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  1. Article: Michel G Bergeron "MGB" - a true success.

    Omar, Rabeea F / Boissinot, Maurice / Giguère, Charlotte / Trottier, Sylvie / Beauchamp, Denis / Lambert, Brigitte / Vincent, Camille B

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2014  Volume 26, Issue 6, Page(s) 287–288

    Language English
    Publishing date 2014-10-30
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2015/837690
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  2. Book: DIE SCHWANGERSCHAFTSPROTEINE BETA1-SP1, SB-BETA-G UND ALPHA2-PAG, IHRE QUALITATIVE UND QUANTITATIVE IMMUNOLOGISCHE UNTERSUCHUNG IN 133 SERUMPAAREN VON GESUNDEN, NORMALEN MUETTERN UND IHREN NEUGEBORENEN

    Trottier, Bernhard H.

    1980  

    Title variant SCHWANGERSCHAFTSPROTEINE BETA-SP, SB-BETA-G UND ALPHA-PAG IHRE QUALITATIVE UND QUANTITATIVE IMMUNOLOGISCHE UNTERSUCHUNG IN HUNDERTDREIUNDDREISSIG SERUMPAAREN VON GESUNDEN, NORMALEN MUETTERN UND IHREN NEUGEBORENEN
    Size 172 S. : ILL., GRAPH. DARST.
    Document type Book
    Note MARBURG, UNIV., FACHBEREICH HUMANMEDIZIN, DISS., 1980
    HBZ-ID HT002597904
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Peaks and transient dynamics of ecological and biogeochemical variables following impoundment in boreal reservoirs.

    Trottier, Gabrielle / Tremblay, Alain / Bilodeau, François / Turgeon, Katrine

    The Science of the total environment

    2024  Volume 924, Page(s) 171256

    Abstract: ... strongly alters the hydrological regime of aquatic ecosystems which subsequently affect the ecological (e.g ... primary production, fish biomass) and biogeochemical variables (e.g., nutrient, mercury, and carbon cycles ...

    Abstract Across the globe, reservoirs represent nearly 10 % of the world's freshwater. River impoundment strongly alters the hydrological regime of aquatic ecosystems which subsequently affect the ecological (e.g., primary production, fish biomass) and biogeochemical variables (e.g., nutrient, mercury, and carbon cycles which includes Green House Gas emissions; GHG). We examined the transient dynamics and co-variation of biogeochemical and ecological variables from unique long-term time series (40 years of data) from Hydro-Québec boreal reservoirs, with data before and after impoundment. To do so, we applied curve fitting analysis on the data from eight plausible scenarios and model selection. Following impoundment, most variables increased, peaked, and then decreased over time (clear hump-shaped patterns; six over eight variables). Model predictions peaked between three- and 11-years post-impoundment and returned to pre-impoundment levels after about nine- to 40-years. Variables also followed a clear sequence where GHG emissions (CO
    MeSH term(s) Animals ; Ecosystem ; Rivers ; Fresh Water ; Mercury/analysis ; Fishes
    Chemical Substances Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2024-02-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171256
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  4. Article ; Online: Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.

    Trottier, Amy M / Feurstein, Simone / Godley, Lucy A

    Best practice & research. Clinical haematology

    2024  Volume 37, Issue 1, Page(s) 101537

    Abstract: ... In this review, we will shed light on high malignant penetrance (e.g., CEBPA, GATA2, SAMD9/SAMD9L, and TP53 ... versus variable malignant penetrance syndromes (e.g., ANKRD26, DDX41, ETV6, RUNX1, and various ...

    Abstract Myeloid neoplasms with germline predisposition have been recognized increasingly over the past decade with numerous newly described disorders. Penetrance, age of onset, phenotypic heterogeneity, and somatic driver events differ widely among these conditions and sometimes even within family members with the same variant, making risk assessment and counseling of these individuals inherently difficult. In this review, we will shed light on high malignant penetrance (e.g., CEBPA, GATA2, SAMD9/SAMD9L, and TP53) versus variable malignant penetrance syndromes (e.g., ANKRD26, DDX41, ETV6, RUNX1, and various bone marrow failure syndromes) and their clinical features, such as variant type and location, course of disease, and prognostic markers. We further discuss the recommended management of these syndromes based on penetrance with an emphasis on somatic aberrations consistent with disease progression/transformation and suggested timing of allogeneic hematopoietic stem cell transplant. This review will thereby provide important data that can help to individualize and improve the management for these patients.
    MeSH term(s) Humans ; Myelodysplastic Syndromes ; Genetic Predisposition to Disease ; Penetrance ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/therapy ; Neoplasms ; Germ Cells ; Germ-Line Mutation ; Intracellular Signaling Peptides and Proteins
    Chemical Substances SAMD9 protein, human ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2024.101537
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  5. Article: Clinical characteristics, treatment course and outcome of adults treated for avoidant/restrictive food intake disorder (ARFID) at a tertiary care eating disorders program.

    MacDonald, Danielle E / Liebman, Rachel / Trottier, Kathryn

    Journal of eating disorders

    2024  Volume 12, Issue 1, Page(s) 15

    Abstract: ... indicators during treatment.: Results: Patients were diverse with respect to demographics (e.g., 62 ... cisgender women; 21% cisgender men; 17% transgender, non-binary, or other gender) and comorbid concerns (e.g ...

    Abstract Background: Avoidant/restrictive food intake disorder (ARFID) is now recognized as a feeding/eating disorder that affects individuals across the lifespan, but research on ARFID in general and particularly in adults remains limited. The purpose of this study was to describe the demographic and clinical characteristics of adults with ARFID seeking treatment at a tertiary care eating disorders program, and to describe the course and outcomes of treatment at three levels of care-inpatient, intensive outpatient, and outpatient individual therapy.
    Method: This retrospective chart review study examined the charts of 42 patients who received treatment for ARFID between April 2020 and March 2023. Following diagnostic assessment, patients were referred to either inpatient treatment, intensive outpatient treatment, or outpatient individual therapy. All three levels of care involved individual cognitive behaviour therapy. Inpatients typically transitioned to one of the outpatient treatments as part of a continuous care plan. We examined demographic and clinical characteristics, treatment length and completion, and changes in key indicators during treatment.
    Results: Patients were diverse with respect to demographics (e.g., 62% cisgender women; 21% cisgender men; 17% transgender, non-binary, or other gender) and comorbid concerns (e.g., 43% had neurodevelopmental disorders; > 50% had mood and anxiety disorders; 40% had posttraumatic stress disorder [PTSD]; 35% had medical conditions impacting eating/digestion). Most patients presented with more than one ARFID maintaining mechanism (i.e., lack of appetite/interest, sensory sensitivities, and/or fear of aversive consequences of eating). Treatment completion rates and outcomes were good. On average, patients showed significant improvement in impairment related to their eating disorder, and those who were underweight significantly improved on BMI and were not underweight at end of treatment.
    Discussion: These findings add to the literature by indicating that ARFID patients are commonly male or have diverse gender identities, and have high rates of neurodevelopmental, mood, anxiety, and gastrointestinal disorders. We also found high rates of PTSD. The findings show promise for treatment outcomes across the continuum of care. Next steps in ARFID treatment and research include incorporating ARFID-specific assessments into routine care, and ongoing research investigating the efficacy and effectiveness of treatments such as CBT-AR.
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699357-0
    ISSN 2050-2974
    ISSN 2050-2974
    DOI 10.1186/s40337-024-00973-6
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  6. Article ; Online: Naturally developed HPV16 antibodies and risk of newly detected cervical HPV infection outcomes.

    Trevisan, Andrea / Candeias, João M G / Thomann, Patrícia / Villa, Luisa L / Franco, Eduardo L / Trottier, Helen

    Journal of medical virology

    2024  Volume 96, Issue 4, Page(s) e29608

    Abstract: Little is known about the protection conferred by antibodies from natural human papillomavirus (HPV) infection. Our objective was to evaluate the association between HPV16 seroreactivity and HPV16 redetection, newly detected HPV infections, and loss of ... ...

    Abstract Little is known about the protection conferred by antibodies from natural human papillomavirus (HPV) infection. Our objective was to evaluate the association between HPV16 seroreactivity and HPV16 redetection, newly detected HPV infections, and loss of HPV DNA detection during follow-up. We analyzed data from 2462 unvaccinated Brazilian women. HPV16 IgG and neutralizing antibodies at baseline were assessed by enzyme-linked immunosorbent assay (n = 1975) and by the pseudovirus-based papillomavirus neutralization assay (n = 487). HPV detection, genotyping, and viral load were assessed by PCR-based methods. The associations were analyzed by Cox proportional hazards models. We observed a positive association between HPV16 IgG seroreactivity and redetection of HPV16 infections. Age-adjusted hazard ratios (HR) with 95% confidence intervals (CI) ranged from 2.45 (1.04-5.74) to 5.10 (1.37-19.00). Positive associations were also observed between HPV16 IgG antibodies and (1) newly detected HPV infections by genotypes unrelated to HPV16 (age-adjusted HR [95% CI] = 1.32 [1.08-1.2]) and (2) loss of detection of HPV infections by genotypes unrelated to HPV16 (age-adjusted HR [95% CI] = 1.24 [1.03-1.50]). Naturally developed HPV16 antibodies do not prevent recurrent HPV infections. Overall HPV16 IgG and neutralizing antibodies seem to be serological markers for latent or past infections.
    MeSH term(s) Humans ; Female ; Papillomavirus Infections/diagnosis ; Human papillomavirus 16/genetics ; Antibodies, Viral ; Immunoglobulin G ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Antibodies, Neutralizing
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29608
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    Zs.A 1320: Show issues Location:
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  7. Article ; Online: The effects of vitamin D supplementation on inflammatory biomarkers in patients with asthma: a systematic review and meta-analysis of randomized controlled trials.

    El Abd, Asmae / Dasari, Harika / Dodin, Philippe / Trottier, Helen / Ducharme, Francine M

    Frontiers in immunology

    2024  Volume 15, Page(s) 1335968

    Abstract: ... other markers of type 2 inflammation (e.g., sputum eosinophils, fractional exhaled nitric oxide, etc ... anti-inflammatory biomarkers (e.g., interleukin (IL)-10, etc.), markers of non-type 2 inflammation (e.g., high ... sensitivity C-reactive protein, etc.), and non-specific biomarkers (e.g., macrophages, etc.). Data were ...

    Abstract Background: While the association between vitamin D and several inflammatory biomarkers in asthma patients has been extensively reported, it remains unclear whether supplementation modifies these biomarkers. This review aims to evaluate the impact of vitamin D supplementation on inflammatory biomarkers measured
    Methods: We conducted a systematic review of randomized controlled trials (RCTs) published until November 2022 in six electronic databases evaluating the impact of vitamin D supplementation (any dose, form, administration route, frequency, or duration) compared to placebo in children or adults. The two co-primary outcomes were serum IgE and blood eosinophils reported at the endpoint. Secondary outcomes included other markers of type 2 inflammation (e.g., sputum eosinophils, fractional exhaled nitric oxide, etc.), anti-inflammatory biomarkers (e.g., interleukin (IL)-10, etc.), markers of non-type 2 inflammation (e.g., high-sensitivity C-reactive protein, etc.), and non-specific biomarkers (e.g., macrophages, etc.). Data were aggregated using fixed or random effect models.
    Results: Thirteen RCTs (5 in adults, 5 in pediatric patients, and 3 in mixed age groups) testing doses of vitamin D supplementation ranging from 800 to 400,000 IU over periods of 6 weeks to 12 months were included. Eight studies provided data on serum IgE and four on blood eosinophils. As secondary outcomes, three studies reported on sputum eosinophils, four on FeNO, five on serum IL-10, and two on airway IL-10. Compared to placebo, vitamin D supplementation had no significant effect on serum IgE (Mean difference [MD] [95% CI]: 0.06 [-0.13, 0.26] IU/mL), blood eosinophils (MD [95% CI]: - 0.02 [-0.11, 0.07] 10
    Conclusion: Vitamin D supplementation in individuals with asthma was not associated with lower inflammatory biomarkers related to type 2 inflammation. However, it was significantly associated with higher serum IL-10 compared to placebo.
    Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022365666.
    MeSH term(s) Adult ; Humans ; Child ; Interleukin-10 ; Randomized Controlled Trials as Topic ; Vitamin D ; Vitamins/therapeutic use ; Asthma/drug therapy ; Asthma/chemically induced ; Biomarkers ; Inflammation/drug therapy ; Inflammation/chemically induced ; Immunoglobulin E ; Dietary Supplements
    Chemical Substances Interleukin-10 (130068-27-8) ; Vitamin D (1406-16-2) ; Vitamins ; Biomarkers ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1335968
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  8. Article ; Online: Quality and Implementation of Diabetic Care at a Free Clinic.

    Chowdhury, Noumi / Trottier, Mark / Akram, Ghufraan

    Spartan medical research journal

    2022  Volume 7, Issue 1, Page(s) 30026

    Abstract: Introduction: Although typically receiving little government funding, free clinics help ensure access to affordable quality health care to the medically underserved. Established in 2004, the authors' metropolitan Detroit Health Unit on Davison Avenue ( ... ...

    Abstract Introduction: Although typically receiving little government funding, free clinics help ensure access to affordable quality health care to the medically underserved. Established in 2004, the authors' metropolitan Detroit Health Unit on Davison Avenue (HUDA) Clinic delivers primary care and specialized services to uninsured populations. The authors compared proportionate changes in A1c levels compared to prior national averages to evaluate the significance of care a free diabetes clinic can provide to uninsured populations.
    Methods: Retrospective data from 2017-2019 were reviewed of adult patients who have been diagnosed with Type 2 Diabetes. From HUDA Clinic medical records, data were collected concerning patient demographics, insurance status, pregnancy, major comorbidities and several factors related to diabetes standards of care.
    Results: There were a total of 2,231 patient visits to HUDA Clinic in 2019, of which 125 patients (5.6%) received care for their Type 2 diabetes. Forty (32%) clinic patients who had a visit in 2019 had an HbA1c <7.0 and 29 (23%) had an HbA1c > 9.5. This is comparable to the 2020 National Diabetes Statistics Report in which approximately 50% (n = 15.6 million) of Americans had an HbA1c < 7.0 and 14% (n = 5.1 million) had an HbA1c > 9.5.
    Conclusions: Huda Clinic's diabetes care percentages were quite comparable to state and national data and CDC parameters, although these comparative results need to be considered in terms of the authors' smaller sample size. These overall results indicate that health care providers can meet major recommended diabetic care at inner-city free clinics in metropolitan communities. Future provider and patient study studies regarding free clinic care patterns are clearly required to identify gaps in healthcare access and formulate and test specific strategies to improve diabetes-related outcomes.
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 2474-7629
    ISSN (online) 2474-7629
    DOI 10.51894/001c.30026
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  9. Article ; Online: Momentary skills use predicts decreased binge eating and purging early in day treatment: An ecological momentary assessment study.

    MacDonald, Danielle E / Trottier, Kathryn / Cao, Li / Crosby, Ross D / Wonderlich, Stephen A / Engel, Scott G / Olmsted, Marion P

    The International journal of eating disorders

    2024  Volume 57, Issue 3, Page(s) 548–557

    Abstract: Objective: Emerging research indicates that skills acquisition may be important to behavior change in cognitive behavior therapy (CBT) for eating disorders. This study investigated whether skills use assessed in real time during the initial 4 weeks of ... ...

    Abstract Objective: Emerging research indicates that skills acquisition may be important to behavior change in cognitive behavior therapy (CBT) for eating disorders. This study investigated whether skills use assessed in real time during the initial 4 weeks of CBT-based day treatment was associated with momentary eating disorder behavior change and rapid response to treatment.
    Methods: Participants with DSM-5 bulimia nervosa or purging disorder (N = 58) completed ecological momentary assessments (EMA) several times daily for the first 28 days of treatment. EMA assessed skills use, the occurrence of binge eating and/or purging, and state negative affect. Rapid response was defined as abstinence from binge eating and/or purging in the first 4 weeks of treatment.
    Results: Greater real-time skills use overall, and use of "planning ahead," "distraction," "social support," and "mechanical eating" skills in particular, were associated with a lower likelihood of engaging in binge eating or purging during the same period. After controlling for baseline group differences in overall difficulties with emotion regulation, rapid and non-rapid responders did not differ in overall skills use, or skills use at times of higher negative affect, during the EMA period.
    Discussion: Momentary use of skills appears to play an important role in preventing binge eating and purging, and certain skills appear to be particularly helpful. These findings contribute to the literature elucidating the processes by which CBT treatments for eating disorders work by providing empirical evidence that skills use helps to prevent binge eating and purging behaviors.
    Public significance: Individuals with eating disorders learn new skills during treatment to help them improve their symptoms. This study shows that for people with eating disorders, using skills helps prevent eating disorder behaviors in the moment. Certain skills may be particularly helpful, including planning ahead, distracting activities, support from others, and focusing on eating meals and snacks regardless of how one is feeling. These findings help us better understand how treatments work.
    MeSH term(s) Humans ; Binge-Eating Disorder/diagnosis ; Binge-Eating Disorder/therapy ; Binge-Eating Disorder/psychology ; Ecological Momentary Assessment ; Cognitive Behavioral Therapy ; Bulimia Nervosa/psychology ; Emotions
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603170-5
    ISSN 1098-108X ; 0276-3478
    ISSN (online) 1098-108X
    ISSN 0276-3478
    DOI 10.1002/eat.24128
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  10. Article ; Online: The impacts of hydropower on freshwater macroinvertebrate richness: A global meta-analysis.

    Trottier, Gabrielle / Turgeon, Katrine / Boisclair, Daniel / Bulle, Cécile / Margni, Manuele

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0273089

    Abstract: ... for the 24 studies) might be important (e.g., temperature, granulometry, wave disturbance and macrophytes ...

    Abstract Hydroelectric dams and their reservoirs have been suggested to affect freshwater biodiversity. Nevertheless, studies investigating the consequences of hydroelectric dams and reservoirs on macroinvertebrate richness have reached opposite conclusions. We performed a meta-analysis devised to elucidate the effects of hydropower, dams and reservoirs on macroinvertebrate richness while accounting for the potential role played by moderators such as biomes, impact types, study designs, sampling seasons and gears. We used a random/mixed-effects model, combined with robust variance estimation, to conduct the meta-analysis on 107 pairs of observations (i.e., impacted versus reference) extracted from 24 studies (more than one observation per study). Hydropower, dams and reservoirs did significantly impact (P = 0.04) macroinvertebrate richness in a clear, directional and statistically significant way, where macroinvertebrate richness in hydropower, dams and reservoirs impacted environments were significantly lower than in unimpacted environments. We also observed a large range of effect sizes, from very negative to very positive impacts of hydropower. We tried to account for the large variability in effect sizes using moderators, but none of the moderators included in the meta-analysis had statistically significant effects. This suggests that some other moderators (unavailable for the 24 studies) might be important (e.g., temperature, granulometry, wave disturbance and macrophytes) and that macroinvertebrate richness may be driven by local, smaller scale processes. As new studies become available, it would be interesting to keep enriching this meta-analysis, as well as collecting local habitat variables, to see if we could statistically strengthen and deepen the conclusions of this meta-analysis.
    MeSH term(s) Animals ; Biodiversity ; Ecosystem ; Fresh Water ; Invertebrates ; Rivers ; Seasons
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273089
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