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Article ; Online: Modulation of Near-Infrared Mitochondria-Targetable fluorescent probe for H

Li, Xuewei / Zang, Liu / Zhao, Hanqing / Qi, Fenghui / Lau, Choiwan / Lu, Jianzhong

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 298, Page(s) 122767

Abstract: H ...

Abstract	H
MeSH term(s)	Humans ; Fluorescent Dyes ; HeLa Cells ; Mitochondria ; Microscopy, Fluorescence/methods ; Optical Imaging/methods ; Hydrogen Sulfide
Chemical Substances	Fluorescent Dyes ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2023-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.122767
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Article: 24-H movement behaviors and physical fitness in preschoolers: A compositional and isotemporal reallocation analysis.

Song, Huiqi / Lau, Patrick W C / Wang, Jingjing / Liu, Yunfei / Song, Yi / Shi, Lei

Journal of exercise science and fitness

2024 Volume 22, Issue 3, Page(s) 187–193

Abstract: Background/objectives: This study examined the relationships between 24-h movement behaviors and ... respectively. The compositional data analysis was used to examine the association between 24-h movement ...

Abstract	Background/objectives: This study examined the relationships between 24-h movement behaviors and physical fitness (PF) in preschool children. Methods: The study was conducted on 474 children aged 3-6 years in Zhuhai. Physical activity (PA) and sedentary behavior (SB) were collected by the accelerometer, and sleep time was assessed through the parent-report questionnaire. Balance, cardiorespiratory fitness (CRF), flexibility, muscle strength, muscular endurance, and speed-agility were measured using a balance beam test, 20 m shuttle run test, sit and reach test, handgrip test, sit-ups, and 4 × 10 m shuttle run test respectively. The compositional data analysis was used to examine the association between 24-h movement behaviors and PF, and the compositional isotemporal substitution analysis was used for the time reallocation. Results: The daily composition, adjusted for age, gender, and body mass index (BMI), was significantly associated with CRF (p < 0.001, r Conclusion: These findings offer useful insight for the replacement of movement behaviors within the recommended range to facilitate PF development in early childhood.
Language	English
Publishing date	2024-03-15
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2205204-5
ISSN	1728-869X
ISSN	1728-869X
DOI	10.1016/j.jesf.2024.03.002
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Article ; Online: BRD4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H pylori Infection.

Modi, Nikita / Chen, Yanheng / Dong, Xingchen / Hu, Xiangming / Lau, Gee W / Wilson, Keith T / Peek, Richard M / Chen, Lin-Feng

Cellular and molecular gastroenterology and hepatology

2023 Volume 17, Issue 2, Page(s) 292–308.e1

Abstract: ... conditional knockout (Brd4-CKO) mice were infected with H pylori. RNA sequencing was performed to evaluate ... the differential gene expression between WT and Brd4-deficient BMDMs upon infection. An in vivo model of H pylori ... to infection.: Results: Depletion of Brd4 in BMDMs showed impaired H pylori-induced glycolysis. In addition ...

Abstract	Background & aims: Metabolic reprogramming is essential for the activation and functions of macrophages, including bacterial killing and cytokine production. Bromodomain-containing protein 4 (BRD4) has emerged as a critical regulator of innate immune response. However, the potential role of BRD4 in the metabolic reprogramming of macrophage activation upon Helicobacter pylori infection remains unclear. Methods: Bone marrow-derived macrophages (BMDMs) from wild-type (WT) and Brd4-myeloid deletion conditional knockout (Brd4-CKO) mice were infected with H pylori. RNA sequencing was performed to evaluate the differential gene expression between WT and Brd4-deficient BMDMs upon infection. An in vivo model of H pylori infection using WT and Brd4-CKO mice was used to confirm the role of BRD4 in innate immune response to infection. Results: Depletion of Brd4 in BMDMs showed impaired H pylori-induced glycolysis. In addition, H pylori-induced expression of glycolytic genes, including Slc2a1 and Hk2, was decreased in Brd4-deficient BMDMs. BRD4 was recruited to the promoters of Slc2a1 and Hk2 via hypoxia-inducible factor-1α, facilitating their expression. BRD4-mediated glycolysis stabilized H pylori-induced nitric oxide synthase (Nos2) messenger RNA to produce nitric oxide. The NO-mediated killing of H pylori decreased in Brd4-deficient BMDMs, which was rescued by pyruvate. Furthermore, Brd4-CKO mice infected with H pylori showed reduced gastric inflammation and increased H pylori colonization with reduced inducible NO synthase expression in gastric macrophages. Conclusions: Our study identified BRD4 as a key regulator of hypoxia-inducible factor-1α-dependent glycolysis and macrophage activation. Furthermore, we show a novel regulatory role of BRD4 in innate immunity through glycolysis to stabilize Nos2 messenger RNA for NO production to eliminate H pylori infection.
MeSH term(s)	Animals ; Mice ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Helicobacter Infections/microbiology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Helicobacter pylori/metabolism ; Macrophages/metabolism ; Nitric Oxide Synthase/metabolism ; RNA, Messenger/metabolism ; Glycolysis ; Nitric Oxide Synthase Type II/metabolism
Chemical Substances	Nuclear Proteins ; Hypoxia-Inducible Factor 1, alpha Subunit ; Nitric Oxide Synthase (EC 1.14.13.39) ; RNA, Messenger ; Nos2 protein, mouse (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2819778-1
ISSN	2352-345X ; 2352-345X
ISSN (online)	2352-345X
ISSN	2352-345X
DOI	10.1016/j.jcmgh.2023.10.001
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Article ; Online: Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy.

Bendre, Shreya / Merkens, Helen / Kuo, Hsiou-Ting / Ng, Pauline / Wong, Antonio A W L / Lau, Wing Sum / Zhang, Zhengxing / Kurkowska, Sara / Chen, Chao-Cheng / Uribe, Carlos / Bénard, François / Lin, Kuo-Shyan

European journal of medicinal chemistry

2024 Volume 268, Page(s) 116238

Abstract: ... SB04033 comprising of an atypical benzo[h]quinoline construct were synthesized and either chelated ...

Abstract	Fibroblast activation protein-α (FAP) is a marker of cancer-associated fibroblasts (CAFs) that constitute a significant portion of most carcinomas. Since it plays a critical role in tumor growth and metastasis, its timely detection to identify tumor lesions in early developmental stages using targeted radiopharmaceuticals has gained significant impetus. In the present work, two novel FAP-targeted precursors SB03178 and SB04033 comprising of an atypical benzo[h]quinoline construct were synthesized and either chelated to diagnostic radionuclide gallium-68 or therapeutic radionuclide lutetium-177, with ≥90% radiochemical purities and 22-76% decay-corrected radiochemical yields.
MeSH term(s)	Humans ; Animals ; Mice ; Gallium Radioisotopes ; Tissue Distribution ; HEK293 Cells ; Radioisotopes ; Radiopharmaceuticals/pharmacokinetics ; Carcinoma ; Quinolines/chemistry ; Positron Emission Tomography Computed Tomography/methods ; Cell Line, Tumor ; Membrane Proteins ; Endopeptidases
Chemical Substances	fibroblast activation protein alpha (EC 3.4.21.-) ; Gallium Radioisotopes ; Radioisotopes ; Radiopharmaceuticals ; Quinolines ; Membrane Proteins ; Endopeptidases (EC 3.4.-)
Language	English
Publishing date	2024-02-13
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116238
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Article ; Online: Gastric Microbiota beyond H. pylori

Jun Wen / Harry Cheuk-Hay Lau / Maikel Peppelenbosch / Jun Yu

Biomedicines, Vol 9, Iss 1680, p

An Emerging Critical Character in Gastric Carcinogenesis

2021 Volume 1680

Abstract: ... accumulating evidence has demonstrated the presence of a large population of microorganisms other than H ... in gastric carcinogenesis. Here, we provide an overview of non- H. pylori gastric microbes in gastric ...

Abstract	Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori , which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than H. pylori in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non- H. pylori gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.
Keywords	gastric microbiota ; gastric carcinogenesis ; gastric dysbiosis ; non- H. pylori commensals ; microbiota-related carcinogenesis ; diagnostic biomarker ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: H-atom and O-atom methods

Yuen Pong Kau / Lau Cheng Man Diana

Chemistry Teacher International, Vol 4, Iss 3, Pp 207-

from balancing redox reactions to determining the number of transferred electrons

2022 Volume 220

Abstract: ... electrons. However, the task of calculating oxidation numbers is often challenging. In this article, the H ... operating procedures, H-atom, O-atom, and H2O molecule act as artificial devices to balance both inorganic and organic ... equations in molecular forms. By using the H-atom and O-atom methods, the number of transferred electrons ...

Abstract	Defining and balancing redox reaction requires both chemical knowledge and mathematical skills. The prevalent approach is to use the concept of oxidation number to determine the number of transferred electrons. However, the task of calculating oxidation numbers is often challenging. In this article, the H-atom method and O-atom method are developed for balancing redox equations. These two methods are based on the definition of redox reaction, which is the gain and loss of hydrogen or oxygen atoms. They complement current practices and provide an alternate path to balance redox equations. The advantage of these methods is that calculation of oxidation number is not required. Atoms are balanced instead. By following standard operating procedures, H-atom, O-atom, and H2O molecule act as artificial devices to balance both inorganic and organic equations in molecular forms. By using the H-atom and O-atom methods, the number of transferred electrons can be determined by the number of transferred H-atoms or O-atoms, which are demonstrated as electron-counting concepts for balancing redox reactions. In addition, the relationships among the number of transferred H-atom, the number of transferred O-atom, the number of transferred electrons, and the change of oxidation numbers are established.
Keywords	balancing redox reaction ; change of oxidation numbers ; number of transferred electrons ; number of transferred hydrogen atoms ; number of transferred oxygen atoms ; Chemistry ; QD1-999
Subject code	540 ; 541
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis.

Ilter, Didem / Drapela, Stanislav / Schild, Tanya / Ward, Nathan P / Adhikari, Emma / Low, Vivien / Asara, John / Oskarsson, Thordur / Lau, Eric K / DeNicola, Gina M / McReynolds, Melanie R / Gomes, Ana P

Redox biology

2023 Volume 61, Page(s) 102627

Abstract: Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NADPH ... ...

Abstract	Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NADPH is a central co-factor for both lipid and redox homeostasis, suggesting that cancer cells may require larger pools of NADPH to efficiently metastasize. NADPH is recycled through reduction of NADP
MeSH term(s)	Humans ; Female ; NADP/metabolism ; Breast Neoplasms ; Epigenesis, Genetic ; Oxidative Stress ; NAD/metabolism ; Melanoma, Cutaneous Malignant
Chemical Substances	NADP (53-59-8) ; NAD (0U46U6E8UK)
Language	English
Publishing date	2023-02-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102627
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Article ; Online: Substrate-Dependent Band Structures in Trilayer Graphene/h-BN Heterostructures.

Che, Shi / Stepanov, Petr / Ge, Supeng / Zhu, Menglin / Wang, Dongying / Lee, Yongjin / Myhro, Kevin / Shi, Yanmeng / Chen, Ruoyu / Pi, Ziqi / Pan, Cheng / Cheng, Bin / Taniguchi, Takashi / Watanabe, Kenji / Barlas, Yafis / Lake, Roger K / Bockrath, Marc / Hwang, Jinwoo / Lau, Chun Ning

Physical review letters

2021 Volume 125, Issue 24, Page(s) 246401

Abstract: ... between h-BN. Moreover, the addition or removal of the h-BN substrate results in an inversion of the K and ...

Abstract	The tight-binding model has been spectacularly successful in elucidating the electronic and optical properties of a vast number of materials. Within the tight-binding model, the hopping parameters that determine much of the band structure are often taken as constants. Here, using ABA-stacked trilayer graphene as the model system, we show that, contrary to conventional wisdom, the hopping parameters and therefore band structures are not constants, but are systematically variable depending on their relative alignment angle between h-BN. Moreover, the addition or removal of the h-BN substrate results in an inversion of the K and K^{'} valley in trilayer graphene's lowest Landau level. Our work illustrates the oft-ignored and rather surprising impact of the substrates on band structures of 2D materials.
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.246401
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Article ; Online: Tuning Supramolecular Selectivity for Hydrosulfide: Linear Free Energy Relationships Reveal Preferential C-H Hydrogen Bond Interactions.

Fargher, Hazel A / Lau, Nathanael / Richardson, H Camille / Cheong, Paul Ha-Yeon / Haley, Michael M / Pluth, Michael D / Johnson, Darren W

Journal of the American Chemical Society

2020 Volume 142, Issue 18, Page(s) 8243–8251

Abstract: Supramolecular anion receptors can be used to study the molecular recognition properties of the reactive yet biologically critical hydrochalcogenide anions ( ... ...

Abstract	Supramolecular anion receptors can be used to study the molecular recognition properties of the reactive yet biologically critical hydrochalcogenide anions (HCh
MeSH term(s)	Hydrogen Bonding ; Macromolecular Substances/chemical synthesis ; Macromolecular Substances/chemistry ; Molecular Structure ; Sulfides/chemical synthesis ; Sulfides/chemistry ; Thermodynamics
Chemical Substances	Macromolecular Substances ; Sulfides
Language	English
Publishing date	2020-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.0c00441
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Article: Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and cardiometabolic parameters and agreement for pre-diabetes diagnosis in patients with morbid obesity.

Guerreiro, Vanessa / Maia, Isabel / Neves, João Sérgio / Salazar, Daniela / Ferreira, Maria João / Mendonça, Fernando / Silva, Maria Manuel / Borges-Canha, Marta / Viana, Sara / Costa, Cláudia / Pedro, Jorge / Varela, Ana / Lau, Eva / Freitas, Paula / Carvalho, Davide

Diabetology & metabolic syndrome

2022 Volume 14, Issue 1, Page(s) 91

Abstract: ... OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification ...

Abstract	Background: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with cardiometabolic risk markers and the level of agreement for prediabetes mellitus diagnosis, in a sample of patients with morbid obesity. Methods: We retrospectively evaluated 656 patients with morbid obesity without diagnosed diabetes. To define prediabetes with 2hPG, 2022 American Diabetes Association guidelines criteria were used, while for 1hPG, glucose ≥ 155 mg/dL was considered. Cohen's Kappa coefficient was used to assess the agreement between both measures of prediabetes mellitus diagnosis. Results: A Cohen's Kappa coefficient of 0.405 (p < 0.001) was obtained. The 1hPG were positively correlated with homeostatic model assessment for insulin resistance (HOMA-IR) (ρ = 0.281, p < 0.001), fasting plasma glucose (FPG) (ρ = 0.581, p < 0.001), glycated haemoglobin (Hb1AC) (ρ = 0.347, p < 0.001) and were negatively correlated with homeostatic model assessment for cell-β function (HOMA-β) (ρ = -0.092, p = 0.018). 2hPG were also correlated with the same parameters, except for HOMA-β. Conclusion: A fair agreement between 1 and 2hPG was verified. 1hPG criteria may be a useful indicator of β-cell dysfunction and insulin resistance in patients with morbid obesity without diabetes diagnosis.
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-022-00865-2
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