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  1. Article: Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD.

    Patel, Maulin Mukeshchandra / Gerakopoulos, Vasileios / Petsouki, Eleni / Zimmerman, Kurt A / Tsiokas, Leonidas

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Nephronophthisis (NPHP) and autosomal dominant Polycystic Kidney Disease (ADPKD) are two genetically distinct forms of Polycystic Kidney Disease (PKD), yet both diseases present with kidney cysts and a gradual decline in renal function. Prevailing dogma ... ...

    Abstract Nephronophthisis (NPHP) and autosomal dominant Polycystic Kidney Disease (ADPKD) are two genetically distinct forms of Polycystic Kidney Disease (PKD), yet both diseases present with kidney cysts and a gradual decline in renal function. Prevailing dogma in PKD is that changes in kidney architecture account for the decline in kidney function, but the molecular/cellular basis of such coupling is unknown. To address this question, we induced a form of proteome reprogramming by deleting
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.29.582788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Insights into the Regulation of Ciliary Disassembly

    Maulin M. Patel / Leonidas Tsiokas

    Cells, Vol 10, Iss 2977, p

    2021  Volume 2977

    Abstract: The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical ... ...

    Abstract The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical signals to carry out various cellular processes such as proliferation, migration, differentiation, and many others. At any given time, cilia length is determined by a dynamic balance of cilia assembly and disassembly processes. Abnormally short or long cilia can cause a plethora of human diseases commonly referred to as ciliopathies, including, but not limited to, skeletal malformations, obesity, autosomal dominant polycystic kidney disease, retinal degeneration, and bardet-biedl syndrome. While the process of cilia assembly is studied extensively, the process of cilia disassembly and its biological role(s) are less well understood. This review discusses current knowledge on ciliary disassembly and how different cellular processes and molecular signals converge to carry out this process. This information will help us understand how the process of ciliary disassembly is regulated, identify the key steps that need further investigation, and possibly design therapeutic targets for a subset of ciliopathies that are causally linked to defective ciliary disassembly.
    Keywords cilia ; cilia disassembly ; ciliopathies ; Biology (General) ; QH301-705.5
    Subject code 650
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Insights into the Regulation of Ciliary Disassembly.

    Patel, Maulin M / Tsiokas, Leonidas

    Cells

    2021  Volume 10, Issue 11

    Abstract: The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical ... ...

    Abstract The primary cilium, an antenna-like structure that protrudes out from the cell surface, is present in most cell types. It is a microtubule-based organelle that serves as a mega-signaling center and is important for sensing biochemical and mechanical signals to carry out various cellular processes such as proliferation, migration, differentiation, and many others. At any given time, cilia length is determined by a dynamic balance of cilia assembly and disassembly processes. Abnormally short or long cilia can cause a plethora of human diseases commonly referred to as ciliopathies, including, but not limited to, skeletal malformations, obesity, autosomal dominant polycystic kidney disease, retinal degeneration, and bardet-biedl syndrome. While the process of cilia assembly is studied extensively, the process of cilia disassembly and its biological role(s) are less well understood. This review discusses current knowledge on ciliary disassembly and how different cellular processes and molecular signals converge to carry out this process. This information will help us understand how the process of ciliary disassembly is regulated, identify the key steps that need further investigation, and possibly design therapeutic targets for a subset of ciliopathies that are causally linked to defective ciliary disassembly.
    MeSH term(s) Animals ; Cilia/metabolism ; Humans ; Microtubules/metabolism ; Models, Biological ; Polymerization ; Signal Transduction
    Language English
    Publishing date 2021-11-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10112977
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  4. Article: Hiccups: Nerve Irritation or Masquerading as Acute Coronary Syndrome.

    Cordero, Dessiree / Schmidt, Patrik / Sosa, Franklin / Patel, Maulin / Sklyar, Eduard

    Cureus

    2023  Volume 15, Issue 10, Page(s) e48069

    Abstract: The typical clinical presentation of acute coronary syndrome (ACS) includes chest pain that may radiate to the left arm, shoulder, jaw, and neck, accompanied by diaphoresis, dyspnea, nausea, vomiting, and hiccups, which have been observed as the sole ... ...

    Abstract The typical clinical presentation of acute coronary syndrome (ACS) includes chest pain that may radiate to the left arm, shoulder, jaw, and neck, accompanied by diaphoresis, dyspnea, nausea, vomiting, and hiccups, which have been observed as the sole symptom of presentation. The mechanism of hiccups involves the activation of the vagus and phrenic nerves, leading to the activation of the diaphragm and intercostal muscles. Several hypotheses link hiccups to ACS, associating irritation of the left anterior descending artery with activation of sympathetic phrenic and vagal nerves. This case report highlights the occurrence of hiccups in patients with inferior and right ventricular myocardial infarction (MI), indicating possible nerve synapse involvement. Timely recognition of hiccups as a possible atypical symptom of ACS can facilitate early evaluation and management, preventing delays in patient care and ensuring better outcomes.
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48069
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  5. Article ; Online: Effects of pericardiocentesis on renal function and cardiac hemodynamics.

    Shmueli, Hezzy / Shah, Maulin / Patel, Yatindra / Nguyen, Long-Co / Hardy, Hannah / Rader, Florian / Siegel, Robert J

    Echocardiography (Mount Kisco, N.Y.)

    2024  Volume 41, Issue 2, Page(s) e15764

    Abstract: Background: Previous case studies have reported reversal of acute renal failure after pericardiocentesis in pericardial effusion. This study examines the effects of pericardiocentesis on preprocedural low cardiac output and acute renal dysfunction in ... ...

    Abstract Background: Previous case studies have reported reversal of acute renal failure after pericardiocentesis in pericardial effusion. This study examines the effects of pericardiocentesis on preprocedural low cardiac output and acute renal dysfunction in patients with pericardial effusion.
    Methods: This is a retrospective study of 95 patients undergoing pericardiocentesis between 2015 and 2020. Pre- and post-procedure transthoracic echocardiograms (TTE) were reviewed for evidence of cardiac tamponade, resolution of pericardial effusion, and for estimation of right atrial (RA) pressure and cardiac output. Laboratory values were compared at presentation and post-procedure. Patients on active renal replacement therapy were excluded.
    Results: Ninety-five patients were included for analysis (mean age 62.2 ± 17.8 years, 58% male). There was a significant increase in glomerular filtration rate pre- and post-procedure. Fifty-six patients (58.9%) had an improvement in glomerular filtration rate after pericardiocentesis (termed "responders"), and these patients had a lower pre-procedure glomerular filtration rate than "non-responders." There was a significant improvement in estimated cardiac output and right atrial pressure for patients in both groups. Patients who had an improvement in renal function had significantly lower pre-procedural diastolic blood pressure and mean arterial pressure.
    Conclusions: Pericardial drainage may improve effusion-mediated acute renal dysfunction by reducing right atrial pressure and thus systemic venous congestion, and by increasing forward stroke volume and perfusion pressure.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Pericardiocentesis ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/surgery ; Retrospective Studies ; Cardiac Tamponade/surgery ; Hemodynamics ; Kidney Diseases ; Kidney/diagnostic imaging
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15764
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  6. Article ; Online: Non-bacterial thrombotic endocarditis: a rare presentation and literature review.

    Patel, Maulin J / Elzweig, Joel

    BMJ case reports

    2020  Volume 13, Issue 12

    Abstract: A 66-year-old woman with a remote history of breast cancer and prior tobacco use presented to the hospital with chest pain. She was found to have an elevated troponin consistent with a diagnosis of a non-ST segment elevation myocardial infarction (NSTEMI) ...

    Abstract A 66-year-old woman with a remote history of breast cancer and prior tobacco use presented to the hospital with chest pain. She was found to have an elevated troponin consistent with a diagnosis of a non-ST segment elevation myocardial infarction (NSTEMI). A left heart catheterisation revealed non-obstructive coronary disease, and subsequent transthoracic and transoesophageal echocardiograms demonstrated vegetations on both the mitral and aortic valves. Multiple blood cultures showed no growth raising suspicion for non-bacterial thrombotic endocarditis (NBTE). A CT of the chest, abdomen and pelvis was obtained that was consistent with metastatic pancreatic cancer. Her hospital course was complicated by recurrent embolic strokes leading to a rapid clinical deterioration. As a result, she was transitioned to comfort measures and passed away shortly thereafter. To our knowledge, this is the first reported case of an NSTEMI as the initial presentation of NBTE due to underlying malignancy.
    MeSH term(s) Aged ; Aortic Valve/pathology ; Breast Neoplasms/complications ; Breast Neoplasms/pathology ; Chest Pain/etiology ; Echocardiography, Transesophageal ; Endocarditis, Non-Infective/diagnosis ; Endocarditis, Non-Infective/etiology ; Fatal Outcome ; Female ; Humans ; Mitral Valve/pathology ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/etiology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/secondary ; Stroke/diagnostic imaging ; Stroke/etiology ; Tomography, X-Ray Computed ; Troponin/blood
    Chemical Substances Troponin
    Language English
    Publishing date 2020-12-13
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-238585
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  7. Article ; Online: Correction to "Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation".

    Elechalawar, Chandra Kumar / Rao, Geeta / Gulla, Suresh Kumar / Patel, Maulin Mukeshchandra / Frickenstein, Alex / Means, Nicolas / Roy, Ram Vinod / Tsiokas, Leonidas / Asfa, Sima / Panja, Prasanta / Rao, Chinthalapally / Wilhelm, Stefan / Bhattacharya, Resham / Mukherjee, Priyabrata

    ACS nano

    2024  Volume 18, Issue 12, Page(s) 9242

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Published Erratum
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.4c01293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease.

    Lupu, Cristina / Patel, Maulin M / Lupu, Florea

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: The novel protein ADTRP, identified and described by us in 2011, is androgen-inducible and regulates the expression and activity of Tissue Factor Pathway Inhibitor, the major inhibitor of the Tissue Factor-dependent pathway of coagulation on endothelial ... ...

    Abstract The novel protein ADTRP, identified and described by us in 2011, is androgen-inducible and regulates the expression and activity of Tissue Factor Pathway Inhibitor, the major inhibitor of the Tissue Factor-dependent pathway of coagulation on endothelial cells. Single-nucleotide polymorphisms in ADTRP associate with coronary artery disease and myocardial infarction, and deep vein thrombosis/venous thromboembolism. Some athero-protective effects of androgen could exert through up-regulation of
    MeSH term(s) Blood Coagulation ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/pathology ; Humans ; Membrane Proteins/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Thrombosis/metabolism ; Thrombosis/pathology
    Chemical Substances ADTRP protein, human ; Membrane Proteins
    Language English
    Publishing date 2021-04-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094451
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  9. Article ; Online: Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease

    Cristina Lupu / Maulin M. Patel / Florea Lupu

    International Journal of Molecular Sciences, Vol 22, Iss 4451, p

    2021  Volume 4451

    Abstract: The novel protein ADTRP, identified and described by us in 2011, is androgen-inducible and regulates the expression and activity of Tissue Factor Pathway Inhibitor, the major inhibitor of the Tissue Factor-dependent pathway of coagulation on endothelial ... ...

    Abstract The novel protein ADTRP, identified and described by us in 2011, is androgen-inducible and regulates the expression and activity of Tissue Factor Pathway Inhibitor, the major inhibitor of the Tissue Factor-dependent pathway of coagulation on endothelial cells. Single-nucleotide polymorphisms in ADTRP associate with coronary artery disease and myocardial infarction, and deep vein thrombosis/venous thromboembolism. Some athero-protective effects of androgen could exert through up-regulation of ADTRP expression. We discovered a critical role of ADTRP in vascular development and vessel integrity and function, manifested through Wnt signaling-dependent regulation of matrix metalloproteinase-9. ADTRP also hydrolyses fatty acid esters of hydroxy-fatty acids, which have anti-diabetic and anti-inflammatory effects and can control metabolic disorders. Here we summarize and analyze the knowledge on ADTRP and try to decipher its functions in health and disease.
    Keywords ADTRP ; TFPI ; cardiovascular disease ; coagulation ; FAHFA ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation.

    Houser, Jeremy S / Patel, Maulin / Wright, Kyle / Onopiuk, Marta / Tsiokas, Leonidas / Humphrey, Mary Beth

    Blood cells, molecules & diseases

    2023  Volume 102, Page(s) 102760

    Abstract: Hematopoiesis and lineage commitment are regulated by several conserved cell-intrinsic signaling pathways, including MAPKs and β-catenin/TCF/LEF. The Inhibitor of MyoD Family A (I-MFA), a transcriptional repressor and tumor suppressor gene, interacts ... ...

    Abstract Hematopoiesis and lineage commitment are regulated by several conserved cell-intrinsic signaling pathways, including MAPKs and β-catenin/TCF/LEF. The Inhibitor of MyoD Family A (I-MFA), a transcriptional repressor and tumor suppressor gene, interacts with these pathways and is dysregulated in chronic and acute myeloid leukemias, suggesting it may play a role in development and differentiation during hematopoiesis. To study this, immune cell populations in the bone marrow (BM) and periphery were analyzed in mice lacking Mdfi, encoding I-MFA (I-MFA-/-), and wild type (WT) controls. I-MFA-/- mice had reduced spleen and BM cellularity, with significant hyposplenism, compared to WT mice. In blood, total red blood cells and platelet counts were significantly reduced in I-MFA-/- mice, accompanied by a reduction in megakaryocyte (MK)/erythrocyte progenitor cells and an increase in myeloid progenitors in BM compared to WT mice. The K562 cell line exhibits PMA-induced MK differentiation, and shRNA knockdown of I-MFA resulted in reduced differentiation compared to control, with an increase and prolongation in phospho-JNK and phospho-ERK signaling. Overexpression of I-MFA promoted MK differentiation. These results suggest I-MFA plays a cell-intrinsic role in the response to differentiation signals, an effect that can be explored in the context of hematological cancers or other blood proliferative disorders.
    MeSH term(s) Mice ; Animals ; Megakaryocytes ; Bone Marrow/metabolism ; Cell Differentiation ; Hematopoiesis ; Bone Marrow Cells/pathology ; Cell Lineage
    Language English
    Publishing date 2023-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2023.102760
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