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  1. Article ; Online: Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

    Jay, Raman / Brennan, P / Brenner / Overvad, K / Olsen, A / Tjønneland, A / Boutron-Ruault, M C / Clavel-Chapelon, F / Fagherazzi / Katzke, V / Kühn, T / Boeing, H / Bergmann, M M / Steffen, A / Naska, A / Trichopoulou, A / Trichopoulos, D / Saieva, C / Grioni, S /
    Panico, S / Tumino, R / Vineis, P / Bueno-de-Mesquita, H B / Peeters, P H / Hjartåker, A / Weiderpass, E / Arriola, L / Molina-Montes, E / Duell, E J / Santiuste, C / Alonso de la Torre, R / Barricarte Gurrea, A / Stocks, T / Johansson, M / Ljungberg, B / Wareham, N / Khaw, K T / Travis, R C / Cross, A J / Murphy, N / Riboli, E / Scelo, G

    Urologic oncology

    2017  Volume 35, Issue 3, Page(s) 117

    Abstract: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women ...

    Abstract Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
    MeSH term(s) Alcohol Drinking ; Female ; Humans ; Kidney Neoplasms ; Male ; Nutritional Status ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2017-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2016.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: IBD and IBS: novel mechanisms and future practice

    Travis, Simon

    (Digestive diseases ; 27, Suppl. 1)

    2010  

    Event/congress Falk Symposium (170, 2009, Glasgow)
    Author's details Falk Symposium 170, September 11 and 12, 2009, Glasgow. Ed. S. P. L. Travis
    Series title Digestive diseases ; 27, Suppl. 1
    Collection
    Keywords Chronische Darmentzündung ; Reizcolon ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Colon irritabile ; Spastisches Colon ; Irritables Colon ; Reizkolon ; Spastisches Kolon ; Reizdarm ; Reizdarm-Syndrom ; Inflammatory bowel disease ; Irritable Bowel Syndrome ; Entzündliche Darmkrankheit ; Chronisch-entzündliche Darmerkrankung
    Language English
    Size 149 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT016283863
    ISBN 978-3-8055-9385-4 ; 3-8055-9385-6
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Conference proceedings: IBD and IBS: novel mechanisms and future practice

    Travis, Simon

    Falk Symposium 170, September 11 and 12, 2009, Glasgow ; 13 tables

    (Falk symposium ; 170)

    2010  

    Event/congress Falk Symposium (170, 2009, Glasgow)
    Author's details ed. S. P. Travis
    Series title Falk symposium ; 170
    Falk symposium series
    Collection Falk symposium series
    Keywords Irritable Bowel Syndrome / physiopathology ; Irritable Bowel Syndrome / therapy ; Inflammatory Bowel Diseases / physiopathology ; Inflammatory Bowel Diseases / therapy ; Pain
    Language English
    Size 149 S. : graph. Drast.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    Note Repr. of: Digestive diseases 2009, Vol. 27, Suppl. 1, 2009
    HBZ-ID HT016328986
    ISBN 978-3-8055-9420-2 ; 3-8055-9420-8
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Conference proceedings: Your IBD patient: challenges and advances in patient care

    Travis, Simon

    [Satellite Symposium "Your IBD Patient: Challenges and Advances in Patient Care" ... Glasgow in March 2007]

    (Alimentary pharmacology & therapeutics ; 27, Suppl. 1)

    2008  

    Title variant Highlights of gastroenterology
    Event/congress Satellite Symposium Your IBD Patient: Challenges and Advances in Patient Care (2007, Glasgow)
    Author's details guest ed. S. P. L. Travis
    Series title Alimentary pharmacology & therapeutics ; 27, Suppl. 1
    Collection
    Language English
    Size V, 21 S. : graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015489445
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Mesalazine in ulcerative colitis

    Travis, Simon

    is it time to revise treatment guidelines in the UK?

    (Alimentary pharmacology & therapeutics ; 24, Suppl. 1)

    2006  

    Author's details guest ed. S. P. L. Travis
    Series title Alimentary pharmacology & therapeutics ; 24, Suppl. 1
    Collection
    Language English
    Size 22 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014845207
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Guidelines for the management of inflammatory bowel disease in adults

    Carter, Martyn J. / Lobo, Alan J. / Travis, Simon

    (Gut ; 53, Suppl. 5)

    2004  

    Author's details M. J. Carter ; A. J. Lobo ; S. P. L. Travis
    Series title Gut ; 53, Suppl. 5
    Collection
    Language English
    Size v16 S.
    Publisher BMJ Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014112901
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Trends in ototoxicity monitoring among cisplatin-treated patients with cancer.

    Lee, David S / Travis, Emma Y / Wong, Susan K / Munyemana, Marie-Ange / Mueller, Lauren / Rowling, Cathryn Collopy / Rich, Jason T / Pipkorn, Patrik / Puram, Sidharth V / Jackson, Ryan S / Adkins, Douglas R / Oppelt, Peter / Thorstad, Wade L / Wick, Cameron C / Zevallos, Jose P / McClannahan, Kate / Mazul, Angela L

    Journal of cancer survivorship : research and practice

    2024  

    Abstract: Purpose: This study aims to characterize patterns in ototoxicity monitoring and identify potential barriers to audiologic follow-up.: Methods: We performed a single-institution retrospective cohort study on adult (≥ 18 years old) cancer patients ... ...

    Abstract Purpose: This study aims to characterize patterns in ototoxicity monitoring and identify potential barriers to audiologic follow-up.
    Methods: We performed a single-institution retrospective cohort study on adult (≥ 18 years old) cancer patients treated with cisplatin from January 2014 to September 2021. Our primary outcomes were rates of baseline and post-treatment audiograms at the following time points: 3, 6, 12, and greater than 12 months. Time-to-event analyses were performed to describe additional insights to ototoxicity monitoring patterns.
    Results: Nine hundred fifty-five patients with cancer were included for analysis. The most common primary cancer sites were head and neck (64%), followed by cervical (24%). Three hundred seventy-three patients (39%) underwent baseline audiometric assessment, 38 patients (4%) received audiologic evaluation during chemotherapy, and 346 patients (36%) obtained at least one post-treatment audiogram. Audiologic follow-up was greatest within 3 months of completing chemotherapy (26%), but this tapered dramatically to less than 10% at every other post-treatment time point. Patients with head and neck cancer achieved higher rates of audiologic follow-up at every time point than patients with non-head and neck cancer except for during treatment.
    Conclusions: Ototoxicity monitoring is an inconsistent practice, particularly during chemotherapy and for long-term surveillance of hearing loss. Patients with non-head and neck cancer may be at increased risk for loss of audiologic follow-up.
    Implications for cancer survivors: Cisplatin ototoxicity is a common occurrence that can be effectively managed with auditory rehabilitation. Therefore, referrals to audiology and counseling on treatment-related ototoxicity are recommended throughout chemotherapy and cancer survivorship.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-024-01586-3
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  8. Article ; Online: Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV.

    Mahalingam, S S / Jayaraman, S / Bhaskaran, N / Schneider, E / Faddoul, F / Paes da Silva, A / Lederman, M M / Asaad, R / Adkins-Travis, K / Shriver, L P / Pandiyan, P

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 399

    Abstract: Metabolic changes in immune cells contribute to both physiological and pathophysiological outcomes of immune reactions. Here, by comparing protein expression, transcriptome, and salivary metabolome profiles of uninfected and HIV+ individuals, we found ... ...

    Abstract Metabolic changes in immune cells contribute to both physiological and pathophysiological outcomes of immune reactions. Here, by comparing protein expression, transcriptome, and salivary metabolome profiles of uninfected and HIV+ individuals, we found perturbations of polyamine metabolism in the oral mucosa of HIV+ patients. Mechanistic studies using an in vitro human tonsil organoid infection model revealed that HIV infection of T cells also resulted in increased polyamine synthesis, which was dependent on the activities of caspase-1, IL-1β, and ornithine decarboxylase-1. HIV-1 also led to a heightened expression of polyamine synthesis intermediates including ornithine decarboxylase-1 as well as an elevated dysfunctional regulatory T cell (T
    MeSH term(s) Humans ; Caspases/immunology ; HIV Infections/immunology ; Mouth Mucosa/immunology ; Ornithine Decarboxylase/immunology ; Polyamines/immunology ; T-Lymphocytes/immunology
    Chemical Substances Caspases (EC 3.4.22.-) ; Ornithine Decarboxylase (EC 4.1.1.17) ; Polyamines
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36163-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Impact of Pre-Trauma Steroid Use on Wound Healing and Outcomes.

    Derouen, Kaleb / Aleman, Sarah / Travis, Harrison / Hunt, John P / Marr, Alan / Greiffenstein, Patrick / Stuke, Lance / Schoen, Jonathan / Smith, Alison

    The American surgeon

    2024  , Page(s) 31348241241710

    Abstract: This study presents data on pre-trauma steroid use, a topic underrepresented in the trauma literature. Long-term steroid use has been linked to impaired wound healing, compromised immune responses, and hindrance of bone healing, alongside the potential ... ...

    Abstract This study presents data on pre-trauma steroid use, a topic underrepresented in the trauma literature. Long-term steroid use has been linked to impaired wound healing, compromised immune responses, and hindrance of bone healing, alongside the potential for adrenal insufficiency during traumatic events. The aim of this study was to conduct a retrospective analysis of clinical outcomes for trauma patients with chronic steroid use. Examining adult trauma cases with pre-trauma steroid use at a level 1 trauma center (January 2016-September 2023), we identified 18 patients (58.6 ± 19.4 years, 55.6% males). All were on prednisone prior to trauma activation and 66.7% had autoimmune disease. Complications included orthopedic fractures (72.2%), ICU admissions (16.7%), and low mortality (5.6%). Future larger, multi-center studies are needed to determine the impact of immunosuppression and pre-trauma steroids on clinical outcomes.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348241241710
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  10. Article ; Conference proceedings: Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses, and outcomes in the 2022 prospective audit of 5000 patients

    Nigam, G. / Davies, P. / Dhiman, P. / Estcourt, L. / Grant-Casey, J. / Ratcliffe, E. / Kumar, B. / Uberoi, R. / Oakland, K. / Leithead, J. A. / Hearnshaw, S. / Jairath, V. / Murphy, M. F. / Travis, S. / Stanley, A. / Douds, A.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783059
    Database Thieme publisher's database

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