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Article: S

Nicolas, Fadia / Wu, Changgong / Bukhari, Salwa / de Toledo, Sonia M / Li, Hong / Shibata, Masayuki / Azzam, Edouard I

2015 Volume 3, Issue 2, Page(s) 56–73

Abstract: The covalent addition of nitric oxide ( ... ...

Abstract	The covalent addition of nitric oxide (NO
Language	English
Publishing date	2015-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720995-7
ISSN	2227-7382
ISSN	2227-7382
DOI	10.3390/proteomes3020056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between car driving and successful ageing. A cross sectional study on the "S.AGES" cohort.

Baudouin, Edouard / Zitoun, Sarah / Corruble, Emmanuelle / Vidal, Jean-Sébastien / Becquemont, Laurent / Duron, Emmanuelle

PloS one

2023 Volume 18, Issue 5, Page(s) e0285313

Abstract: ... Methods: This cross-sectional study is ancillary to the S.AGES (Sujets AGÉS-Aged Subjects) study ...

Abstract	Background: Assessing successful ageing (SA) is essential to identify modifiable factors in order to enforce health promotion and prevention actions. SA comprises 3 dimensions: an active engagement with life, a low probability of disease and disease-related disability, and a high cognitive and physical functional capacity. Driving seems to be linked to SA as it is a mean to preserve social interactions and requires preserved functional and cognitive status. This study aims to investigate whether driving status can be considered a proxy of SA, by describing determinants associated with driving status in the 65+. Methods: This cross-sectional study is ancillary to the S.AGES (Sujets AGÉS-Aged Subjects) study, an observational prospective cohort study which included patients suffering from chronic pain, type-2 diabetes mellitus or atrial fibrillation from 2009 to 2014. SA was defined by the success of three dimensions: physiological comprised of comorbidity and autonomy scores, psychological comprised of cognitive status and emotional state, and a social dimension. Results: 2,098 patients were included of whom 1,226 (58.4%) reported being drivers. 351/2,092 (16.7%) were classified as successful agers: 292/1,266 (23.8%) in the driver group vs. 59/872 (6.8%) in the non-driver group; p < .001. In the final logistic model, after adjustment for relevant variables, SA was associated with driver status OR 1.94 [1.36-2.77]. Conclusion: Driving may be considered as a proxy to SA: it reflects elders' independence, cognitive ability and a means to maintain social interactions. To preserve their mobility and enable them to achieve SA, regular screening of driving skills, specific rehabilitation programs are needed. Moreover development and communication on special transports services, communal rides or even driverless car to avoid apprehension around older adults driving could be solutions.
MeSH term(s)	Humans ; Aged ; Cross-Sectional Studies ; Prospective Studies ; Automobiles ; Aging/psychology ; Physical Examination ; Automobile Driving
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285313
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Article ; Online: The impact of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr long-lasting insecticidal nets on density of primary malaria vectors Anopheles gambiae s.s. and Anopheles coluzzii in Benin: a secondary analysis of a cluster randomised controlled trial.

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 7

Abstract: ... on the density of Anopheles gambiae s.s. and An. coluzzii compared to pyrethroid-only nets in a three-arm cluster ... morphological identification, around 15% of randomly selected samples of An. gambiae s.l. were dissected ... distribution, approximately 70% of the specimens of An. gambiae s.l. speciated were An. coluzzii ...

Abstract	Background: Long-lasting insecticidal nets (LLINs) may have different impacts on distinct mosquito vector species. We assessed the efficacy of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr LLINs on the density of Anopheles gambiae s.s. and An. coluzzii compared to pyrethroid-only nets in a three-arm cluster randomised control trial in Benin. Methods: Indoor and outdoor collections of adult mosquitoes took place in 60 clusters using human landing catches at baseline and every 3 months for 2 years. After morphological identification, around 15% of randomly selected samples of An. gambiae s.l. were dissected to determine parity, species (using PCR). Results: Overall, a total of 46,613 mosquito specimens were collected at baseline and 259,250 in the eight quarterly collections post-net distribution. Post-net distribution, approximately 70% of the specimens of An. gambiae s.l. speciated were An. coluzzii, while the rest were mostly composed of An. gambiae s.s. with a small proportion (< 1%) of hybrids (An. gambiae/coluzzii). There was no evidence of a significant reduction in vector density indoors in either primary vector species [An. coluzzii: DR (density ratio) = 0.62 (95% CI 0.21-1.77), p = 0.3683 for the pyrethroid-pyriproxyfen LLIN and DR = 0.56 (95% CI 0.19-1.62), p = 0.2866 for the pyrethroid-chlorfenapyr LLIN, An. gambiae s.s.: DR = 0.52 (95% CI 0.18-1.46), p = 0.2192 for the pyrethroid-pyriproxyfen LLIN and DR = 0.53 (95% CI 0.19-1.46), p = 0.2222 for the pyrethroid-chlorfenapyr]. The same trend was observed outdoors. Parity rates of An. gambiae s.l. were also similar across study arms. Conclusions: Compared with pyrethroid-only LLINs, pyrethroid-chlorfenapyr LLINs and pyrethroid-pyriproxyfen LLINs performed similarly against the two primary mosquito species An. gambiae s.s. and An. coluzzii in Benin.
MeSH term(s)	Animals ; Humans ; Anopheles ; Benin ; Insecticide Resistance ; Insecticide-Treated Bednets ; Insecticides/pharmacology ; Malaria/prevention & control ; Mosquito Control ; Mosquito Vectors ; Pyrethrins/pharmacology
Chemical Substances	chlorfenapyr (NWI20P05EB) ; Insecticides ; Pyrethrins ; pyriproxyfen (3Q9VOR705O)
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-023-06104-5
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Article ; Online: Epidemiology of injuries in elite Women’s Artistic Gymnastics

Pascal Edouard / Joris Chapon / Pierre-Eddy Dandrieux / Séréna Charpy / Pierre Billard

BMJ Open Sport & Exercise Medicine, Vol 9, Iss

a retrospective analysis of six seasons

2023 Volume 4

Abstract: Background Women’s Artistic Gymnastics (WAG) is a sport well known for requiring a heavy and ... season among French high-level Women’s Artistic Gymnasts from the France Gymnastics National Centre ...

Abstract	Background Women’s Artistic Gymnastics (WAG) is a sport well known for requiring a heavy and difficult training load from a younger age to reach a high level of performance. This also is associated with an injury risk. Epidemiological studies are thus needed to improve injury prevention strategies.Objective We aimed to determine the injury epidemiology in French high-level WAG.Methods We conducted a retrospective analysis of injury data collected prospectively over six seasons from the 2014–2015 season to the 2019–2020 season among French high-level Women’s Artistic Gymnasts from the France Gymnastics National Centre of Saint-Etienne. We performed descriptive analyses, including the calculation of the 1-year injury prevalence.Results 43 gymnasts were included in this study, representing 111 gymnast-seasons. A total of 285 injuries were collected over the study period, that was, an average of 2.6 injuries per gymnast per season. On average, 91.4% of gymnasts had at least one injury per season. The estimated injury incidence rate was 1.8 injuries per 1000 hours of gymnastics practice. The knee was the most affected joint (16%), followed by the elbow (12%) and the ankle (12%). The most frequent injury type was physis pathologies (16%) and bone injuries (15%). Eighty-eight per cent of injuries required a modification of the gymnastics practice.Conclusions The results of this study allowed a description of the epidemiology of injuries in this population of young and elite gymnasts. This very high injury prevalence supports the need to improve injury risk reduction strategies in WAG.
Keywords	Medicine (General) ; R5-920
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
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Article ; Online: Pharmacologic Treatment of Type 2 Diabetes in the U.S., Sweden, and Israel.

Lyu, Beini / Sang, Yingying / Selvin, Elizabeth / Chang, Alex R / Alexander, G Caleb / Cohen, Cheli Melzer / Coresh, Josef / Shalev, Varda / Chodick, Gabriel / Karasik, Avraham / Carrero, Juan-Jesus / Fu, Edouard L / Xu, Yang / Grams, Morgan E / Shin, Jung-Im

Diabetes care

2022 Volume 45, Issue 12, Page(s) 2926–2934

Abstract: ... S., Sweden, and Israel, including adoption of newer medications and prescribing patterns ... from the U.S., the Stockholm CREAtinine Measurements (SCREAM) project from Sweden, and Maccabi Healthcare ... differences in real-world use of glucose-lowering medications across the U.S., Sweden, and Israel, with more ...

Abstract	Objective: To characterize and compare glucose-lowering medication use in type 2 diabetes in the U.S., Sweden, and Israel, including adoption of newer medications and prescribing patterns. Research design and methods: We used data from the National Health and Nutrition Examination Survey (NHANES) from the U.S., the Stockholm CREAtinine Measurements (SCREAM) project from Sweden, and Maccabi Healthcare Services (Maccabi) from Israel. Specific pharmacotherapy for type 2 diabetes between 2007 and 2018 was examined. Results: Use of glucose-lowering medications among patients with type 2 diabetes was substantially lower in NHANES and SCREAM than in Maccabi (66.0% in NHANES, 68.4% in SCREAM, and 88.1% in Maccabi in 2017-2018). Among patients who took at least one glucose-lowering medication in 2017-2018, metformin use was also lower in NHANES and SCREAM (74.1% in NHANES, 75.9% in SCREAM, and 92.6% in Maccabi) whereas sulfonylureas use was greater in NHANES (31.5% in NHANES, 16.0% in SCREAM, and 14.9% in Maccabi). Adoption of dipeptidyl peptidase 4 inhibitors and sodium-glucose cotransporter 2 inhibitors (SGLT2i) was slower in NHANES and SCREAM than in Maccabi. History of atherosclerotic cardiovascular disease, heart failure, reduced kidney function, or albuminuria was not consistently associated with greater use of SGLT2i or glucagon-like peptide 1 receptor agonists (GLP1RA) across the three countries. Conclusions: There were substantial differences in real-world use of glucose-lowering medications across the U.S., Sweden, and Israel, with more optimal pharmacologic management in Israel. Variation in access to care and medication cost across countries may have contributed to these differences. SGLT2i and GLP1RA use in patients at high risk was limited in all three countries during this time period.
MeSH term(s)	Humans ; Cardiovascular Diseases/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucose/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Israel/epidemiology ; Nutrition Surveys ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sweden/epidemiology ; United States/epidemiology
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-1253
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Article ; Online: Spread of SARS-CoV-2 Delta variant infections bearing the S:E484Q and S:T95I mutations in July and August 2021 in France

Verdume, Laura / Danesh, Gonché / Trombert, Sabine / Sofonea, Mircea T. / Noel, Valérie / Foulongne, Vincent / Montès, Brigitte / TUAILLON, Edouard / Haim-Boukobza, Stéphanie / Roquebert, Bénédicte / Alizon, Samuel

medRxiv

Abstract: ... genome sequencing reveals that these correspond to Delta variants bearing the S:E484Q mutation. Most ... of these sequences belong to a phylogenetic cluster and also bear the S:T95I mutation. Further monitoring is needed ...

Abstract	Analysing 92,598 variant screening tests performed on SARS-CoV-2 positive samples collected in France between 1 July and 31 August 2021 shows an increase of Kappa-like infections. Full genome sequencing reveals that these correspond to Delta variants bearing the S:E484Q mutation. Most of these sequences belong to a phylogenetic cluster and also bear the S:T95I mutation. Further monitoring is needed to determine if this trend is driven by undocumented superspreading events or an early signal of future viral evolutionary dynamics
Keywords	covid19
Language	English
Publishing date	2021-09-16
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.09.13.21263371
Database	COVID19

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Article ; Online: IRF4 haploinsufficiency in a family with Whipple’s disease

Antoine Guérin / Gaspard Kerner / Nico Marr / Janet G Markle / Florence Fenollar / Natalie Wong / Sabri Boughorbel / Danielle T Avery / Cindy S Ma / Salim Bougarn / Matthieu Bouaziz / Vivien Béziat / Erika Della Mina / Carmen Oleaga-Quintas / Tomi Lazarov / Lisa Worley / Tina Nguyen / Etienne Patin / Caroline Deswarte /

Rubén Martinez-Barricarte / Soraya Boucherit / Xavier Ayral / Sophie Edouard / Stéphanie Boisson-Dupuis / Vimel Rattina / Benedetta Bigio / Guillaume Vogt / Frédéric Geissmann / Lluis Quintana-Murci / Damien Chaussabel / Stuart G Tangye / Didier Raoult / Laurent Abel / Jacinta Bustamante / Jean-Laurent Casanova

eLife, Vol

2018 Volume 7

Abstract: Most humans are exposed to Tropheryma whipplei (Tw). Whipple’s disease (WD) strikes only a small ...

Abstract	Most humans are exposed to Tropheryma whipplei (Tw). Whipple’s disease (WD) strikes only a small minority of individuals infected with Tw (<0.01%), whereas asymptomatic chronic carriage is more common (<25%). We studied a multiplex kindred, containing four WD patients and five healthy Tw chronic carriers. We hypothesized that WD displays autosomal dominant (AD) inheritance, with age-dependent incomplete penetrance. We identified a single very rare non-synonymous mutation in the four patients: the private R98W variant of IRF4, a transcription factor involved in immunity. The five Tw carriers were younger, and also heterozygous for R98W. We found that R98W was loss-of-function, modified the transcriptome of heterozygous leukocytes following Tw stimulation, and was not dominant-negative. We also found that only six of the other 153 known non-synonymous IRF4 variants were loss-of-function. Finally, we found that IRF4 had evolved under purifying selection. AD IRF4 deficiency can underlie WD by haploinsufficiency, with age-dependent incomplete penetrance.
Keywords	Whipple's disease ; primary immunodeficiency ; IRF4 ; haploinsufficiency ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
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Article ; Online: Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea.

Kangale, Luis Johnson / Raoult, Didier / Fournier, Pierre-Edouard / Ghigo, Eric

Scientific reports

2021 Volume 11, Issue 1, Page(s) 24311

Abstract: ... we characterized the bacterial constituents of a 10-year-old laboratory culture of planarian species S ... that parts of the bacterial flora of the planarian S. mediterranea can be classified as fish pathogens and ...

Abstract	The planarian species Schmidtea mediterranea is a flatworm living in freshwater that is used in the research laboratory as a model to study developmental and regeneration mechanisms, as well as antibacterial mechanisms. However, the cultivable microbial repertoire of the microbes comprising its microbiota remains unknown. Here, we characterized the bacterial constituents of a 10-year-old laboratory culture of planarian species S. mediterranea via culturomics analysis. We isolated 40 cultivable bacterial species, including 1 unidentifiable species. The predominant phylum is Proteobacteria, and the most common genus is Pseudomonas. We discovered that parts of the bacterial flora of the planarian S. mediterranea can be classified as fish pathogens and opportunistic human pathogens.
MeSH term(s)	Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/growth & development ; Bacteria/isolation & purification ; Culture Techniques ; Laboratories/statistics & numerical data ; Microbiota ; Planarians/microbiology ; RNA, Ribosomal, 16S/genetics ; Regeneration ; Specimen Handling
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-03719-5
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Book ; Online: An algorithmic weakening of the Erd\H{o}s-Hajnal conjecture

Bonnet, Édouard / Thomassé, Stéphan / Tran, Xuan Thang / Watrigant, Rémi

2020

Abstract: ... of the input graph. We first prove that a constructive version of the celebrated Erd\H{o}s-Hajnal conjecture ... for which the Erd\H{o}s-Hajnal conjecture is still open. We then focus on improving the constant $\delta$ ...

Abstract	We study the approximability of the Maximum Independent Set (MIS) problem in $H$-free graphs (that is, graphs which do not admit $H$ as an induced subgraph). As one motivation we investigate the following conjecture: for every fixed graph $H$, there exists a constant $\delta > 0$ such that MIS can be $n^{1 - \delta}$-approximated in $H$-free graphs, where $n$ denotes the number of vertices of the input graph. We first prove that a constructive version of the celebrated Erd\H{o}s-Hajnal conjecture implies ours. We then prove that the set of graphs $H$ satisfying our conjecture is closed under the so-called graph substitution. This, together with the known polynomial-time algorithms for MIS in $H$-free graphs (e.g. $P_6$-free and fork-free graphs), implies that our conjecture holds for many graphs $H$ for which the Erd\H{o}s-Hajnal conjecture is still open. We then focus on improving the constant $\delta$ for some graph classes: we prove that the classical Local Search algorithm provides an $OPT^{1-\frac{1}{t}}$-approximation in $K_{t,t}$-free graphs (hence a $\sqrt{OPT}$-approximation in $C_4$-free graphs), and, while there is a simple $\sqrt{n}$-approximation in triangle-free graphs, it cannot be improved to $n^{\frac{1}{4}-\varepsilon}$ for any $\varepsilon > 0$ unless $NP \subseteq BPP$. More generally, we show that there is a constant $c$ such that MIS in graphs of girth $\gamma$ cannot be $n^{\frac{c}{\gamma}}$-approximated. Up to a constant factor in the exponent, this matches the ratio of a known approximation algorithm by Monien and Speckenmeyer, and by Murphy. To the best of our knowledge, this is the first strong (i.e., $\Omega(n^\delta)$ for some $\delta > 0$) inapproximability result for Maximum Independent Set in a proper hereditary class.
Keywords	Computer Science - Data Structures and Algorithms ; Computer Science - Computational Complexity ; Computer Science - Discrete Mathematics ; 68Q25 ; 68Q17 ; 68R10 ; F.2.2
Subject code	511
Publishing date	2020-04-25
Publishing country	us
Document type	Book ; Online
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Article ; Online: Recent Trends in the Diagnostic and Surgical Management of Benign Prostatic Hyperplasia in the U.S. from 2004 to 2017

Francesco Del Giudice / Jin Kyu Oh / Satvir Basran / Edouard Nicaise / Phil Hyun Song / Wansuk Kim / Sang Youn Kim / Gyeong Eun Min / Koo Han Yoo / Hyuk Jin Cho / Sinyeong Lee / Alessandro Sciarra / Stefano Salciccia / Ettore De Berardinis / Vincenzo Asero / Carlo Maria Scornajenghi / Benjamin Pradere / Wojciech Krajewski / Andrea Gallioli /

Matteo Ferro / Felice Crocetto / Savio Domenico Pandolfo / Riccardo Autorino / Federico Belladelli / Andrea Mari / Gian Maria Busetto / Shufeng Li / Simone Crivellaro / Benjamin Inbeh Chung

Applied Sciences, Vol 12, Iss 8697, p

Annual Changes in the Selection of Treatment Options and Medical Costs

2022 Volume 8697

Abstract: ... the annual incidence, management trends, and costs of BPH procedures in the U.S. Methods: Data analyses of U ... S. health insurance claims from 2004 to 2017, collected from the de-identified Optum Clinformatics ...

Abstract	Background: Transurethral resection of the prostate (TURP) is the gold-standard treatment for benign prostatic hyperplasia (BPH). However, laser surgery techniques (e.g., photoselective vaporization of the prostate (PVP), holmium laser, thulium laser enucleation of the prostate (HoLEP or ThuLEP)), and minimally invasive treatment options (e.g., UroLift) are increasingly replacing TURP. This study seeks to report the annual incidence, management trends, and costs of BPH procedures in the U.S. Methods: Data analyses of U.S. health insurance claims from 2004 to 2017, collected from the de-identified Optum Clinformatics Claims Database, were performed to determine the number of BPH patients and the treatment selected. Results: A total of 51,448 patients underwent BPH procedures from 2004 to 2017. There was a significant increase in the annual rate from 770 in 2004 to 6571 in 2017. The mean patient age (±SD) increased from 67.6 years old (±8.4) in 2004 to 73.4 years old (±8.4) in 2017. More than 60% of patients underwent cystourethroscopy and a post-void residual urine check for workup prior to surgical management. TURP was the most-common, and PVP was the second-most-common BPH procedure. Medical and total treatment costs increased, while the detection rate of prostate cancer after BPH surgery gradually decreased from 19.87% in 2004 to 5.78% in 2017. Conclusions: Our study demonstrates a recent trend in BPH management that replaces the traditional TURP technique with alternative methods. Due to rising costs, future studies should assess whether these newer methods are cost effective over the long term.
Keywords	benign prostatic hyperplasia ; surgery ; trends ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	001
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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