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Article ; Online: Measurement of the Λ_{c}^{+} Lifetime.

Abudinén, F / Aggarwal, L / Ahmed, H / Ahn, J K / Aihara, H / Akopov, N / Aloisio, A / Anh Ky, N / Asner, D M / Atmacan, H / Aushev, T / Aushev, V / Babu, V / Bae, H / Bambade, P / Banerjee, Sw / Bansal, S / Baudot, J / Bauer, M /

Baur, A / Beaubien, A / Becker, J / Bennett, J V / Bernieri, E / Bernlochner, F U / Bertacchi, V / Bertemes, M / Bertholet, E / Bessner, M / Bettarini, S / Bhardwaj, V / Bianchi, F / Bilka, T / Biswas, D / Bodrov, D / Bolz, A / Bonvicini, G / Bozek, A / Bračko, M / Branchini, P / Briere, R A / Browder, T E / Budano, A / Bussino, S / Campajola, M / Cao, L / Casarosa, G / Cecchi, C / Chang, M-C / Chang, P / Cheaib, R / Cheema, P / Chen, C / Chen, Y Q / Chen, Y-T / Cheon, B G / Chilikin, K / Chirapatpimol, K / Cho, H-E / Cho, K / Cho, S-J / Choi, S-K / Choudhury, S / Cinabro, D / Corona, L / Cremaldi, L M / Cunliffe, S / Dattola, F / De La Cruz-Burelo, E / De La Motte, S A / De Nardo, G / De Nuccio, M / De Pietro, G / de Sangro, R / Destefanis, M / De Yta-Hernandez, A / Dhamija, R / Di Canto, A / Di Capua, F / Dingfelder, J / Doležal, Z / Domínguez Jiménez, I / Dong, T V / Dorigo, M / Dort, K / Dossett, D / Dreyer, S / Dujany, G / Eliachevitch, M / Epifanov, D / Feichtinger, P / Ferber, T / Ferlewicz, D / Fillinger, T / Finocchiaro, G / Flood, K / Fodor, A / Forti, F / Frey, A / Fulsom, B G / Gabrielli, A / Ganiev, E / Garcia-Hernandez, M / Gaz, A / Gellrich, A / Ghevondyan, G / Giordano, R / Giri, A / Glazov, A / Gobbo, B / Godang, R / Goldenzweig, P / Gradl, W / Granderath, S / Greenwald, D / Gu, T / Guan, Y / Gudkova, K / Guilliams, J / Halder, S / Hara, K / Hartbrich, O / Hayasaka, K / Hayashii, H / Hazra, S / Hearty, C / Heredia de la Cruz, I / Hernández Villanueva, M / Hershenhorn, A / Higuchi, T / Hohmann, M / Humair, T / Iijima, T / Inami, K / Inguglia, G / Ipsita, N / Ishikawa, A / Ito, S / Itoh, R / Iwasaki, M / Iwasaki, Y / Jackson, P / Jacobs, W W / Jaffe, D E / Ji, Q P / Jin, Y / Junkerkalefeld, H / Kaleta, M / Kandra, J / Kang, K H / Karl, R / Karyan, G / Kiesling, C / Kim, C-H / Kim, D Y / Kim, K-H / Kim, Y-K / Kindo, H / Kinoshita, K / Kodyš, P / Koga, T / Kohani, S / Kojima, K / Korobov, A / Korpar, S / Kovalenko, E / Kowalewski, R / Kraetzschmar, T M G / Križan, P / Krokovny, P / Kuhr, T / Kumar, J / Kumar, R / Kumara, K / Kunigo, T / Kwon, Y-J / Lacaprara, S / Lam, T / Lanceri, L / Lange, J S / Laurenza, M / Leboucher, R / Lee, S C / Leitl, P / Levit, D / Li, L K / Li, S X / Li, Y B / Libby, J / Liptak, Z / Liu, Q Y / Liventsev, D / Longo, S / Lueck, T / Lyu, C / Maggiora, M / Maiti, R / Maity, S / Manfredi, R / Manoni, E / Marcello, S / Marinas, C / Martel, L / Martini, A / Massaccesi, L / Masuda, M / Matsuoka, K / Matvienko, D / McKenna, J A / Meier, F / Merola, M / Milesi, M / Miller, C / Miyabayashi, K / Mohanty, G B / Molina-Gonzalez, N / Moneta, S / Moon, H / Moser, H-G / Mrvar, M / Mussa, R / Nakamura, I / Nakao, M / Nakayama, H / Narimani Charan, A / Naruki, M / Natkaniec, Z / Natochii, A / Nayak, L / Nayak, M / Nazaryan, G / Niebuhr, C / Nisar, N K / Nishida, S / Nishimura, K / Ono, H / Oskin, P / Oxford, E R / Pakhlova, G / Paladino, A / Panta, A / Paoloni, E / Pardi, S / Parham, K / Park, H / Park, S-H / Passeri, A / Pedlar, T K / Peruzzi, I / Peschke, R / Pestotnik, R / Pham, F / Piilonen, L E / Pinna Angioni, G / Podesta-Lerma, P L M / Podobnik, T / Pokharel, S / Polat, L / Praz, C / Prell, S / Prencipe, E / Prim, M T / Purwar, H / Rad, N / Rados, P / Raiz, S / Reif, M / Reiter, S / Ripp-Baudot, I / Rizzo, G / Robertson, S H / Roney, J M / Rostomyan, A / Rout, N / Russo, G / Sanders, D A / Sandilya, S / Sangal, A / Santelj, L / Sato, Y / Savinov, V / Scavino, B / Schwanda, C / Schwartz, A J / Seino, Y / Selce, A / Senyo, K / Serrano, J / Sfienti, C / Shen, C P / Shillington, T / Shiu, J-G / Sibidanov, A / Simon, F / Sobie, R J / Soffer, A / Sokolov, A / Solovieva, E / Spataro, S / Spruck, B / Starič, M / Stefkova, S / Stroili, R / Strube, J / Sumihama, M / Sumisawa, K / Sutcliffe, W / Suzuki, S Y / Svidras, H / Takahashi, M / Takizawa, M / Tamponi, U / Tanaka, S / Tanida, K / Tanigawa, H / Taniguchi, N / Tenchini, F / Tiwary, R / Tonelli, D / Torassa, E / Toutounji, N / Trabelsi, K / Uchida, M / Unger, K / Unno, Y / Uno, K / Uno, S / Urquijo, P / Ushiroda, Y / Vahsen, S E / van Tonder, R / Varner, G S / Varvell, K E / Vinokurova, A / Vitale, L / Vobbilisetti, V / Waheed, E / Wakeling, H M / Wang, E / Wang, M-Z / Wang, X L / Warburton, A / Watanuki, S / Welsch, M / Wessel, C / Wiechczynski, J / Windel, H / Won, E / Xu, X P / Yabsley, B D / Yamada, S / Yang, S B / Ye, H / Yelton, J / Yin, J H / Yoshihara, K / Yusa, Y / Zhang, Y / Zhilich, V / Zhou, Q D / Zhukova, V I / Žlebčík, R

Physical review letters

2023 Volume 130, Issue 7, Page(s) 71802

Abstract: An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays ... at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203 ...

Abstract	An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays in events reconstructed from data collected by the Belle II experiment at the SuperKEKB asymmetric-energy electron-positron collider. The total integrated luminosity of the data sample, which was collected at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203.20±0.89±0.77 fs, where the first uncertainty is statistical and the second systematic, is the most precise measurement to date and is consistent with previous determinations.
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.071802
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Article ; Online: Oldest evidence of abundant C

Peppe, Daniel J / Cote, Susanne M / Deino, Alan L / Fox, David L / Kingston, John D / Kinyanjui, Rahab N / Lukens, William E / MacLatchy, Laura M / Novello, Alice / Strömberg, Caroline A E / Driese, Steven G / Garrett, Nicole D / Hillis, Kayla R / Jacobs, Bonnie F / Jenkins, Kirsten E H / Kityo, Robert M / Lehmann, Thomas / Manthi, Fredrick K / Mbua, Emma N /

Michel, Lauren A / Miller, Ellen R / Mugume, Amon A T / Muteti, Samuel N / Nengo, Isaiah O / Oginga, Kennedy O / Phelps, Samuel R / Polissar, Pratigya / Rossie, James B / Stevens, Nancy J / Uno, Kevin T / McNulty, Kieran P

Science (New York, N.Y.)

2023 Volume 380, Issue 6641, Page(s) 173–177

Abstract: The assembly of Africa's iconic C ...

Abstract	The assembly of Africa's iconic C
MeSH term(s)	Animals ; Africa, Eastern ; Biological Evolution ; Ecosystem ; Grassland ; Hominidae ; Mammals ; Poaceae
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abq2834
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Surgeon reported treatment choices for AO type B and C thoracolumbar fractures without neurological deficits: An expert survey.

Kitzen, J / Bakker, W M / Jacobs, E / Kuijper, M T / Öner, F C

Injury

2024 Volume 55, Issue 3, Page(s) 111389

Abstract: ... the adequacy of LISS for more unstable AO type B and C injuries, as it does not allow for formal open fusion ... treatment for AO type B1, B2 (L1: A1 and L1: A3), B3 and C (L1: A4) injuries at level Th12-L1. Taking ... with substantial agreement (VR 0.871-0.923). Conversely, for AO type-C injuries, there was less agreement ...

Abstract	Introduction: Less invasive spine surgery (LISS) has become well-established for thoracolumbar burst fractures without neurological deficits. However, notable controversy persists regarding the adequacy of LISS for more unstable AO type B and C injuries, as it does not allow for formal open fusion. Materials and methods: In this cross-sectional survey experienced spine surgeons of the Dutch Spine Society were invited to participate (56 participants). They were asked to indicate the most appropriate treatment for AO type B1, B2 (L1: A1 and L1: A3), B3 and C (L1: A4) injuries at level Th12-L1. Taking into account: age, AO N0-N1, or polytrauma. Specific agreement between participants was obtained applying Variation Ratio (VR). Results: A significant level of overall agreement was observed for AO type-B1 injuries with 73.8% of participants opting for percutaneous short-segment fixation (VR 0.775). For AO type-B3 injuries, 79.4% of participants favored percutaneous long-segment fixation (VR 0.794). for AO type-B2 injuries, there was less overall agreement (VR 0.571-0.657). Nonetheless, when considering all AO type-B injuries combined, percutaneous fixation emerged as the most preferred treatment option with substantial agreement (VR 0.871-0.923). Conversely, for AO type-C injuries, there was less agreement among the participants (VI 0.411), 26.5% of them chose additional open spinal fusion. Conclusion: For all AO type-B injuries there was substantial agreement to treat these fractures with percutaneous techniques. For AO type-C injuries, the survey results do not support a consensus. Nevertheless, the responses raise important questions about the necessity of spinal fusion for such injuries.
MeSH term(s)	Humans ; Infant, Newborn ; Spinal Fractures/surgery ; Cross-Sectional Studies ; Thoracic Vertebrae/surgery ; Thoracic Vertebrae/injuries ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/injuries ; Fracture Fixation, Internal/methods ; Fractures, Compression ; Surgeons ; Treatment Outcome ; Pedicle Screws
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2024.111389
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review.

Jacobs, Jeremy W / Sharma, Deva / Stephens, Laura D / Figueroa Villalba, Cristina A / Rinder, Henry M / Woo, Jennifer S / Wheeler, Allison P / Gerberi, Dana / Goel, Ruchika / Tormey, Christopher A / Booth, Garrett S / Bloch, Evan M / Adkins, Brian D

British journal of haematology

2024 Volume 204, Issue 4, Page(s) 1500–1506

Abstract: The thrombotic risk with haemoglobin C trait (HbAC) or haemoglobin C disease (HbCC) is unclear ...

Abstract	The thrombotic risk with haemoglobin C trait (HbAC) or haemoglobin C disease (HbCC) is unclear. However, individuals with HbCC have demonstrated chronic haemolysis, higher blood viscosity and altered rheology when compared to individuals with wild-type haemoglobin (HbAA). These physiological alterations may theoretically translate to increased risk of thrombosis; therefore, a systematic literature review was performed to investigate the possible association between HbAC and/or HbCC and thrombosis. Twenty-two studies met inclusion criteria representing 782 individuals with HbAC (n = 694) or HbCC (n = 88). Fifteen studies described the presence/absence of venous thromboembolism (VTE) in patients with HbAC (n = 685) or HbCC (n = 79), while seven studies described patients with HbAC (n = 9) or HbCC (n = 9) and arterial thrombosis. Most (n = 20) studies were case reports or case series; however, two studies suggested a potential increased VTE risk with HbAC compared to HbAA in (i) all patients (OR 2.2, 95% CI: 0.9-5.5) and in (ii) pregnant individuals (RR 3.7, 95% CI 0.9-16). This review is the largest assessment of patients with HbC trait or disease and thrombosis to date; despite its limitations, the findings suggest HbC may be a predisposing risk factor to thrombosis. Prospective cohort studies are warranted to definitively elucidate the risk of thrombosis in this population.
MeSH term(s)	Pregnancy ; Female ; Humans ; Hemoglobin C ; Hemoglobin C Disease ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Prospective Studies ; Hemoglobinopathies ; Thrombosis/etiology ; Risk Factors
Chemical Substances	Hemoglobin C (9008-00-8)
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19313
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Article ; Online: MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking.

Trac, Noah / Chen, Zixi / Oh, Hyun-Seok / Jones, Leila / Huang, Yi / Giblin, Joshua / Gross, Mitchell / Sta Maria, Naomi S / Jacobs, Russell E / Chung, Eun Ji

ACS nano

2024 Volume 18, Issue 3, Page(s) 2091–2104

Abstract: ... accumulation. Nanoparticles targeted to the C-C chemokine receptor 2 (CCR2), a biomarker highly expressed ...

Abstract	Biopsy is the clinical standard for diagnosing lymph node (LN) metastasis, but it is invasive and poses significant risk to patient health. Magnetic resonance imaging (MRI) has been utilized as a noninvasive alternative but is limited by low sensitivity, with only ∼35% of LN metastases detected, as clinical contrast agents cannot discriminate between healthy and metastatic LNs due to nonspecific accumulation. Nanoparticles targeted to the C-C chemokine receptor 2 (CCR2), a biomarker highly expressed in metastatic LNs, have the potential to guide the delivery of contrast agents, improving the sensitivity of MRI. Additionally, cancer cells in metastatic LNs produce monocyte chemotactic protein 1 (MCP1), which binds to CCR2
MeSH term(s)	Animals ; Mice ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Contrast Media/chemistry ; Monocytes ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Molecular Targeted Therapy ; Magnetic Resonance Imaging/methods ; Receptors, Chemokine
Chemical Substances	Contrast Media ; Receptors, Chemokine
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09201
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Book ; Online: Verifying C++ Dynamic Binding

Mommen, Niels / Jacobs, Bart

2023

Abstract: ... where, like in C++, the same virtual method call is bound to different methods at different points during ... it in our VeriFast tool for semi-automated modular formal verification of C++ programs. ... Comment: 9 pages ...

Abstract	We propose an approach for modular verification of programs written in an object-oriented language where, like in C++, the same virtual method call is bound to different methods at different points during the construction or destruction of an object. Our separation logic combines Parkinson and Bierman's abstract predicate families with essentially explicitly tracking each subobject's vtable pointer. Our logic supports polymorphic destruction. Virtual inheritance is not yet supported. We formalised our approach and implemented it in our VeriFast tool for semi-automated modular formal verification of C++ programs. Comment: 9 pages
Keywords	Computer Science - Programming Languages
Publishing date	2023-06-03
Publishing country	us
Document type	Book ; Online
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Article: Exploring the Relationship Between Hepatitis C Virus Infection and Prostate Cancer Risk: A National Health and Nutrition Examination Survey Analysis.

Ganz, Marc / Alessandro, Christopher / Jacobs, Menachem / Gejerman, Yehuda / Miller, Daniel / Okoye, Frederick / Jamieson, Scott / Winer, Andrew

Cureus

2024 Volume 16, Issue 2, Page(s) e54523

Abstract: Introduction Prostate cancer and hepatitis C virus (HCV) infection stand as notable worldwide ...

Abstract	Introduction Prostate cancer and hepatitis C virus (HCV) infection stand as notable worldwide health issues. Investigating the connection between HCV infection and the risk of prostate cancer remains an ongoing endeavor, complicated by contradictory findings in prior research. It is imperative to comprehend this potential relationship in order to enhance strategies for prevention and treatment. This paper seeks to delve into the association between HCV infection and prostate cancer by analyzing data from the National Health and Nutrition Examination Survey (NHANES), a comprehensive cross-section of the US population. Methods Information extracted from the NHANES dataset encompassed the period spanning from March 2017 to March 2020, with a focus on the "medical conditions" and "hepatitis" segments. Employing logistic regression analysis, we aimed to discern the connection between HCV infection and the prior occurrence of prostate cancer. This analysis was conducted while factoring in variables such as weight, hypertension, hyperlipidemia, race, educational level, and marital status to ensure the accuracy of the findings. The results of this examination yielded adjusted odds ratios (OR), coefficients of association (B), and corresponding confidence intervals (CI). Results The outcomes derived from the comprehensive multivariate logistic regression analysis, utilizing NHANES data, indicated an absence of a statistically noteworthy correlation between HCV infection and the probability of prostate cancer occurrence. While accounting for diverse variables like weight, hypertension, hyperlipidemia, race, educational level, and marital status, no substantial relationship was observed between HCV infection and the risk of prostate cancer. These results are consistent with earlier investigations that similarly struggled to establish a definitive connection between HCV infection and the incidence of prostate cancer. Conclusion Drawing from NHANES data, this study indicates the absence of a substantial link between HCV infection and the incidence of prostate cancer. The divergent findings observed in prior research accentuate the intricate nature of the connection between HCV infection and prostate cancer. Future investigations should encompass more extensive sample sizes, prospective frameworks, and a meticulous assessment of potential variables that might confound the results. Furthermore, it is important to examine the potential protective impact of HCV infection due to antiviral interventions and its effect on the associated risk of prostate cancer. Such endeavors would offer valuable insights for individuals grappling with these health challenges.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54523
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Article ; Online: cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities.

De Lange, Willem J / Farrell, Emily T / Hernandez, Jonathan J / Stempien, Alana / Kreitzer, Caroline R / Jacobs, Derek R / Petty, Dominique L / Moss, Richard L / Crone, Wendy C / Ralphe, J Carter

The Journal of general physiology

2023 Volume 155, Issue 4

Abstract: Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes ... cMyBP-C+/-) and homozygous (cMyBP-C-/-) frame-shift mutations into MYBPC3 in human iPSCs. Cardiomyocytes ... sensitivity. While heterozygous frame shifts did not alter cMyBP-C protein levels in 2-D cardiomyocytes, cMyBP ...

Abstract	Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidly progress to heart failure. We used CRISPR-Cas9 to introduce heterozygous (cMyBP-C+/-) and homozygous (cMyBP-C-/-) frame-shift mutations into MYBPC3 in human iPSCs. Cardiomyocytes derived from these isogenic lines were used to generate cardiac micropatterns and engineered cardiac tissue constructs (ECTs) that were characterized for contractile function, Ca2+-handling, and Ca2+-sensitivity. While heterozygous frame shifts did not alter cMyBP-C protein levels in 2-D cardiomyocytes, cMyBP-C+/- ECTs were haploinsufficient. cMyBP-C-/- cardiac micropatterns produced increased strain with normal Ca2+-handling. After 2 wk of culture in ECT, contractile function was similar between the three genotypes; however, Ca2+-release was slower in the setting of reduced or absent cMyBP-C. At 6 wk in ECT culture, the Ca2+-handling abnormalities became more pronounced in both cMyBP-C+/- and cMyBP-C-/- ECTs, and force production became severely depressed in cMyBP-C-/- ECTs. RNA-seq analysis revealed enrichment of differentially expressed hypertrophic, sarcomeric, Ca2+-handling, and metabolic genes in cMyBP-C+/- and cMyBP-C-/- ECTs. Our data suggest a progressive phenotype caused by cMyBP-C haploinsufficiency and ablation that initially is hypercontractile, but progresses to hypocontractility with impaired relaxation. The severity of the phenotype correlates with the amount of cMyBP-C present, with more severe earlier phenotypes observed in cMyBP-C-/- than cMyBP-C+/- ECTs. We propose that while the primary effect of cMyBP-C haploinsufficiency or ablation may relate to myosin crossbridge orientation, the observed contractile phenotype is Ca2+-mediated.
MeSH term(s)	Humans ; Calcium/metabolism ; Tissue Engineering ; Myocardial Contraction ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Myocytes, Cardiac/metabolism ; Cardiomyopathy, Hypertrophic ; Mutation
Chemical Substances	Calcium (SY7Q814VUP) ; Carrier Proteins
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202213204
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Article ; Online: Measurement of the Cross Sections of Ξ_{c}^{0} and Ξ_{c}^{+} Baryons and of the Branching-Fraction Ratio BR(Ξ_{c}^{0}→Ξ^{-}e^{+}ν_{e})/BR(Ξ_{c}^{0}→Ξ^{-}π^{+}) in pp Collisions at sqrt[s]=13 TeV.

Acharya, S / Adamová, D / Adler, A / Adolfsson, J / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akbar, Z / Akindinov, A / Al-Turany, M / Alam, S N / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R /

Ali, B / Ali, Y / Alici, A / Alizadehvandchali, N / Alkin, A / Alme, J / Alt, T / Altenkamper, L / Altsybeev, I / Anaam, M N / Andrei, C / Andreou, D / Andronic, A / Angeletti, M / Anguelov, V / Antinori, F / Antonioli, P / Anuj, C / Apadula, N / Aphecetche, L / Appelshäuser, H / Arcelli, S / Arnaldi, R / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Aziz, S / Azmi, M D / Badalà, A / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Bala, R / Balbino, A / Baldisseri, A / Balis, B / Ball, M / Banerjee, D / Barbera, R / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Bartels, C / Barth, K / Bartsch, E / Baruffaldi, F / Bastid, N / Basu, S / Batigne, G / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Belyaev, V / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Berenyi, D / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / 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Physical review letters

2022 Volume 127, Issue 27, Page(s) 272001

Abstract: The p_{T}-differential cross sections of prompt charm-strange baryons Ξ_{c}^{0} and Ξ_{c}^{+} were ... TeV with the ALICE detector at the LHC. The Ξ_{c}^{0} baryon was reconstructed via ... both the semileptonic decay (Ξ^{-}e^{+}ν_{e}) and the hadronic decay (Ξ^{-}π^{+}) channels. The Ξ_{c}^{+} baryon was ...

Abstract	The p_{T}-differential cross sections of prompt charm-strange baryons Ξ_{c}^{0} and Ξ_{c}^{+} were measured at midrapidity (\|y\|<0.5) in proton-proton (pp) collisions at a center-of-mass energy sqrt[s]=13 TeV with the ALICE detector at the LHC. The Ξ_{c}^{0} baryon was reconstructed via both the semileptonic decay (Ξ^{-}e^{+}ν_{e}) and the hadronic decay (Ξ^{-}π^{+}) channels. The Ξ_{c}^{+} baryon was reconstructed via the hadronic decay (Ξ^{-}π^{+}π^{+}) channel. The branching-fraction ratio BR(Ξ_{c}^{0}→Ξ^{-}e^{+}ν_{e})/BR(Ξ_{c}^{0}→Ξ^{-}π^{+})=1.38±0.14(stat)±0.22(syst) was measured with a total uncertainty reduced by a factor of about 3 with respect to the current world average reported by the Particle Data Group. The transverse momentum (p_{T}) dependence of the Ξ_{c}^{0}- and Ξ_{c}^{+}-baryon production relative to the D^{0} meson and to the Σ_{c}^{0,+,++}- and Λ_{c}^{+}-baryon production are reported. The baryon-to-meson ratio increases toward low p_{T} up to a value of approximately 0.3. The measurements are compared with various models that take different hadronization mechanisms into consideration. The results provide stringent constraints to these theoretical calculations and additional evidence that different processes are involved in charm hadronization in electron-positron (e^{+}e^{-}) and hadronic collisions.
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.272001
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Article ; Online: Tools to differentiate between Filamin C and Titin truncating variant carriers: value of MRI.

Jacobs, Johanna / Van Aelst, Lucas / Breckpot, Jeroen / Corveleyn, Anniek / Kuiperi, Cuno / Dupont, Matthias / Heggermont, Ward / De Vadder, Katrien / Willems, Rik / Van Cleemput, Johan / Bogaert, Jan G / Robyns, Tomas

European journal of human genetics : EJHG

2023 Volume 31, Issue 11, Page(s) 1323–1332

Abstract: ... dilated cardiomyopathy (DCM), recently Filamin C truncating variants (FLNCtv) were identified as a cause ...

Abstract	Whereas truncating variants of the giant protein Titin (TTNtv) are the main cause of familial dilated cardiomyopathy (DCM), recently Filamin C truncating variants (FLNCtv) were identified as a cause of arrhythmogenic cardiomyopathy (ACM). Our aim was to characterize and compare clinical and MRI features of TTNtv and FLNCtv in the Belgian population. In index patients referred for genetic testing of ACM/DCM, FLNCtv and TTNtv were found in 17 (3.6%) and 33 (12.3%) subjects, respectively. Further family cascade screening yielded 24 and 19 additional truncating variant carriers in FLNC and TTN, respectively. The main phenotype was ACM in FLNCtv carriers whereas TTNtv carriers showed either an ACM or DCM phenotype. Non-sustained Ventricular Tachycardia was frequent in both populations. MRI data, available in 28/40 FLNCtv and 32/52 TTNtv patients, showed lower Left Ventricular (LV) ejection fraction and lower LV strain in TTNtv patients (p < 0.01). Conversely, both the frequency (68% vs 22%) and extent of non-ischemic myocardial late gadolinium enhancement (LGE) was significantly higher in FLNCtv patients (p < 0.01). Hereby, ring-like LGE was found in 16/19 (84%) FLNCtv versus 1/7 (14%) of TTNtv patients (p < 0.01). In conclusion, a large number of FLNCtv and TTNtv patients present with an ACM phenotype but can be separated by cardiac MRI. Whereas FLNCtv patients often have extensive myocardial fibrosis, typically following a ring-like pattern, LV dysfunction without or limited replacement fibrosis is the common TTNtv phenotype.
MeSH term(s)	Humans ; Connectin/genetics ; Filamins/genetics ; Contrast Media ; Gadolinium ; Fibrosis ; Magnetic Resonance Imaging
Chemical Substances	Connectin ; Filamins ; Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-023-01357-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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