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Article ; Online: Onze nieuwe donorwet – meer autonomie?

Bakker, Marleen

2020 Volume 164

Abstract: On 1 July 2020, the registration of organ and tissue donors in the Netherlands changed from an opt-in to an opt-out system. This means that everyone in the Netherlands will be registered as an organ and tissue donor unless they have registered a ... ...

Title translation	Our new donation law: more autonomy?
Abstract	On 1 July 2020, the registration of organ and tissue donors in the Netherlands changed from an opt-in to an opt-out system. This means that everyone in the Netherlands will be registered as an organ and tissue donor unless they have registered a different choice in the donor register. The hope is that this new method for donor registration will lead to more donors. Only a small majority of members of the Senate and the House of Representatives in the Netherlands voted for the legislative amendment that enabled this new system to come into effect. In the Senate the amendment was defended on the grounds that it would do more justice to the autonomy of the deceased; the new law will, however, have to be defended from the principles of justice and solidarity by a government that feels responsibility towards those needing a donor organ.
MeSH term(s)	Donor Selection/ethics ; Donor Selection/legislation & jurisprudence ; Humans ; Netherlands ; Relational Autonomy ; Social Justice/ethics ; Tissue Donors/ethics ; Tissue Donors/legislation & jurisprudence ; Tissue and Organ Procurement/ethics ; Tissue and Organ Procurement/legislation & jurisprudence
Language	Dutch
Publishing date	2020-06-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Alteration of functional connectivity despite preserved cerebral oxygenation during acute hypoxia.

Bakker, Marleen E / Djerourou, Ismaël / Belanger, Samuel / Lesage, Frédéric / Vanni, Matthieu P

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13269

Abstract: Resting state networks (RSN), which show the connectivity in the brain in the absence of any stimuli, are increasingly important to assess brain function. Here, we investigate the changes in RSN as well as the hemodynamic changes during acute, global ... ...

Abstract	Resting state networks (RSN), which show the connectivity in the brain in the absence of any stimuli, are increasingly important to assess brain function. Here, we investigate the changes in RSN as well as the hemodynamic changes during acute, global hypoxia. Mice were imaged at different levels of oxygen (21, 12, 10 and 8%) over the course of 10 weeks, with hypoxia and normoxia acquisitions interspersed. Simultaneous GCaMP and intrinsic optical imaging allowed tracking of both neuronal and hemodynamic changes. During hypoxic conditions, we found a global increase of both HbO and HbR in the brain. The saturation levels of blood dropped after the onset of hypoxia, but surprisingly climbed back to levels similar to baseline within the 10-min hypoxia period. Neuronal activity also showed a peak at the onset of hypoxia, but dropped back to baseline as well. Despite regaining baseline sO2 levels, changes in neuronal RSN were observed. In particular, the connectivity as measured with GCaMP between anterior and posterior parts of the brain decreased. In contrast, when looking at these same connections with HbO measurements, an increase in connectivity in anterior-posterior brain areas was observed suggesting a potential neurovascular decoupling.
MeSH term(s)	Mice ; Animals ; Brain/diagnostic imaging ; Brain/physiology ; Hypoxia ; Oxygen ; Hemodynamics
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40321-3
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Thesis ; Online: The positive effect of biodiversity

Bakker, Lisette Marleen

Using root traits to understand effects of plant diversity and drought on grassland productivity

2018

Abstract: The more plant species grow together, the higher the yield. Higher plant species richness may also increase drought resistance, i.e. yield preservation during droughts. However, the mechanisms underlying these positive biodiversity effects are still ... ...

Abstract	The more plant species grow together, the higher the yield. Higher plant species richness may also increase drought resistance, i.e. yield preservation during droughts. However, the mechanisms underlying these positive biodiversity effects are still debated. I this thesis, I investigated whether diversity in root characteristics or ‘traits’, such as rooting depth, can explain increased yield, or ‘overyielding’, and drought resistance in grassland plant communities. My results show that, although diversity in roots traits could not explain overyielding, root traits – and deep rooting in particular – were important: communities with deep-rooting species performed better than expected. Further, overyielding of deep-rooting species in diverse communities increased when growing with shallow-rooting neighbours, supporting the importance of rooting depth diversity. This research shows that rooting strategies play an important role in the positive effect of plant diversity on yield production. We found no evidence that plant species richness or root trait diversity increased drought resistance, perhaps due to extremeness of the drought treatment. On the contrary, drought decreased overyielding. Future biodiversity research at different drought intensity levels may further increase our insights on how biodiversity affect the drought resistance of our grasslands.
Keywords	arable land ; grassland birds ; grasslands ; soil ; species-rich grasslands ; bodem ; bouwland ; graslanden ; kruidenrijke graslanden ; weidevogels
Subject code	580
Language	English
Publisher	Wageningen University
Publishing country	nl
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ethische principes in het gedrang door COVID-19?

Bakker, Marleen / van de Vathorst, Suzanne

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: In the late 1970s, the American bioethicists Tom Beauchamp and James Childress described the four ethical principles that should guide a physician's actions in individual patient care. These principles are: (a) respect for autonomy; (b) doing well ( ... ...

Title translation	Ethical principles compromised during the COVID-19 pandemic?
Abstract	In the late 1970s, the American bioethicists Tom Beauchamp and James Childress described the four ethical principles that should guide a physician's actions in individual patient care. These principles are: (a) respect for autonomy; (b) doing well (beneficence); (c) not harming (non-maleficence); and (d) justice. In many countries, the global outbreak of SARS-CoV-2 has led to overloaded healthcare systems due to large numbers of COVID-19 patients. In order to provide care to this high volume of patients, far-reaching measures are taken that affect everyone. These measures are not taken from an individual patient's perspective but in the interest of public health; nonetheless, they can directly affect the individual patient's interests. This article examines the extent to which Beauchamp and Childress' ethical principles may be compromised during the COVID-19 pandemic.
MeSH term(s)	Beneficence ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Moral Obligations ; Pandemics/ethics ; Personal Autonomy ; Pneumonia, Viral ; Quality of Health Care ; SARS-CoV-2 ; Social Justice
Keywords	covid19
Language	Dutch
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Binnen de grenzen van de wet?

Bakker, Marleen / Plomp, Emke

Nederlands tijdschrift voor geneeskunde

2018 Volume 162

Abstract: We discuss two patients with infectious tuberculosis who underwent compulsory isolation and treatment without their consent. We describe the threat to the patient's rights, i.e. the right of freedom, the right of autonomy and the right of protection of ... ...

Title translation	Within the limits of the law? Compulsory isolation and compulsory treatment for tuberculosis.
Abstract	We discuss two patients with infectious tuberculosis who underwent compulsory isolation and treatment without their consent. We describe the threat to the patient's rights, i.e. the right of freedom, the right of autonomy and the right of protection of the integrity of the body. We describe the application of the relevant laws and of the differing safeguards, and discuss the unlimited length of the Dutch Public Health Act orders. We refer to a Dutch statement and the WHO ethics guidelines on the implementation of their End TB Strategy. Forced isolation may be the last resort to protect society from patients with infectious diseases who do not comply with isolation measures, but compulsory treatment for tuberculosis patients is considered unacceptable. We suggest an amendment of the Dutch Public Health Act to enable better protection of the rights of tuberculosis patients.
MeSH term(s)	Hospitalization/legislation & jurisprudence ; Humans ; Mandatory Programs/legislation & jurisprudence ; Mental Competency ; Netherlands ; Patient Isolation/legislation & jurisprudence ; Personal Autonomy ; Tuberculosis/therapy
Language	Dutch
Publishing date	2018-08-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Sonication of Vascular Grafts and Endografts to Diagnose Vascular Graft Infection: a Head-To-Head Comparison with Conventional Culture and Its Clinical Impact.

Braams, Lisanne / Vlaspolder, Gro / Boiten, Kathleen / Salomon, Elisa / Winter, Rik / Saleem, Ben / Wouthuyzen-Bakker, Marjan / van Oosten, Marleen

Microbiology spectrum

2023 , Page(s) e0372222

Abstract: Vascular graft and endograft infection (VGEI) is a severe complication associated with high mortality and is often challenging to diagnose. For the definitive microbiological diagnosis, sonication of vascular grafts may increase the microbiological yield ...

Abstract	Vascular graft and endograft infection (VGEI) is a severe complication associated with high mortality and is often challenging to diagnose. For the definitive microbiological diagnosis, sonication of vascular grafts may increase the microbiological yield of these biofilm-associated infections. The objective of this study was to determine whether sonication of explanted vascular grafts and endografts results in a higher diagnostic accuracy than conventional culture methods and aids in clinical decision-making. A prospective diagnostic study was performed comparing conventional culture with sonication culture of explanted vascular grafts in patients treated for VGEI. Explanted (endo)grafts were cut in halves and were either subjected to sonication or conventional culture. Criteria based on the Management of Aortic Graft Infection Collaboration (MAGIC) case definition of VGEI were used for definitive diagnosis. The relevance of sonication cultures was assessed by expert opinion to determine the clinical impact on decision-making. Fifty-seven vascular (endo)graft samples from 36 patients (four reoperations; 40 episodes) treated for VGEI were included; 32 episodes were diagnosed with VGEI. Both methods showed a positive culture in 81% of the cases. However, sonication culture detected clinically relevant microorganisms that went unnoticed by conventional culturing in 9 out of 57 samples (16%, 8 episodes) and provided additional relevant information regarding growth densities in another 11 samples (19%, 10 episodes). Sonication of explanted vascular grafts and endografts improves the microbiological yield and aids in the clinical decision-making for patients with a suspected VGEI compared to conventional culture alone.
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03722-22
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Article ; Online: Water level drawdown induces a legacy effect on the seed bank and retains sediment chemistry in a eutrophic clay wetland.

Bouma, Kerstin / Bakker, Elisabeth S / Wilborts, Marleen / Robroek, Bjorn J M / Lamers, Leon L / Cornelissen, Perry / van Eerden, Mennobart R / Temmink, Ralph J M

The Science of the total environment

2024 Volume 929, Page(s) 172531

Abstract: The lack of extreme water level fluctuations in managed, non-peat forming wetland ecosystems can result in decreased productivity through the loss of heterogeneity of these ecosystems. Stochastic disruption, such as a water level drawdown, can ... ...

Abstract	The lack of extreme water level fluctuations in managed, non-peat forming wetland ecosystems can result in decreased productivity through the loss of heterogeneity of these ecosystems. Stochastic disruption, such as a water level drawdown, can effectively reverse this effect and return the wetland to a more productive state, associated with higher biodiversity through new vegetation development. Yet, aside from the effect on vegetation dynamics, little is known about longer-term effects (30 years) of a water level drawdown, hereafter referred to as legacy effects, and how this may impact future water level drawdowns. Here, we aim to unravel the legacy effects of a water level drawdown, stand alone and along a water level gradient, on seed bank properties and nutrient availability in a eutrophic clay wetland. To identify these, we studied the hydrologically managed nature reserve Oostvaardersplassen in the Netherlands. Here, one section was subjected to a multi-year water level drawdown and another section was kept inundated. We determined seed bank properties in both areas, spatially and along a soil elevation gradient (20 cm). Nutrient availability was measured by taking sediment samples along the water level gradient and through experimental manipulation of the water level in an indoor mesocosm experiment. Germination was higher in locations with a water level drawdown history, especially at relatively high elevations. Additionally, the proportion of pioneer species in the seed bank was higher in the water level drawdown area. Overall, nutrient concentrations were higher compared to other aquatic systems. Nutrient availability was higher in the inundated area and did not respond to the water level gradient. We conclude that 30 years after an induced water level drawdown there is no depletion of nutrients, while we still observe a legacy effect in the number of viable seeds in the seed bank.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172531
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Article ; Online: Correction to: A fluorogenic micrococcal nuclease‑based probe for fast detection and optical imaging of Staphylococcus aureus in prosthetic joint and fracture‑related infections.

Schoenmakers, Jorrit W A / López-Álvarez, Marina / IJpma, Frank F A / Wouthuyzen-Bakker, Marjan / McNamara, James O / van Oosten, Marleen / Jutte, Paul C / van Dijl, Jan Maarten

European journal of nuclear medicine and molecular imaging

2023

Language	English
Publishing date	2023-11-23
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06538-0
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Article: First evaluation of a commercial multiplex PCR panel for rapid detection of pathogens associated with acute joint infections.

Schoenmakers, Jorrit Willem Adriaan / de Boer, Rosanne / Gard, Lilli / Kampinga, Greetje Anna / van Oosten, Marleen / van Dijl, Jan Maarten / Jutte, Paulus Christiaan / Wouthuyzen-Bakker, Marjan

Journal of bone and joint infection

2023 Volume 8, Issue 1, Page(s) 45–50

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-01-18
Publishing country	Germany
Document type	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.5194/jbji-8-45-2023
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Article ; Online: The effect of beclomethasone-formoterol

van der Veer, Tjeerd / de Koning Gans, Johanna Margaretha / Braunstahl, Gerrit J / Pieters, Angelina L P / van den Berg, Johanna M W / Hoek, Rogier A S / Kamphuis, Lieke S J / Bakker, Marleen / Dubois, Alain V F / Aerts, Joachim G J V / van der Eerden, Menno M

The European respiratory journal

2023 Volume 61, Issue 6

MeSH term(s)	Humans ; Formoterol Fumarate/therapeutic use ; Beclomethasone/therapeutic use ; Cough/drug therapy ; Asthma/drug therapy ; Bronchiectasis/complications ; Bronchiectasis/drug therapy ; Double-Blind Method ; Administration, Inhalation
Chemical Substances	Formoterol Fumarate (W34SHF8J2K) ; Beclomethasone (KGZ1SLC28Z)
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Randomized Controlled Trial ; Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.00186-2023
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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