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Book: Pharmacological treatment of dyslipidaemias

Rubenfire, Melvyn

(Best practice & research : Clinical endocrinology & metabolism ; 28,3)

2014

Author's details	M. Rubenfire, guest ed
Series title	Best practice & research : Clinical endocrinology & metabolism ; 28,3 Best practice & research Best practice & research ; Clinical endocrinology & metabolism
Collection	Best practice & research Best practice & research ; Clinical endocrinology & metabolism
Language	English
Size	S. 279 - 461 : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT018300056
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Best Practice & Research Clinical Endocrinology & Metabolism. Pharmacological treatment of dyslipidaemias. Preface.

Rubenfire, Melvyn

Best practice & research. Clinical endocrinology & metabolism

2014 Volume 28, Issue 3, Page(s) 279

MeSH term(s)	Biomedical Research/standards ; Dyslipidemias/drug therapy ; Endocrinology/standards ; Expert Testimony ; Humans ; Hypolipidemic Agents/therapeutic use ; Professional Practice/standards
Chemical Substances	Hypolipidemic Agents
Language	English
Publishing date	2014-06
Publishing country	Netherlands
Document type	Introductory Journal Article
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2014.01.007
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Article ; Online: Educational Attainment and Cardiovascular Risk Among Patients in Cardiac Rehabilitation.

Irani, Suzanne / Brandt, Eric J / Pai, Chih-Wen / Garfein, Joshua / Kline-Rogers, Eva / Rubenfire, Melvyn

The American journal of cardiology

2023 Volume 207, Page(s) 465–469

Abstract: We explored whether patient educational attainment impacted changes in cardiovascular risk factors during cardiac rehabilitation (CR). An observational study was conducted using participant data who completed phase 2 of CR from January 2011 to February ... ...

Abstract	We explored whether patient educational attainment impacted changes in cardiovascular risk factors during cardiac rehabilitation (CR). An observational study was conducted using participant data who completed phase 2 of CR from January 2011 to February 2020 at an academic medical center. The patient cohort was referred to CR after a major cardiac event or to outpatients with stable angina. Patients were excluded if they had no recorded food frequency assessment (FFA) score at CR orientation and graduation. The eligible sample of 1,307 patients were further divided: (1) low educational attainment group (<16 years formal education: high school, high school/general educational development, trade school, and associate's degree) and (2) high educational attainment group (>16 years formal education: bachelor's degree, some postgraduate, master's degree, PhD, and MD). The outcomes included measurements of the FFA, body composition, biophysical health, and psychologic distress. Most patients were male (71.2%), non-Hispanic White (82.2%), and married (73.0%). There were more patients with a high educational attainment (56.8%) than patients with a low educational attainment (43.2%). All measured cardiovascular markers improved after CR for both education level groups. The change in mean FFA score (0.163, p = 0.11) and Brief Symptom Inventory-53 global severity index score (0.422, p = 0.34) did not differ significantly. We observed an improvement in cardiovascular risk measures upon CR participation. These improvements were not limited to high educational attainment patients because we found few differences in the change of risk between the 2 groups. Future studies should continue investigating the impact of education on cardiovascular outcomes as an important social determinant of health.
MeSH term(s)	Humans ; Male ; Female ; Cardiac Rehabilitation ; Cardiovascular Diseases/epidemiology ; Risk Factors ; Educational Status ; Heart Disease Risk Factors
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.08.105
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Article ; Online: Coronary artery calcium scoring in patients with hypertension.

Weinberg, Richard L / Rubenfire, Melvyn / Brook, Robert D

Journal of human hypertension

2020 Volume 34, Issue 9, Page(s) 609–616

Abstract: Coronary artery calcium (CAC) is increased by high blood pressure (BP), predicts new-onset hypertension, and is a powerful predictor of atherosclerotic cardiovascular disease events in patients with and without hypertension. Unlike other diseases (e.g., ... ...

Abstract	Coronary artery calcium (CAC) is increased by high blood pressure (BP), predicts new-onset hypertension, and is a powerful predictor of atherosclerotic cardiovascular disease events in patients with and without hypertension. Unlike other diseases (e.g., hypercholesterolemia), the clinical use of CAC scoring to personalize the treatment of high BP has not received much attention and therefore remains less well defined. Herein, we provide an updated review of studies investigating the relationship between CAC and BP. Finally, we propose a clinical algorithm to incorporate CAC into hypertension management, with a focus on its potential value in tailoring the timing of medication therapy and in helping to personalize BP goals.
MeSH term(s)	Atherosclerosis ; Calcium ; Coronary Artery Disease ; Coronary Vessels ; Humans ; Hypertension/complications ; Risk Assessment ; Risk Factors ; Vascular Calcification/complications
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-05-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-020-0350-4
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Article ; Online: Cardiovascular Impact of Nutritional Supplementation With Omega-3 Fatty Acids: JACC Focus Seminar.

Weinberg, Richard L / Brook, Robert D / Rubenfire, Melvyn / Eagle, Kim A

Journal of the American College of Cardiology

2021 Volume 77, Issue 5, Page(s) 593–608

Abstract: Omega-3 polyunsaturated fatty acids (PUFAs) are a key component of a heart-healthy diet. For patients without clinical atherosclerotic cardiovascular disease, 2 or more servings of fatty fish per week is recommended to obtain adequate intake of omega-3 ... ...

Abstract	Omega-3 polyunsaturated fatty acids (PUFAs) are a key component of a heart-healthy diet. For patients without clinical atherosclerotic cardiovascular disease, 2 or more servings of fatty fish per week is recommended to obtain adequate intake of omega-3 PUFAs. If this not possible, dietary supplementation with an appropriate fish oil may be reasonable. Supplementation with omega-3 PUFA capsules serves 2 distinct but overlapping roles: treatment of hypertriglyceridemia and prevention of cardiovascular events. Marine-derived omega-3 PUFAs reduce triglycerides and have pleiotropic effects including decreasing inflammation, improving plaque composition and stability, and altering cellular membranes. Clinical trial data have shown inconsistent results with omega-3 PUFAs improving cardiovascular outcomes. In this paper, the authors provide an overview of PUFAs and a summary of key clinical trial data. Recent trial data suggest the use of prescription eicosapentaenoic acid ethyl ester for atherosclerotic cardiovascular disease event reduction in selected populations.
MeSH term(s)	Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/prevention & control ; Dietary Supplements ; Fatty Acids, Omega-3/administration & dosage ; Humans ; Triglycerides/blood
Chemical Substances	Biomarkers ; Fatty Acids, Omega-3 ; Triglycerides
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.11.060
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Article ; Online: Identifying Factors for Low-Risk Participation in Alternative Cardiac Rehabilitation Models for Patients with Coronary Heart Disease Using MI'S SCOREPAD.

Brandt, Eric J / Garfein, Joshua / Pai, Chih-Wen / Bryant, Joseph / Kline-Rogers, Eva / Fink, Samantha / Rubenfire, Melvyn

Cardiovascular therapeutics

2023 Volume 2023, Page(s) 7230325

Abstract: Introduction: Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is ... ...

Abstract	Introduction: Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. Methods: We reviewed a decade of data from all patients with coronary heart disease enrolled in a single CR center (University of Michigan) to identify the prevalence of low-risk factors, which may inform on consideration for participation in alternative models of CR. Low-risk factors included not having any of the following: metabolic syndrome, presence of implantable cardioverter defibrillator or permanent pacemaker, active smoking, prior stroke, congestive heart failure, obesity, advanced renal disease, poor exercise capacity, peripheral arterial disease, angina, or clinical depression (MI'S SCOREPAD). We report on the proportion of participants with these risk factors and the proportion with all of these low-risk factors. Results: The mean age of CR participants ( Conclusion: In this observational study, we provide a first paradigm of identifying factors among coronary heart disease patients that may be considered low-risk and likely high-gain for participation in alternative models of CR. Further work is needed to track clinical outcomes in patients with these factors to determine thresholds for enrolling participants in alternative forms of CR.
MeSH term(s)	United States ; Humans ; Female ; Middle Aged ; Male ; Cardiac Rehabilitation ; Coronary Disease/diagnosis ; Coronary Disease/epidemiology ; Risk Factors ; Angina Pectoris ; Heart ; Observational Studies as Topic
Language	English
Publishing date	2023-09-08
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2428378-2
ISSN	1755-5922 ; 1755-5914
ISSN (online)	1755-5922
ISSN	1755-5914
DOI	10.1155/2023/7230325
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Article ; Online: Cardiac rehabilitation and acute aortic dissection: understanding and addressing the evidence GAP a systematic review.

Carbone, Andreina / Lamberti, Nicola / Manfredini, Roberto / Trimarchi, Santi / Palladino, Raffaele / Savriè, Caterina / Marra, Alberto M / Ranieri, Brigida / Crisci, Giulia / Izzo, Raffaele / Esposito, Giovanni / Cittadini, Antonio / Manfredini, Fabio / Rubenfire, Melvyn / Bossone, Eduardo

Current problems in cardiology

2024 Volume 49, Issue 3, Page(s) 102348

Abstract: Despite guideline recommendations, strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD) are not well established with little evidence to risk stratify prudent and effective guidelines for the many ... ...

Abstract	Despite guideline recommendations, strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD) are not well established with little evidence to risk stratify prudent and effective guidelines for the many required variables. We conducted a systematic review of studies (2004-2023) reporting CR following type A (TA) and type B (TB) AAD. Our review is limited to open surgical repair for TA and medical treatment for TB. A total of 5 studies were included (4 TA-AAD and 1 TB-AAD) in the qualitative analysis. In general, observational data included 311 patients who had an overall favorable effect of CR in AAD consisting of a modestly improved exercise capacity and work load during cycle cardiopulmonary exercise test (TB-AAD), and improved quality of life (QoL). No adverse events were reported during symptom limited pre-CR treadmill or cycle exercise VO
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Quality of Life ; Evidence Gaps ; Treatment Outcome ; Aortic Dissection/surgery ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2023.102348
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Article ; Online: Hypertriglyceridaemia-induced pancreatitis prompted by acute corticosteroid treatment: caution for clinicians.

Kim, Daniel Seung / O'Hayer, Patrick J / Rubenfire, Melvyn / Brook, Robert D

Internal medicine journal

2019 Volume 49, Issue 3, Page(s) 411–412

MeSH term(s)	Acute Disease ; Adrenal Cortex Hormones/adverse effects ; Adult ; Female ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/drug therapy ; Middle Aged ; Pancreatitis/blood ; Pancreatitis/chemically induced ; Probability ; Triglycerides/blood
Chemical Substances	Adrenal Cortex Hormones ; Triglycerides
Language	English
Publishing date	2019-03-21
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.14228
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Article ; Online: Trends in Calcium Channel Blocker Use in Patients with Heart Failure with Reduced Ejection Fraction and Comorbid Atrial Fibrillation.

Cholack, George / Garfein, Joshua / Krallman, Rachel / Montgomery, Daniel / Kline-Rogers, Eva / Rubenfire, Melvyn / Bumpus, Sherry / Md, Thomas Cascino / Barnes, Geoffrey D

The American journal of medicine

2021 Volume 134, Issue 11, Page(s) 1413–1418.e1

Abstract: Background: Heart failure with reduced ejection fraction and atrial fibrillation commonly coexist. Most calcium channel blockers are not recommended in heart failure with reduced ejection fraction, but their use has been seldom evaluated. For patients ... ...

Abstract	Background: Heart failure with reduced ejection fraction and atrial fibrillation commonly coexist. Most calcium channel blockers are not recommended in heart failure with reduced ejection fraction, but their use has been seldom evaluated. For patients with heart failure with reduced ejection fraction and comorbid atrial fibrillation, we sought to 1) determine the proportion discharged on contraindicated calcium channel blockers, 2) describe how clinicians' use of these medications at discharge have changed over time, and 3) identify predictors for contraindicated calcium channel blocker prescription at discharge. Methods: We analyzed 395 patients discharged with heart failure with reduced ejection fraction and atrial fibrillation between 2008 and 2018. Discharge on a contraindicated calcium channel blocker (any calcium channel blocker except amlodipine) was the primary outcome. Changes in calcium channel blocker prescription over time were evaluated with a Cochran-Armitage trend test. Multivariable logistic regression was used to identify predictors of calcium channel blocker prescription at discharge. Results: Twenty-nine (7.3%) patients were discharged on a contraindicated calcium channel blocker without change over time (P Conclusion: One in 14 patients with heart failure with reduced ejection fraction and comorbid atrial fibrillation were discharged on a contraindicated calcium channel blocker, without change over time. Most patients were discharged on multiple atrioventricular nodal blockers, highlighting potential need for greater coordination between discharging physicians, pharmacists, and electrophysiology.
MeSH term(s)	Aged ; Aged, 80 and over ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Calcium Channel Blockers/therapeutic use ; Cohort Studies ; Contraindications, Drug ; Female ; Heart Failure/complications ; Heart Failure/physiopathology ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Patient Discharge ; Practice Patterns, Physicians'/trends ; Retrospective Studies ; Risk Factors ; Sex Factors ; Stroke Volume
Chemical Substances	Calcium Channel Blockers
Language	English
Publishing date	2021-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2021.06.013
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Article ; Online: Cardiac Transitional Care Effectiveness: Does Overall Comorbidity Burden Matter?

Garfein, Joshua / Cholack, George / Krallman, Rachel / Feldeisen, Delaney / Montgomery, Daniel / Kline-Rogers, Eva / Eagle, Kim / Rubenfire, Melvyn / Bumpus, Sherry

The American journal of medicine

2021 Volume 134, Issue 12, Page(s) 1506–1513

Abstract: Background: Cardiovascular disease is the most common cause of mortality and hospitalization in the United States. Transitional care initiatives can improve outcomes for cardiac patients, but it is unclear whether patients with different baseline ... ...

Abstract	Background: Cardiovascular disease is the most common cause of mortality and hospitalization in the United States. Transitional care initiatives can improve outcomes for cardiac patients, but it is unclear whether patients with different baseline comorbidity burden benefit equally. We evaluated the effectiveness of the Bridging the Discharge Gap Effectively (BRIDGE) program, a nurse-practitioner-led transitional care clinic, in mitigating adverse clinical outcomes in cardiac patients with varying Charlson comorbidity index (CCI). Methods: We studied patients referred to BRIDGE between 2008 and 2017 postdischarge for a cardiac condition. Using proportional hazards regression models, we evaluated associations between attendance at BRIDGE and hospital readmission, emergency department (ED) visit, and a composite outcome consisting of readmission, ED visit, or mortality, and assessed interaction between BRIDGE attendance and CCI. Results: Of 4559 patients, 3256 (71.4%) attended BRIDGE. In patients with low CCI, attendance at BRIDGE was inversely associated with hospital readmission (adjusted hazard ratio = 0.82, 95% confidence interval [CI]: 0.69, 0.97, P = .02) and the composite endpoint (adjusted hazard ratio = 0.84, 95% CI: 0.72, 0.98, P = .02). Associations of BRIDGE attendance with both readmission and ED visit were significantly weaker in patients with high CCI (adjusted P, interaction = .007 and .03, respectively). Overall, BRIDGE attendance was associated with an 11% lower hazard of developing the composite endpoint (95% CI: 2%, 19%, P = .01). Conclusions: Attendance at a transitional care clinic is inversely associated with risk of readmission and a composite endpoint in cardiac patients with low CCI. Future research should investigate modified transitional care programs in patients with varying comorbidity burden.
MeSH term(s)	Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/therapy ; Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy ; Cerebrovascular Disorders/epidemiology ; Comorbidity ; Dementia/epidemiology ; Diabetes Mellitus/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Heart Diseases/epidemiology ; Heart Diseases/therapy ; Heart Failure/epidemiology ; Heart Failure/therapy ; Hospital to Home Transition ; Humans ; Kidney Diseases/epidemiology ; Liver Diseases/epidemiology ; Lung Diseases/epidemiology ; Middle Aged ; Mortality ; Neoplasms/epidemiology ; Nurse Practitioners ; Patient Readmission/statistics & numerical data ; Program Evaluation ; Proportional Hazards Models ; Transitional Care
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2021.06.018
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