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  1. Article ; Online: Culturally Concordant Community-Health Workers: Building Sustainable Community-Based Interventions that Eliminate Kidney Health Disparities.

    Cervantes, Lilia / Robinson, Bruce M / Steiner, John F / Myaskovsky, Larissa

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 7, Page(s) 1252–1254

    MeSH term(s) Health Status Disparities ; Healthcare Disparities ; Humans ; Kidney ; United States
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022030319
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  2. Article ; Online: What's next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination.

    Redwood, Alec J / Dick, Ian M / Creaney, Jenette / Robinson, Bruce W S

    Oncoimmunology

    2022  Volume 11, Issue 1, Page(s) 2038403

    Abstract: The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune targets. Neoantigen vaccines that capitalize on this potential immunogenicity have shown ... ...

    Abstract The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune targets. Neoantigen vaccines that capitalize on this potential immunogenicity have shown efficacy in preclinical models and have now entered clinical trials. Here we discuss the status of personalized neoantigen vaccines and the current major challenges to this nascent field. In particular, we focus on the types of antigens that can be targeted by vaccination and on the role that preexisting immunosuppression, and in particular T-cell exhaustion, will play in the development of effective cancer vaccines.
    MeSH term(s) Antigens, Neoplasm/genetics ; Cancer Vaccines/therapeutic use ; Humans ; Immunotherapy ; Neoplasms/drug therapy ; Vaccination
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2022.2038403
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  3. Article ; Online: The DOPPS Practice Monitor-Peritoneal Dialysis (DPM-PD): From Practice to Policy and Policy to Practice.

    Perl, Jeffrey / Bieber, Brian / Tu, Charlotte / Pecoits-Filho, Roberto / Robinson, Bruce M / Pisoni, Ronald L

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 80, Issue 3, Page(s) 301–303

    MeSH term(s) Humans ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis ; Policy ; Practice Patterns, Physicians' ; Renal Dialysis
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.03.005
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  4. Article ; Online: At the Crossroads for Intravenous Iron Dosing.

    Kshirsagar, Abhijit V / Li, Xiaojuan / Robinson, Bruce M / Brookhart, M Alan

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 7, Page(s) 1653–1654

    MeSH term(s) Administration, Intravenous ; Humans ; Iron ; Renal Dialysis
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020040540
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  5. Article ; Online: The Contribution of Neighborhood Characteristics to Psychological Symptom Severity in a Cohort of Injured Black Men.

    Bruce, Marta M / Robinson, Andrew J / Wiebe, Douglas J / Shults, Justine / Richmond, Therese S

    Journal of racial and ethnic health disparities

    2022  Volume 10, Issue 5, Page(s) 2284–2293

    Abstract: Background: Traumatic injury is not evenly distributed by race and class in the USA. Black men are marginalized in the society, often reside in disadvantaged neighborhoods, and are at higher risk for injury mortality and ongoing physical and ... ...

    Abstract Background: Traumatic injury is not evenly distributed by race and class in the USA. Black men are marginalized in the society, often reside in disadvantaged neighborhoods, and are at higher risk for injury mortality and ongoing physical and psychological problems following injury. Post-traumatic stress disorder (PTSD) and depressive symptom severity are among several problematic and disabling conditions faced by injury survivors. While much research has examined individual factors that lead to increased post-injury psychological symptom severity, the contribution of the social and physical environment has been relatively understudied.
    Objective: To examine the contribution of neighborhood characteristics to PTSD and depressive symptom severity in Black men following traumatic injury.
    Design: Prospective cohort study. Participant data were linked via GIS to neighborhood characteristics (constructs established by factor analysis) to spatially model factors associated with increased post-injury psychological symptom severity using a GEE regression analysis, adjusting for injury mechanism and severity, age, and insurance.
    Participants: Four hundred fifty-one adult Black males hospitalized for traumatic injury.
    Results: The 4 constructs were neighborhood disconnectedness, concentrated disadvantage/deprivation, crime/violence/vacancy, and race/ethnicity. High depressive and PTSD symptom severity was reported by 36.8% and 30.4% of participants, respectively. Higher PTSD symptom severity was associated with crime/violence/vacancy, and higher depressive symptom severity was associated with neighborhood disconnectedness. PTSD and depressive symptom severity were associated with intentional injury mechanisms and Medicaid/no insurance. Higher injury severity was associated with depressive symptoms.
    Conclusion: Neighborhood characteristics are associated with psychological symptom severity after injury.
    MeSH term(s) Adult ; Male ; Humans ; Prospective Studies ; Stress Disorders, Post-Traumatic/psychology ; Neighborhood Characteristics ; Violence ; Residence Characteristics
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-022-01407-2
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  6. Article: Adverse Gastrointestinal Events With Sodium Polystyrene Sulfonate Use in Patients on Maintenance Hemodialysis: An International Cohort Study.

    Farfan Ruiz, Ana Cecilia / Malick, Ranjeeta / Rhodes, Emily / Clark, Edward / Hundemer, Greg / Karaboyas, Angelo / Robinson, Bruce / Pecoits, Roberto / Sood, Manish M

    Canadian journal of kidney health and disease

    2023  Volume 10, Page(s) 20543581231172405

    Abstract: Background: There are concerns regarding the gastrointestinal (GI) safety of sodium polystyrene sulfonate (SPS), a medication commonly used in the management of hyperkalemia.: Objective: To compare the risk of GI adverse events among users versus non- ...

    Abstract Background: There are concerns regarding the gastrointestinal (GI) safety of sodium polystyrene sulfonate (SPS), a medication commonly used in the management of hyperkalemia.
    Objective: To compare the risk of GI adverse events among users versus non-users of SPS in patients on maintenance hemodialysis.
    Design: International prospective cohort study.
    Setting: Seventeen countries (Dialysis Outcomes and Practice Patterns Study [DOPPS] phase 2-6 from 2002 to 2018).
    Patients: 50 147 adults on maintenance hemodialysis.
    Measurements: An adverse GI event defined by a GI hospitalization or GI fatality with SPS prescription compared with no SPS prescription.
    Methods: Overlap propensity score-weighted Cox models.
    Results: Sodium polystyrene sulfonate prescription was present in 13.4% of patients and ranged from 0.42% (Turkey) to 20.6% (Sweden) with 12.5% use in Canada. A total of 935 (1.9%) adverse GI events (140 [2.1%] with SPS, 795 [1.9%] with no SPS; absolute risk difference 0.2%) occurred. The weighted hazard ratio (HR) of a GI event was not elevated with SPS use compared with non-use (HR = 0.93, 95% confidence interval = 0.83-1.6). The results were consistent when examining fatal GI events and/or GI hospitalization separately.
    Limitations: Sodium polystyrene sulfonate dose and duration were unknown.
    Conclusions: Sodium polystyrene sulfonate use in patients on hemodialysis was not associated with a higher risk of an adverse GI event. Our findings suggest that SPS use is safe in an international cohort of maintenance hemodialysis patients.
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2765462-X
    ISSN 2054-3581
    ISSN 2054-3581
    DOI 10.1177/20543581231172405
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  7. Article ; Online: In Reply to 'Stepwise Attempts on the Forearm Protect Against Exhaustion of Vascular Access Options'.

    Pisoni, Ronald L / Fluck, Richard / Robinson, Bruce M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2018  Volume 71, Issue 5, Page(s) 758–759

    MeSH term(s) Arteriovenous Shunt, Surgical ; Forearm ; Humans ; Renal Dialysis ; Vascular Patency
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2018.01.040
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
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  8. Article ; Online: International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS.

    Nitta, Kosaku / Bieber, Brian / Karaboyas, Angelo / Johnson, David W / Kanjanabuch, Talerngsak / Kim, Yong-Lim / Lambie, Mark / Hartman, John / Shen, Jenny I / Naljayan, Mihran / Pecoits-Filho, Roberto / Robinson, Bruce M / Pisoni, Ronald L / Perl, Jeffrey / Kawanishi, Hideki

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2024  , Page(s) 8968608241235516

    Abstract: Background: Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular disease and increased morbidity and mortality. CKD-MBD studies have been limited in ... ...

    Abstract Background: Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular disease and increased morbidity and mortality. CKD-MBD studies have been limited in peritoneal dialysis (PD) patients. Here, we describe calcium and parathyroid hormone (PTH) control, related treatments and mortality associations in PD patients.
    Methods: We used data from eight countries (Australia and New Zealand (A/NZ), Canada, Japan, Thailand, South Korea, United Kingdom, United States (US)) participating in the prospective cohort Peritoneal Dialysis Outcomes and Practice Patterns Study (2014-2022) among patients receiving PD for >3 months. We analysed the association of baseline PTH and albumin-adjusted calcium (calcium
    Results: Mean age ranged from 54.6 years in South Korea to 63.5 years in Japan. PTH and serum calcium
    Conclusions: A large proportion of PD patients in this multi-national study have calcium and/or PTH levels in ranges associated with substantially higher mortality. These observations point to the need to substantially improve MBD management in PD to optimise patient outcomes.
    Lay summary: Chronic kidney disease-mineral bone disorder (MBD) is a systemic condition, common in dialysis patients, that results in abnormalities in parathyroid hormone (PTH), calcium, phosphorus and vitamin D metabolism. A large proportion of peritoneal dialysis (PD) patients in this current multi-national study had calcium and/or PTH levels in ranges associated with substantially higher risks of death. Our observational study design limits our ability to determine whether these abnormal calcium and PTH levels cause more death due to possible confounding that was not accounted for in our analysis. However, our findings, along with other recent work showing 48-75% higher risk of death for the one-third of PD patients having high phosphorus levels (>5.5 mg/dL), should raise strong concerns for a greater focus on improving MBD management in PD patients.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608241235516
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  9. Article ; Online: Sickle cell bone disease and response to intravenous bisphosphonates in children.

    Grimbly, C / Escagedo, P Diaz / Jaremko, J L / Bruce, A / Alos, N / Robinson, M E / Konji, V N / Page, M / Scharke, M / Simpson, E / Pastore, Y D / Girgis, R / Alexander, R T / Ward, L M

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2022  Volume 33, Issue 11, Page(s) 2397–2408

    Abstract: Children with sickle cell disease (SCD) have the potential for extensive and early-onset bone morbidity. This study reports on the diversity of bone morbidity seen in children with SCD followed at three tertiary centers. IV bisphosphonates were effective ...

    Abstract Children with sickle cell disease (SCD) have the potential for extensive and early-onset bone morbidity. This study reports on the diversity of bone morbidity seen in children with SCD followed at three tertiary centers. IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
    Introduction: To evaluate bone morbidity and the response to intravenous (IV) bisphosphonate therapy in children with SCD.
    Methods: We conducted a retrospective review of patient records from 2003 to 2019 at three Canadian pediatric tertiary care centers. Radiographs, magnetic resonance images, and computed tomography scans were reviewed for the presence of avascular necrosis (AVN), bone infarcts, and myositis. IV bisphosphonates were offered for bone pain management. Bone mineral density was assessed by dual-energy X-ray absorptiometry (DXA).
    Results: Forty-six children (20 girls, 43%) had bone morbidity at a mean age of 11.8 years (SD 3.9) including AVN of the femoral (17/46, 37%) and humeral (8/46, 17%) heads, H-shaped vertebral body deformities due to endplate infarcts (35/46, 76%), and non-vertebral body skeletal infarcts (15/46, 32%). Five children (5/26, 19%) had myositis overlying areas of AVN or bone infarcts visualized on magnetic resonance imaging. Twenty-three children (8/23 girls) received IV bisphosphonate therapy. They all reported significant or complete resolution of bone pain. There were no reports of sickle cell hemolytic crises, pain crises, or stroke attributed to IV bisphosphonate therapy.
    Conclusion: Children with SCD have the potential for extensive and early-onset bone morbidity. In this series, IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/pathology ; Canada ; Child ; Diphosphonates/adverse effects ; Female ; Humans ; Infarction/complications ; Myositis ; Osteonecrosis ; Pain/drug therapy ; Pain/etiology
    Chemical Substances Diphosphonates
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-022-06455-2
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  10. Article ; Online: Hemoglobin and Clinical Outcomes in Hemodialysis: An Analysis of US Medicare Data From 2018 to 2020.

    Young, Eric W / Wang, Dongyu / Kapke, Alissa / Pearson, Jeffrey / Turenne, Marc / Robinson, Bruce M / Huff, Edwin D

    Kidney medicine

    2022  Volume 5, Issue 2, Page(s) 100578

    Abstract: Rationale & objective: Anemia management in patients treated with maintenance dialysis remains a challenge. We sought to update information in this area by evaluating the association between hemoglobin and various outcome and utilization measures using ... ...

    Abstract Rationale & objective: Anemia management in patients treated with maintenance dialysis remains a challenge. We sought to update information in this area by evaluating the association between hemoglobin and various outcome and utilization measures using data-rich Medicare sources.
    Study design: Observational cohort study using data from the Consolidated Renal Operations in a Web-enabled Network and Medicare claims.
    Setting & participants: We studied 371,250 prevalent patients treated with hemodialysis, covering 3,326,072 patient-months in 2019.
    Exposure: Monthly patient hemoglobin concentrations.
    Outcomes: We examined several outcomes, including mortality, all-cause hospitalization, cause-specific hospitalization, and emergency department utilization in the month following the exposure measurement.
    Analytical approach: For each monthly observation period, we calculated unadjusted and adjusted (for demographics and comorbid condition) hazard ratios using Cox regression.
    Results: The hemoglobin concentration was <10.5 g/dL for 40% of observations. We found an inverse association between mortality and hemoglobin measured over a range from <9 g/dL (HR, 2.53; 95% CI, 2.45-2.61;
    Limitations: As with prior observational studies, the observed associations are not necessarily causal.
    Conclusions: In a large US hemodialysis population, there were better clinical outcomes at higher hemoglobin concentrations over short exposure and follow-up periods, consistent with other observational studies that generally used longer exposure and follow-up times. Mortality risk increased at hemoglobin concentrations >11.5 g/dL, consistent with findings from erythropoiesis-stimulating agent clinical trials. The apparently beneficial short-term effects associated with higher hemoglobin concentrations suggest that hemoglobin measurements capture unmeasured elements of patient risk.
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2022.100578
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