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Article ; Online: Ultrathin Piezoelectric Resonators Based on Graphene and Free-Standing Single-Crystal BaTiO

Lee, Martin / Renshof, Johannes R / van Zeggeren, Kasper J / Houmes, Maurits J A / Lesne, Edouard / Šiškins, Makars / van Thiel, Thierry C / Guis, Ruben H / van Blankenstein, Mark R / Verbiest, Gerard J / Caviglia, Andrea D / van der Zant, Herre S J / Steeneken, Peter G

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 44, Page(s) e2204630

Abstract: Suspended piezoelectric thin films are key elements enabling high-frequency filtering in telecommunication devices. To meet the requirements of next-generation electronics, it is essential to reduce device thickness for reaching higher resonance ... ...

Abstract	Suspended piezoelectric thin films are key elements enabling high-frequency filtering in telecommunication devices. To meet the requirements of next-generation electronics, it is essential to reduce device thickness for reaching higher resonance frequencies. Here, the high-quality mechanical and electrical properties of graphene electrodes are combined with the strong piezoelectric performance of the free-standing complex oxide, BaTiO
Language	English
Publishing date	2022-10-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202204630
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Article ; Online: Vaccination practices of pediatric oncologists from eight states.

van Thiel Berghuijs, Karely M / Kaddas, Heydon K / Warner, Echo L / Fair, Douglas B / Fluchel, Mark / Knackstedt, Elizabeth D / Verma, Anupam / Kepka, Deanna / Green, Adam L / Smitherman, Andrew B / Draper, Lauren / Johnson, Rebecca H / Kirchhoff, Anne C

BMC health services research

2023 Volume 23, Issue 1, Page(s) 1215

Abstract: Background: Vaccinations are a vital part of routine childhood and adolescent preventive care. We sought to identify current oncology provider practices, barriers, and attitudes towards vaccinating childhood and adolescent cancer patients and survivors.! ...

Abstract	Background: Vaccinations are a vital part of routine childhood and adolescent preventive care. We sought to identify current oncology provider practices, barriers, and attitudes towards vaccinating childhood and adolescent cancer patients and survivors. Methods: We conducted a one-time online survey distributed from March-October 2018 to pediatric oncologists at nine institutions across the United States (N = 111, 68.8% participation rate). The survey included 32 items about vaccination practices, barriers to post-treatment vaccination, availability of vaccinations in oncology clinic, familiarity with vaccine guidelines, and attitudes toward vaccination responsibilities. Descriptive statistics were calculated in STATA 14.2. Results: Participants were 54.0% female and 82.9% white, with 12.6% specializing in Bone Marrow Transplants. Influenza was the most commonly resumed vaccine after treatment (7030%). About 50%-60% were familiar with vaccine guidelines for immunocompromised patients. More than half (62.7%) recommended that patients restart most immunizations 6 months to 1 year after chemotherapy. Common barriers to providers recommending vaccinations included not having previous vaccine records for patients (56.8%) or lacking time to ascertain which vaccines are needed (32.4%). Of participants, 66.7% stated that vaccination should be managed by primary care providers, but with guidance from oncologists. Conclusions: Many pediatric oncologists report being unfamiliar with vaccine guidelines for immunocompromised patients and almost all report barriers in supporting patients regarding vaccines after cancer treatment. Our findings show that further research and interventions are needed to help bridge oncology care and primary care regarding immunizations after treatment.
MeSH term(s)	Child ; Adolescent ; Humans ; Female ; United States ; Male ; Vaccination ; Immunization ; Influenza Vaccines ; Neoplasms/drug therapy ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-10160-z
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Article ; Online: Self-Sealing Complex Oxide Resonators.

Lee, Martin / Robin, Martin P / Guis, Ruben H / Filippozzi, Ulderico / Shin, Dong Hoon / van Thiel, Thierry C / Paardekooper, Stijn P / Renshof, Johannes R / van der Zant, Herre S J / Caviglia, Andrea D / Verbiest, Gerard J / Steeneken, Peter G

Nano letters

2022 Volume 22, Issue 4, Page(s) 1475–1482

Abstract: Although 2D materials hold great potential for next-generation pressure sensors, recent studies revealed that gases permeate along the membrane-surface interface, necessitating additional sealing procedures. In this work, we demonstrate the use of free- ... ...

Abstract	Although 2D materials hold great potential for next-generation pressure sensors, recent studies revealed that gases permeate along the membrane-surface interface, necessitating additional sealing procedures. In this work, we demonstrate the use of free-standing complex oxides as self-sealing membranes that allow the reference cavity beneath to be sealed by a simple anneal. To test the hermeticity, we study the gas permeation time constants in nanomechanical resonators made from SrRuO
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.1c03498
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Article ; Online: Influence of esomeprazole on the bioavailability of afatinib: A pharmacokinetic cross-over study in patients with non-small cell lung cancer.

Veerman, G D Marijn / Hurkmans, Daan P / Paats, Marthe S / Oomen-de Hoop, Esther / van der Leest, Cor H / van Thiel, Eric R E / Aerts, Joachim G J V / van Leeuwen, Roelof W / Dingemans, Anne-Marie C / Mathijssen, Ron H J

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 155, Page(s) 113695

Abstract: Afatinib is an oral small-molecule kinase inhibitor (SMKI) approved for treatment of metastatic non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) driver mutation. Although oral administration is convenient, most SMKIs ... ...

Abstract	Afatinib is an oral small-molecule kinase inhibitor (SMKI) approved for treatment of metastatic non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) driver mutation. Although oral administration is convenient, most SMKIs experience pH-dependent solubility. A drug-drug interaction between afatinib and proton-pump inhibitors (PPIs) has, however, never been studied in humans. Hence, we performed a randomized, three-period cross-over study. Afatinib (30 mg or 40 mg) was administered without PPI (period A), concomitantly with esomeprazole (period B) and three hours after esomeprazole intake (period C). Primary objective was the area under the curve (AUC
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Afatinib/therapeutic use ; Erlotinib Hydrochloride ; Esomeprazole ; Gefitinib/therapeutic use ; Cross-Over Studies ; Biological Availability ; Proton Pump Inhibitors/adverse effects ; Lung Neoplasms/pathology ; ErbB Receptors/genetics ; Protein Kinase Inhibitors/adverse effects ; Mutation
Chemical Substances	Afatinib (41UD74L59M) ; Erlotinib Hydrochloride (DA87705X9K) ; Esomeprazole (N3PA6559FT) ; Gefitinib (S65743JHBS) ; Proton Pump Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2022-09-19
Publishing country	France
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113695
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Ud II Zs.198: Show issues

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Article ; Online: Back and joint pain according to good old Virchow.

van Stapele, K / Geijteman, E C T / van Thiel, T C / Postema, P T E / Schweitzer, D H

The Netherlands journal of medicine

2018 Volume 76, Issue 8, Page(s) 383

Language	English
Publishing date	2018-10-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193149-0
ISSN	1872-9061 ; 0300-2977
ISSN (online)	1872-9061
ISSN	0300-2977
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Zs.A 576: Show issues

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Article ; Online: Care for the organ transplant recipient on the intensive care unit.

van den Hoogen, M W F / Seghers, L / Manintveld, O C / Roest, S / Bekkers, J A / den Hoed, C M / Minnee, R C / de Geus, H R H / van Thiel, R J / Hesselink, D A

Journal of critical care

2021 Volume 64, Page(s) 37–44

Abstract: All transplant recipients receive tacrolimus, mycophenolate and glucocorticoids and these drugs have many side-effects and drug-drug interactions. Common complications include surgical complications, infections, rejection and acute kidney injury. ... ...

Abstract	All transplant recipients receive tacrolimus, mycophenolate and glucocorticoids and these drugs have many side-effects and drug-drug interactions. Common complications include surgical complications, infections, rejection and acute kidney injury. Infections as CMV and PJP can be prevented with prophylactic treatment. Given the complexity of organ transplant recipients a multi-disciplinary team of intensivists, surgeons, pharmacists and transplant specialists is essential. After heart transplantation a temporary pacemaker is required until the conduction system recovers. Stiffening of the heart and increased cardiac markers indicate rejection. An endomyocardial biopsy is performed via the right jugular vein, necessitating its preservation. For lung transplant patients, early intervention for aspiration is warranted to prevent chronic rejection. Risk of any infection is high, requiring active surveillance and intensive treatment, mainly of fungal infections. The liver is immunotolerant requiring lower immunosuppression. Transplantation surgery is often accompanied by massive blood loss and coagulopathy. Other complications include portal vein or hepatic artery thrombosis and biliary leakage or stenosis. Kidney transplant recipients have a high risk of cardiovascular disease and posttransplant anemia should be treated liberally. After postmortal transplantation, delayed graft function is common and dialysis is continued. Ureteral anastomosis complications can be diagnosed with ultrasound.
MeSH term(s)	Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents ; Intensive Care Units ; Organ Transplantation/adverse effects ; Renal Dialysis ; Transplant Recipients
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2021.03.003
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Zs.A 2152: Show issues

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Article ; Online: How should discordance between molecular and growth-based assays for rifampicin resistance be investigated?

Hofmann-Thiel, S / Hoffmann, H / Hillemann, D / Rigouts, L / Van Deun, A / Kranzer, K

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2017 Volume 21, Issue 7, Page(s) 721–726

Abstract: Molecular tests to detect the presence of Mycobacterium tuberculosis and genetic polymorphisms in the rpoB gene conferring resistance to rifampicin (RMP) have become integral parts of tuberculosis diagnostics worldwide. These assays are often performed ... ...

Abstract	Molecular tests to detect the presence of Mycobacterium tuberculosis and genetic polymorphisms in the rpoB gene conferring resistance to rifampicin (RMP) have become integral parts of tuberculosis diagnostics worldwide. These assays are often performed sequentially or in parallel to phenotypic drug susceptibility testing. Discordances between molecular and phenotypic tests invariably occur. Root causes range from pre-, post- and analytic errors to co-existence of non-tuberculous mycobacteria, silent mutations, mutations outside the 81 base-pair RMP resistance-determining region, non-canonical mutations conferring increased minimal inhibitory concentrations below the critical concentration in some phenotypic drug susceptibility tests, and heteroresistance. Resolving discordant results is challenging. This guide aims to assist both clinicians and microbiologists in interpreting discordances by providing a structured approach to manage further investigations. Case scenarios are discussed, including the likelihood of occurrence.
MeSH term(s)	Antibiotics, Antitubercular/pharmacology ; Bacterial Proteins/genetics ; DNA-Directed RNA Polymerases/genetics ; Drug Resistance, Bacterial ; Humans ; Microbial Sensitivity Tests ; Molecular Diagnostic Techniques/methods ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Polymorphism, Genetic ; Rifampin/pharmacology ; Tuberculosis/diagnosis ; Tuberculosis/microbiology
Chemical Substances	Antibiotics, Antitubercular ; Bacterial Proteins ; rpoB protein, Mycobacterium tuberculosis ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2017-06-21
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.17.0140
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Zs.A 4776: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Vaccination practices of pediatric oncologists from eight states

Karely M. van Thiel Berghuijs / Heydon K. Kaddas / Echo L. Warner / Douglas B. Fair / Mark Fluchel / Elizabeth D. Knackstedt / Anupam Verma / Deanna Kepka / Adam L. Green / Andrew B. Smitherman / Lauren Draper / Rebecca H. Johnson / Anne C. Kirchhoff

BMC Health Services Research, Vol 23, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Background Vaccinations are a vital part of routine childhood and adolescent preventive care. We sought to identify current oncology provider practices, barriers, and attitudes towards vaccinating childhood and adolescent cancer patients and ... ...

Abstract	Abstract Background Vaccinations are a vital part of routine childhood and adolescent preventive care. We sought to identify current oncology provider practices, barriers, and attitudes towards vaccinating childhood and adolescent cancer patients and survivors. Methods We conducted a one-time online survey distributed from March-October 2018 to pediatric oncologists at nine institutions across the United States (N = 111, 68.8% participation rate). The survey included 32 items about vaccination practices, barriers to post-treatment vaccination, availability of vaccinations in oncology clinic, familiarity with vaccine guidelines, and attitudes toward vaccination responsibilities. Descriptive statistics were calculated in STATA 14.2. Results Participants were 54.0% female and 82.9% white, with 12.6% specializing in Bone Marrow Transplants. Influenza was the most commonly resumed vaccine after treatment (7030%). About 50%-60% were familiar with vaccine guidelines for immunocompromised patients. More than half (62.7%) recommended that patients restart most immunizations 6 months to 1 year after chemotherapy. Common barriers to providers recommending vaccinations included not having previous vaccine records for patients (56.8%) or lacking time to ascertain which vaccines are needed (32.4%). Of participants, 66.7% stated that vaccination should be managed by primary care providers, but with guidance from oncologists. Conclusions Many pediatric oncologists report being unfamiliar with vaccine guidelines for immunocompromised patients and almost all report barriers in supporting patients regarding vaccines after cancer treatment. Our findings show that further research and interventions are needed to help bridge oncology care and primary care regarding immunizations after treatment.
Keywords	Immunization ; Childhood ; Survivorship care ; Provider recommendation ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Athlete health protection: Why qualitative research matters.

Journal of science and medicine in sport

2020 Volume 23, Issue 10, Page(s) 898–901

MeSH term(s)	Athletes ; Athletic Injuries/prevention & control ; Humans ; Qualitative Research ; Sports Medicine/trends
Language	English
Publishing date	2020-07-03
Publishing country	Australia
Document type	Editorial
ZDB-ID	1437829-2
ISSN	1878-1861 ; 1440-2440
ISSN (online)	1878-1861
ISSN	1440-2440
DOI	10.1016/j.jsams.2020.06.020
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Article ; Online: Ruling out Pulmonary Embolism in Patients with (Suspected) COVID-19-A Prospective Cohort Study.

Stals, Milou A M / Kaptein, Fleur H J / Bemelmans, Remy H H / van Bemmel, Thomas / Boukema, Inge C / Braeken, Dionne C W / Braken, Sander J E / Bresser, Carlinda / Cate, Hugo Ten / Deenstra, Duco D / Dooren, Yordi P A van / Faber, Laura M / Grootenboers, Marco J J H / Haan, Lianne R de / Haazer, Carolien / Sol, Antonio Iglesias Del / Kelliher, Sarah / Koster, Ted / Kroft, Lucia J M /

Meijer, Rick I / Pals, Fleur / van Thiel, Eric R E / Westerweel, Peter E / Wolde, Marije Ten / Klok, Frederikus A / Huisman, Menno V

TH open : companion journal to thrombosis and haemostasis

2021 Volume 5, Issue 3, Page(s) e387–e399

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2021-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/s-0041-1735155
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