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  1. Article: Role of Ethanolamine Utilization and Bacterial Microcompartment Formation in

    Chatterjee, Ayan / Kaval, Karan Gautam / Garsin, Danielle A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Ethanolamine (EA) affects the colonization and pathogenicity of certain human bacterial pathogens in the gastrointestinal tract. However, EA can also affect the intracellular survival and replication of host-cell invasive bacteria such ... ...

    Abstract Ethanolamine (EA) affects the colonization and pathogenicity of certain human bacterial pathogens in the gastrointestinal tract. However, EA can also affect the intracellular survival and replication of host-cell invasive bacteria such as
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.19.572424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The pathogenesis of cardiac microlesion formation during severe bacteremic infection.

    Brown, Armand O / Garsin, Danielle A

    PLoS pathogens

    2020  Volume 16, Issue 11, Page(s) e1009021

    MeSH term(s) Bacteremia/complications ; Bacteremia/microbiology ; Bacteremia/pathology ; Gammaproteobacteria/pathogenicity ; Heart Diseases/complications ; Heart Diseases/microbiology ; Heart Diseases/pathology ; Humans ; Mycobacterium avium/pathogenicity ; Virulence
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis.

    Guha, Shantanu / Cristy, Shane A / Buda De Cesare, Giuseppe / Cruz, Melissa R / Lorenz, Michael C / Garsin, Danielle A

    mBio

    2024  , Page(s) e0057024

    Abstract: Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by : Importance: Since the early 1980s, the incidence of ... ...

    Abstract Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by
    Importance: Since the early 1980s, the incidence of disseminated life-threatening fungal infections has been on the rise. Worldwide,
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00570-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.

    Wu, Chenggang / Karakuzu, Ozgur / Garsin, Danielle A

    Cell reports

    2021  Volume 36, Issue 7, Page(s) 109529

    Abstract: In Caenorhabditis elegans, ROS generated in response to intestinal infection induces SKN-1, a protective transcription factor homologous to nuclear factor erythroid 2-related factor 1 or 2 (NRF1/2) in mammals. Many factors regulate SKN-1, including the ... ...

    Abstract In Caenorhabditis elegans, ROS generated in response to intestinal infection induces SKN-1, a protective transcription factor homologous to nuclear factor erythroid 2-related factor 1 or 2 (NRF1/2) in mammals. Many factors regulate SKN-1, including the p38 mitogen-activated protein kinase (MAPK) cascade that activates SKN-1 by phosphorylation. In this work, another positive regulator of SKN-1 is identified: NIPI-3, a Tribbles pseudokinase. NIPI-3 has been reported to protect against intestinal infection by negatively regulating the CCAT enhancer binding protein (C/EBP) bZIP transcription factor CEBP-1. Here we demonstrate that CEBP-1 positively regulates the vhp-1 transcript, which encodes a phosphatase that dephosphorylates the p38 MAPK called PMK-1. The increased levels of VHP-1 caused by CEBP-1 transcriptional enhancement result in less PMK-1 phosphorylation, affecting SKN-1 activity and intestinal resistance to the pathogen. The data support a model in which NIPI-3's negative regulation of CEBP-1 decreases VHP-1 phosphatase activity, allowing increased stimulation of SKN-1 activity by the p38 MAPK phosphorylation cascade in the intestine.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/immunology ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; DNA-Binding Proteins/metabolism ; Feedback, Physiological ; Gene Expression Regulation ; Immunity, Innate ; Intestines/immunology ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Transcription Factors/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; DNA-Binding Proteins ; Transcription Factors ; skn-1 protein, C elegans (148733-36-2) ; Protein Kinases (EC 2.7.-) ; NIPI-3 protein, C elegans (EC 2.7.11.1)
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ethanolamine Utilization in Bacteria.

    Kaval, Karan Gautam / Garsin, Danielle A

    mBio

    2018  Volume 9, Issue 1

    Abstract: Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is ... ...

    Abstract Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is membrane rich due to turnover of the intestinal epithelium and the resident microbiota. Intriguingly, many gut pathogens carry the
    MeSH term(s) Animals ; Carbon/metabolism ; Enterobacteriaceae/genetics ; Enterobacteriaceae/metabolism ; Enterobacteriaceae Infections/microbiology ; Ethanolamine/metabolism ; Gastrointestinal Tract/microbiology ; Gene Expression Regulation, Bacterial ; Humans ; Metabolic Networks and Pathways/genetics ; Nitrogen/metabolism
    Chemical Substances Ethanolamine (5KV86114PT) ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2018-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00066-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Amplex Red Assay for Measuring Hydrogen Peroxide Production from

    Karakuzu, Ozgur / Cruz, Melissa R / Liu, Yi / Garsin, Danielle A

    Bio-protocol

    2020  Volume 9, Issue 21

    Abstract: Reagents such as ... ...

    Abstract Reagents such as Amplex
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3.

    Oneissi, Mazen / Cruz, Melissa R / Ramírez-Zavala, Bernardo / Lindemann-Perez, Elena / Morschhäuser, Joachim / Garsin, Danielle A / Perez, J Christian

    PLoS pathogens

    2023  Volume 19, Issue 9, Page(s) e1011692

    Abstract: The signals that denote mammalian host environments and dictate the activation of signaling pathways in human-associated microorganisms are often unknown. The transcription regulator Rtg1/3 in the human fungal pathogen Candida albicans is a crucial ... ...

    Abstract The signals that denote mammalian host environments and dictate the activation of signaling pathways in human-associated microorganisms are often unknown. The transcription regulator Rtg1/3 in the human fungal pathogen Candida albicans is a crucial determinant of host colonization and pathogenicity. Rtg1/3's activity is controlled, in part, by shuttling the regulator between the cytoplasm and nucleus of the fungus. The host signal(s) that Rtg1/3 respond(s) to, however, have remained unclear. Here we report that neutrophil-derived reactive oxygen species (ROS) direct the subcellular localization of this C. albicans transcription regulator. Upon engulfment of Candida cells by human or mouse neutrophils, the regulator shuttles to the fungal nucleus. Using genetic and chemical approaches to disrupt the neutrophils' oxidative burst, we establish that the oxidants produced by the NOX2 complex-but not the oxidants generated by myeloperoxidase-trigger Rtg1/3's migration to the nucleus. Furthermore, screening a collection of C. albicans kinase deletion mutants, we implicate the MKC1 signaling pathway in the ROS-dependent regulation of Rtg1/3 in this fungus. Finally, we show that Rtg1/3 contributes to C. albicans virulence in the nematode Caenorhabditis elegans in an ROS-dependent manner as the rtg1 and rtg3 mutants display virulence defects in wild-type but not in ROS deficient worms. Our findings establish NOX2-derived ROS as a key signal that directs the activity of the pleiotropic fungal regulator Rtg1/3.
    MeSH term(s) Animals ; Mice ; Humans ; Candida albicans ; Reactive Oxygen Species/metabolism ; Neutrophils/metabolism ; Candida ; Oxidants/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Mammals
    Chemical Substances Reactive Oxygen Species ; Oxidants ; Fungal Proteins
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011692
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  8. Article ; Online: The pathogenesis of cardiac microlesion formation during severe bacteremic infection.

    Armand O Brown / Danielle A Garsin

    PLoS Pathogens, Vol 16, Iss 11, p e

    2020  Volume 1009021

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Ethanolamine: a signal to commence a host-associated lifestyle?

    Garsin, Danielle A

    mBio

    2012  Volume 3, Issue 4, Page(s) e00172–12

    Abstract: Ethanolamine (EA) is a compound prevalent in the gastrointestinal (GI) environment. The ability to catabolize this compound has been associated with important GI pathogens, including enterohemorrhagic Escherichia coli O157:H7 (EHEC). It has been ... ...

    Abstract Ethanolamine (EA) is a compound prevalent in the gastrointestinal (GI) environment. The ability to catabolize this compound has been associated with important GI pathogens, including enterohemorrhagic Escherichia coli O157:H7 (EHEC). It has been hypothesized that the ability of EHEC to utilize EA as a source of nitrogen provides EHEC with an important competitive advantage in the gut. However, new work by Kendall et al. (mBio 3:e00050-12, 2012) suggests that the role of EA in EHEC pathogenesis may be more fundamental; EA appears to be a signal for EHEC to commence its virulence program. In this commentary, I review the previously described connections of EA to bacterial pathogenesis in the GI tract, highlight the important findings of this new study, and note areas where further research is needed to fully comprehend the connection of EA utilization to bacterial pathogenesis.
    MeSH term(s) Escherichia coli Infections/metabolism ; Escherichia coli Infections/microbiology ; Escherichia coli O157/pathogenicity ; Escherichia coli Proteins/genetics ; Ethanolamine/metabolism ; Gene Expression Regulation, Bacterial ; Humans
    Chemical Substances Escherichia coli Proteins ; Ethanolamine (5KV86114PT)
    Language English
    Publishing date 2012-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00172-12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis.

    Miller, William R / Nguyen, April / Singh, Kavindra V / Rizvi, Samie / Khan, Ayesha / Erickson, Sam G / Egge, Stephanie L / Cruz, Melissa / Dinh, An Q / Diaz, Lorena / Thornton, Philip C / Zhang, Rutan / Xu, Libin / Garsin, Danielle A / Shamoo, Yousif / Arias, Cesar A

    The Journal of infectious diseases

    2024  

    Abstract: Enterococci have evolved resistance mechanisms to protect their cell envelopes against bacteriocins and host cationic antimicrobial peptides (CAMPs) produced in the gastrointestinal environment. Activation of the membrane stress response has also been ... ...

    Abstract Enterococci have evolved resistance mechanisms to protect their cell envelopes against bacteriocins and host cationic antimicrobial peptides (CAMPs) produced in the gastrointestinal environment. Activation of the membrane stress response has also been tied to resistance to the lipopeptide antibiotic daptomycin. However, the actual effectors mediating resistance have not been elucidated. Here, we show that the MadRS (formerly YxdJK) membrane antimicrobial peptide defense system controls a network of genes, including a previously uncharacterized three gene operon (madEFG) that protects the E. faecalis cell envelope from antimicrobial peptides. Constitutive activation of the system confers protection against CAMPs and daptomycin in the absence of a functional LiaFSR system and leads to persistence of cardiac microlesions in vivo. Moreover, changes in the lipid cell membrane environment alter CAMP susceptibility and expression of the MadRS system. Thus, we provide a framework supporting a multilayered envelope defense mechanism for resistance and survival coupled to virulence.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae173
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