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Article ; Online: Comparative efficacy and safety of tisagenlecleucel and axicabtagene ciloleucel among adults with r/r follicular lymphoma.

Dickinson, Michael / Martinez-Lopez, Joaquin / Jousseaume, Etienne / Yang, Hongbo / Chai, Xinglei / Xiang, Cheryl / Wang, Travis / Zhang, Jie / Ramos, Roberto / Schuster, Stephen J / Fowler, Nathan

Leukemia & lymphoma

2024 Volume 65, Issue 3, Page(s) 323–332

Abstract: ... with relapsed or refractory follicular lymphoma (r/r FL). This study used individual patient data from ELARA ... outcomes in r/r FL using matching-adjusted indirect comparison methods. After adjustment for baseline ...

Abstract	Regulatory approvals of tisagenlecleucel (tisa-cel) and axicabtagene ciloleucel (axi-cel) have established the feasibility of chimeric antigen receptor T-cell therapies for the treatment of adults with relapsed or refractory follicular lymphoma (r/r FL). This study used individual patient data from ELARA (tisa-cel) and aggregate published patient data from ZUMA-5 (axi-cel) to compare efficacy and safety outcomes in r/r FL using matching-adjusted indirect comparison methods. After adjustment for baseline differences in the trial populations, the results suggested that tisa-cel (
MeSH term(s)	Adult ; Humans ; Lymphoma, Follicular/therapy ; Immunotherapy, Adoptive/adverse effects ; Biological Products/adverse effects ; Cytokine Release Syndrome ; Lymphoma, Large B-Cell, Diffuse ; Antigens, CD19/adverse effects ; Receptors, Antigen, T-Cell
Chemical Substances	tisagenlecleucel (Q6C9WHR03O) ; axicabtagene ciloleucel (U2I8T43Y7R) ; Biological Products ; Antigens, CD19 ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2023.2289854
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Zs.A 2997: Show issues

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Article ; Online: Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet.

Davis, Rachel A H / Deemer, Sarah E / Bergeron, Jonathan M / Little, Jason T / Warren, Jonathan L / Fisher, Gordon / Smith, Daniel L / Fontaine, Kevin R / Dickinson, Stephanie L / Allison, David B / Plaisance, Eric P

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2018 Volume 33, Issue 2, Page(s) 2409–2421

Abstract: The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure ... of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc ...

Abstract	The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure (REE) and markers of brown and white adipose thermogenesis in lean mice. The purpose of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc
MeSH term(s)	Acetoacetates/administration & dosage ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, White/drug effects ; Adiposity/drug effects ; Animals ; Body Composition ; Body Weight/drug effects ; Butylene Glycols/administration & dosage ; Diet, High-Fat/adverse effects ; Energy Intake ; Energy Metabolism/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/physiopathology ; Obesity/prevention & control
Chemical Substances	1,3-butanediol diacetoacetate ; Acetoacetates ; Butylene Glycols
Language	English
Publishing date	2018-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201800821RR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation.

Hu, Chunyan / Mori, Takefumi / Lu, Yi / Guo, Qi / Sun, Ying / Yoneki, Yoshimi / Ohsaki, Yusuke / Nakamichi, Takashi / Oba, Ikuko / Sato, Emiko / Ogawa, Susumu / Dickinson, Bryan C / Chang, Christopher J / Miyata, Toshio / Sato, Hiroshi / Ito, Sadayoshi

Journal of hypertension

2012 Volume 30, Issue 8, Page(s) 1620–1631

Abstract: ... Studies were designed to determine the effects of a specific TCC blocker, R(-) efonidipine [R(-)EFO ... or renal interstitial (r.i.) infusion of R(-)EFO (0.25 mg/h, i.v. or r.i.) significantly increased ... The nitric oxide (NO) synthase inhibitor NG-nitro-L-argininemethylester (L-NAME, 1 μg/kg per min, i.v. or r ...

Abstract	Objectives: Blockade of the T-type calcium channel (TCC), which is expressed in the renal efferent arterioles of the juxtamedullary nephron and vasa recta, has been shown to protect against renal injury. Studies were designed to determine the effects of a specific TCC blocker, R(-) efonidipine [R(-)EFO], on the regulation of renal circulation. Methods and results: Renal medullary blood flux (MBF) and cortical blood flux (CBF) were simultaneously monitored using laser-Doppler flowmetry in Sprague-Dawley rats. Responses were also determined in rats with angiotensin II (AngII) induced renal ischemia. Intravenous (i.v.) or renal interstitial (r.i.) infusion of R(-)EFO (0.25 mg/h, i.v. or r.i.) significantly increased MBF by 24.0 ± 7.0 and 21.0 ± 4.4%, respectively, but without changing CBF or mean arterial pressure. The nitric oxide (NO) synthase inhibitor NG-nitro-L-argininemethylester (L-NAME, 1 μg/kg per min, i.v. or r.i.) significantly attenuated R(-)EFO-induced increase in MBF. R(-)EFO inhibited the AngII-mediated (50 ng/kg per min, i.v.) reduction of MBF (28.4 ± 1.7%), which was associated with increased urinary NO(2) + NO(3) excretion and decreased urinary hydrogen peroxide (H(2)O(2)) excretion. Intracellular H(2)O(2) fluorescence (real-time fluorescence imaging) in the epithelial cells of isolated medullary thick ascending limb (mTAL) significantly increased following AngII stimulation (1 μmol/L, 235 ± 52 units), which was significantly inhibited by pre and coincubation with R(-)EFO. R(-)EFO stimulation also increased the intracellular NO concentration in the epithelial cells of mTAL (220 ± 62 units). Conclusion: These results suggest that TCC blockade with R(-)EFO selectively increases MBF, an effect that appears to be mediated by changes in renal NO and oxidative stress balance, which may protect against ischemic renal injury in the renal medullary region.
MeSH term(s)	Angiotensin II/pharmacology ; Animals ; Blood Flow Velocity ; Calcium Channel Blockers/administration & dosage ; Calcium Channel Blockers/pharmacology ; Calcium Channels, T-Type/metabolism ; Dihydropyridines/administration & dosage ; Dihydropyridines/pharmacology ; Disease Models, Animal ; Drug Antagonism ; Infusions, Intravenous ; Ischemia/chemically induced ; Ischemia/metabolism ; Kidney Medulla/blood supply ; Kidney Medulla/drug effects ; Laser-Doppler Flowmetry ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitrogen Dioxide/urine ; Nitrogen Oxides/urine ; Nitrophenols/administration & dosage ; Nitrophenols/pharmacology ; Organophosphorus Compounds/administration & dosage ; Organophosphorus Compounds/pharmacology ; Rats ; Rats, Sprague-Dawley ; Renal Circulation/physiology ; Vasoconstrictor Agents/pharmacology
Chemical Substances	Calcium Channel Blockers ; Calcium Channels, T-Type ; Dihydropyridines ; Nitrogen Oxides ; Nitrophenols ; Organophosphorus Compounds ; Vasoconstrictor Agents ; Angiotensin II (11128-99-7) ; nitrogen trioxide (16E0524PXI) ; efonidipine (40ZTP2T37Q) ; Nitrogen Dioxide (S7G510RUBH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
Language	English
Publishing date	2012-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0b013e3283550e9f
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article: Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonists.

Hancock, A A / Bitner, R S / Krueger, K M / Otte, S / Nikkel, A L / Fey, T A / Bush, E N / Dickinson, R W / Shapiro, R / Knourek-Segel, V / Droz, B A / Brune, M E / Jacobson, P B / Cowart, M D / Esbenshade, T A

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2006 Volume 55 Suppl 1, Page(s) S42–4

MeSH term(s)	Animals ; Anti-Obesity Agents/pharmacology ; Brain/drug effects ; Brain/metabolism ; Cognition/drug effects ; Histamine Antagonists/pharmacology ; Ligands ; Male ; Mice ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Histamine H3/drug effects
Chemical Substances	Anti-Obesity Agents ; Histamine Antagonists ; Ligands ; Proto-Oncogene Proteins c-fos ; Receptors, Histamine H3
Language	English
Publishing date	2006-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-005-0034-0
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Zs.A 675: Show issues

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Article: NEO PI-R predictors of alcohol use and alcohol-related problems.

Ruiz, Mark A / Pincus, Aaron L / Dickinson, Kelly A

Journal of personality assessment

2003 Volume 81, Issue 3, Page(s) 226–236

Abstract: We investigated the relationships between Five-factor model domains and facets and drinking and alcohol-related problems. We also examined the moderating effects of gender. Two hundred students (99 men and 101 women) who had used alcohol in the past year ...

Abstract	We investigated the relationships between Five-factor model domains and facets and drinking and alcohol-related problems. We also examined the moderating effects of gender. Two hundred students (99 men and 101 women) who had used alcohol in the past year completed self-report and interview assessments. Bivariate analyses demonstrated some significant relationships. In the multivariate analyses that controlled for gender, Neuroticism and Conscientiousness were linked to drinking, but only some of the facets from these domains had significant relationships to drinking. Facets of Extraversion and Agreeableness, but not these domains, were associated with drinking. Neuroticism and Conscientiousness and most of their facets were related to alcohol-related problems in the multivariate analyses. The interactions between gender and traits were not significant.
MeSH term(s)	Adolescent ; Adult ; Alcohol Drinking/psychology ; Alcoholism/psychology ; Female ; Humans ; Interpersonal Relations ; Male ; Personality Assessment/statistics & numerical data ; Probability ; Regression Analysis ; Self-Assessment ; Sex Factors ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2003-12
Publishing country	England
Document type	Journal Article
ZDB-ID	121962-5
ISSN	1532-7752 ; 0022-3891
ISSN (online)	1532-7752
ISSN	0022-3891
DOI	10.1207/S15327752JPA8103_05
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Zs.B 1007: Show issues

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Article: Cloning and characterization of a new intercellular adhesion molecule ICAM-R.

Vazeux, R / Hoffman, P A / Tomita, J K / Dickinson, E S / Jasman, R L / St John, T / Gallatin, W M

Nature

1992 Volume 360, Issue 6403, Page(s) 485–488

Abstract: ... such as a glycoprotein of M(r) 124K that binds LFA-1 and has been designated ICAM-3 on the basis of this function ... We have molecularly cloned a new member of the ICAM family, ICAM-R, which is related to ICAM-1 and ICAM-2 ... The complementary DNA encoding ICAM-R is 1,781 base pairs long and the protein has five extracellular immunoglobulin ...

Abstract	The human intercellular adhesion molecules ICAM-1, ICAM-2 and their counter-receptors, the beta 2 or leukointegrins, mediate a variety of homotypic and heterotypic leukocyte and endothelial cell-cell adhesions central to immunocompetence. It has been found that cell-cell adhesion which is dependent on expression of the leukocyte function-associated antigen LFA-1 is not always blocked completely by antibodies raised against ICAM-1 and ICAM-2. Other leukointegrin ligands therefore probably exist, such as a glycoprotein of M(r) 124K that binds LFA-1 and has been designated ICAM-3 on the basis of this function. We have molecularly cloned a new member of the ICAM family, ICAM-R, which is related to ICAM-1 and ICAM-2. The complementary DNA encoding ICAM-R is 1,781 base pairs long and the protein has five extracellular immunoglobulin-family type domains. The mature cell-surface form of the ICAM-R protein has an M(r) which varies from 116 to 140K in a cell type-specific fashion. Overall identities in protein sequence with ICAM-1 and ICAM-2 are 48% and 31% respectively, with the degree of similarity varying between individual domains. The high level of expression of ICAM-R on resting leukocytes of all lineages and its lack of expression on either resting or cytokine-activated endothelial cells indicates a pattern of expression distinct from ICAM-1 and ICAM-2. In common with ICAM-1 and ICAM-2, ICAM-R is a ligand for the beta 2-integrin CD11a/LFA-1 (CD18).
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Base Sequence ; Cell Adhesion ; Cell Adhesion Molecules ; Cell Line ; Cells, Cultured ; Cloning, Molecular ; DNA/genetics ; DNA/isolation & purification ; Endothelium, Vascular/physiology ; Flow Cytometry ; Humans ; L Cells (Cell Line) ; Leukocytes/physiology ; Mice ; Models, Structural ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Protein Conformation ; RNA, Messenger/analysis ; RNA, Messenger/metabolism ; Transcription, Genetic ; Transfection ; Tumor Cells, Cultured
Chemical Substances	Antibodies, Monoclonal ; Cell Adhesion Molecules ; Oligodeoxyribonucleotides ; RNA, Messenger ; DNA (9007-49-2)
Language	English
Publishing date	1992-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/360485a0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: G and R banding of 11p deletions in aniridia--Wilms' tumour.

Howell, R T / Gardner, A / Dickinson, V

Journal of medical genetics

1987 Volume 24, Issue 2, Page(s) 114–115

MeSH term(s)	Chromosome Banding ; Chromosome Deletion ; Chromosomes, Human, Pair 11 ; Humans ; Infant ; Iris/abnormalities ; Wilms Tumor/genetics
Language	English
Publishing date	1987-02
Publishing country	England
Document type	Journal Article
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmg.24.2.114
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Article ; Online: C linical e valuation of ma gnetic r esonance imaging in c oronary heart disease

Sculpher Mark / Ridgway John P / Younger John F / Dickinson Catherine / Farrin Amanda J / Brown Julia M / Nixon Jane / Radjenovic Aleksandra / Maredia Neil / Greenwood John P / Ball Stephen G / Plein Sven

Trials, Vol 10, Iss 1, p

The CE-MARC study

2009 Volume 62

Abstract: Abstract Background Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment ... ...

Abstract	Abstract Background Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the diagnostic accuracy of multi-parametric CMR for the detection of CHD in unselected populations are lacking, and there are few data on the performance of CMR compared with current diagnostic tests, its prognostic value and cost-effectiveness. Methods/design This is a prospective diagnostic accuracy cohort study of 750 patients referred to a cardiologist with suspected CHD. Exercise tolerance testing (ETT) will be preformed if patients are physically able. Recruited patients will then undergo CMR and single photon emission tomography (SPECT) followed in all patients by invasive X-ray coronary angiography. The order of the CMR and SPECT tests will be randomised. The CMR study will comprise rest and adenosine stress perfusion, cine imaging, late gadolinium enhancement and whole-heart MR coronary angiography. SPECT will use a gated stress/rest protocol. The primary objective of the study is to determine the diagnostic accuracy of CMR in detecting significant coronary stenosis, as defined by X-ray coronary angiography. Secondary objectives include an assessment of the prognostic value of CMR imaging, a comparison of its diagnostic accuracy against SPECT and ETT, and an assessment of cost-effectiveness. Discussion The CE-MARC study is a prospective, diagnostic accuracy cohort study of 750 patients assessing the performance of a multi-parametric CMR study in detecting CHD using invasive X-ray coronary angiography as the reference standard and comparing it with ETT and SPECT. Trial Registration Current Controlled Trials ISRCTN77246133
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2009-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation.

Stark, Gail L / Dickinson, Anne M / Jackson, Graham H / Taylor, Penelope R / Proctor, Stephen J / Middleton, Peter G

Transplantation

2003 Volume 76, Issue 12, Page(s) 1742–1749

Abstract: ... gene, codon 196, results in the substitution of arginine (R allele) for methionine (M allele). The 196R ... in multivariate analysis (OR 11, P=0.02). To investigate the functional impact of the TNFRII 196 M/R polymorphism, 79 ...

Abstract	Background: A single nucleotide polymorphism in the tumor necrosis factor type II receptor (TNFRII) gene, codon 196, results in the substitution of arginine (R allele) for methionine (M allele). The 196R allele is reportedly associated with an increased susceptibility to autoimmune disease, and donor 196R allele carriage correlates with increased severity of acute graft-versus-host disease (GVHD) after matched unrelated bone marrow transplantation (BMT). Methods: We investigated the impact of donor and recipient TNFRII genotype on GVHD incidence and severity among 104 adult recipients of myeloablative sibling BMTs. Results: 196R allele frequency was 0.28 among recipients, donors, and controls. There was an increased incidence of acute GVHD among 196R-positive recipients (odds ratio [OR] 3.6, P=0.05). This association was confirmed in multivariate analysis (relative risk 4, P=0.04), correcting for previously established clinical and genetic risk factors. Donor 196R homozygosity was associated with an increased incidence of extensive chronic GVHD (OR 18.5, P=0.02). This association was also confirmed in multivariate analysis (OR 11, P=0.02). To investigate the functional impact of the TNFRII 196 M/R polymorphism, 79 volunteer blood donors were genotyped at this locus, by polymerase chain reaction and single-strand conformational polymorphism analysis, and plasma soluble TNFRII (sTNFRII) levels were measured by ELISA. Mean plasma sTNFRII levels (pg/mL: +/-SEM) were 1224 (+/-26) and 1063 (+/-65) for 196M-postive (196 M homozygous or heterozygous) individuals and 196R homozygotes, respectively (P=0.02). Conclusions: Because sTNFRIIs can act as TNF antagonists, the association between recipient and donor TNFRII 196R allele status and acute or extensive chronic GVHD incidence, respectively, may reflect reduced circulating sTNFRII.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antigens, CD/blood ; Antigens, CD/genetics ; Bone Transplantation/immunology ; Cohort Studies ; Female ; Genotype ; Graft vs Host Disease/genetics ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Leukemia/classification ; Leukemia/surgery ; Male ; Middle Aged ; Receptors, Tumor Necrosis Factor/blood ; Receptors, Tumor Necrosis Factor/genetics ; Receptors, Tumor Necrosis Factor, Type II ; Reference Values ; Siblings ; Transplantation, Homologous
Chemical Substances	Antigens, CD ; Immunosuppressive Agents ; Receptors, Tumor Necrosis Factor ; Receptors, Tumor Necrosis Factor, Type II
Language	English
Publishing date	2003-12-27
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/01.TP.0000092496.05951.D5
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.

Thörn, Helena Anna / Hedeland, Mikael / Bondesson, Ulf / Knutson, Lars / Yasin, Mohammed / Dickinson, Paul / Lennernäs, Hans

Drug metabolism and disposition: the biological fate of chemicals

2009 Volume 37, Issue 11, Page(s) 2186–2196

Abstract: ... with the S-isomer being more extensively extracted. For VER the ratio of R- enantiomer to S-enantiomer was ... in the intestine. Ketoconazole increased the area under the curve from time 0 to 6 h and C(max) of R- and S-VER ...

Abstract	In this acute study a pig jejunal intestinal perfusion model with multiple plasma sampling sites and three different administration routes was used to investigate the quantitative contribution of the intestine versus liver to the first-pass extraction of each enantiomer of verapamil (VER). A subclinical dose of ketoconazole (8 mg) was coadministered in the perfusion solution to selectively inhibit gut wall CYP3A. Both enantiomers of VER and its main metabolite norverapamil (NOR) as well as the inhibitor ketoconazole were quantified in all plasma compartments by liquid chromatography-tandem mass spectrometry. The overall first-pass metabolic extraction of VER and the metabolite NOR was shown to be stereoselective with the S-isomer being more extensively extracted. For VER the ratio of R- enantiomer to S-enantiomer was greater in the hepatic vein than in the portal vein (approximately 2.2 versus 1.4), indicating that the stereoselective metabolism of VER in pigs mainly occurs on the first pass through the liver and not in the intestine. Ketoconazole increased the area under the curve from time 0 to 6 h and C(max) of R- and S-VER at least 3-fold in the portal vein, most likely explained by inhibition of gut wall metabolism. Conversely, hepatic extraction was increased because the effect of gut wall metabolism was not observed at the peripheral sampling sites. In conclusion, this study provided novel and more direct information on the contribution of the intestine and the liver, respectively, to the overall first-pass extraction of racemic VER.
MeSH term(s)	Animals ; Drug Interactions/physiology ; Female ; Intestines/drug effects ; Intestines/metabolism ; Jejunum/drug effects ; Jejunum/metabolism ; Ketoconazole/chemistry ; Ketoconazole/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Stereoisomerism ; Swine ; Verapamil/chemistry ; Verapamil/metabolism
Chemical Substances	Verapamil (CJ0O37KU29) ; Ketoconazole (R9400W927I)
Language	English
Publishing date	2009-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186795-7
ISSN	1521-009X ; 0090-9556
ISSN (online)	1521-009X
ISSN	0090-9556
DOI	10.1124/dmd.109.028027
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito