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Article ; Online: Teenage Boy With a Painful Forearm.

Liao, Chien-Yu / Tsai, Tou-Yuan / Lee, Yi-Kung / Chen, Yu-Ting

2024 Volume 83, Issue 5, Page(s) 492–493

MeSH term(s)	Male ; Adolescent ; Humans ; Forearm ; Pain/etiology
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2023.11.004
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Article ; Online: Correction: Different autism measures targeting different severity levels in children with autism spectrum disorder.

Huang, Chien-Yu / Chen, Kuan-Shu / Lee, Kuan-Ying / Lin, Chien-Ho / Chen, Kuan-Lin

European archives of psychiatry and clinical neuroscience

2023

Language	English
Publishing date	2023-10-28
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-023-01703-w
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Article ; Online: Mineralocorticoid Receptor Mediates Cortisol Regulation of Ionocyte Development in Tilapia ( Oreochromis mossambicus )

Chien-Yu Wu / Tsung-Han Lee / Deng-Yu Tseng

Fishes, Vol 8, Iss 283, p

2023 Volume 283

Abstract: Cortisol is the predominant corticosteroid in ray-finned fish since it does not possess the aldosterone synthase necessary to produce specific mineralocorticoids. Cortisol is traditionally believed to function as a fish mineralocorticoid. However, the ... ...

Abstract	Cortisol is the predominant corticosteroid in ray-finned fish since it does not possess the aldosterone synthase necessary to produce specific mineralocorticoids. Cortisol is traditionally believed to function as a fish mineralocorticoid. However, the effects of cortisol are mediated through corticosteroid receptors in other vertebrates, and there is an ongoing debate about whether cortisol acts through the glucocorticoid receptor (GR) or the mineralocorticoid receptor (MR) in teleosts. To investigate this issue, we conducted a study using euryhaline Mozambique tilapia ( Oreochromis mossambicus ) as the experimental species. The experiment was designed to investigate the effect of cortisol on ionocyte development at both the cellular and gene expression levels in tilapia. We administered exogenous cortisol and receptor antagonists, used immunohistochemistry to quantify ionocyte numbers, and performed real-time PCR to assess the expression of the differentiation factor tumor protein 63 (P63) mRNA, an epidermal stem cell marker. We observed that cortisol increased the number of Na + -K + -ATPase (NKA)-immunoactive ionocytes (increased by 1.6-fold) and promoted the gene expression of P63 mRNA (increased by 1.4-fold). Furthermore, we found that the addition of the mineralocorticoid receptor antagonist Spironolactone inhibited the increase in the number of ionocytes (decreased to the level of the control group) and suppressed the gene expression of P63 (similarly decreased to the level of the control group). We also provided evidence for gr , mr , and p63 localization in epidermal cells. At the transcript level, mr mRNA is ubiquitously expressed in gill sections and present in epidermal stem cells (cells labeled with p63 ), supporting the antagonism and functional assay results in larvae. Our results confirmed that cortisol stimulates ionocyte differentiation in tilapia through the MR, rather than the GR. Therefore, we provide a new direction for investigating the dual action of osmotic regulation and skin/gill ...
Keywords	cortisol ; ionocytes ; ionocyte development ; mineralocorticoid receptor ; P63 ; tilapia ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The complex nexus of alcohol consumption and rheumatoid arthritis: Unraveling insights for disease management.

Lin, Chien-Yu / Lee, Yung-Heng / Chang, Hsuan / Huo, An-Ping

International journal of rheumatic diseases

2023 Volume 27, Issue 1, Page(s) e14966

MeSH term(s)	Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Disease Management
Language	English
Publishing date	2023-11-05
Publishing country	England
Document type	Editorial
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14966
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Article ; Online: Machine learning-based brief version of the Caregiver-Teacher Report Form for preschoolers.

Lin, Gong-Hong / Lee, Shih-Chieh / Yu, Yen-Ting / Huang, Chien-Yu

Research in developmental disabilities

2023 Volume 134, Page(s) 104437

Abstract: Background: The Caregiver-Teacher Report Form of the Child Behavior Checklist for Ages 1½-5 (C-TRF) is a widely used checklist to identify emotional and behavioral problems in preschoolers. However, the 100-item C-TRF restricts its utility.: Aims: ... ...

Abstract	Background: The Caregiver-Teacher Report Form of the Child Behavior Checklist for Ages 1½-5 (C-TRF) is a widely used checklist to identify emotional and behavioral problems in preschoolers. However, the 100-item C-TRF restricts its utility. Aims: This study aimed to develop a machine learning-based short-form of the C-TRF (C-TRF-ML). Methods and procedures: Three steps were executed. First, we split the data into three datasets in a ratio of 3:1:1 for training, validation, and cross-validation, respectively. Second, we selected a shortened item set and trained a scoring algorithm using joint learning for classification and regression using the training dataset. Then, we evaluated the similarity of scores between the C-TRF-ML and the C-TRF by r-squared and weighted kappa values using the validation dataset. Third, we cross-validated the C-TRF-ML by calculating the r-squared and weighted kappa values using the cross-validation dataset. Outcomes and results: Data of 363 children were analyzed. Thirty-six items of the C-TRF were retained. The r-squared values of C-TRF-ML scores were 0.86-0.96 in the cross-validation dataset. Weighted kappa values of the syndrome/problem grading were 0.72-0.94 in the cross-validation dataset. Conclusions and implications: The C-TRF-ML had about 60 % fewer items than the C-TRF but yielded comparable scores with the C-TRF.
MeSH term(s)	Child ; Humans ; Caregivers ; Problem Behavior ; Emotions
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	639175-8
ISSN	1873-3379 ; 0891-4222
ISSN (online)	1873-3379
ISSN	0891-4222
DOI	10.1016/j.ridd.2023.104437
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Article ; Online: Interfacial Layer Materials with a Truxene Core for Dopant-Free NiO

Ramanujam, Rajarathinam / Hsu, Hsiang-Lin / Shi, Zhong-En / Lung, Chien-Yu / Lee, Chin-Han / Wubie, Gebremariam Zebene / Chen, Chih-Ping / Sun, Shih-Sheng

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310939

Abstract: Nickel oxide ( ... ...

Abstract	Nickel oxide (NiO
Language	English
Publishing date	2024-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310939
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Article ; Online: ADMM-SRNet: Alternating Direction Method of Multipliers Based Sparse Representation Network for One-Class Classification.

Chiou, Chien-Yu / Lee, Kuang-Ting / Huang, Chun-Rong / Chung, Pau-Choo

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 32, Page(s) 2843–2856

Abstract: One-class classification aims to learn one-class models from only in-class training samples. Because of lacking out-of-class samples during training, most conventional deep learning based methods suffer from the feature collapse problem. In contrast, ... ...

Abstract	One-class classification aims to learn one-class models from only in-class training samples. Because of lacking out-of-class samples during training, most conventional deep learning based methods suffer from the feature collapse problem. In contrast, contrastive learning based methods can learn features from only in-class samples but are hard to be end-to-end trained with one-class models. To address the aforementioned problems, we propose alternating direction method of multipliers based sparse representation network (ADMM-SRNet). ADMM-SRNet contains the heterogeneous contrastive feature (HCF) network and the sparse dictionary (SD) network. The HCF network learns in-class heterogeneous contrastive features by using contrastive learning with heterogeneous augmentations. Then, the SD network models the distributions of the in-class training samples by using dictionaries computed based on ADMM. By coupling the HCF network, SD network and the proposed loss functions, our method can effectively learn discriminative features and one-class models of the in-class training samples in an end-to-end trainable manner. Experimental results show that the proposed method outperforms state-of-the-art methods on CIFAR-10, CIFAR-100 and ImageNet-30 datasets under one-class classification settings. Code is available at https://github.com/nchucvml/ADMM-SRNet.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3274488
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interpreting the results of explicit and applied theory of mind collectively in autistic children: A solution from Rasch analysis.

Lee, Shih-Chieh / Huang, Chien-Yu / Fu, I-Ning / Chen, Kuan-Lin

Autism : the international journal of research and practice

2023 Volume 28, Issue 2, Page(s) 355–366

Abstract: Lay abstract: Theory of mind is an ability to infer others' mental states, which is a foundation for generating appropriate social responses. Theory of mind can be conceptually divided into two related but distinguishable constructs: explicit theory of ... ...

Abstract	Lay abstract: Theory of mind is an ability to infer others' mental states, which is a foundation for generating appropriate social responses. Theory of mind can be conceptually divided into two related but distinguishable constructs: explicit theory of mind (conceptual knowledge/information about others' mental states) and applied theory of mind (the ability to use theory of mind skills in real-life contexts). Although these two theory of mind scores can be described by the percentages of children in the early, basic, and advanced developmental stages, the resulting information may not be sufficient to determine the corresponding relationships between these two theory of mind constructs or identify children with mismatched theory of mind abilities (e.g. children who have difficulty in effectively applying their theory of mind knowledge in real-life contexts). To resolve these limitations, methods for simultaneously interpreting the relationships between the two theory of mind scores are proposed. Based on the findings, each applied theory of mind score can reflect multiple scores of explicit theory of mind. In particular, the results do not take measurement error into consideration, which would make them more ambiguous. Therefore, the scores of applied theory of mind should be interpreted carefully, given that children who have the same applied theory of mind score may actually have high or low explicit theory of mind. Regarding the method for joint interpretation, cutoff scores were selected to identify children who have mismatched theory of mind abilities (high explicit theory of mind with low applied theory of mind or low explicit theory of mind with high applied theory of mind) and determine the priority for interventions.
MeSH term(s)	Child ; Humans ; Autism Spectrum Disorder ; Theory of Mind/physiology ; Autistic Disorder
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1338513-6
ISSN	1461-7005 ; 1362-3613
ISSN (online)	1461-7005
ISSN	1362-3613
DOI	10.1177/13623613231170698
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Article ; Online: Different autism measures targeting different severity levels in children with autism spectrum disorder.

Huang, Chien-Yu / Chen, Kuan-Shu / Lee, Kuan-Ying / Lin, Chien-Ho / Chen, Kuan-Lin

European archives of psychiatry and clinical neuroscience

2023 Volume 274, Issue 1, Page(s) 27–33

Abstract: The Childhood Autism Rating Scale™, Second Edition (CARS™-2) and Social Responsiveness Scale™, Second Edition (SRS™-2) are two measures for identifying autism symptoms. The CARS™-2 has two versions: Standard (CARS-ST) and High-Functioning (CARS-HF). To ... ...

Abstract	The Childhood Autism Rating Scale™, Second Edition (CARS™-2) and Social Responsiveness Scale™, Second Edition (SRS™-2) are two measures for identifying autism symptoms. The CARS™-2 has two versions: Standard (CARS-ST) and High-Functioning (CARS-HF). To better understand their properties, this study aimed to investigate: (1) the associations among the CARS-ST, CARS-HF and the SRS™-2, and (2) the severity consistency between the CARS-ST and the CARS-HF. A sample of 125 children with autism spectrum disorder was recruited (mean age: 80.98 months, SD = 16.08). Based on Verbal Comprehension Index (VCI), children were divided into two groups: low severity level of autism spectrum disorder (LSL-ASD: VCI ≥ 80) and high severity level of autism spectrum disorder (HSL-ASD: VCI < 80). All children were evaluated with the CARS-ST and the SRS™-2, and the HF group, with the CARS-HF as well. In the LSL group, the CARS-ST and the CARS-HF had high correlation (r = 0.852, p < .001). Both versions had small to moderate correlations with the SRS™-2 (r = 0.130-0.491). In the HSL group, no significant correlations were found between the CARS-ST and SRS™-2 (p > .05). The CARS-HF and the CARS-ST had low severity consistency (Kappa = 0.376, p < .01). The CARS-ST and the CARS-HF had high correlations but low severity consistency. Different correlation patterns were found between the CARS™-2 and the SRS™-2 in the LSL and HSL groups. The results should help clinicians better understand the properties of the measures and choose appropriate measures when assessing autism symptoms.
MeSH term(s)	Child ; Humans ; Autism Spectrum Disorder/diagnosis ; Autistic Disorder ; Severity of Illness Index
Language	English
Publishing date	2023-08-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-023-01673-z
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Article ; Online: Glucocorticoid Receptor Mediates Cortisol Regulation of Glycogen Metabolism in Gills of the Euryhaline Tilapia (Oreochromis mossambicus)

Wu, Chien-Yu / Lee, Tsung-Han / Tseng, Deng-Yu

Fishes. 2023 May 18, v. 8, no. 5

2023

Abstract: In this study, we investigated the effects of cortisol on the regulation of the glycogen metabolism biomarkers glycogen synthase (GS) and glycogen phosphorylase (GP) in the glycogen-rich cells of the gills of tilapia (Oreochromis mossambicus). In the ... ...

Abstract	In this study, we investigated the effects of cortisol on the regulation of the glycogen metabolism biomarkers glycogen synthase (GS) and glycogen phosphorylase (GP) in the glycogen-rich cells of the gills of tilapia (Oreochromis mossambicus). In the gills of tilapia, GP, GS, and glycogen were immunocytochemically colocalized in a specific group of glycogen-rich cells adjacent to the gills’ main ionocytes and mitochondria-rich cells. Cortisol plays a vital role in the regulation of physiological functions in animals, including energy metabolism, respiration, immune response, and ion regulation. However, no studies have elucidated the mechanisms regulating cortisol and glycogen-rich cells in the gills. Therefore, we treated tilapia larvae with exogenous cortisol and a glucocorticoid receptor (GR) antagonist to investigate the regulatory mechanisms between cortisol and glycogen-rich cells in the gills. Our results showed that cortisol promoted the expression of gill glycogen phosphorylase isoform (GPGG) mRNA via GR, whereas the GS gene expression remained unaffected. We also found that GR mRNA was colocalized with some glycogen-rich cells in the gills, further confirming our hypothesis that cortisol directly acts on glycogen-rich cells in the gills of tilapia and regulates glycogen metabolism by promoting GPGG mRNA expression.
Keywords	Oreochromis mossambicus ; antagonists ; biomarkers ; cortisol ; energy metabolism ; euryhaline species ; gene expression ; glucocorticoid receptors ; glycogen ; glycogen (starch) synthase ; immune response ; phosphorylase
Language	English
Dates of publication	2023-0518
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ISSN	2410-3888
DOI	10.3390/fishes8050267
Database	NAL-Catalogue (AGRICOLA)

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