LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 14

Search options

  1. Article ; Online: Etoposide for Cytokine Storm Because of Coronavirus Disease 2019.

    Delgado-López, Pedro David / Buzón-Martín, Luis / Montero-Baladia, Miguel / Astigarraga, Itziar

    Chest

    2021  Volume 159, Issue 4, Page(s) 1678–1679

    MeSH term(s) COVID-19 ; Cytokine Release Syndrome ; Cytokines ; Etoposide ; Humans ; SARS-CoV-2 ; Salvage Therapy
    Chemical Substances Cytokines ; Etoposide (6PLQ3CP4P3)
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.10.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality.

    Cusacovich, Ivan / Aparisi, Álvaro / Marcos, Miguel / Ybarra-Falcón, Cristina / Iglesias-Echevarria, Carolina / Lopez-Veloso, Maria / Barraza-Vengoechea, Julio / Dueñas, Carlos / Juarros Martínez, Santiago Antonio / Rodríguez-Alonso, Beatriz / Martín-Oterino, José-Ángel / Montero-Baladia, Miguel / Moralejo, Leticia / Andaluz-Ojeda, David / Gonzalez-Fuentes, Roberto

    Mediators of inflammation

    2021  Volume 2021, Page(s) 6637227

    Abstract: Objectives: To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19.: Methods: We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y León, Spain (865, ... ...

    Abstract Objectives: To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19.
    Methods: We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y León, Spain (865,096 people). We selected patients with confirmed COVID-19 and lung involvement with a pO2/FiO2<300, excluding those exposed to immunosuppressors before or during hospitalization, patients terminally ill at admission, or those who died in the first 24 hours. We performed a propensity score matching (PSM) adjusting covariates that modify the probability of being treated. Then, we used a Cox regression model in the PSM group to consider factors affecting mortality.
    Results: From 2933 patients, 257 fulfilled the inclusion and exclusion criteria. 124 patients were on corticosteroid pulses (250 mg of methylprednisolone for three days), and 133 were not. 30.3% (37/122) of patients died in the corticosteroid pulse group and 42.9% (57/133) in the nonexposed cohort. These differences (12.6%, 95% CI [8·54-16.65]) were statically significant (log-rank 4.72,
    Conclusions: This study provides evidence about treatment with corticosteroid pulses in severe COVID-19 that might significantly reduce mortality. Strict inclusion and exclusion criteria with that selection process set a reliable frame to compare mortality in both the exposed and nonexposed groups.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Aged ; Aged, 80 and over ; COVID-19/drug therapy ; COVID-19/mortality ; Female ; Hospitalization ; Humans ; Immunosuppressive Agents/therapeutic use ; Inpatients ; Male ; Middle Aged ; Propensity Score ; Proportional Hazards Models ; Retrospective Studies ; Spain/epidemiology ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones ; Immunosuppressive Agents
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2021/6637227
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3575: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Heart attack and something else: Caseous degeneration of mitral anullus.

    Arroyo Diez, M / Montero Baladía, M / Zabalegui Pérez, A

    Medicina intensiva

    2018  Volume 43, Issue 1, Page(s) 60

    Title translation Infarto agudo de miocardio y algo más: degeneración caseosa del anillo mitral.
    MeSH term(s) Aged ; Calcinosis/diagnostic imaging ; Diagnosis, Differential ; Echocardiography ; Heart Valve Diseases/diagnostic imaging ; Humans ; Male ; Mitral Valve/diagnostic imaging ; Myocardial Infarction/complications ; Myocardial Infarction/diagnostic imaging ; Tomography, X-Ray Computed
    Language Spanish
    Publishing date 2018-03-19
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medin.2018.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Etoposide treatment adjunctive to immunosuppressants for critically ill COVID-19 patients.

    M, Montero-Baladía / L, Buzón / I, Astigarraga / P, Delgado / E, Iglesias / F, Callejo / M, López-Veloso / J, Minguito / M, Fernández-Regueras / M, Ubeira / G, Hermida

    The Journal of infection

    2020  Volume 81, Issue 3, Page(s) 452–482

    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Critical Illness ; Etoposide/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Topoisomerase II Inhibitors/therapeutic use
    Chemical Substances Topoisomerase II Inhibitors ; Etoposide (6PLQ3CP4P3)
    Keywords covid19
    Language English
    Publishing date 2020-06-21
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: High dose subcutaneous Anakinra to treat acute respiratory distress syndrome secondary to cytokine storm syndrome among severely ill COVID-19 patients.

    Iglesias-Julián, Enrique / López-Veloso, María / de-la-Torre-Ferrera, Noelia / Barraza-Vengoechea, Julio Cesar / Delgado-López, Pedro David / Colazo-Burlato, María / Ubeira-Iglesias, Marta / Montero-Baladía, Miguel / Lorenzo-Martín, Andrés / Minguito-de-la-Iglesia, Javier / García-Muñoz, Juan Pablo / Sanllorente-Sebastián, Rodrigo / Vicente-González, Blanca / Alemán-Alemán, Ana / Buzón-Martín, Luis

    Journal of autoimmunity

    2020  Volume 115, Page(s) 102537

    Abstract: Objective: Severely ill COVID-19 patients may end in acute respiratory distress syndrome (ARDS) and multi-organ failure. Some of them develop a systemic hyperinflammatory state produced by the massive release of inflammatory agents, known as cytokine ... ...

    Abstract Objective: Severely ill COVID-19 patients may end in acute respiratory distress syndrome (ARDS) and multi-organ failure. Some of them develop a systemic hyperinflammatory state produced by the massive release of inflammatory agents, known as cytokine storm syndrome (CSS). Inhibition of IL-1 by Anakinra (ANK) is a potential life-saving therapy for severe CSS cases. We propose a rationale for the use of subcutaneous ANK and review our initial experience in a small cohort of severe COVID-19 CSS patients.
    Methods: Retrospective cohort study of COVID-19 patients developing ARDS (PaO2/FiO2 <300) and exhibiting signs of hyperinflammation (ferritin >1000 ng/mL and/or d-dimers > 1.5 μg/mL, plus IL-6 < 40 mg/mL) that received ANK. For comparison, a propensity score matched historical cohort of patients treated with IL-6 inhibitor Tocilizumab (TCZ) was used. Patients had previously received combinations of azithromycin, hydroxy-chloroquine, and methyl-prednisolone. Laboratory findings, respiratory function and adverse effects were monitored. Resolution of ARDS within the first 7 days of treatment was considered a favorable outcome.
    Results: Subcutaneous ANK (100 mg every 6 h) was given to 9 COVID-19 ARDS CSS patients (77.8% males). Median age was 62 years (range, 42 to 87). A TCZ cohort of 18 patients was selected by propensity score matching and treated with intravenous single dose of 600 mg for patients weighing >75 Kg, or 400 mg if < 75 Kg. Prior to treatment, median PaO2/FiO2 ratio of the ANK and TCZ cohorts were 193 and 249, respectively (p = 0.131). After 7 days of treatment, PaO2/FiO2 ratio improved in both groups to 279 (104-335) and 331 (140-476, p = 0.099) respectively. On day 7, there was significant reduction of ferritin (p = 0.046), CRP (p = 0.043), and IL-6 (p = 0.043) levels in the ANK cohort but only of CRP (p = 0.001) in the TCZ group. Favorable outcome was achieved in 55.6% and 88.9% of the ANK and TCZ cohorts, respectively (p = 0.281). Two patients that failed to respond to TCZ improved after ANK treatment. Aminotransferase levels significantly increased between day 1 and day 7 (p = 0.004) in the TCZ group. Mortality was the same in both groups (11%). There were not any opportunistic infection in the groups nor other adverse effects attributable to treatment.
    Conclusion: Overall, 55.6% of COVID-19 ARDS CSS patients treated with ANK exhibited favorable outcome, not inferior to a TCZ treated matched cohort. ANK may be a potential alternative to TCZ for patients with elevated aminotransferases, and may be useful in non-responders to TCZ.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Cohort Studies ; Cytokine Release Syndrome/drug therapy ; Disease Progression ; Female ; Humans ; Injections, Subcutaneous ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Interleukin-6/antagonists & inhibitors ; Male ; Middle Aged ; Respiratory Distress Syndrome/drug therapy ; SARS-CoV-2/physiology ; Spain ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1 ; Interleukin-6 ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2020.102537
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Basic sign in lung echography. Liquid and air bronchogram: Differentiation.

    Montero Baladía, M / Arroyo Diez, M / Badallo Areválo, O

    Medicina intensiva

    2017  Volume 42, Issue 8, Page(s) e19

    Title translation Signos básicos en ecografía pulmonar. Broncograma líquido y broncograma aéreo: diferenciación.
    MeSH term(s) Air ; Body Fluids ; Humans ; Lung/diagnostic imaging ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Pulmonary Atelectasis/diagnostic imaging ; Pulmonary Atelectasis/etiology ; Respiration, Artificial ; Respiratory Distress Syndrome/complications ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/therapy ; Ultrasonography, Doppler
    Language Spanish
    Publishing date 2017-09-21
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medin.2017.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Corticosteroid Pulses for Hospitalized Patients with COVID-19

    Cusacovich, Ivan / aparisi, alvaro / Marcos, Miguel / Ybarra-Falcón, Cristina / Iglesias-Echevarria, Carolina / Lopez-Veloso, Maria / Barraza-Vengoechea, Julio / Dueñas, Carlos / Juarros Martínez, Santiago Antonio / Rodríguez-Alonso, Beatriz / Martín-Oterino, José-Ángel / Montero-Baladia, Miguel / Moralejo, Leticia / Andaluz-Ojeda, David / Gonzalez-Fuentes, Roberto

    SSRN Electronic Journal ; ISSN 1556-5068

    Effects on Mortality

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3706050
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: High dose subcutaneous Anakinra to treat acute respiratory distress syndrome secondary to cytokine storm syndrome among severely ill COVID-19 patients

    Iglesias-Julián, Enrique / López-Veloso, María / de-la-Torre-Ferrera, Noelia / Barraza-Vengoechea, Julio Cesar / Delgado-López, Pedro David / Colazo-Burlato, María / Ubeira-Iglesias, Marta / Montero-Baladía, Miguel / Lorenzo-Martín, Andrés / Minguito-de-la-Iglesia, Javier / García-Muñoz, Juan Pablo / Sanllorente-Sebastián, Rodrigo / Vicente-González, Blanca / Alemán-Alemán, Ana / Buzón-Martín, Luis

    Journal of Autoimmunity

    2020  , Page(s) 102537

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639452-8
    ISSN 0896-8411
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2020.102537
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Etoposide treatment adjunctive to immunosuppressants for critically ill COVID-19 patients

    M, Montero-Baladía / L, Buzón / I, Astigarraga / P, Delgado / E, Iglesias / F, Callejo / M, López-Veloso / J, Minguito / M, Fernández-Regueras / M, Ubeira / G, Hermida

    J Infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #609141
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Etoposide treatment adjunctive to immunosuppressants for critically ill COVID-19 patients

    M, Montero-Baladía / L, Buzón / I, Astigarraga / P, Delgado / E, Iglesias / F, Callejo / M, López-Veloso / J, Minguito / M, Fernández-Regueras / M, Ubeira / G, Hermida

    Journal of Infection

    2020  Volume 81, Issue 3, Page(s) 452–482

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top