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Article ; Online: Switchable 3D optofluidic Y-branch waveguides tuned by Dean flows.

Li, L / Zhu, X Q / Liang, L / Zuo, Y F / Xu, Y S / Yang, Y / Yuan, Y J / Huang, Q Q

2016 Volume 6, Page(s) 38338

Abstract: ... waveguides in plannar microchannels by simply introducing Dean flow. This device can reconfigure 3D Y-branch ... than that of solid channels. This paper demonstrates the tunable three-dimensional (3D) optofluidic Y-branch ... The Y-branch waveguides show potential in applications of integrated optofluidic devices. ...

Abstract	Optical branch waveguides are one of the most important optical elements and have been widely exploited for optical communication systems. However, prevailing devices are typically solid and have limit in tunability. Liquid optical devices have attracted more interest for the advantage of tunability of liquid media, but their signals suffer serious leakage if the refractive index (RI) of liquid is smaller than that of solid channels. This paper demonstrates the tunable three-dimensional (3D) optofluidic Y-branch waveguides in plannar microchannels by simply introducing Dean flow. This device can reconfigure 3D Y-branch profiles and separate the intensity of light as tunable ratio from 0 to 1 by adjusting the flow rates with low loss. Different from the prevailing 2D liquid counterparts, the 3D configuration offer much more freedom in the selection of liquid media as liquid's RI can be totally independent to the solid channel structure. The transmission loss through the device is estimated to 0.97 db when the splitting angle is 10°, which shows the light is confined better in the 3D liquid structures than traditional 2D liquid counterparts. The Y-branch waveguides show potential in applications of integrated optofluidic devices.
Language	English
Publishing date	2016-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep38338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnetically propagating Hund's exciton in van der Waals antiferromagnet NiPS

He, W / Shen, Y / Wohlfeld, K / Sears, J / Li, J / Pelliciari, J / Walicki, M / Johnston, S / Baldini, E / Bisogni, V / Mitrano, M / Dean, M P M

Nature communications

2024 Volume 15, Issue 1, Page(s) 3496

Abstract: Magnetic van der Waals (vdW) materials have opened new frontiers for realizing novel many-body phenomena. Recently ... ...

Abstract	Magnetic van der Waals (vdW) materials have opened new frontiers for realizing novel many-body phenomena. Recently NiPS
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47852-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tumour-retained activated CCR7

Lee, Colin Y C / Kennedy, Bethany C / Richoz, Nathan / Dean, Isaac / Tuong, Zewen K / Gaspal, Fabrina / Li, Zhi / Willis, Claire / Hasegawa, Tetsuo / Whiteside, Sarah K / Posner, David A / Carlesso, Gianluca / Hammond, Scott A / Dovedi, Simon J / Roychoudhuri, Rahul / Withers, David R / Clatworthy, Menna R

Nature communications

2024 Volume 15, Issue 1, Page(s) 682

Abstract: Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, including PD-L1. ... ...

Abstract	Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, including PD-L1. However, the spatio-temporal dynamics of CCR7
MeSH term(s)	Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes ; Receptors, CCR7/genetics ; Neoplasms/genetics ; Neoplasms/therapy ; Antigen Presentation ; Dendritic Cells
Chemical Substances	Receptors, CCR7 ; CCR7 protein, human
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44787-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Two-Dimensional Moiré Polaronic Electron Crystals.

Arsenault, Eric A / Li, Yiliu / Yang, Birui / Wang, Xi / Park, Heonjoon / Mosconi, Edoardo / Ronca, Enrico / Taniguchi, Takashi / Watanabe, Kenji / Gamelin, Daniel / Millis, Andrew / Dean, Cory R / de Angelis, Filippo / Xu, Xiaodong / Zhu, X Y

Physical review letters

2024 Volume 132, Issue 12, Page(s) 126501

Abstract: Two-dimensional moiré materials have emerged as the most versatile platform for realizing quantum phases of electrons. Here, we explore the stability origins of correlated states in WSe_{2}/WS_{2} moiré superlattices. We find that ultrafast electronic ... ...

Abstract	Two-dimensional moiré materials have emerged as the most versatile platform for realizing quantum phases of electrons. Here, we explore the stability origins of correlated states in WSe_{2}/WS_{2} moiré superlattices. We find that ultrafast electronic excitation leads to partial melting of the Mott states on timescales 5 times longer than predictions from the charge hopping integrals and that the melting rates are thermally activated, with activation energies of 18±3 and 13±2 meV for the one- and two-hole Mott states, respectively, suggesting significant electron-phonon coupling. A density functional theory calculation of the one-hole Mott state confirms polaron formation and yields a hole-polaron binding energy of 16 meV. These findings reveal a close interplay of electron-electron and electron-phonon interactions in stabilizing the polaronic Mott insulators at transition metal dichalcogenide moiré interfaces.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.126501
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility.

Zhang, Yingnan / Do, Khoi K / Wang, Fuhua / Lu, Xiaoqin / Liu, John Y / Li, Chi / Ceresa, Brian P / Zhang, Lijun / Dean, Douglas C / Liu, Yongqing

Communications biology

2023 Volume 6, Issue 1, Page(s) 434

Abstract: The cornea is the outmost ocular tissue and plays an important role in protecting the eye from environmental insults. Corneal epithelial wounding provokes pain and fear and contributes to the most ocular trauma emergency assessments worldwide. ZEB1 is an ...

Abstract	The cornea is the outmost ocular tissue and plays an important role in protecting the eye from environmental insults. Corneal epithelial wounding provokes pain and fear and contributes to the most ocular trauma emergency assessments worldwide. ZEB1 is an essential transcription factor in development; but its roles in adult tissues are not clear. We identify Zeb1 is an intrinsic factor that facilitates corneal epithelial wound healing. In this study, we demonstrate that monoallelic deletion of Zeb1 significantly expedites corneal cell death and inhibits corneal epithelial EMT-related cell migration upon an epithelial debridement. We provide evidence that Zeb1-regulation of corneal epithelial wound healing is through the repression of genes required for Tnfa-induced epithelial cell death and the induction of genes beneficial for epithelial cell migration. We suggest utilizing TNF-α antagonists would reduce TNF/TNFR1-induced cell death in the corneal epithelium and inflammation in the corneal stroma to help corneal wound healing.
MeSH term(s)	Humans ; Epithelium, Corneal/metabolism ; Cornea/metabolism ; Wound Healing/genetics ; Corneal Injuries/genetics ; Corneal Injuries/metabolism ; Epithelial Cells ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism
Chemical Substances	ZEB1 protein, human ; Zinc Finger E-box-Binding Homeobox 1
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04831-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number.

Blechter, Batel / Wong, Jason Y Y / Hu, Wei / Cawthon, Richard / Downward, George S / Portengen, Lützen / Zhang, Yongliang / Ning, Bofu / Rahman, Mohammad L / Ji, Bu-Tian / Li, Jihua / Yang, Kaiyun / Dean Hosgood, H / Silverman, Debra T / Huang, Yunchao / Rothman, Nathaniel / Vermeulen, Roel / Lan, Qing

Carcinogenesis

2023 Volume 44, Issue 5, Page(s) 404–410

Abstract: Household air pollution (HAP) from indoor combustion of solid fuel is a global health burden that has been linked to multiple diseases including lung cancer. In Xuanwei, China, lung cancer rate for non-smoking women is among the highest in the world and ... ...

Abstract	Household air pollution (HAP) from indoor combustion of solid fuel is a global health burden that has been linked to multiple diseases including lung cancer. In Xuanwei, China, lung cancer rate for non-smoking women is among the highest in the world and largely attributed to high levels of polycyclic aromatic hydrocarbons (PAHs) that are produced from combustion of smoky (bituminous) coal. Alu retroelements, repetitive mobile DNA sequences that can somatically multiply and promote genomic instability have been associated with risk of lung cancer and diesel engine exhaust exposure. We conducted analyses for 160 non-smoking women in an exposure assessment study in Xuanwei, China with a repeat sample from 49 subjects. Quantitative PCR was used to measure Alu repeat copy number relative to albumin gene copy number (Alu/ALB ratio). Associations between clusters derived from predicted levels of 43 HAP constituents, 5-methylchrysene (5-MC), a PAH previously associated with lung cancer in Xuanwei and was selected a priori for analysis, and Alu repeats were analyzed using generalized estimating equations. A cluster of 31 PAHs reflecting current exposure was associated with increased Alu copy number (β:0.03 per standard deviation change; 95% confidence interval (CI):0.01,0.04; P-value = 2E-04). One compound within this cluster, 5-MC, was also associated with increased Alu copy number (P-value = 0.02). Our findings suggest that exposure to PAHs due to indoor smoky coal combustion may contribute to genomic instability. Additionally, our study provides further support for 5-MC as a prominent carcinogenic component of smoky coal emissions. Further studies are needed to replicate our findings.
MeSH term(s)	Humans ; Female ; Retroelements/genetics ; Coal/adverse effects ; Coal/analysis ; DNA Copy Number Variations/genetics ; China/epidemiology ; Lung Neoplasms/chemically induced ; Lung Neoplasms/epidemiology ; Polycyclic Aromatic Hydrocarbons/toxicity ; Leukocytes ; Air Pollution, Indoor/analysis
Chemical Substances	Retroelements ; Coal ; Polycyclic Aromatic Hydrocarbons
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgad027
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Article ; Online: Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity.

Nature communications

2024 Volume 15, Issue 1, Page(s) 683

Abstract: Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mechanistic ... ...

Abstract	Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mechanistic underpinning and functional significance of the NK cell compartment remains incompletely understood. Here, we use photo-labeling, combined with longitudinal transcriptomic and cellular analyses, to interrogate the fate of intratumoral NK cells. We reveal that NK cells rapidly lose effector functions and adopt a distinct phenotypic state with features associated with tissue residency. NK cell depletion from established tumors did not alter tumor growth, indicating that intratumoral NK cells cease to actively contribute to anti-tumor responses. IL-15 administration prevented loss of function and improved tumor control, generating intratumoral NK cells with both tissue-residency characteristics and enhanced effector function. Collectively, our data reveals the fate of NK cells after recruitment into tumors and provides insight into how their function may be revived.
MeSH term(s)	Humans ; Neoplasms ; Gene Expression Profiling ; Internship and Residency ; Killer Cells, Natural ; Transcriptome ; Tumor Microenvironment
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44789-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Self-Healable, Solvent Response Cellulose Nanocrystal/Waterborne Polyurethane Nanocomposites with Encryption Capability.

Xue, Rui / Zhao, Hui / An, Ze-Wei / Wu, Wei / Jiang, Yan / Li, Peng / Huang, Chong-Xing / Shi, Dean / Li, Robert K Y / Hu, Guo-Hua / Wang, Shuang-Fei

ACS nano

2023 Volume 17, Issue 6, Page(s) 5653–5662

Abstract: Cellulose nanocrystal (CNC)-based chiral nematic structure is widely used in stimulus response and sensing. A popular area of research is enhancing the mechanical characteristics and environmental adaptability of chiral nematic materials. In this paper, ... ...

Abstract	Cellulose nanocrystal (CNC)-based chiral nematic structure is widely used in stimulus response and sensing. A popular area of research is enhancing the mechanical characteristics and environmental adaptability of chiral nematic materials. In this paper, a flexible photonic film with self-healing ability (FPFS) was prepared by combining waterborne polyurethane containing dynamic covalent disulfide bonds (SSWPU) with CNC. The results found that the FPFS showed excellent toughness under the action of stretching, bending, twisting, and folding. The FPFS exhibited an amazing self-healing efficiency, which can be self-healed within 2 h at room temperature. Moreover, the FPFS could respond immediately and produce reversible color change when it was soaked in typical solvents. In addition, when ethanol was used as ink to paint on the FPFS, a visible pattern only under polarized light was formed. This study offers fresh perspectives in the areas of self-healing, biological anticounterfeiting, solvent response, and flexible photonic materials.
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c11809
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fluorescence lifetime predicts performance of voltage sensitive fluorophores in cardiomyocytes and neurons.

Boggess, Steven C / Lazzari-Dean, Julia R / Raliski, Benjamin K / Mun, Dong Min / Li, Amy Y / Turnbull, Joshua L / Miller, Evan W

RSC chemical biology

2020 Volume 2, Issue 1, Page(s) 248–258

Abstract: Voltage imaging with fluorescent indicators offers a powerful complement to traditional electrode or ... ...

Abstract	Voltage imaging with fluorescent indicators offers a powerful complement to traditional electrode or Ca
Language	English
Publishing date	2020-12-11
Publishing country	England
Document type	Journal Article
ISSN	2633-0679
ISSN (online)	2633-0679
DOI	10.1039/d0cb00152j
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Article ; Online: Dissipation-enabled hydrodynamic conductivity in a tunable bandgap semiconductor.

Tan, Cheng / Ho, Derek Y H / Wang, Lei / Li, Jia I A / Yudhistira, Indra / Rhodes, Daniel A / Taniguchi, Takashi / Watanabe, Kenji / Shepard, Kenneth / McEuen, Paul L / Dean, Cory R / Adam, Shaffique / Hone, James

Science advances

2022 Volume 8, Issue 15, Page(s) eabi8481

Abstract: Electronic transport in the regime where carrier-carrier collisions are the dominant scattering mechanism has taken on new relevance with the advent of ultraclean two-dimensional materials. Here, we present a combined theoretical and experimental study ... ...

Abstract	Electronic transport in the regime where carrier-carrier collisions are the dominant scattering mechanism has taken on new relevance with the advent of ultraclean two-dimensional materials. Here, we present a combined theoretical and experimental study of ambipolar hydrodynamic transport in bilayer graphene demonstrating that the conductivity is given by the sum of two Drude-like terms that describe relative motion between electrons and holes, and the collective motion of the electron-hole plasma. As predicted, the measured conductivity of gapless, charge-neutral bilayer graphene is sample- and temperature-independent over a wide range. Away from neutrality, the electron-hole conductivity collapses to a single curve, and a set of just four fitting parameters provides quantitative agreement between theory and experiment at all densities, temperatures, and gaps measured. This work validates recent theories for dissipation-enabled hydrodynamic conductivity and creates a link between semiconductor physics and the emerging field of viscous electronics.
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abi8481
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