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  1. Article ; Online: Ethics of HIV and hepatitis B cure research.

    Sugarman, Jeremy

    Current opinion in HIV and AIDS

    2020  Volume 15, Issue 3, Page(s) 180–184

    Abstract: Purpose of review: Achieving a cure for HIV or hepatitis B virus (HBV) is expected to have a range of salutary effects including eliminating the need for continued treatments, minimizing risk to sexual and injecting partners, reducing prevalence, and ... ...

    Abstract Purpose of review: Achieving a cure for HIV or hepatitis B virus (HBV) is expected to have a range of salutary effects including eliminating the need for continued treatments, minimizing risk to sexual and injecting partners, reducing prevalence, and decreasing stigma. Nevertheless, conducting research to achieve such laudable goals is necessarily associated with a broad set of ethical challenges. This review aims at describing key findings from selected peer-reviewed literature published in the last 2 years (2018-2019) that enhance understanding of some of these issues.
    Recent findings: A variety of ethical issues in HIV cure research have been informed by recent conceptual and empirical scholarship. These include: analytical treatment interruptions; attitudes towards participation; responsibilities to nonparticipants; consent and terminology; and selected other issues.
    Summary: Understanding of the ethical issues in HIV cure research has been enhanced by sustained normative and empirical scholarship with a range of stakeholders. This work has crucial implications for HBV cure research, but there is also a pressing need for directed work on HBV cure research. In both HIV and HBV cure research, such scholarship promises to help ensure that critically important research efforts are ethically sound.
    MeSH term(s) Ethics, Research ; HIV Infections ; Hepatitis B ; Humans
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies.

    Blasimme, Alessandro / Sugarman, Jeremy

    Cell stem cell

    2023  Volume 30, Issue 8, Page(s) 1008–1012

    Abstract: Human pluripotent stem cells can be used to derive in vitro models recapitulating post-implantation human embryos. While useful for research purposes, such integrated embryo models raise ethical issues that need to be addressed to facilitate ethically ... ...

    Abstract Human pluripotent stem cells can be used to derive in vitro models recapitulating post-implantation human embryos. While useful for research purposes, such integrated embryo models raise ethical issues that need to be addressed to facilitate ethically appropriate policies and regulations that permit scientific ingenuity and medical progress.
    MeSH term(s) Humans ; Pluripotent Stem Cells ; Embryo, Mammalian ; Embryonic Development
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2023.06.007
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  3. Article ; Online: Toward Responsible Public Engagement in Neuroethics.

    Boyd, J Lomax / Sugarman, Jeremy

    AJOB neuroscience

    2022  Volume 13, Issue 2, Page(s) 103–106

    MeSH term(s) Neurosciences
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2576262-X
    ISSN 2150-7759 ; 2150-7740
    ISSN (online) 2150-7759
    ISSN 2150-7740
    DOI 10.1080/21507740.2022.2048736
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  4. Article ; Online: Response to Open Peer Commentaries on "Do Clinicians Have a Duty to Participate in Pragmatic Clinical Trials?"

    Garland, Andrew / Morain, Stephanie / Sugarman, Jeremy

    The American journal of bioethics : AJOB

    2023  Volume 23, Issue 10, Page(s) W1–W3

    MeSH term(s) Humans ; Pragmatic Clinical Trials as Topic
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2023.2250277
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  5. Book: Methods in medical ethics

    Sugarman, Jeremy

    2001  

    Author's details ed. by Jeremy Sugarman
    Keywords Medizinische Ethik ; Forschung ; Forschungsmethode
    Subject Forschung ; Wissenschaftliche Forschung ; Forschungen ; Ärztliche Ethik ; Klinische Ethik ; Ärztliches Ethos ; Arzt ; Medizin ; Heilberuf ; Medizinethik
    Language English
    Size XIV, 314 S. : graph. Darst.
    Publisher Georgetown Univ. Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT013118263
    ISBN 0-87840-873-8 ; 978-0-87840-873-3
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Short-cycle therapy is short on ethics.

    Sugarman, Jeremy / Eron, Joseph

    International journal of antimicrobial agents

    2021  Volume 57, Issue 5, Page(s) 106331

    Language English
    Publishing date 2021-03-30
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2021.106331
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  7. Article ; Online: Decentralised clinical trials: ethical opportunities and challenges.

    Vayena, Effy / Blasimme, Alessandro / Sugarman, Jeremy

    The Lancet. Digital health

    2023  Volume 5, Issue 6, Page(s) e390–e394

    Abstract: Fuelled by adaptations to clinical trial implementation during the COVID-19 pandemic, decentralised clinical trials are burgeoning. Decentralised clinical trials involve many digital tools to facilitate research without physical contact between research ... ...

    Abstract Fuelled by adaptations to clinical trial implementation during the COVID-19 pandemic, decentralised clinical trials are burgeoning. Decentralised clinical trials involve many digital tools to facilitate research without physical contact between research teams and participants at various stages, such as recruitment, enrolment, informed consent, administering study interventions, obtaining patient-reported outcome measures, and safety monitoring. These tools can provide ways of ensuring participants' safety and research integrity, while sometimes reducing participant burden and trial cost. Research sponsors and investigators are interested in expanding the use of decentralised clinical trials. The US Food and Drug Administration and other regulators worldwide have issued guidance on how to implement such adaptations. However, there has been little focus on the distinct ethical challenges these trials pose. In this Health Policy report, which is informed by both traditional research ethics and digital ethics frameworks, we group the related ethical issues under three areas requiring increased ethical vigilance: participants' safety and rights, scientific validity, and ethics oversight. Our aim is to describe these issues, offer practical means of addressing them, and prompt the delineation of ethical standards for decentralised trials.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; Informed Consent ; Ethics, Research ; Research Personnel
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(23)00052-3
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  8. Book ; Conference proceedings: Ethical issues in cord blood banking

    Sugarman, Jeremy

    on 22 - 23 September, 1997 a workshop ... was held in Crystal City, Virginia

    (Cancer research therapy & control ; 8,4 = Special issue)

    1999  

    Author's details guest eds.: Jeremy Sugarman
    Series title Cancer research therapy & control ; 8,4 = Special issue
    Cancer research, therapy and control
    Collection Cancer research, therapy and control
    Language English
    Size S. 315 - 380
    Publisher Harwood
    Publishing place St. Helier
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT011266208
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Examining Provisions Related to Consent in the Revised Common Rule.

    Sugarman, Jeremy

    The American journal of bioethics : AJOB

    2017  Volume 17, Issue 7, Page(s) 22–26

    Abstract: The long-standing overarching policy governing research with human subjects conducted and supported by most federal agencies and departments in the United States, known as the Common Rule, has recently been revised, with most requirements slated to ... ...

    Abstract The long-standing overarching policy governing research with human subjects conducted and supported by most federal agencies and departments in the United States, known as the Common Rule, has recently been revised, with most requirements slated to become effective in 2018. Although there are multiple alterations to the current regulations, some of the most significant changes aim to enhance consent for research. While some of the particular provisions in this regard will be easy to apply and promise to help meet this goal, others may be more challenging to implement despite their intuitive appeal. In this article, I examine some of the provisions in the revised Common Rule that relate to consent: (1) new required consent elements; (2) the goal of comprehension in the consent process; (3) consent forms; and (4) broad consent. By raising issues about these provisions now and suggesting possible ways to overcome their potential shortfalls, the hope is that future efforts can be taken to help clarify and appropriately implement them.
    MeSH term(s) Biomedical Research/ethics ; Biomedical Research/legislation & jurisprudence ; Ethical Review ; Ethics Committees, Research ; Federal Government ; Government Regulation ; Human Experimentation/ethics ; Human Experimentation/legislation & jurisprudence ; Humans ; Informed Consent/ethics ; Informed Consent/legislation & jurisprudence ; Research Subjects ; United States
    Language English
    Publishing date 2017-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2017.1329483
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  10. Book: Ethics of research with human subjects

    Sugarman, Jeremy

    selected policies and resources

    1998  

    Author's details ed. by Jeremy Sugarman
    Keywords Mensch ; Forschungsgegenstand ; Ethik ; Menschenversuch
    Subject Ethische Theorie ; Moral ; Philosophische Ethik ; Sittenlehre ; Moralphilosophie ; Humanexperiment ; Humanversuch ; Mensch ; Forschungsobjekt ; Forschungsthema ; Forschung ; Menschen ; Homo sapiens
    Language English
    Size VII, 244 S.
    Publisher Univ. Publ. Group
    Publishing place Frederick, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT010612455
    ISBN 1-55572-057-9 ; 978-1-55572-057-5
    Database Catalogue ZB MED Medicine, Health

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