting a societal perspective taking into account the effect of treatment on the use of health, social, and family resources.
MeSH term(s)	Humans ; Alzheimer Disease/therapy ; Alzheimer Disease/drug therapy ; Spain/epidemiology ; Mental Status and Dementia Tests ; Cost-Benefit Analysis
Language	English
Publishing date	2022-11-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-022-01111-7
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Article ; Online: Follicular CD8+ T Cells Are Elevated in HIV Infection and Induce PD-L1 on B Cells.

Martínez, Laura E / Ibarrondo, Javier / Guo, Yu / Penichet, Manuel L / Epeldegui, Marta

Journal of immunology (Baltimore, Md. : 1950)

2022 Volume 210, Issue 1, Page(s) 33–39

Abstract: Follicular CD8+CXCR5+ T cells are a specialized CD8+ T cell subset with unique follicular-homing capabilities that have been reported to display effector functions in viral immunity, tumor immunity, and autoimmunity. CD8+CXCR5+ T cells exhibit B cell ... ...

Abstract	Follicular CD8+CXCR5+ T cells are a specialized CD8+ T cell subset with unique follicular-homing capabilities that have been reported to display effector functions in viral immunity, tumor immunity, and autoimmunity. CD8+CXCR5+ T cells exhibit B cell helper functions and express CD40L, ICOS, programmed cell death protein 1 (PD-1), and BCL-6, the transcriptional regulator of CD4+CXCR5+ T follicular helper cells and of germinal center B cells. HIV is known to be sequestered in lymphoid follicles, and CD8+CXCR5+ T cell frequency is a marker for disease severity, given that HIV-infected patients with lower numbers of circulating CD8+CXCR5+ T cells display lower CD4+ T cell counts. Likewise, several groups have reported a direct correlation between the quantity of CD8+CXCR5+ T cells and suppression of HIV viral load. In this study, we observed elevated absolute numbers of CD8+CXCR5+ and CD8+CXCR5+BCL-6+PD-1+ T cells in the blood of HIV-infected participants of the Multicenter AIDS Cohort Study. We further demonstrated in vitro that activated human CD8+CXCR5+ T cells isolated from peripheral blood and tonsil from healthy donors show increased CD40L expression and induce the production of PD ligand 1 (PD-L1)+IgG+ B cells. Moreover, absolute numbers of CD8+CXCR5+ T cells significantly and positively correlated with numbers of PD-L1+ B cells found in blood of HIV-infected individuals. Altogether, these results show that activated CD8+CXCR5+ T cells have the ability to activate B cells and increase the percentage of PD-L1+ and PD-L1+IgG+ B cells, which provides insights into the early events of B cell activation and differentiation and may play a role in disease progression and lymphomagenesis in HIV-infected individuals.
MeSH term(s)	Humans ; Programmed Cell Death 1 Receptor/metabolism ; B7-H1 Antigen/metabolism ; T-Lymphocytes, Helper-Inducer ; HIV Infections ; CD40 Ligand/metabolism ; Cohort Studies ; Ligands ; CD8-Positive T-Lymphocytes ; Immunoglobulin G/metabolism ; Receptors, CXCR5
Chemical Substances	Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; CD40 Ligand (147205-72-9) ; Ligands ; Immunoglobulin G ; Receptors, CXCR5
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2200194
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