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  1. Article: Relationship between compression pressure, mechanical strength and release properties of tablets.

    Adeleye, Olutayo Ademola

    Polimery w medycynie

    2019  Volume 49, Issue 1, Page(s) 27–33

    Abstract: Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipients. Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses, such as compression ... ...

    Abstract Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipients. Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses, such as compression pressure, thus imposing changes in the properties of these materials. Variations in the compression pressure and other processing parameters may affect the mechanical strength and release properties of the final tablet. It is generally expected that an increase in compression pressure should lead to an increase in mechanical strength and a decrease in release properties of tablets, but this may not be true in some practical situation, since tablet production is the result of complex interaction between many factors involving the drug, excipient, the formulation, and processing variables. The degree and extent of interaction of these variables are not absolutely dependent on one factor. The aim of this review is to study the interaction between compression pressure, mechanical strength and release properties of immediate and controlled release tablets. The effect of compression pressure on tablets is complemented by such factors as the material properties of the drug and excipient, the formulation and processing factors, which in turn affects mechanical strength and release properties.
    MeSH term(s) Chemistry, Pharmaceutical ; Excipients ; Pressure ; Solubility ; Tablets
    Chemical Substances Excipients ; Tablets
    Language English
    Publishing date 2019-11-22
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 193157-x
    ISSN 0370-0747
    ISSN 0370-0747
    DOI 10.17219/pim/111888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 920: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Physicochemical Evaluation and Antibacterial Activity of

    Adeleye, Olutayo Ademola / Bamiro, Oluyemisi / Akpotu, Mark / Adebowale, Modupe / Daodu, John / Sodeinde, Mariam Adeola

    Turkish journal of pharmaceutical sciences

    2021  Volume 18, Issue 4, Page(s) 476–482

    Abstract: Objectives: Oral hygiene, an integral part of the body's general well-being, should be maintained to prevent dental problems. This study was conducted to incorporate the ethanol extract of : Materials and methods: The content of dried : Results: ... ...

    Abstract Objectives: Oral hygiene, an integral part of the body's general well-being, should be maintained to prevent dental problems. This study was conducted to incorporate the ethanol extract of
    Materials and methods: The content of dried
    Results: All toothpastes were smooth and sweet and smelled pleasant. They all had good retention ability on the bristles of toothbrush and had a pH range of 7.18-7.83. The toothpastes of the extracts of different concentration demonstrated antibacterial activities against the test organisms. The antibacterial activity of the formulated toothpastes increased significantly with an increase in the extract concentration. F5 that contained 5% extract showed the highest activity, with an inhibition zone of 19.30±0.17 mm and 12.60±0.52 mm against
    Conclusion: The incorporation of the
    Language English
    Publishing date 2021-09-08
    Publishing country Turkey
    Document type Journal Article
    ISSN 2148-6247
    ISSN (online) 2148-6247
    DOI 10.4274/tjps.galenos.2020.42966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Medicinal Plants with Potential Inhibitory Bioactive Compounds against Coronaviruses.

    Adeleye, Olutayo Ademola / Bamiro, Oluyemisi Adebowale / Bakre, Lateef Gbenga / Odeleye, Florence Olubola / Adebowale, Modupe Nofisat / Okunye, Olufemi Lionel / Sodeinde, Mariam Adeola / Adebona, Adannaya Charity / Menaa, Farid

    Advanced pharmaceutical bulletin

    2021  Volume 12, Issue 1, Page(s) 7–16

    Abstract: Medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and in the Middle East use herbal medicine for disease management such as severe acute respiratory syndrome (SARS) caused by coronavirus. ... ...

    Abstract Medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and in the Middle East use herbal medicine for disease management such as severe acute respiratory syndrome (SARS) caused by coronavirus. Infection from coronavirus is initiated by entry of the virus into a susceptible host cell. The two human coronaviruses of public health importance two decades ago were SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) and now SARS-CoV-2. These three viruses belong to the same class of beta coronavirus and are somewhat similar in genome sequencing, life cycle, mode of entry into a host, mode of transmission and clinical manifestations. This review identified twenty medicinal plants with potential inhibitory bioactive compounds from natural sources that are active against coronaviruses that could be developed into various drug delivery systems. It also highlighted several evidences to show that medicinal plant used in the treatment of SARSCoV may offer some sort of relief from the burden of coronavirus disease 2019 (COVID-19) pandemic. Since there is no specific treatment for COVID-19 yet, the search for medicinal plants with inhibitory bioactive compounds against coronavirus could be the long awaited breakthrough scientists have been searching to change the narratives of COVID-19 pandemic.
    Language English
    Publishing date 2021-01-30
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2022.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019.

    Adeleye, Olutayo Ademola / Femi-Oyewo, Mbang Nyong / Bamiro, Oluyemisi Adebowale / Bakre, Lateef Gbenga / Alabi, Akinyinka / Ashidi, Joseph Senu / Balogun-Agbaje, Olalekan Adeyinka / Hassan, Oluwakemi Mary / Fakoya, Gbemisola

    Future journal of pharmaceutical sciences

    2021  Volume 7, Issue 1, Page(s) 72

    Abstract: Background: Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it. ...

    Abstract Background: Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it.
    Main text: The deadly coronavirus disease 2019 (COVID-19) caused by a novel coronavirus known as SARS-CoV-2 has widely spread globally with high mortality and morbidity. Its prevention, treatment and management still pose a serious challenge. A drug for the cure of this disease is yet to be developed. The clinical management at present is based on symptomatic treatment as presented by individuals infected and this is by combination of more than two drugs such as antioxidants, anti-inflammatory, anti-pyretic, and anti-microbials. Literature search was performed through electronic searches of PubMed, Google Scholar, and several research reports including WHO technical documents and monographs.
    Conclusion: Drug discovery from herbs is essential and should be exploited for the discovery of drugs for the management of COVID-19. This review is aimed at identifying ethnomedicinal herbs available in Africa that could be used for the discovery and development of a drug for the prevention, treatment, and management of the novel coronavirus disease 2019.
    Language English
    Publishing date 2021-03-20
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2834845-X
    ISSN 2314-7253 ; 2314-7253
    ISSN (online) 2314-7253
    ISSN 2314-7253
    DOI 10.1186/s43094-021-00223-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019

    Olutayo Ademola Adeleye / Mbang Nyong Femi-Oyewo / Oluyemisi Adebowale Bamiro / Lateef Gbenga Bakre / Akinyinka Alabi / Joseph Senu Ashidi / Olalekan Adeyinka Balogun-Agbaje / Oluwakemi Mary Hassan / Gbemisola Fakoya

    Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Abstract Background Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed ... ...

    Abstract Abstract Background Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it. Main text The deadly coronavirus disease 2019 (COVID-19) caused by a novel coronavirus known as SARS-CoV-2 has widely spread globally with high mortality and morbidity. Its prevention, treatment and management still pose a serious challenge. A drug for the cure of this disease is yet to be developed. The clinical management at present is based on symptomatic treatment as presented by individuals infected and this is by combination of more than two drugs such as antioxidants, anti-inflammatory, anti-pyretic, and anti-microbials. Literature search was performed through electronic searches of PubMed, Google Scholar, and several research reports including WHO technical documents and monographs. Conclusion Drug discovery from herbs is essential and should be exploited for the discovery of drugs for the management of COVID-19. This review is aimed at identifying ethnomedicinal herbs available in Africa that could be used for the discovery and development of a drug for the prevention, treatment, and management of the novel coronavirus disease 2019.
    Keywords Coronavirus ; SARS-CoV-2 ; COVID-19 ; Traditional medicine ; Ethnomedicinal herbs ; Therapeutics. Pharmacology ; RM1-950 ; Pharmacy and materia medica ; RS1-441
    Subject code 360
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient.

    Adeleye, Olutayo Ademola / Femi-Oyewo, Mbang Nyong / Odeniyi, Michael Ayodele

    Polimery w medycynie

    2014  Volume 44, Issue 4, Page(s) 209–220

    Abstract: Background: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics.: Objectives: To evaluate different methods of gum ... ...

    Abstract Background: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics.
    Objectives: To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporating cissus gum as controlled release polymer.
    Material and methods: Water (CW) and acetone (CA) extracts of cissus gum were obtained from Cissus populea stem and two methods - wet granulation and direct compression - were used to compress the tablet and compare it with xanthan gum (X) formulations. Crushing strength and friability were used to assess mechanical properties while dissolution rate were used to assess release properties. Data were analysed using t-test and ANOVA at p < 0.05.
    Results: The crushing strength of tramadol tablets has increased together with the increase in polymer concentration in all formulations, while friability has decreased for both methods. Tablets made by wet granulation had higher crushing strength than those made by direct compression method. The release mechanism for both direct compression and wet granulation methods was Fickian and non-Fickian respectively. The rank order for t25, t50 and t75 for all formulations was X > CA > CW. Generally, wet granulation method decreased the rate of tramadol release more than direct compression method, indicating a higher drug retarding ability.
    Conclusions: Incorporation of cissus gum controlled the release of tramadol hydrochloride from the matrix tablets. Extraction method and formulation variables influenced mechanical and release properties of the tablets. Cissus gum acetone extract had comparable release properties with xanthan gum and could serve as a cheaper alternative in controlled release tablet formulations.
    MeSH term(s) Administration, Oral ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/chemistry ; Analgesics, Opioid/pharmacokinetics ; Analysis of Variance ; Chemistry, Pharmaceutical ; Cissus ; Delayed-Action Preparations ; Excipients/administration & dosage ; Excipients/chemistry ; Excipients/pharmacokinetics ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; Plant Gums/administration & dosage ; Plant Gums/chemistry ; Plant Gums/pharmacokinetics ; Solubility ; Tablets ; Tramadol/administration & dosage ; Tramadol/chemistry ; Tramadol/pharmacokinetics
    Chemical Substances Analgesics, Opioid ; Delayed-Action Preparations ; Excipients ; Plant Extracts ; Plant Gums ; Tablets ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2014-10
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 193157-x
    ISSN 0370-0747
    ISSN 0370-0747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 920: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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