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  1. Article ; Online: Vasospasm: Role of Imaging in Detection and Monitoring Treatment.

    Ivanidze, Jana / Sanelli, Pina C

    Neuroimaging clinics of North America

    2021  Volume 31, Issue 2, Page(s) 147–155

    Abstract: Cerebral vasospasm (VS) and delayed cerebral ischemia (DCI) are important complications of aneurysmal subarachnoid hemorrhage (ASAH). Imaging approaches to VS monitoring include noninvasive bedside assessment with transcranial Doppler ultrasonography, ... ...

    Abstract Cerebral vasospasm (VS) and delayed cerebral ischemia (DCI) are important complications of aneurysmal subarachnoid hemorrhage (ASAH). Imaging approaches to VS monitoring include noninvasive bedside assessment with transcranial Doppler ultrasonography, angiographic evaluation with digital subtraction angiography, and computed tomography (CT) angiography. DCI is a clinical diagnosis and is not fully explained by the presence of angiographic VS. CT perfusion has shown clinical utility and implications for future research in the evaluation of DCI in patients with ASAH. This review article discusses the common approaches to diagnosis and monitoring of VS and DCI, current treatment strategies, and future research directions.
    MeSH term(s) Angiography, Digital Subtraction ; Brain Ischemia ; Humans ; Subarachnoid Hemorrhage/diagnostic imaging ; Tomography, X-Ray Computed ; Vasospasm, Intracranial/diagnostic imaging ; Vasospasm, Intracranial/etiology
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1314594-0
    ISSN 1557-9867 ; 1052-5149
    ISSN (online) 1557-9867
    ISSN 1052-5149
    DOI 10.1016/j.nic.2021.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Posterior cortical atrophy.

    Parasram, Melvin / Roytman, Michelle / Lee, Andrea / Ivanidze, Jana

    Journal of osteopathic medicine

    2022  Volume 123, Issue 1, Page(s) 55–56

    MeSH term(s) Humans ; Atrophy
    Language English
    Publishing date 2022-08-24
    Publishing country Germany
    Document type Journal Article
    ISSN 2702-3648
    ISSN (online) 2702-3648
    DOI 10.1515/jom-2022-0147
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  3. Article ; Online: Alternate CMS Payment Structure for Outpatient Services: A Road to Improving Access to Molecular Imaging in Oncologic Care.

    Subramanian, Kritika / Ivanidze, Jana / Paris, Manny / Ricaurte Fajardo, Andres / Osborne, Joseph R

    Radiology. Imaging cancer

    2023  Volume 5, Issue 6, Page(s) e230166

    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Editorial
    ISSN 2638-616X
    ISSN (online) 2638-616X
    DOI 10.1148/rycan.230166
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  4. Article ; Online: Medicare Coverage of Amyloid PET: Implications for Clinical Practice.

    Ivanidze, J / Nordvig, A S / Fajardo, A R / Tsiouris, A J / Chiang, G C-Y / Osborne, J R

    AJNR. American journal of neuroradiology

    2023  Volume 44, Issue 11, Page(s) E45

    MeSH term(s) Aged ; Humans ; United States ; Medicare ; Positron-Emission Tomography ; Radiopharmaceuticals ; Amyloid ; Insurance Coverage
    Chemical Substances Radiopharmaceuticals ; Amyloid
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Letter
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A8027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1580: Show issues Location:
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  5. Article ; Online: PET/CT and PET/MR Imaging of the Post-treatment Head and Neck: Traps and Tips.

    Guzmán Pérez-Carrillo, Gloria J / Ivanidze, Jana

    Neuroimaging clinics of North America

    2020  Volume 32, Issue 1, Page(s) 111–132

    Abstract: PET/computed tomography and PET/MR imaging are used to evaluate the post-treatment neck. Although 18F-FDG is helpful in the staging and treatment response assessment of head and neck cancer, recently developed PET radiotracers targeting specific surface ... ...

    Abstract PET/computed tomography and PET/MR imaging are used to evaluate the post-treatment neck. Although 18F-FDG is helpful in the staging and treatment response assessment of head and neck cancer, recently developed PET radiotracers targeting specific surface markers are promising for applications of diagnostic problem solving and improved extent delineation. Diffusion-weighted MR imaging is helpful in the differential diagnosis of head and neck neoplasms, and improves the sensitivity and specificity for the detection of certain pathologies. Following standardized imaging parameters for PET/computed tomography and diffusion-weighted imaging in PET/MR imaging improves diagnostic accuracy and allows for future research data mining.
    MeSH term(s) Fluorodeoxyglucose F18 ; Head and Neck Neoplasms/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; Sensitivity and Specificity
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1314594-0
    ISSN 1557-9867 ; 1052-5149
    ISSN (online) 1557-9867
    ISSN 1052-5149
    DOI 10.1016/j.nic.2021.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Introducing the American Society of Neuroradiology PET-Guided Diagnosis and Management in Neuro-Oncology Study Group.

    Nabavizadeh, A / Galldiks, N / Veronesi, M / Lohmann, P / McConathy, J E / Johnson, D R / Aboian, M S / Barajas, R F / Ivanidze, J

    AJNR. American journal of neuroradiology

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A8243
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  7. Article ; Online: Clinical Arterial Spin-Labeling MR Imaging to Screen for Typical and Atypical Neurodegenerative Disease in the New Era of Alzheimer Treatment.

    Lee, Kevin / Mahmud, Meem / Marx, Darby / Yasen, Weiye / Sharma, Omna / Ivanidze, Jana / Zan, Elcin / Zhou, Liangdong / Li, Yi / de Leon, Mony J / Nordvig, Anna S / Chiang, Gloria C

    AJNR. American journal of neuroradiology

    2024  

    Abstract: The clinical standard of care in the diagnosis of neurodegenerative diseases relies on [ ...

    Abstract The clinical standard of care in the diagnosis of neurodegenerative diseases relies on [
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A8164
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  8. Article ; Online: Diagnostic accuracy of shuttle CT angiography (CTA) and helical CTA in the diagnosis of vasospasm.

    Smith, Natasha M / Sweeney, Elizabeth M / Gupta, Ajay / Patsalides, Athos / Sanelli, Pina / Ivanidze, Jana

    Clinical imaging

    2021  Volume 81, Page(s) 37–42

    Abstract: ... for CTAh (0.72-1.00, p = 0.028). Cohen's kappa was 0.843 (95%CI 0.548-1.000). Thresholding with Youden's J ...

    Abstract Purpose: To evaluate the diagnostic accuracy of computed tomography angiography (CTA) acquired with shuttle technique (CTAs) and helical CTA (CTAh) for vasospasm, using digital subtraction angiography (DSA) obtained within 24 h as reference standard.
    Methods: Thirty-six patients with suspected vasospasm in the setting of aneurysmal subarachnoid hemorrhage (ASAH, 30/36) or acute inflammatory/infectious conditions (6/36) who underwent CTAs (17/36) or CTAh (19/36) followed by DSA within 24 h were identified retrospectively. Presence of vasospasm in the proximal cerebral arterial segments was assessed qualitatively and semi-quantitatively on CTA and subsequent DSA. Sensitivity, specificity, and receiver operating characteristic (ROC) curves were calculated. Inter-rater variability was assessed using Cohen's kappa.
    Results: On CTAs, 35% of patients had low and 65% had high vasospasm burden. On CTAh, 37% had low and 63% had high vasospasm burden. ROC analysis demonstrated an AUC of 0.87 for CTAs (95%CI 0.67-1.00, p = 0.015) and 0.88 for CTAh (0.72-1.00, p = 0.028). Cohen's kappa was 0.843 (95%CI 0.548-1.000). Thresholding with Youden's J index, CTAs had a sensitivity of 85.71% (95%CI 48.69 to 99.27) and specificity of 66.67% (35.42 to 87.94). CTAh had sensitivity of 100% (56.55 to 100.00) and specificity of 78.57% (52.41 to 92.43).
    Conclusion: CTAs and CTAh yielded similar sensitivity, specificity, and AUC values on ROC analysis for the detection of vasospasm using DSA as reference standard. Our findings suggest that CTAs is a promising alternative to CTAh especially in patients requiring serial imaging, given its potential advantages of decreased radiation exposure, contrast dose, and cost-effectiveness.
    MeSH term(s) Angiography, Digital Subtraction ; Cerebral Angiography ; Computed Tomography Angiography ; Humans ; Retrospective Studies ; Sensitivity and Specificity ; Subarachnoid Hemorrhage/diagnostic imaging ; Vasospasm, Intracranial/diagnostic imaging
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2021.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1469: Show issues Location:
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  9. Article: Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging.

    Ford, Jeremy N / Zhang, Qihao / Sweeney, Elizabeth M / Merkler, Alexander E / de Leon, Mony J / Gupta, Ajay / Nguyen, Thanh D / Ivanidze, Jana

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 867452

    Abstract: Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate ( ... ...

    Abstract Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (k
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.867452
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  10. Article: Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults.

    Zhou, Liangdong / Li, Yi / Sweeney, Elizabeth M / Wang, Xiuyuan H / Kuceyeski, Amy / Chiang, Gloria C / Ivanidze, Jana / Wang, Yi / Gauthier, Susan A / de Leon, Mony J / Nguyen, Thanh D

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1162001

    Abstract: Background and purpose: Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20-80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.: ...

    Abstract Background and purpose: Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20-80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.
    Materials and methods: A total of 60 volunteers (age range, 22-80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analyses were performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. ROIs include the cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM). In each model, a quadratic term for age was tested using an ANOVA test. A Spearman's correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed.
    Results: Regression analyses showed that there was a statistically significant quadratic relationship with age for CSFF in the cortex (
    Conclusion: Our cross-sectional data demonstrate that brain tissue water in different compartments shows complex age-dependent patterns. Parenchymal CSFF, a measure of subvoxel CSF-like water in the brain tissue, is quadratically associated with age in the cerebral cortex and linearly associated with age in the cerebral deep GM and WM.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1162001
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