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  1. Article ; Online: Faut-il ne plus traiter les cancers de la prostate localisés du groupe favorable ?

    Kamel Hamizi / Souad Aouidane

    Batna Journal of Medical Sciences, Vol 8, Iss 2, Pp 157-

    2021  Volume 161

    Abstract: Contrairement à l'abstention-surveillance, la surveillance active est une modalité de prise en charge curative. Elle vise à retarder le traitement d'une tumeur peu agressive jusqu’au moment où elle le deviendra tout en restant dans la fenêtre de ... ...

    Abstract Contrairement à l'abstention-surveillance, la surveillance active est une modalité de prise en charge curative. Elle vise à retarder le traitement d'une tumeur peu agressive jusqu’au moment où elle le deviendra tout en restant dans la fenêtre de curabilité de la maladie. À travers une lecture de littératures, nous allons essayer de maitre la lumière sur la place et les modalités de la surveillance active, dans les groupes favorables des cancers de la prostate et de répondre aux questions suivantes : Pourquoi la surveillance active ? Pour qui ? Comment l’instauré ? et quand doit-on l’arrêter ? La majorité des essais, cliniques publiés s’accordent à dire, que la surveillance active est une attitude parfaitement adaptée aux patients du groupe favorable d’AMICO, voire même une partie du groupe intermédiaire bas risque. Les résultats en matière de survie globale et d’évènement métastatiques, sont similaires à ceux des patients traités d’emblée par chirurgie et ou radiothérapie, avec en plus moins de toxicité. La surveillance est basée essentiellement sur le dosage périodique du PSA, rebiopsie selon des protocoles propres à chaque équipe. La décision du passage aux traitements invasifs, sera conditionnée par la progression du score Gleason, selon des algorithmes dont certains, sont déjà validés à l’international. La surveillance active, doit faire partie intégrante des décisions de prise en charge des adénocarcinomes prostatiques localisés favorables. Cette attitude nous permet, d’éviter de surtraiter un grand nombre, de petites lésions non évolutives, tout en ayant la possibilité et les moyens, de rattraper les lésions qui progressent
    Keywords prostate ; sa ; gleason ; psa ; groupe favorable ; Medicine ; R
    Language Arabic
    Publishing date 2021-12-01T00:00:00Z
    Publisher Association de la Recherche Pharmaceutique & d'Enrichissement des connaissances (ARPEC)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Etoposide-based therapy for severe forms of COVID-19.

    Hamizi, Kamel / Aouidane, Souhila / Belaaloui, Ghania

    Medical hypotheses

    2020  Volume 142, Page(s) 109826

    Abstract: The new coronavirus infection COVID-19 has quickly become a global health emergency. Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. Numerous pathological, clinical and ... ...

    Abstract The new coronavirus infection COVID-19 has quickly become a global health emergency. Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. Numerous pathological, clinical and laboratory findings rise the similarity between moderate to severe COVID-19 and haemophagocytic lymphohistiocytosis (HLH). Etoposide-based protocol including dexametasone is the standard of care for secondary HLH. The protocol has been successfully used in HLHs that are secondary to EBV and H1N1 infections by inducing complete response and prolonged survival. These observations prompt to consider this cytotoxic therapy in HLH associated to moderately severe to severe forms of COVID-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Dexamethasone/administration & dosage ; Epstein-Barr Virus Infections/complications ; Etoposide/therapeutic use ; Humans ; Influenza, Human/complications ; Lymphohistiocytosis, Hemophagocytic/complications ; Models, Theoretical ; Pandemics ; Pneumonia, Viral/drug therapy ; Respiratory Distress Syndrome/complications ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Etoposide (6PLQ3CP4P3) ; Dexamethasone (7S5I7G3JQL)
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Etoposide-based therapy for severe forms of COVID-19

    Hamizi, Kamel / Aouidane, Souhila / Belaaloui, Ghania

    Medical Hypotheses

    2020  Volume 142, Page(s) 109826

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109826
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Etoposide-based therapy for severe forms of COVID-19

    Hamizi, Kamel / Aouidane, Souhila / Belaaloui, Ghania

    Med Hypotheses

    Abstract: The new coronavirus infection COVID-19 has quickly become a global health emergency. Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. Numerous pathological, clinical and ... ...

    Abstract The new coronavirus infection COVID-19 has quickly become a global health emergency. Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. Numerous pathological, clinical and laboratory findings rise the similarity between moderate to severe COVID-19 and haemophagocytic lymphohistiocytosis (HLH). Etoposide-based protocol including dexametasone is the standard of care for secondary HLH. The protocol has been successfully used in HLHs that are secondary to EBV and H1N1 infections by inducing complete response and prolonged survival. These observations prompt to consider this cytotoxic therapy in HLH associated to moderately severe to severe forms of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32416415
    Database COVID19

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  5. Article ; Online: ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer.

    Kaabi, Batoul / Belaaloui, Ghania / Benbrahim, Wassila / Hamizi, Kamel / Sadelaoud, Mourad / Toumi, Wided / Bounecer, Hocine

    Pathology oncology research : POR

    2016  Volume 22, Issue 2, Page(s) 357–365

    Abstract: Breast cancer (BC) prognosis and risk were associated to obesity, metabolic syndrome and type 2 diabetes mellitus. Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to ... ...

    Abstract Breast cancer (BC) prognosis and risk were associated to obesity, metabolic syndrome and type 2 diabetes mellitus. Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders. We investigated these SNPs in BC risk and prognosis. A total of 102 BC patients and 102 healthy controls were included. The rs1800544 and rs553668 were determined by real-time PCR. Genotypes and haplotypes frequencies between patients and controls, and for different clinico-pathologic parameters were compared. We found a significant association of rs1800544 GG genotype with young age at diagnosis, premenopausal status, higher tumor size, metastasis in lymph nodes, advanced TNM stages and higher Nottingham Prognosis Indicator (NPI) (p < 0.05). There was no association between rs1800544 and SBR stages, Her2, ER and PR statuses and the molecular classification. The rs553668 AA genotype was associated to young age at diagnosis and premenopausal status (p < 0.05). The haplotype GA was associated to the early age of diagnosis (p = 0.03), and the haplotype GG to higher tumor size, lymph node involvement, advanced TNM stages and Her2 positive status (p < 0.05). There was no polymorphism or haplotype association with BC risk (p > 0.05). ADRA2A polymorphism is associated with indicators BC poor prognosis but not with BC susceptibility. This is the first report suggesting that ADRA2A germline gene polymorphism could represent a predictor factor for BC outcome. Further investigation of other ADRA2A polymorphisms in BC risk or prognosis are needed and may lead to a genotype-based therapy.
    MeSH term(s) Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genotype ; Germ-Line Mutation/genetics ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Polymorphism, Single Nucleotide/genetics ; Prognosis ; Real-Time Polymerase Chain Reaction ; Receptors, Adrenergic, alpha-2/genetics ; Risk Factors ; Severity of Illness Index ; Survival Rate
    Chemical Substances ADRA2A protein, human ; Biomarkers, Tumor ; Receptors, Adrenergic, alpha-2
    Language English
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.1007/s12253-015-0010-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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