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Article ; Online: Si Miao San relieves hyperuricemia by regulating intestinal flora.

Qian, Yue / Shen, Yan

2023 Volume 38, Issue 3, Page(s) e5807

Abstract: This study seeks to investigate the therapeutic effects of Si Miao San (SMS) on hyperuricemia and ...

Abstract	This study seeks to investigate the therapeutic effects of Si Miao San (SMS) on hyperuricemia and its underlying mechanisms, particularly focusing on the role of intestinal flora. The key components of SMS were identified using high-performance liquid chromatography (HPLC). To establish a rat model of hyperuricemia, an intraperitoneal injection of potassium oxonate was performed, followed by oral administration of various concentrations of SMS. The study evaluated the status of hyperuricemia, renal pathology, xanthine oxidase (XO) activity, and intestinal flora. Utilizing HPLC, we identified five active components of SMS. Following SMS intervention, there was a significant reduction in serum levels of uric acid (UA), blood urea nitrogen, and creatinine, accompanied by an increase in urine UA levels in rats with hyperuricemia. Distinct pathological injuries were evident in the renal tissues of hyperuricemic rats, and these were partially alleviated following SMS intervention. Moreover, SMS exhibited a dose-dependent reduction in XO activity both in the serum and hepatic tissues. Notably, SMS contributed to an enhancement in the diversity of intestinal flora in hyperuricemic rats. The intervention of SMS resulted in a reduction in the abundance of certain bacterial species, including Parabacteroides johnsonii, Corynebacterium urealyticum, and Burkholderiales bacterium. This suggests that SMS may exert anti-hyperuricemia effects, potentially by modulating the composition of intestinal flora.
MeSH term(s)	Rats ; Animals ; Hyperuricemia/drug therapy ; Gastrointestinal Microbiome ; Kidney ; Uric Acid ; Drugs, Chinese Herbal ; Xanthine Oxidase
Chemical Substances	Uric Acid (268B43MJ25) ; Drugs, Chinese Herbal ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5807
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Article: Hemiboea shimentaiensis S. Y. Miao, Y. Q. Li & T. Chen (Gesneriaceae), a new species from northern Guangdong, China

Miao, Shen‐yu / Guo, Guo‐xin / Dai, Ke‐yuan / Xiao, Jin‐hai / Li, Yuan‐qiu / Chen, Tao

Nordic journal of botany. 2022 Sept., v. 2022, no. 9

2022

Abstract: Hemiboea shimentaiensis (Gesneriaceae), a new species from northern Guangdong, China, is described and illustrated. It is most similar to H. gamosepala, H. rubribracteata and H. malipoensis in the nearly white corolla, which appears in a few species of ... ...

Abstract	Hemiboea shimentaiensis (Gesneriaceae), a new species from northern Guangdong, China, is described and illustrated. It is most similar to H. gamosepala, H. rubribracteata and H. malipoensis in the nearly white corolla, which appears in a few species of Hemiboea, and nearly glabrous inner base of the corolla tube. It can be easily distinguished from the latter three species by the stoloniferous habit, distinct silvery veins, glabrous corolla except for a ring of hairs inside, anther coherent along ventral face when young, but cohering apically at maturity, three separate staminodes with lateral ones resembling deformed anthers, and with few sterile pollen grains inside, to antheroids at the tips of the staminodes. The life cycle and fluctuations in the population are unknown and need further study, the conservation status of H. shimentaiensis was not assessed.
Keywords	Gesneriaceae ; conservation status ; corolla ; new species ; pollen ; China
Language	English
Dates of publication	2022-09
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2406507-9
ISSN	1756-1051 ; 0107-055X
ISSN (online)	1756-1051
ISSN	0107-055X
DOI	10.1111/njb.03611
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes.

Cui, Wei / Nie, Shengjie / Fang, Yating / Chen, Man / Zhao, Ming / Lan, Qiong / Shen, Chunmei / Zhu, Bofeng

Hereditas

2022 Volume 159, Issue 1, Page(s) 22

Abstract: ... This study aims to investigate the genetic polymorphisms of these 39 AIM-InDel loci in Yunnan Hani and Miao ... Materials and methods: In this research, 39 AIM-InDel profiles of 203 unrelated Miao individuals and 203 ... the genetic polymorphisms of 39 InDel loci in Yunnan Miao and Hani groups. Moreover, the genetic relationships among Yunnan ...

Abstract	Background: Ancestry informative markers are regarded as useful tools for inferring the ancestral information of an individual, which have been widely used in the criminal investigations and population genetic studies. Previously, a multiplex amplification panel containing 39 AIM-InDel loci was constructed. This study aims to investigate the genetic polymorphisms of these 39 AIM-InDel loci in Yunnan Hani and Miao ethnic groups, and to uncover their genetic affinities with reference populations based on the AIM-InDel markers. Materials and methods: In this research, 39 AIM-InDel profiles of 203 unrelated Miao individuals and 203 unrelated Hani individuals in Yunnan province of China were acquired. Additionally, we evaluated the genetic polymorphisms of 39 InDel loci in Yunnan Miao and Hani groups. Moreover, the genetic relationships among Yunnan Miao, Hani and reference populations were also clarified based on Nei's genetic distances, pairwise fixation indexes, principal component analyses, phylogenetic analyses, and STRUCTURE analyses. Results: Genetic diversity analyses demonstrated that these InDel loci showed varying degrees of genetic polymorphisms, and could be utilized in forensic identifications in Yunnan Miao and Hani groups. The results of principal component analyses, phylogenetic analyses and Structure analyses revealed that Yunnan Miao and Hani groups had closer genetic relationships with East Asian populations, especially with the populations from Southern China. This research enriched the genetic data of Chinese ethnic minority, and provided ancestral information of Yunnan Miao and Hani groups from the perspective of population genetics.
MeSH term(s)	China ; Ethnicity/genetics ; Gene Frequency ; Genetics, Population ; Humans ; Minority Groups ; Phylogeny
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	214294-6
ISSN	1601-5223 ; 0018-0661
ISSN (online)	1601-5223
ISSN	0018-0661
DOI	10.1186/s41065-022-00238-9
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Article ; Online: Modified Si-Miao Pill for Rheumatoid Arthritis

Hui Wang / Yao Huang / Pan Shen / Yu Wang / Kai Qin / Ying Huang / Xin Ba / Weiji Lin / Zhe Chen / Shenghao Tu

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review and Meta-Analysis

2020 Volume 2020

Abstract: ... of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis. Design. A systematic literature search ...

Abstract	Objective. The aim of this review and meta-analysis was to assess the effects and safety of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis. Design. A systematic literature search was carried out in eight databases from their available dates of inception to April 2020. After screening, fifteen randomized, controlled trials (RCTs) comparing the effects and safety of mSMP in combination with western medicine (including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs)) in treating rheumatoid arthritis patients were included after screening. Results. In comparison with DMARDs, or coadministration of DMARDs and NSAIDs, mSMP in combination with western medicine significantly lowered erythrocyte sedimentation rate (mean difference (MD) = -10.61, 95% confidence interval (CI) [−12.19, −9.03]), C-reactive protein (MD = −6.50, 95% CI [−8.43, −4.56]), rheumatoid factors (MD = −17.31, 95% CI [−24.34, −10.27]), swollen joint count (MD = −1.63, 95% CI [−2.29, −0.97]), tender joint count (MD = −1.98, 95% CI [−2.34, −1.62]), and morning stiffness time (MD = −24.37, 95% CI [−29.41, 19.33]) and ameliorated the condition of patients (odds ratio (OR) = 3.69, 95% CI [2.64, 5.14]). Additionally, mSMP in combination with western medicine seemed safer (OR = 0.49, 95% CI [0.30, 0.81]). Conclusion. The results of the meta-analysis study have shown that mSMP in combination with western medicine therapies appears to be more effective and safer than western medicine alone in the treatment of rheumatoid arthritis including reducing inflammatory markers and adverse events and improving symptoms. Howbeit, more high-grade, large-scale RCTs of mSMP in various countries and regions are still needed.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years: a case report.

Zhou, Jing / Shen, Xiaoping / Wang, Xiaodong / Xiao, Kun / Cao, Yu / Jiang, Yanping

Journal of medical case reports

2021 Volume 15, Issue 1, Page(s) 179

Abstract: ... rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic ... background in southwestern China.: Case presentation: A 63-year-old Miao (southwestern China) man was ... Conclusions: We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China ...

Abstract	Background: Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi's sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic background in southwestern China. Case presentation: A 63-year-old Miao (southwestern China) man was initially diagnosed with CKS in 2010, having a history of limb lesions for 37 years, with left eyelid and binaural lesions for 9 years. He did not have sexual contact with men and was human immunodeficiency virus (HIV)-negative. Due to his lumbago and fever, spinal tuberculosis in the lumbar vertebra was highly suspected after computed tomography (CT) scan. However, diagnostic antituberculosis treatment for 4 weeks failed. The patient was followed up in 2016, when the rash was recovering as the systemic symptoms improved. A new CT was performed, which showed a partial response despite the absence of any medical treatment. The open reading frame (ORF)-K1 of KSHV from skin tissue of the foot was amplified and sequenced, and K1 belonged to subtype A. This genotype is consistent with the typical subtype present in Xinjiang. Conclusions: We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample may represent an unknown, novel genotype. Surveillance and regulating the immune state may represent a valuable approach for this rare disease.
MeSH term(s)	Adult ; Aged ; China ; Ethnic Groups ; Genome, Viral ; Genotype ; Herpesvirus 8, Human/classification ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/isolation & purification ; Humans ; Male ; Membrane Proteins ; Middle Aged ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology ; Skin Neoplasms/pathology ; Skin Neoplasms/virology ; Viral Envelope Proteins/classification ; Viral Envelope Proteins/genetics
Chemical Substances	Membrane Proteins ; ORF-K1 protein, Human herpesvirus 8 ; Viral Envelope Proteins
Language	English
Publishing date	2021-04-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-021-02777-7
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Article: Si Miao San Attenuates Inflammation and Oxidative Stress in Rats with CIA via the Modulation of the Nrf2/ARE/PTEN Pathway.

Shen, Pan / Huang, Yao / Ba, Xin / Lin, Weiji / Qin, Kai / Wang, Hui / Du, Maotao / Haung, Ying / Wang, Yu / Chen, Zhe / Tu, Shenghao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 2843623

Abstract: Objective: Si Miao San (SMS) is a traditional Chinese formula used in China to treat ...

Abstract	Objective: Si Miao San (SMS) is a traditional Chinese formula used in China to treat rheumatic diseases. To date, its mechanism in rheumatoid arthritis (RA) treatment is uncertain. Our study aims to assess the antiarthritic effects of SMS in experimental arthritic rats. Materials and methods: SMS (8.63, 4.31, and 2.16 g/kg/day) was orally administered after the first immunization from day 14 to day 53. The effects of SMS on rats with collagen-induced arthritis (CIA) were evaluated by arthritis score and histological assessment. The levels of cytokines and anti-CII antibodies in rat serum were measured by ELISAs. The expression of oxidative stress parameters was detected by biochemical assay kits. The levels of Nrf2, HO-1, NQO1, and PTEN were determined by western blotting. Results: Medium- and high-dose SMS treatment significantly decreased arthritis scores and alleviated ankle joint histopathology in the rats with CIA. It inhibited the production of IL-6, TNF- Conclusions: This study demonstrated that SMS effectively alleviated the disease progression of CIA by decreasing the levels of proinflammatory cytokines and reducing oxidative stress damage, as indicated by IL-6, TNF-
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/2843623
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Article: Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury.

Cui, Wenwen / Xin, Shen / Zhu, Lingjuan / Wang, Mingye / Hao, Yuanyuan / Zhao, Yuqian / Li, Yang / Hou, Yunlong

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 8968464

Abstract: Objective: The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD ...

Abstract	Objective: The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could protect cardiomyocytes from ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods: C57BL/6 mice were used to establish a model of myocardial infarction by I/R injury and treated by SMYAD for 4 weeks. Then, the cardiac functions of mice were evaluated by cardiac magnetic resonance (CMR). Histopathological analysis for the heart remodeling was detected by H&E and Masson staining. The protein expression of collagen I, MMP9, and TNF Results: SMYAD improved cardiac functions such as ventricular volume and ejection fraction of the rats with ischemia/reperfusion injury. Morphological assay indicated that SMYAD reduced the scar size and inhibited fibrosis formation. It was found that SMYAD could regulate collagen I, MMP9, and TNF Conclusion: SMYAD exerted protective effects on ischemia/reperfusion injury in myocardial cells by activating autophagy and inhibiting pyroptosis. This might be the reason why SMYAD protected myocardial tissue and improved cardiac function in mice with ischemia/reperfusion.
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/8968464
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Article ; Online: Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years

Jing Zhou / Xiaoping Shen / Xiaodong Wang / Kun Xiao / Yu Cao / Yanping Jiang

Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-

a case report

2021 Volume 7

Abstract: ... rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic ... background in southwestern China. Case presentation A 63-year-old Miao (southwestern China) man was initially ... We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample ...

Abstract	Abstract Background Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi’s sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic background in southwestern China. Case presentation A 63-year-old Miao (southwestern China) man was initially diagnosed with CKS in 2010, having a history of limb lesions for 37 years, with left eyelid and binaural lesions for 9 years. He did not have sexual contact with men and was human immunodeficiency virus (HIV)-negative. Due to his lumbago and fever, spinal tuberculosis in the lumbar vertebra was highly suspected after computed tomography (CT) scan. However, diagnostic antituberculosis treatment for 4 weeks failed. The patient was followed up in 2016, when the rash was recovering as the systemic symptoms improved. A new CT was performed, which showed a partial response despite the absence of any medical treatment. The open reading frame (ORF)-K1 of KSHV from skin tissue of the foot was amplified and sequenced, and K1 belonged to subtype A. This genotype is consistent with the typical subtype present in Xinjiang. Conclusions We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample may represent an unknown, novel genotype. Surveillance and regulating the immune state may represent a valuable approach for this rare disease.
Keywords	Human herpesvirus 8 ; Kaposi sarcoma ; Tomography ; Ethnic groups ; Genotype ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes

Cui, Wei / Nie, Shengjie / Fang, Yating / Chen, Man / Zhao, Ming / Lan, Qiong / Shen, Chunmei / Zhu, Bofeng

Hereditas. 2022 Dec., v. 159, no. 1

2022

Abstract: ... This study aims to investigate the genetic polymorphisms of these 39 AIM-InDel loci in Yunnan Hani and Miao ... MATERIALS AND METHODS: In this research, 39 AIM-InDel profiles of 203 unrelated Miao individuals and 203 ... the genetic polymorphisms of 39 InDel loci in Yunnan Miao and Hani groups. Moreover, the genetic relationships among Yunnan ...

Abstract	BACKGROUND: Ancestry informative markers are regarded as useful tools for inferring the ancestral information of an individual, which have been widely used in the criminal investigations and population genetic studies. Previously, a multiplex amplification panel containing 39 AIM-InDel loci was constructed. This study aims to investigate the genetic polymorphisms of these 39 AIM-InDel loci in Yunnan Hani and Miao ethnic groups, and to uncover their genetic affinities with reference populations based on the AIM-InDel markers. MATERIALS AND METHODS: In this research, 39 AIM-InDel profiles of 203 unrelated Miao individuals and 203 unrelated Hani individuals in Yunnan province of China were acquired. Additionally, we evaluated the genetic polymorphisms of 39 InDel loci in Yunnan Miao and Hani groups. Moreover, the genetic relationships among Yunnan Miao, Hani and reference populations were also clarified based on Nei’s genetic distances, pairwise fixation indexes, principal component analyses, phylogenetic analyses, and STRUCTURE analyses. RESULTS: Genetic diversity analyses demonstrated that these InDel loci showed varying degrees of genetic polymorphisms, and could be utilized in forensic identifications in Yunnan Miao and Hani groups. The results of principal component analyses, phylogenetic analyses and Structure analyses revealed that Yunnan Miao and Hani groups had closer genetic relationships with East Asian populations, especially with the populations from Southern China. This research enriched the genetic data of Chinese ethnic minority, and provided ancestral information of Yunnan Miao and Hani groups from the perspective of population genetics.
Keywords	ancestry ; forensic sciences ; genetic variation ; minorities (people) ; phylogeny ; China
Language	English
Dates of publication	2022-12
Size	p. 22.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	214294-6
ISSN	1601-5223 ; 0018-0661
ISSN (online)	1601-5223
ISSN	0018-0661
DOI	10.1186/s41065-022-00238-9
Database	NAL-Catalogue (AGRICOLA)

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Article: Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Wang, Hui / Huang, Yao / Shen, Pan / Wang, Yu / Qin, Kai / Huang, Ying / Ba, Xin / Lin, Weiji / Chen, Zhe / Tu, Shenghao

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 7672152

Abstract: ... of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis.: Design: A systematic literature ...

Abstract	Objective: The aim of this review and meta-analysis was to assess the effects and safety of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis. Design: A systematic literature search was carried out in eight databases from their available dates of inception to April 2020. After screening, fifteen randomized, controlled trials (RCTs) comparing the effects and safety of mSMP in combination with western medicine (including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs)) in treating rheumatoid arthritis patients were included after screening. Results: In comparison with DMARDs, or coadministration of DMARDs and NSAIDs, mSMP in combination with western medicine significantly lowered erythrocyte sedimentation rate (mean difference (MD) = -10.61, 95% confidence interval (CI) [-12.19, -9.03]), C-reactive protein (MD = -6.50, 95% CI [-8.43, -4.56]), rheumatoid factors (MD = -17.31, 95% CI [-24.34, -10.27]), swollen joint count (MD = -1.63, 95% CI [-2.29, -0.97]), tender joint count (MD = -1.98, 95% CI [-2.34, -1.62]), and morning stiffness time (MD = -24.37, 95% CI [-29.41, 19.33]) and ameliorated the condition of patients (odds ratio (OR) = 3.69, 95% CI [2.64, 5.14]). Additionally, mSMP in combination with western medicine seemed safer (OR = 0.49, 95% CI [0.30, 0.81]). Conclusion: The results of the meta-analysis study have shown that mSMP in combination with western medicine therapies appears to be more effective and safer than western medicine alone in the treatment of rheumatoid arthritis including reducing inflammatory markers and adverse events and improving symptoms. Howbeit, more high-grade, large-scale RCTs of mSMP in various countries and regions are still needed.
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/7672152
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