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  1. AU=Song Kyung Chul
  2. AU=Klimovich Pavel V.
  3. AU="Jingbo Chen"
  4. AU="Viazlo, Oleksander"
  5. AU="Toshiki Iwabuchi"
  6. AU="Dissanayake, Lakmali"
  7. AU="Michael Denkinger"
  8. AU="Abilio J. F. N. Sobral"
  9. AU="Geller, Alan"
  10. AU=Petrat Sren
  11. AU="Sterling, Shanique"
  12. AU="Qi, Zeqiang"
  13. AU="Thongstisubskul, A"
  14. AU="Daniel C. Schneider, PhD"
  15. AU="Völker, Christoph"
  16. AU="El Aoud, S"
  17. AU="Yi, Tongpei"
  18. AU="Anil K. Mantha"
  19. AU="Artzner, Christoph"
  20. AU=Diana Giovanni
  21. AU="Kinloch, Sabine"
  22. AU="Nuertey, David"
  23. AU="Ojubolamo, Olakunle"

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  1. Artikel: Production of ginsenoside compound K from American ginseng extract by fed-batch culture of Aspergillus tubingensis.

    Song, Woo-Seok / Shin, Kyung-Chul / Oh, Deok-Kun

    AMB Express

    2023  Band 13, Heft 1, Seite(n) 64

    Abstract: Compound K (C-K), one of the most bioactive ginsenoside, is produced by hydrolyzing the glycoside moieties of protopanaxadiol (PPD)-type glycosylated ginsenosides in the ginseng extract. To enhance the biotransformation of PPD-type ginsenosides in ... ...

    Abstract Compound K (C-K), one of the most bioactive ginsenoside, is produced by hydrolyzing the glycoside moieties of protopanaxadiol (PPD)-type glycosylated ginsenosides in the ginseng extract. To enhance the biotransformation of PPD-type ginsenosides in American ginseng extract (AGE) into C-K, the optimization of the feed type, concentration, and period for the carbon source sucrose and the reactant AGE was performed in fed-batch fermentation of Aspergillus tubingensis using a fermenter. The concentration (3.94 g/L) and productivity (27.4 mg/L/h) of C-K after feed optimization in fed-batch fermentation increased 3.1-fold compared to those (1.29 g/L and 8.96 mg/L/h) in batch fermentation, and a molar conversion of 100% was achieved. To the best of our knowledge, this is the first trial of fed-batch fermentation to convert ginseng extract into deglycosylated ginsenoside and the highest reported C-K concentration and productivity using ginseng extract via fermentation. After ethanol and resin treatments, C-K solids with purities of 59% and 96% were obtained from the fermentation broth as food- and pharmaceutical-grade products, respectively.
    Sprache Englisch
    Erscheinungsdatum 2023-06-25
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2621432-5
    ISSN 2191-0855
    ISSN 2191-0855
    DOI 10.1186/s13568-023-01556-5
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  2. Artikel ; Online: Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations.

    Song, Boram / Lee, Seok Hyun / Park, Jeong Hwan / Moon, Kyung Chul

    Cancer research and treatment

    2023  Band 56, Heft 1, Seite(n) 280–293

    Abstract: Purpose: This study aimed to evaluate the molecular features of clear cell adenocarcinoma (CCA) of the urinary tract and investigate its pathogenic pathways and possible actionable targets.: Materials and methods: We retrospectively collected the ... ...

    Abstract Purpose: This study aimed to evaluate the molecular features of clear cell adenocarcinoma (CCA) of the urinary tract and investigate its pathogenic pathways and possible actionable targets.
    Materials and methods: We retrospectively collected the data of patients with CCA between January 1999 and December 2016; the data were independently reviewed by two pathologists. We selected five cases of urinary CCA, based on the clinicopathological features. We analyzed these five cases by whole exome sequencing (WES) and subsequent bioinformatics analyses to determine the mutational spectrum and possible pathogenic pathways.
    Results: All patients were female with a median age of 62 years. All tumors were located in the urethra and showed aggressive behavior with disease progression. WES revealed several genetic alterations, including driver gene mutations (AMER1, ARID1A, CHD4, KMT2D, KRAS, PBRM1, and PIK3R1) and mutations in other important genes with tumor-suppressive and oncogenic roles (CSMD3, KEAP1, SMARCA4, and CACNA1D). We suggest putative pathogenic pathways (chromatin remodeling pathway, mitogen-activated protein kinase signaling pathway, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Wnt/β-catenin pathway) as candidates for targeted therapies.
    Conclusion: Our findings shed light on the molecular background of this extremely rare tumor with poor prognosis and can help improve treatment options.
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Male ; Adenocarcinoma, Clear Cell/genetics ; Adenocarcinoma, Clear Cell/pathology ; Kelch-Like ECH-Associated Protein 1/genetics ; Urethra/pathology ; Phosphatidylinositol 3-Kinases ; Retrospective Studies ; NF-E2-Related Factor 2/genetics ; Mutation ; DNA Helicases/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics
    Chemische Substanzen Kelch-Like ECH-Associated Protein 1 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; NF-E2-Related Factor 2 ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; Nuclear Proteins ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-09-11
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2133613-1
    ISSN 2005-9256 ; 1598-2998
    ISSN (online) 2005-9256
    ISSN 1598-2998
    DOI 10.4143/crt.2023.577
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  3. Artikel ; Online: Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease.

    Yoon, Hyeon-Jeong / Song, Ga-Young / Yoon, Kyung Chul

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 12985

    Abstract: We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into ... ...

    Abstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69) groups. Factors associated with oGVHD severity and poor vision outcomes were examined using multivariate logistic regression. In the severe oGVHD group, the disease activity pattern tended to be persistent, whereas flare-up episodes were more frequent and occurred over shorter intervals in this group. Myelodysplastic syndrome (MDS) and lung GVHD were more common and systemic calcineurin inhibitors were used more frequently in the severe group than in the non-severe group. Finally, 5-year survival rates were poorer in the severe group. Multivariate analysis revealed that MDS, lung GVHD involvement, and no history of systemic calcineurin inhibitor use were risk factors for severe oGVHD. Risk factors for poor vision outcomes were conjunctival scarring and persistent epithelial defects. In conclusion, MDS, lung GVHD, and no history of systemic calcineurin inhibitors are associated with severe oGVHD. Conjunctival scarring and persistent epithelial defects are risk factors for poor vision outcomes.
    Mesh-Begriff(e) Calcineurin Inhibitors/therapeutic use ; Chronic Disease ; Cicatrix/complications ; Conjunctival Diseases/etiology ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Myelodysplastic Syndromes/etiology ; Retrospective Studies
    Chemische Substanzen Calcineurin Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-07-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-17032-2
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  4. Artikel ; Online: Increased Production of Ginsenoside Compound K by Optimizing the Feeding of American Ginseng Extract during Fermentation by

    Song, Woo-Seok / Kim, Min-Ju / Shin, Kyung-Chul / Oh, Deok-Kun

    Journal of microbiology and biotechnology

    2022  Band 32, Heft 7, Seite(n) 902–910

    Abstract: The ginsenoside compound K (C-K) is widely used in traditional medicines, nutritional supplements, and cosmetics owing to its diverse pharmacological activities. Although many studies on C-K production have been conducted, fermentation is reported to ... ...

    Abstract The ginsenoside compound K (C-K) is widely used in traditional medicines, nutritional supplements, and cosmetics owing to its diverse pharmacological activities. Although many studies on C-K production have been conducted, fermentation is reported to produce C-K with low concentration and productivity. In the present study, addition of an inducer and optimization of the carbon and nitrogen sources in the medium were performed using response surface methodology to increase the C-K production via fermentation by
    Mesh-Begriff(e) Aspergillus ; Carbon ; Fermentation ; Ginsenosides ; Nitrogen ; Panax/metabolism ; Plant Extracts/metabolism
    Chemische Substanzen Ginsenosides ; Plant Extracts ; Carbon (7440-44-0) ; ginsenoside M1 (A9RLM212CY) ; Nitrogen (N762921K75)
    Sprache Englisch
    Erscheinungsdatum 2022-06-10
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2412195-2
    ISSN 1738-8872 ; 1017-7825
    ISSN (online) 1738-8872
    ISSN 1017-7825
    DOI 10.4014/jmb.2203.03059
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  5. Artikel ; Online: Gamma-Aminobutyric Acid in Rice Bran Extract Exerts Antistress Effects in Mouse Models with Depressive-Like Behaviors.

    Song, Ji-Hye / Kim, Hyunhee / Kong, Min-Jeong / Hong, Yoon-Taek / Oh, Su-Jin / Choi, Kyung-Chul

    Journal of medicinal food

    2024  Band 27, Heft 3, Seite(n) 231–241

    Abstract: Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the effects of gamma-aminobutyric acid-rich rice bran extract (GRBe) in mice stressed by forced swimming and tail suspension tests. Four weeks of oral ... ...

    Abstract Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the effects of gamma-aminobutyric acid-rich rice bran extract (GRBe) in mice stressed by forced swimming and tail suspension tests. Four weeks of oral administration of GRBe (500-2000 mg/kg) reduced the levels of dopamine and corticosterone in the blood and brain while increasing serotonin levels. GRBe was involved not only in stress but also in regulating sleep and obesity-related genes. Modern society experiences diverse and tense lives because of urbanization and informatization, which cause excessive stress due to complicated interpersonal relationships, heavy work burden, and fatigue from the organized society. High levels of stress cause psychological instability and disrupt the balance in the autonomic nervous system, which maintains the body's equilibrium, resulting in cardiovascular and cerebrovascular diseases, hormonal imbalances, and sleep disorders. Therefore, our results suggest that GRBe is a useful substance that can relieve tension by ultimately influencing a depressive-like state by lowering the levels of neuronal substances, hormones, and cytokines involved in stress and sleep disorders.
    Mesh-Begriff(e) Mice ; Animals ; Oryza ; Depression/drug therapy ; Swimming ; gamma-Aminobutyric Acid ; Biological Products ; Sleep Wake Disorders ; Disease Models, Animal ; Stress, Psychological/drug therapy
    Chemische Substanzen gamma-Aminobutyric Acid (56-12-2) ; Biological Products
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2023.K.0107
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  6. Artikel ; Online: Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease

    Hyeon-Jeong Yoon / Ga-Young Song / Kyung Chul Yoon

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Abstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified ...

    Abstract Abstract We investigate long-term clinical outcomes and predictive factors associated with poor vision outcomes in patients with ocular graft-versus-host disease (oGVHD). This retrospective cohort study involved 94 patients with chronic oGVHD, classified into severe (n = 25) and non-severe (n = 69) groups. Factors associated with oGVHD severity and poor vision outcomes were examined using multivariate logistic regression. In the severe oGVHD group, the disease activity pattern tended to be persistent, whereas flare-up episodes were more frequent and occurred over shorter intervals in this group. Myelodysplastic syndrome (MDS) and lung GVHD were more common and systemic calcineurin inhibitors were used more frequently in the severe group than in the non-severe group. Finally, 5-year survival rates were poorer in the severe group. Multivariate analysis revealed that MDS, lung GVHD involvement, and no history of systemic calcineurin inhibitor use were risk factors for severe oGVHD. Risk factors for poor vision outcomes were conjunctival scarring and persistent epithelial defects. In conclusion, MDS, lung GVHD, and no history of systemic calcineurin inhibitors are associated with severe oGVHD. Conjunctival scarring and persistent epithelial defects are risk factors for poor vision outcomes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Effects of Exercise on Physical Function and Quality of Life in Prostate Cancer Patients Receiving Androgen Deprivation Therapy: High-Intensity Interval Training versus Moderate-Intensity Continuous Training.

    Yoo, Sangjun / Lee, Kyung Hee / Jamrasi, Parivash / Cho, Min Chul / Song, Wook / Jeong, Hyeon

    Urologia internationalis

    2023  Band 107, Heft 6, Seite(n) 624–631

    Abstract: Introduction: We assessed the effects of exercise on the physical function and health quality of life (hQoL) in prostate cancer patients underwent androgen deprivation therapy (ADT). Additionally, the effects of high-intensity interval training (HIIT) ... ...

    Abstract Introduction: We assessed the effects of exercise on the physical function and health quality of life (hQoL) in prostate cancer patients underwent androgen deprivation therapy (ADT). Additionally, the effects of high-intensity interval training (HIIT) on the physical function and hQoL in these patients were compared with those of moderate-intensity continuous training (MICT).
    Methods: Seventeen prostate cancer patients who underwent ADT were prospectively allocated to either HIIT (n = 9) or MICT (n = 8). In these patients, physical function and hQoL were measured before and after 12 weeks of exercise and 3-6 months after the exercise program, respectively.
    Results: Although the whole-body total mass significantly increased after the exercise program, it was equivalent regardless of the exercise methods. After the exercise program, muscle strength and endurance improved and tended to be maintained until 3-6 months later. Improvement in muscle endurance was more prominent after HIIT, and that in muscle strength was more prominent after MICT. Performance in the senior fitness test improved after the exercise program, and HIIT was more effective for lower and upper muscle endurance and flexibility, although MICT was more effective for the others. The hQoL significantly improved 3-6 months after the exercise program.
    Conclusion: The 12-week exercise program has a positive effect on the physical function and hQoL in prostate cancer patients who underwent ADT. In these patients, compared with MICT, HIIT may be a better option for improving muscle endurance, which is thought to be significant for preventing falls and fractures in elderly patients.
    Mesh-Begriff(e) Male ; Humans ; Aged ; High-Intensity Interval Training/methods ; Androgen Antagonists/therapeutic use ; Androgens ; Quality of Life ; Prostatic Neoplasms/drug therapy
    Chemische Substanzen Androgen Antagonists ; Androgens
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000527839
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  8. Artikel ; Online: Correction: Inflammation promotes synucleinopathy propagation.

    Kim, Tae-Kyung / Bae, Eun-Jin / Jung, Byung Chul / Choi, Minsun / Shin, Soo Jean / Park, Sung Jun / Kim, Jeong Tae / Jung, Min Kyo / Ulusoy, Ayse / Song, Mi-Young / Lee, Jun Sung / Lee, He-Jin / Di Monte, Donato A / Lee, Seung-Jae

    Experimental & molecular medicine

    2024  Band 56, Heft 4, Seite(n) 1029–1030

    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01217-y
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  9. Artikel ; Online: Saliva-based Proteinase K method: A rapid and reliable diagnostic tool for the detection of SARS-COV-2 in children.

    Kim, Min Jung / Park, Pil-Gu / Hwang, Su Jin / Bang, Seung Jun / Jung, Jae Hwa / Kown, Eun Bin / Sul, Eun Kyung / Song, Kyung Chul / Choi, Joon-Sik / Han, Kyeo Re / Lee, Hye Young / Kim, Dong Hyun / Lee, Jae Myun

    Journal of medical virology

    2024  Band 96, Heft 1, Seite(n) e29361

    Abstract: Early and accurate detection of viruses in children might help prevent transmission and severe diseases. In this study, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) detection in children was evaluated using saliva specimens with a ... ...

    Abstract Early and accurate detection of viruses in children might help prevent transmission and severe diseases. In this study, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) detection in children was evaluated using saliva specimens with a Proteinase K (PTK)-based RNA preparation, as saliva collection is a simple and noninvasive procedure, even in young children, with fewer concerns about sample contamination. The saliva-based PTK and the conventional paired nasopharyngeal aspiration (NPA)-based detection methods were compared between COVID-19-positive and -negative children. In addition, the detection rate for SARS-COV-2 and the difference between admission and discharge by the saliva-based PTK method was tested in COVID-19 patients. The diagnostic accuracy of the saliva-based PTK method was 98.8% compared to NP swab-based reverse transcriptase polymerase chain reaction. Saliva samples showed high sensitivity (94.1%) and specificity (100%) when using the PTK method. Furthermore, the saliva-based PTK method significantly reduced the test processing time by 2 h. Notably, C
    Mesh-Begriff(e) Child ; Humans ; Child, Preschool ; Saliva ; SARS-CoV-2/genetics ; Endopeptidase K ; COVID-19/diagnosis ; RNA ; Specimen Handling ; Nasopharynx ; COVID-19 Testing
    Chemische Substanzen Endopeptidase K (EC 3.4.21.64) ; RNA (63231-63-0)
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29361
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  10. Artikel ; Online: Development of analytical method for veterinary antibiotics and monitoring of residuals in agricultural environment

    Jin-Wook Kim / Young-Kyu Hong / Song-Hee Ryu / Oh-Kyung Kwon / Yong-Bok Lee / Sung Chul Kim

    Applied Biological Chemistry, Vol 66, Iss 1, Pp 1-

    2023  Band 11

    Abstract: Abstract Veterinary antibiotics (VAs) administered to livestock are introduced into the soil through livestock manure and compost. These antibiotics can run off to surface water or leach into groundwater during rainfall, causing problems such as ... ...

    Abstract Abstract Veterinary antibiotics (VAs) administered to livestock are introduced into the soil through livestock manure and compost. These antibiotics can run off to surface water or leach into groundwater during rainfall, causing problems such as antibiotic contamination or the occurrence of antibiotic-resistant bacteria. In this study, an analytical method for detecting four classes of VAs (penicillin, tetracyclines, macrolides, and sulfonamides) in river water and soil was developed, and the occurrence of residual antibiotics in the agricultural environment was monitored. Soil samples were extracted with the McIlvain buffer solution and pretreatment was conducted using solid-phase extraction, followed by liquid chromatography-tandem mass spectrometry to quantify target VAs. The results of this study showed that the recovery ranged from 62 to 121% in river water and 40.2–149.3% in soil. Among the other VAs, amoxicillin and spiramycin were observed to have low recoveries in all the samples. The method detection limit (MDL) was calculated in the range of 2.1–12.3 ng L−1 in river water and 1.2–13.2 ng kg−1 in soil, and the limit of quantification was 6.6–39.2 ng L−1 and 4.0–42.0 ng kg−1, respectively. This optimal method was then applied to measure the residual concentrations of VAs in river water, sediment, and soil samples around the Muhan watershed in Korea. A total of seven antibiotics were detected, and their concentrations ranged from 0.014 to 0.309 μg L−1in river water, and 1.45–9.04 μg kg−1 in sediment and arable soil. This method can be used to screen VAs in river water and soil and is expected to be used as primary data for examining the occurrence and fate of antibiotics in agricultural environments.
    Schlagwörter Tetracyclines ; Sulfonamides ; Analytical method ; Water ; Sediment ; Soil ; Agriculture (General) ; S1-972 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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