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Article ; Online: Exploring cytologic features and potential diagnostic challenges of metastatic NUT carcinoma to the parotid gland: A case report and a comprehensive literature review.

Li, Crystal Y / Salihoglu, Salih / Civantos, Francisco J / Velez Torres, Jaylou M

2024

Abstract: NUT carcinoma (NC) is a highly aggressive, poorly differentiated carcinoma that harbors a t(15:19) translocation, leading to the fusion of the NUTM1 gene. While the upper aerodigestive tract along the midline (head, neck, thorax, and mediastinum) is ... ...

Abstract	NUT carcinoma (NC) is a highly aggressive, poorly differentiated carcinoma that harbors a t(15:19) translocation, leading to the fusion of the NUTM1 gene. While the upper aerodigestive tract along the midline (head, neck, thorax, and mediastinum) is commonly reported as the primary site of NC, subsequent cases have emerged in diverse locations. Achieving a definitive diagnosis based solely on morphology is challenging; however, it can be achieved using immunohistochemistry (IHC) specific to the NUT antibody or by demonstrating the characteristic BRD4::NUTM1 fusion. Accurate and timely diagnosis can potentially inform patient management and guide treatment. While histologic documentation of NC is commonly found, there is a limited description of its cytologic features. A 39-year-old male with a history of sinonasal squamous cell carcinoma (SCC) presented with a right parotid mass aspirated via fine needle aspiration cytology (FNA). Histologic examination of the previous sinonasal pathology reviewed at our institution revealed sheets of primitive-appearing, monotonous, undifferentiated cells with distinct, prominent nucleoli. Additionally, there were foci of abrupt keratinization, accompanied by a notable neutrophilic infiltrate. The initial diagnosis of SCC was reclassified to NC and confirmed through NUT IHC and molecular testing. Although the parotid FNA initially suggested the possibility of a variety of small round blue cell tumors, it exhibited morphological similarities to the sinonasal tumor, leading to the diagnosis of metastatic NC. Cytomorphologic features of NC are limited and can overlap with various small round blue cell tumors. Correct classification is especially pivotal in the era of targeted therapy, considering the ongoing development and evaluation of BET inhibitors targeting BRD4.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.25335
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Book: Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy

Civantos, Francisco J. / Moffat, Frederick L. / Goodwin, William J.

(The laryngoscope : Supplement ; 109)

2006

Author's details	Francisco J. Civantos ; Frederick L. Moffat ; William J. Goodwin
Series title	The laryngoscope : Supplement ; 109 The laryngoscope The laryngoscope ; Supplement
Collection	The laryngoscope The laryngoscope ; Supplement
Language	English
Size	15 S. : Ill.
Publisher	Lippincott Williams & Wilkins
Publishing place	Omaha, NE
Publishing country	United States
Document type	Book
HBZ-ID	HT014714394
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Primary Site Surgery in Distantly Metastatic Oropharyngeal Squamous Cell Carcinoma.

Carey, Ryan M / Prasad, Aman / Wei, Kimberly / Brant, Jason A / Brody, Robert M / Leibowitz, Jason M / Civantos, Francisco J / Sweeny, Larissa

The Laryngoscope

2023 Volume 134, Issue 5, Page(s) 2243–2251

Abstract: Objectives: Determine if intensive local therapy (i.e., local surgery or radiation) has a survival benefit for patients presenting with distantly metastatic oropharyngeal squamous cell carcinoma (OPSCC).: Methods: Retrospective population-based ... ...

Abstract	Objectives: Determine if intensive local therapy (i.e., local surgery or radiation) has a survival benefit for patients presenting with distantly metastatic oropharyngeal squamous cell carcinoma (OPSCC). Methods: Retrospective population-based cohort study of patients in the National Cancer Database presenting with distantly metastatic OPSCC. Overall survival (OS) was compared for patients receiving systemic therapy alone or in combination with local surgery or curative dose radiation, controlling for various clinicodemographic factors. Results: Between 2010 and 2015, 627 patients presented with newly diagnosed, metastatic OPSCC and an initial treatment course including systemic chemotherapy. Multivariable analysis demonstrated that local radiation therapy was independently associated with improved OS (OR 0.64, CI [0.51-0.81]); local surgery was not independently associated with improved OS (OR 0.99, CI [0.65-1.53]). Higher T stages were associated with worse OS (OR 1.69, CI [1.14-2.50] for T3 and OR 1.77, CI [1.22-2.58] for T4 compared to T1). HPV-positive (HPV+) tumors were associated with improved OS compared to HPV- (OR 0.79, CI [0.64-0.97]). Multiagent chemotherapy was associated with improved OS compared to single-agent (OR 0.78, CI [0.62-1.00]). The best survival for the entire cohort and for HPV+ patients was for radiation with systemic therapy and the worst survival for systemic therapy alone. Conclusions: Curative dose local radiotherapy in addition to systemic therapy is associated with improved OS compared to systemic therapy alone in patients presenting with distantly metastatic OPSCC. There is not a significant survival benefit for local surgery in addition to systemic therapy in this patient population, regardless of HPV status. Level of evidence: 3 Laryngoscope, 134:2243-2251, 2024.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/surgery ; Squamous Cell Carcinoma of Head and Neck/complications ; Carcinoma, Squamous Cell/surgery ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/pathology ; Papillomavirus Infections/complications ; Retrospective Studies ; Cohort Studies ; Head and Neck Neoplasms/complications ; Prognosis
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31177
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Article ; Online: Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.

Coca-Pelaz, Andrés / Rodrigo, Juan P / Agaimy, Abbas / Williams, Michelle D / Saba, Nabil F / Nuyts, Sandra / Randolph, Gregory W / López, Fernando / Vander Poorten, Vincent / Kowalski, Luiz P / Civantos, Francisco J / Zafereo, Mark E / Mäkitie, Antti A / Cohen, Oded / Nixon, Iain J / Rinaldo, Alessandra / Ferlito, Alfio

Virchows Archiv : an international journal of pathology

2024

Abstract: Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given ...

Abstract	Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of "differentiated high-grade follicular cell-derived carcinomas". On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.
Language	English
Publishing date	2024-02-24
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-024-03752-5
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Article: Lymph Node Metastases from Non-Melanoma Skin Cancer of the Head and Neck.

Civantos, Francisco / Helmen, Zachary M / Bradley, Patrick J / Coca-Pelaz, Andrés / De Bree, Remco / Guntinas-Lichius, Orlando / Kowalski, Luiz P / López, Fernando / Mäkitie, Antti A / Rinaldo, Alessandra / Robbins, K Thomas / Rodrigo, Juan P / Takes, Robert P / Ferlito, Alfio

Cancers

2023 Volume 15, Issue 17

Abstract: Non-melanoma skin cancer (NMSC) represents the most common malignancy in the world, comprising exceedingly common lesions such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) and rare lesions such as Merkel cell carcinoma. Risk ...

Abstract	Non-melanoma skin cancer (NMSC) represents the most common malignancy in the world, comprising exceedingly common lesions such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) and rare lesions such as Merkel cell carcinoma. Risk factors are widely recognized and include ultraviolet (UV) light exposure, radiation exposure, immunosuppression, and many others. As a whole, survival and functional outcomes are favorable, but each histopathological subtype of NMSC behaves differently. Treatment regimens for the primary site usually include wide surgical excision and neck dissection in cases of clinically involved metastatic lymph nodes. The elective management of draining nodal basins, however, is a contested topic. Nearly all subtypes, excluding BCC, have a significant risk of lymphatic metastases, and have been studied with regard to sentinel lymph node biopsy (SLNB) and elective neck dissection. To date, no studies have definitively established a true single standard of care, as exists for melanoma, for any of the NMSCs. As a result, the authors have sought to summarize the current literature and identify indications and management options for the management of the cervical lymphatics for each major subtype of NMSC. Further research remains critically necessary in order to develop complete treatment algorithms.
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15174201
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Article ; Online: A Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers.

Rao, Karthik Nagaraja / Arora, Ripudaman / Dange, Prajwal / Nagarkar, Nitin / Mäkitie, Antti A / Kowalski, Luiz P / Eisbruch, Avraham / Hamoir, Marc / Civantos, Francisco J / Vander Poorten, Vincent / Ng, Sweet Ping / Nuyts, Sandra / Zafereo, Mark / Asarkar, Ameya A / Golusinski, Paweł / Ronen, Ohad / Ferlito, Alfio

Oncology and therapy

2023 Volume 11, Issue 4, Page(s) 461–480

Abstract: Objective: To determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers.: Methods: PubMed, EMBASE and Cochrane databases from 2000 to 2022 were systematically searched. Clinical studies reporting at ...

Abstract	Objective: To determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers. Methods: PubMed, EMBASE and Cochrane databases from 2000 to 2022 were systematically searched. Clinical studies reporting at least one outcome following curative surgery and adjuvant therapy for comparison of patients with either infranotch T4b (IN-T4b) or T4a tumour. The heterogeneity of the included studies was determined using Tau-squared, Chi-squared, and the Higgins I Results: The systematic review comprised 11,790 patients from 16 included studies. Seven studies were included in the meta-analysis (n = 11,381). For IN-T4b patients, the pooled 2 and 5 year overall survival (OS) were 59.3% and 53.2%, 2 and 5 year disease-free survival (DFS) 57.9% and 48.4%, 2 and 5 year disease-specific survival (DSS) 72% and 68%, and 2 and 5 year local control (LC), 47% and 56%, respectively. There was no statistically significant difference in 2 year OS [logOR = 0.28 (-0.47, 1.03), p = 0.46, confidence interval (CI) = 95%], 5 year OS [logOR = 0.7 (-0.4, 1.8), p = 0.54, CI = 95%], 2 year DFS [logOR = 0.22 (-0.35, 0.79), p = 0.45, CI = 95%], 5 year DFS [logOR = 0.17 (-0.42, 0.77), p = 0.57, CI = 95%], 2 year LC [logOR = 0.47 (-0.33, 1.26), p = 0.25, CI = 95%] and 5 year LC [logOR = 0.34 (-0.31, 0.99), p = 0.31, CI = 95%] between IN-T4b and T4a oral cancers. Conclusion: Results of this meta-analysis suggest that IN-T4b oral cancers have similar outcomes to T4a oral cancers, which supports down-staging IN-T4b cancers to T4a cancers.
Language	English
Publishing date	2023-10-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2848647-X
ISSN	2366-1089 ; 2366-1070
ISSN (online)	2366-1089
ISSN	2366-1070
DOI	10.1007/s40487-023-00246-3
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Article ; Online: False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic: Clinical implications.

Katz, Andrew P / Civantos, Francisco J / Sargi, Zoukaa / Leibowitz, Jason M / Nicolli, Elizabeth A / Weed, Donald / Moskovitz, Alexander E / Civantos, Alyssa M / Andrews, David M / Martinez, Octavio / Thomas, Giovana R

Head & neck

2020 Volume 42, Issue 7, Page(s) 1621–1628

Abstract: Background: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening.: Methods: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk ...

Abstract	Background: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening. Methods: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated. Results: Forty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97. Conclusions: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful.
MeSH term(s)	Aged, 80 and over ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Emergencies ; False Positive Reactions ; Female ; Florida/epidemiology ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Nasopharynx/virology ; Otorhinolaryngologic Surgical Procedures ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Preoperative Care ; RNA, Viral ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Young Adult
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26317
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Article ; Online: Primary Sarcomas of the Larynx: A Clinicopathologic Study of 27 Cases.

Velez Torres, Jaylou M / Martinez Duarte, Ernesto / Diaz-Perez, Julio A / Leibowitz, Jason / Weed, Donald T / Thomas, Giovanna / Civantos, Francisco J / Arnold, David J / Gomez-Fernandez, Carmen / Rosenberg, Andrew E

Head and neck pathology

2021 Volume 15, Issue 3, Page(s) 905–916

Abstract: Primary sarcomas of the larynx are rare and are associated with diagnostic and treatment challenges. Studies of these tumors are limited, and most examples have been reported as small series. To further increase our understanding of laryngeal sarcomas, ... ...

Abstract	Primary sarcomas of the larynx are rare and are associated with diagnostic and treatment challenges. Studies of these tumors are limited, and most examples have been reported as small series. To further increase our understanding of laryngeal sarcomas, we reviewed our experience of an adult cohort. A retrospective search for laryngeal sarcomas from our pathology archives and consultation files of one of the authors was performed. We studied 27 primary laryngeal sarcomas that included 25 males, and 2 females, with a mean age of 60 years (range 33-85). The cases included conventional chondrosarcoma (16), well-differentiated liposarcoma (2), clear cell chondrosarcoma (1), leiomyosarcoma (2), high grade myxofibrosarcoma (2), high grade myofibroblastic sarcoma (1), low-grade myofibroblastic sarcoma (1), malignant granular cell tumor (1), and Kaposi sarcoma (1). Data on treatment and follow-up was available in 17 and 16 cases, respectively. 12 patients underwent partial laryngeal resection; five had total laryngectomy, and the patient with Kaposi sarcoma received combined highly active antiretroviral therapy and chemotherapy. Three patients developed local recurrence, and two patients developed metastases. The remaining patients with follow up had a favorable outcome and were disease-free after treatment. The important differential diagnosis of spindle cell sarcoma is sarcomatoid squamous cell carcinoma, and their distinction often requires extensive sampling of the mucosal surface and immunohistochemical analysis. The mainstay of treatment for laryngeal sarcomas is surgical removal, with the extent dictated by tumor type and grade. Adjuvant therapy is reserved for high-grade sarcomas and may be given in a neoadjuvant or adjuvant setting.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Male ; Middle Aged ; Retrospective Studies ; Sarcoma/pathology ; Sarcoma/therapy
Language	English
Publishing date	2021-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-021-01314-8
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Article ; Online: Mesenchymal Neoplasms of Salivary Glands: A Clinicopathologic Study of 68 Cases.

Velez Torres, Jaylou M / Duarte, Ernesto Martinez / Diaz-Perez, Julio A / Leibowitz, Jason / Weed, Donald T / Thomas, Giovanna / Sargi, Zoukaa / Civantos, Francisco J / Arnold, David J / Gomez-Fernandez, Carmen / Montgomery, Elizabeth A / Rosenberg, Andrew E

Head and neck pathology

2021 Volume 16, Issue 2, Page(s) 353–365

Abstract: Salivary gland neoplasms are uncommon, and most exhibit epithelial differentiation. Mesenchymal neoplasms of the salivary gland are rare, and the incidence ranges from 1.9% to 5%. The aim of this study is to identify the types and clinical-pathological ... ...

Abstract	Salivary gland neoplasms are uncommon, and most exhibit epithelial differentiation. Mesenchymal neoplasms of the salivary gland are rare, and the incidence ranges from 1.9% to 5%. The aim of this study is to identify the types and clinical-pathological features of mesenchymal salivary neoplasm and review their differential diagnosis. A retrospective search for mesenchymal neoplasms of salivary glands from our institution's pathology archives from the 2004-2021 period and consultation files of one of the authors (AER) was performed. The clinical data were obtained from available medical records, and the histological slides and ancillary studies were retrieved and reviewed. We identified a total of 68 cases that form the study cohort. Thirty-five patients were male, and thirty-three patients were female, with a mean age of 48 years (range, 7 months-79 years), and the male to female ratio was 1:.94. Sixty-three (92.6%) of sixty-eight tumors were benign and included: 38 (56%) lipomas, 9 (13%) hemangiomas, 7 (10.3%) schwannomas, 3 (4.4%) neurofibromas, 3 (4.4%) lymphangioma, 2 (3%) solitary fibrous tumors, 1 (1.5%) myofibroma. Five of sixty-eight (7.4%) were malignant and included: 3 (4.4%) Adamantinoma-like Ewing sarcomas, 1 (1.5%) malignant peripheral nerve sheath tumor (MPNST), and 1 (1.5%) malignant solitary fibrous tumor. The involved sites included: parotid (55), submandibular gland (5), parapharyngeal space (5), buccal mucosa minor salivary gland (2), and sublingual gland (1). Sixty-seven patients underwent surgical resection. One patient with lymphangioma manifested a recurrence/persistence a week post-surgery. One patient with a parotid hemangioma developed post-operative numbness, and another patient developed chronic postauricular pain after surgery. Two patients with MPNST and one patient with adamantinoma-like Ewing sarcoma underwent neoadjuvant chemoradiation and were disease-free after treatment. The remaining 37 patients with available follow-up ranging from 7 days to 96 months (mean, 18 months) had a favorable outcome and were disease-free after treatment. Mesenchymal neoplasms of salivary gland are rare; most are benign and demonstrate adipocytic, endothelial, and schwannian differentiation; awareness of their development is important for adequate diagnosis. The mainstay of treatment is surgical excision, with the extent determined by tumor type. Adjuvant therapy is reserved for high-grade sarcomas and may be given in a neoadjuvant or adjuvant setting.
MeSH term(s)	Adamantinoma/pathology ; Female ; Humans ; Lymphangioma/pathology ; Male ; Middle Aged ; Neurofibrosarcoma/pathology ; Retrospective Studies ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology ; Sarcoma/pathology ; Solitary Fibrous Tumors/pathology
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-021-01360-2
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Article ; Online: Transoral robotic surgery for oropharyngeal squamous cell carcinoma in the era of human papillomavirus.

Mahmoud, Omar / Sung, Kim / Civantos, Francisco J / Thomas, Giovanna R / Samuels, Michael A

Head & neck

2017 Volume 40, Issue 4, Page(s) 710–721

Abstract: Background: The emergence of transoral robotic surgery (TORS) ignited the debate between surgical and nonsurgical strategies on oropharyngeal squamous cell carcinoma (SCC) management; a question further complicated by human papillomavirus (HPV). We ... ...

Abstract	Background: The emergence of transoral robotic surgery (TORS) ignited the debate between surgical and nonsurgical strategies on oropharyngeal squamous cell carcinoma (SCC) management; a question further complicated by human papillomavirus (HPV). We evaluated the survival by treatment strategy independently in HPV-related and HPV-nonrelated oropharyngeal SCC. Methods: The National Cancer Database was queried for patients with oropharyngeal SCC with known HPV status who underwent primary TORS or primary radiotherapy. The overall survival (OS) was compared by treatment strategy, including propensity matching to control for confounders. Results: Of 1873 patients, 73% were HPV-positive and 30% were treated with TORS. The propensity-matched patients with HPV-positive disease displayed no significant difference in 3-year survival; 95% versus 91% (P = .116) for the TORS versus primary radiotherapy. In the HPV-negative cohort, TORS was associated with superior survival; 84% versus 66% (P = .01). Conclusion: The TORS-based approach was associated with superior survival in patients with HPV-negative oropharyngeal SCC; similar difference was not observed in patients with HPV-positive disease.
MeSH term(s)	Adult ; Aged ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Databases, Factual ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Natural Orifice Endoscopic Surgery/methods ; Natural Orifice Endoscopic Surgery/mortality ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/mortality ; Papillomavirus Infections/surgery ; Propensity Score ; Proportional Hazards Models ; Registries ; Risk Assessment ; Robotic Surgical Procedures/methods ; Robotic Surgical Procedures/mortality ; Survival Analysis ; Treatment Outcome ; United States
Language	English
Publishing date	2017-12-15
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.25036
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