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Article ; Online: Anti-Breast Cancer Activity on MCF-7 Cells of Melittin from Indonesia's Apis cerana: An In Vitro Study.

Lischer, Kenny / Sitorus, Shania Rosita Angelica / Guslianto, Brian Wirawan / Avila, Forbes / Khayrani, Apriliana Cahya / Sahlan, Muhamad

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 12, Page(s) 3913–3919

Abstract: Objective: Breast cancer is the most common case of cancers. Apitheraphy has been traditionally used for abundance diseases. This study aims to evaluate and compare the anti-breast cancer activity of melittin from Indonesia's Apic cerana as a potential ... ...

Abstract	Objective: Breast cancer is the most common case of cancers. Apitheraphy has been traditionally used for abundance diseases. This study aims to evaluate and compare the anti-breast cancer activity of melittin from Indonesia's Apic cerana as a potential drug for treating breast cancer. Methods: Apis cerana bee venom (BV) was collected from a bee farm in Cikurutung, Bandung using an electrical venom device. The BV was then purified using the ÄKTA Start system and HiTrap™ SP HP cation exchange chromatography column. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was used to identify melittin based on its molecular mass and lowry's protein assay to measure melittin concentration. Melittin cytotoxicity was measured with brine shrimp lethality test (BSLT), while MCF-7 breast cancer cells MTT assay was used to measure its anti-breast cancer activity, based on inhinition rate. Results: 95.432 μg/mL melittin is purified from 62.8 mg/L BV, using cation exchange chromatography. Melittin in vitro analysis with MCF-7 MTT assay is used to determine anti-breast cancer activity in dose dependent manner. Furthermore, melttin BSLT result showed a LC50 16.67675 μg/mL. Therefore, the MTT assay was conducted in 5, 10 and 15 μg/mL with MCF-7 inhibition values of 0.768 ± 0.014, 3.303 ± 0.011, and 35.714 ± 0.009 %, respectively. Conclusion: Indonesia's Apis cerana has the potential to be used as a therapeutic peptide for breast cancer treatment.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Bees ; Breast Neoplasms/drug therapy ; Female ; Humans ; Indonesia ; MCF-7 Cells/drug effects ; Melitten/pharmacology
Chemical Substances	Antineoplastic Agents ; Melitten (20449-79-0)
Language	English
Publishing date	2021-12-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.12.3913
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent

Hui, Khee Chung / Dhanapalan, Nagaammai / Khayrani, Apriliana Cahya / Imanto, Teguh / Sambudi, Nonni Soraya

Comptes Rendus. Chimie, Vol 25, Iss G1, Pp 295-

2022 Volume 306

Abstract: Hydroxyapatite (HAp) was combined with amino-functionalized carbon quantum dots (CQDs) to enhance the optical and surface area properties of HAp. The loading of amino-functionalized CQDs could enhance the luminescence of HAp and its UV–Vis absorbance. ... ...

Abstract	Hydroxyapatite (HAp) was combined with amino-functionalized carbon quantum dots (CQDs) to enhance the optical and surface area properties of HAp. The loading of amino-functionalized CQDs could enhance the luminescence of HAp and its UV–Vis absorbance. Additionally, surface area of HAp could be increased from 84.16 to 129.94 m$^{2}$/g by loading amino-functionalized CQDs. The drug release experiment was conducted using acetaminophen. The release happened slowly for amino-functionalized CQDs/HAp, with full release of acetaminophen being observed after 24 h. The enhanced luminescence composite shows high potential for the composite to be used for the controlled release of drugs.
Keywords	Hydroxyapatite ; Drug delivery ; Carbon quantum dots ; Chitosan ; Acetaminophen ; Biochemistry ; QD415-436 ; Physical and theoretical chemistry ; QD450-801 ; Mathematics ; QA1-939
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Académie des sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Review of Artificial Nacre for Oil–Water Separation

Apriliana Cahya Khayrani / Nonni Soraya Sambudi / Hans Wijaya / Yose Fachmi Buys / Fitri Ayu Radini / Norwahyu Jusoh / Norashikin Ahmad Kamal / Hazwani Suhaimi

Separations, Vol 10, Iss 205, p

2023 Volume 205

Abstract: Due to their extraordinary prospective uses, particularly in the areas of oil–water separation, underwater superoleophobic materials have gained increasing attention. Thus, artificial nacre has become an attractive candidate for oil–water separation due ... ...

Abstract	Due to their extraordinary prospective uses, particularly in the areas of oil–water separation, underwater superoleophobic materials have gained increasing attention. Thus, artificial nacre has become an attractive candidate for oil–water separation due to its superhydrophilicity and underwater superoleophobicity properties. Synthesized artificial nacre has successfully achieved a high mechanical strength that is close to or even surpasses the mechanical strength of natural nacre. This can be attributed to suitable synthesis methods, the selection of inorganic fillers and polymer matrices, and the enhancement of the mechanical properties through cross-linking, covalent group modification, or mineralization. The utilization of nacre-inspired composite membranes for emerging applications, i.e., is oily wastewater treatment, is highlighted in this review. The membranes show that full separation of oil and water can be achieved, which enables their applications in seawater environments. The self-cleaning mechanism’s basic functioning and antifouling tips are also concluded in this review.
Keywords	nacre ; layered composite ; self-assembly ; layer by layer ; oil–water separation ; antifouling coating ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery.

Sahlan, Muhamad / Irdiani, Rafidha / Flamandita, Darin / Aditama, Reza / Alfarraj, Saleh / Ansari, Mohammad Javed / Khayrani, Apriliana Cahya / Pratami, Diah Kartika / Lischer, Kenny

Journal of King Saud University. Science

2020 Volume 33, Issue 1, Page(s) 101234

Abstract: Coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern, as the World Health Organization declared this outbreak to be a global pandemic in March 2020. ... ...

Abstract	Coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern, as the World Health Organization declared this outbreak to be a global pandemic in March 2020. The need for an effective treatment is urgent because the development of an effective vaccine may take years given the complexity of the virus and its rapid mutation. One promising treatment target for COVID-19 is SARS-CoV-2 main protease. Thus, this study was aimed to examine whether Sulawesi propolis compounds produced by
Keywords	covid19
Language	English
Publishing date	2020-11-17
Publishing country	Saudi Arabia
Document type	Journal Article
ISSN	2213-686X
ISSN (online)	2213-686X
DOI	10.1016/j.jksus.2020.101234
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Article: Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents.

Sahlan, Muhamad / Rizka Alia Hapsari, Nur / Diah Pratami, Kartika / Cahya Khayrani, Apriliana / Lischer, Kenny / Alhazmi, Alaa / Mohammedsaleh, Zuhair M / Shater, Abdullah F / Saleh, Fayez M / Alsanie, Walaa F / Sayed, Samy / Gaber, Ahmed

Saudi journal of biological sciences

2021 Volume 28, Issue 10, Page(s) 5461–5468

Abstract: The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants ...

Abstract	The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that contain in propolis. Most researchers claim that flavonoid can be used to protect the liver. The aim of this study was to test the hepatoprotective effect of flavonoid in propolis from South Sulawesi against doxorubicin and epirubicin. The experiment included male Sprague dawley rats divided into nine groups. The rats received the microcapsule propolis or the quercetin orally for 15 days. The hepatotoxicity was promoted by injection epirubicin and doxorubicin (i.v.) with a cumulative dose of 9 mg/kg. In this study, total polyphenol and flavonoid tests of propolis have been carried out, there were 1.1% polyphenols and 2.7% flavonoids, the antioxidant activity tests showed IC50 value of 9849 ppm and LCMS/MS tests supported the presence of phenolic compounds in propolis from South Sulawesi. Liver parameter was measured and the results showed that the propolis 200 mg/kg group produced the lowest ALT and had potential protective effect against doxorubicin and epirubicin-induced hepatotoxicity.
Language	English
Publishing date	2021-08-13
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.08.022
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Article ; Online: Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study

Apriliana Cahya Khayrani / Rafidha Irdiani / Reza Aditama / Diah Kartika Pratami / Kenny Lischer / Mohammad Javed Ansari / Arunachalam Chinnathambi / Sulaiman Ali Alharbi / Hesham S. Almoallim / Muhamad Sahlan

Journal of King Saud University: Science, Vol 33, Iss 2, Pp 101297- (2021)

2021

Abstract: Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to ... ...

Abstract	Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to control virus transmission. Yet, at the same time, Indonesia has a rich biodiversity of natural medicinal products that potentially become an alternative cure. Thus, this study examined the potency of a natural medicinal product, Sulawesi propolis compounds produced by Tetragonula sapiens, inhibiting angiotensin-converting activity enzyme-2 (ACE-2), a receptor of SARS-CoV-2 in the human body. In this study, molecular docking was done to analyze the docking scores as the representation of binding affinity and the interaction profiles of propolis compounds toward ACE-2. The results illustrated that by considering the docking score and the presence of interaction with targeted sites, five compounds, namely glyasperin A, broussoflavonol F, sulabiroins A, (2S)-5,7-dihydroxy-4′-methoxy-8-prenylflavanone and isorhamnetin are potential to inhibit the binding of ACE-2 and SARS-CoV-2, with the docking score of −10.8, −9.9, −9.5, −9.3 and −9.2 kcal/mol respectively. The docking scores are considered to be more favorable compared to MLN-4760 as a potent inhibitor.
Keywords	COVID-19 ; Molecular docking ; Potent inhibitor ; ACE-2 ; Sulawesi propolis ; Science (General) ; Q1-390
Subject code	540
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery

Muhamad Sahlan / Rafidha Irdiani / Darin Flamandita / Reza Aditama / Saleh Alfarraj / Mohammad Javed Ansari / Apriliana Cahya Khayrani / Diah Kartika Pratami / Kenny Lischer

Journal of King Saud University: Science, Vol 33, Iss 1, Pp 101234- (2021)

2021

Abstract	Coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern, as the World Health Organization declared this outbreak to be a global pandemic in March 2020. The need for an effective treatment is urgent because the development of an effective vaccine may take years given the complexity of the virus and its rapid mutation. One promising treatment target for COVID-19 is SARS-CoV-2 main protease. Thus, this study was aimed to examine whether Sulawesi propolis compounds produced by Tetragonula sapiens inhibit the enzymatic activity of SARS-CoV-2 main protease. In this study, molecular docking was performed to analyze the interaction profiles of propolis compounds with SARS-CoV-2 main protease. The results illustrated that two compounds, namely glyasperin A and broussoflavonol F, are potential drug candidates for COVID-19 based on their binding affinity of −7.8 kcal/mol and their ability to interact with His41 and Cys145 as catalytic sites. Both compounds also displayed favorable interaction profiles with SARS-CoV-2 main protease with binding similarities compared to inhibitor 13b as positive control 63% and 75% respectively.
Keywords	COVID-19 ; Molecular docking ; Potent inhibitor ; SARS-CoV-2 main protease ; Sulawesi propolis ; Science (General) ; Q1-390
Subject code	540
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Molecular Interaction Analysis of Sulawesi Propolis Compounds with SARS-CoV-2 Main Protease as Preliminary Study for COVID-19 Drug Discovery

Sahlan, Muhamad Irdiani Rafidha Flamandita Darin Aditama Reza Alfarraj Saleh Javed Ansari Mohammad Cahya Khayrani Apriliana Kartika Pratami Diah Lischer Kenny

Journal of King Saud University - Science

Abstract	Coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern, as the World Health Organization declared this outbreak to be a global pandemic in March 2020 The need for an effective treatment is urgent because the development of an effective vaccine may take years given the complexity of the virus and its rapid mutation One promising treatment target for COVID-19 is SARS-CoV-2 main protease Thus, this study was aimed to examine whether Sulawesi propolis compounds produced by Tetragonula sapiens inhibit the enzymatic activity of SARS-CoV-2 main protease In this study, molecular docking was performed to analyze the interaction profiles of propolis compounds with SARS-CoV-2 main protease The results illustrated that two compounds, namely glyasperin A and broussoflavonol F, are potential drug candidates for COVID-19 based on their binding affinity of −7 8 kcal/mol and their ability to interact with His41 and Cys145 as catalytic sites Both compounds also displayed favorable interaction profiles with SARS-CoV-2 main protease with binding similarities compared to inhibitor 13b as positive control 63% and 75% respectively
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #926548
Database	COVID19

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Article ; Online: Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells.

Kunoh, Tatsuki / Shimura, Tsutomu / Kasai, Tomonari / Matsumoto, Syuji / Mahmud, Hafizah / Khayrani, Apriliana Cahya / Seno, Masaharu / Kunoh, Hitoshi / Takada, Jun

Nanotechnology

2018 Volume 30, Issue 5, Page(s) 55101

Abstract: The surface reactivity of gold nanoparticles (AuNPs) is receiving attention as a radiosensitizer of cancer cells for radiation therapy and/or as a drug carrier to target cells. This study demonstrates the potential of DNA-AuNPs (prepared by mixing calf ... ...

Abstract	The surface reactivity of gold nanoparticles (AuNPs) is receiving attention as a radiosensitizer of cancer cells for radiation therapy and/or as a drug carrier to target cells. This study demonstrates the potential of DNA-AuNPs (prepared by mixing calf thymus DNA with HAuCl
MeSH term(s)	Annexins/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; DNA/administration & dosage ; DNA Damage/drug effects ; Fluorescent Dyes/administration & dosage ; Glioblastoma/metabolism ; Glioblastoma/radiotherapy ; Glioma/metabolism ; Glioma/radiotherapy ; Gold/administration & dosage ; Histones/metabolism ; Humans ; Metal Nanoparticles/administration & dosage ; Mitosis/drug effects ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Radiation Tolerance/drug effects ; Reactive Oxygen Species/metabolism
Chemical Substances	Annexins ; Fluorescent Dyes ; Histones ; Reactive Oxygen Species ; Gold (7440-57-5) ; DNA (9007-49-2)
Language	English
Publishing date	2018-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/aaedd5
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Article ; Online: Molecular Interaction Analysis of Sulawesi Propolis Compounds with SARS-CoV-2 Main Protease as Preliminary Study for COVID-19 Drug Discovery

Sahlan, Muhamad / Irdiani, Rafidha / Flamandita, Darin / Aditama, Reza / Alfarraj, Saleh / Javed Ansari, Mohammad / Cahya Khayrani, Apriliana / Kartika Pratami, Diah / Lischer, Kenny

Journal of King Saud University - Science

2020 , Page(s) 101234

Keywords	Multidisciplinary ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2514731-6
ISSN	1018-3647
ISSN	1018-3647
DOI	10.1016/j.jksus.2020.101234
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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