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  1. Article ; Online: Letter to the Editor, Re: van der Heijden AG, Mengual L, Lozano JJ, Ingelmo-Torres M, Ribal MJ, Fernández PL, Oosterwijk E, Schalken JA, Alcaraz A, Witjes JA. A five-gene expression signature to predict progression in T1G3 bladder cancer. Eur J Cancer. 2016; 64:127-136.

    Orsola, Anna / Mullane, Stephanie A / Bellmunt, Joaquim

    European journal of cancer (Oxford, England : 1990)

    2016  Volume 68, Page(s) 196–197

    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2016.09.017
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    Zs.A 456: Show issues Location:
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  2. Article ; Online: Adjuvant immunotherapy for muscle-invasive urothelial carcinoma of the bladder.

    Alevizakos, Michail / Bellmunt, Joaquim

    Expert review of anticancer therapy

    2022  Volume 22, Issue 3, Page(s) 259–267

    Abstract: Introduction: There are substantial unmet needs with regards to adjuvant therapy for muscle-invasive urothelial carcinoma (UC) of the bladder, including patients with persistent disease histologically following neoadjuvant platinum-based therapy and ... ...

    Abstract Introduction: There are substantial unmet needs with regards to adjuvant therapy for muscle-invasive urothelial carcinoma (UC) of the bladder, including patients with persistent disease histologically following neoadjuvant platinum-based therapy and radical resection, as well as patients who are not eligible for or refuse cytotoxic chemotherapy. As such, increased interest has been developed in advancing the use of systemic immunotherapy in the postoperative setting.
    Areas covered: We begin by examining current uses of systemic immunotherapy in the treatment of advanced UC. We also review emerging neoadjuvant data and describe current adjuvant approaches. We then report and analyze data on adjuvant immunotherapy, including the recent randomized trials on adjuvant nivolumab and atezolizumab, and conclude with a discussion on the available evidence and likely directions of the field.
    Expert opinion: Systemic immunotherapy can serve to enhance postoperative therapies for muscle-invasive bladder UC, as exemplified by the recent approval of nivolumab. Further research will serve to define optimal immunotherapy timing and combinations with other systemic therapies, as well as identify predictive biomarkers to allow effective tailoring of therapy for each patient.
    MeSH term(s) Carcinoma, Transitional Cell/pathology ; Female ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy ; Male ; Muscles/pathology ; Nivolumab/therapeutic use ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Immunologic Factors ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2038565
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  3. Article ; Online: Re: Martin Swinton, Neethu Billy Graham Mariam, Jean Ling Tan, et al. Bladder-Sparing Treatment with Radical Dose Radiotherapy Is an Effective Alternative to Radical Cystectomy in Patients with Clinically Node-positive Nonmetastatic Bladder Cancer. J Clin Oncol. 2023;41:4406-4415.

    Seisen, Thomas / Rouprêt, Morgan / Trinh, Quoc-Dien / Bellmunt, Joaquim

    European urology

    2023  Volume 85, Issue 1, Page(s) e19–e21

    MeSH term(s) Humans ; Urinary Bladder/pathology ; Cystectomy ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Patients
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.09.028
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    Zs.MO 294: Show issues

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  4. Article ; Online: Management of Advanced Urothelial Carcinoma in Older and Frail Patients: Have Novel Treatment Approaches Improved Their Care?

    Russell, Brian M / Boussi, Leora / Bellmunt, Joaquim

    Drugs & aging

    2022  Volume 39, Issue 4, Page(s) 271–284

    Abstract: Patients with urothelial carcinoma tend to be older and frailer with a large number of chronic medical conditions. This is particularly pronounced in those with unresectable locally advanced and metastatic urothelial carcinoma. Prior to 2016, treatment ... ...

    Abstract Patients with urothelial carcinoma tend to be older and frailer with a large number of chronic medical conditions. This is particularly pronounced in those with unresectable locally advanced and metastatic urothelial carcinoma. Prior to 2016, treatment options in advanced urothelial carcinoma were limited to chemotherapy, and as a result, a large number of patients were not receiving disease-directed management. Over the last 6 years, multiple alternative modalities including immune checkpoint inhibitors and targeted therapies have been introduced. They are being utilized clinically in older and frail patients, but there are limited studies investigating outcomes in these specific populations. Based upon current evidence, age does not impact the efficacy and tolerance of immune checkpoint inhibitors if patients are fit enough to receive therapy. In frailer patients, immune checkpoint inhibitors appear to be safe, but outcomes from largely retrospective studies demonstrate mixed data regarding their efficacy. Although there are indications from clinical trials that enfortumab vedotin, sacituzumab govitecan, and erdafitinib are also efficacious irrespective of age, there is still not enough evidence to draw definitive conclusions about their use in older and frail patients. Regardless, in all older patients with advanced urothelial carcinoma, it is critical to evaluate for frailty through geriatric screening tools and comprehensive assessments. Combining these evaluations with consideration of an individual patient's goals should be the foundation upon which therapeutic decisions are made in this population of patients.
    MeSH term(s) Aged ; Carcinoma, Transitional Cell/drug therapy ; Frail Elderly ; Humans ; Immune Checkpoint Inhibitors ; Retrospective Studies ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-03-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-022-00933-2
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  5. Article ; Online: A Plea for the Use of Video-recorded Cystoscopy for Blinded Independent Central Review of Tumor Response in Open-label Non-muscle invasive Bladder Cancer Trials.

    Basile, Giuseppe / Pradere, Benjamin / Bellmunt, Joaquim / Rouprêt, Morgan / Kamat, Ashish M / Seisen, Thomas

    European urology oncology

    2023  Volume 6, Issue 5, Page(s) 453–455

    Abstract: Given that most of non-muscle invasive bladder cancer trials available in the literature share the same limitation of an open-label design, they are likely prone to detection bias. Indeed, tumor response is currently assessed by unblinded investigators, ... ...

    Abstract Given that most of non-muscle invasive bladder cancer trials available in the literature share the same limitation of an open-label design, they are likely prone to detection bias. Indeed, tumor response is currently assessed by unblinded investigators, mainly via follow-up cystoscopy, which has well-known intraobserver and interobserver variability. Thus, we believe that the use of video-recorded cystoscopy for blinded independent central review of tumor response could help to minimize detection bias in open-label NMIBC trials.
    Language English
    Publishing date 2023-08-19
    Publishing country Netherlands
    Document type Editorial
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.07.005
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  6. Article ; Online: Estudio de contactos en infectados por SARS-CoV-2. El papel fundamental de la Atención Primaria y de la Salud Pública.

    Bellmunt, J M / Caylà, J A / Millet, J P

    Semergen

    2020  Volume 46 Suppl 1, Page(s) 55–64

    Abstract: The aim of this study was to promote the rapid identification of the contacts of patients infected with SARS-CoV-2 and therefore the control of the pandemic. Different methodologies and recommendations on contact tracing for Primary Health Care (PHC) and ...

    Title translation Contact tracing in patients infected with SARS-CoV-2. The fundamental role of Primary Health Care and Public Health.
    Abstract The aim of this study was to promote the rapid identification of the contacts of patients infected with SARS-CoV-2 and therefore the control of the pandemic. Different methodologies and recommendations on contact tracing for Primary Health Care (PHC) and Public Health Services (PHS), like articles in Pubmed about COVID-19 and contact tracing, official contact definitions, the classic contact tracing model in tuberculosis (TB), information about apps for contact tracing and the role of the diagnostic tests, were reviewed. To establish efficient prevention and control measures, it is always necessary to implement contact tracing based on clinical suspicion, early diagnosis and isolation of cases and contacts and their follow-up. The classic contact tracing model in TB can be applied to this new infection, but accelerating the process given its acute nature and its potential severity. Good coordination between PHC and PHS and having sufficient resources is essential.
    MeSH term(s) COVID-19 ; Contact Tracing/methods ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Forms as Topic ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Primary Health Care ; Public Health
    Keywords covid19
    Language Spanish
    Publishing date 2020-06-05
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 1578-8865
    ISSN (online) 1578-8865
    DOI 10.1016/j.semerg.2020.06.001
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  7. Article ; Online: Effects of focal vibration on changes in sports performance in amateur athletes: A randomized clinical trial.

    Canet-Vintró, Max / Rodríguez-Sanz, Jacobo / López-de-Celis, Carlos / Campañá-Arnal, Enric / Hidalgo-Garcia, César / Pérez-Bellmunt, Albert

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2024  

    Abstract: The aim of this study was to evaluate the effectiveness of a focal vibration protocol added to an activation protocol with active muscle contractions and to see what repercussions it has on sprint, countermovement jump (CMJ), and lower limb isometric ... ...

    Abstract The aim of this study was to evaluate the effectiveness of a focal vibration protocol added to an activation protocol with active muscle contractions and to see what repercussions it has on sprint, countermovement jump (CMJ), and lower limb isometric strength. A double-blind randomized clinical trial was conducted in the Functional Anatomy Laboratory and the sample consisted of 70 athletes. The main outcome measures were knee extension force, CMJ, sprint, and surface electromyography. Repeated-measures analysis of variance revealed significant improvements. They were found in the within-group analysis for the Experimental Group in the isometric extension force (p < 0.001; η
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25857
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    Zs.A 1879: Show issues Location:
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  8. Article ; Online: Pembrolizumab plus enfortumab vedotin in urothelial cancer.

    Santoni, Matteo / Takeshita, Hideki / Massari, Francesco / Bamias, Aristotelis / Cerbone, Linda / Fiala, Ondrej / Mollica, Veronica / Buti, Sebastiano / Santoni, Angela / Bellmunt, Joaquim

    Nature reviews. Urology

    2024  

    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-024-00858-y
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  9. Article ; Online: ESMO Clinical Practice Guideline interim update on first-line therapy in advanced urothelial carcinoma.

    Powles, T / Bellmunt, J / Comperat, E / De Santis, M / Huddart, R / Loriot, Y / Necchi, A / Valderrama, B P / Ravaud, A / Shariat, S F / Szabados, B / van der Heijden, M S / Gillessen, S

    Annals of oncology : official journal of the European Society for Medical Oncology

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Practice Guideline
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2024.03.001
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  10. Article ; Online: Natural Compound Boldine Lessens Myotonic Dystrophy Type 1 Phenotypes in DM1 Drosophila Models, Patient-Derived Cell Lines, and HSA

    Álvarez-Abril, Mari Carmen / García-Alcover, Irma / Colonques-Bellmunt, Jordi / Garijo, Raquel / Pérez-Alonso, Manuel / Artero, Rubén / López-Castel, Arturo

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Myotonic dystrophy type 1 (DM1) is a complex rare disorder characterized by progressive muscle dysfunction, involving weakness, myotonia, and wasting, but also exhibiting additional clinical signs in multiple organs and systems. Central dysregulation, ... ...

    Abstract Myotonic dystrophy type 1 (DM1) is a complex rare disorder characterized by progressive muscle dysfunction, involving weakness, myotonia, and wasting, but also exhibiting additional clinical signs in multiple organs and systems. Central dysregulation, caused by an expansion of a CTG trinucleotide repeat in the DMPK gene's 3' UTR, has led to exploring various therapeutic approaches in recent years, a few of which are currently under clinical trial. However, no effective disease-modifying treatments are available yet. In this study, we demonstrate that treatments with boldine, a natural alkaloid identified in a large-scale Drosophila-based pharmacological screening, was able to modify disease phenotypes in several DM1 models. The most significant effects include consistent reduction in nuclear RNA foci, a dynamic molecular hallmark of the disease, and noteworthy anti-myotonic activity. These results position boldine as an attractive new candidate for therapy development in DM1.
    MeSH term(s) Animals ; Mice ; Myotonic Dystrophy/drug therapy ; Myotonic Dystrophy/genetics ; Myotonic Dystrophy/metabolism ; Drosophila/genetics ; Phenotype ; Cell Line ; Trinucleotide Repeat Expansion
    Chemical Substances boldine (8I91GE2769)
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129820
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