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Article: Penicillin-binding protein redundancy in

Mitchell, Stephanie L / Kearns, Daniel B / Carlson, Erin E

bioRxiv : the preprint server for biology

2023

Abstract: Penicillin-binding proteins (PBPs) play critical roles in cell wall construction, cell shape, and bacterial replication. Bacteria maintain a diversity of PBPs, indicating that despite their apparent functional redundancy, there is differentiation across ... ...

Abstract	Penicillin-binding proteins (PBPs) play critical roles in cell wall construction, cell shape, and bacterial replication. Bacteria maintain a diversity of PBPs, indicating that despite their apparent functional redundancy, there is differentiation across the PBP family. Seemingly redundant proteins can be important for enabling an organism to cope with environmental stressors. We sought to evaluate the consequence of environmental pH on PBP enzymatic activity in
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.20.533529
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Article ; Online: Considerations regarding Interpretation of Positive SARS-CoV-2 Molecular Results with Late Cycle Threshold Values.

Mitchell, Stephanie L / Loeffelholz, Michael J

Journal of clinical microbiology

2022 Volume 60, Issue 9, Page(s) e0050122

Abstract: COVID-19 disease lies on a spectrum, ranging from completely asymptomatic to mild disease to severe and critical disease. Studies have shown that prolonged shedding or sporadic detection of SARS-CoV-2 RNA can occur long after symptom resolution. Adding ... ...

Abstract	COVID-19 disease lies on a spectrum, ranging from completely asymptomatic to mild disease to severe and critical disease. Studies have shown that prolonged shedding or sporadic detection of SARS-CoV-2 RNA can occur long after symptom resolution. Adding to these clinical complexities is the demand for testing for SARS-CoV-2 at all stages of diseases, frequently driven by screening of asymptomatic persons, something that traditionally has not been performed for other viral respiratory diseases. This can lead to positive results from nucleic acid amplification tests (NAATs), such as RT-PCR, with late cycle threshold (CT) values near the test's limit of detection. In this commentary, we review unique attributes of COVID-19 and causes of NAAT late CT values. We provide interpretation considerations as well as strategies to aid in test interpretation.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Nucleic Acid Amplification Techniques/methods ; RNA, Viral/genetics ; SARS-CoV-2/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.00501-22
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Article ; Online: Penicillin-binding protein redundancy in

Mitchell, Stephanie L / Kearns, Daniel B / Carlson, Erin E

Applied and environmental microbiology

2023 Volume 90, Issue 1, Page(s) e0054823

Abstract: Penicillin-binding proteins (PBPs) play critical roles in cell wall construction, cell shape maintenance, and bacterial replication. Bacteria maintain a diversity of PBPs, indicating that despite their apparent functional redundancy, there is ... ...

Abstract	Penicillin-binding proteins (PBPs) play critical roles in cell wall construction, cell shape maintenance, and bacterial replication. Bacteria maintain a diversity of PBPs, indicating that despite their apparent functional redundancy, there is differentiation across the PBP family. Apparently-redundant proteins can be important for enabling an organism to cope with environmental stressors. In this study, we evaluated the consequence of environmental pH on PBP enzymatic activity in
MeSH term(s)	Penicillin-Binding Proteins ; Bacillus subtilis/metabolism ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Cytoplasm/metabolism
Chemical Substances	Penicillin-Binding Proteins ; Bacterial Proteins
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.00548-23
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Article ; Online: Vaccine hesitancy in pregnant Women: A narrative review.

Mitchell, Stephanie L / Schulkin, Jay / Power, Michael L

Vaccine

2023 Volume 41, Issue 29, Page(s) 4220–4227

Abstract: Pregnant women are often at higher risk for morbidity and mortality due to contracting vaccine-preventable diseases that result in adverse pregnancy outcomes such as spontaneous abortion, preterm births, and congenital fetal defects. For example, health ... ...

Abstract	Pregnant women are often at higher risk for morbidity and mortality due to contracting vaccine-preventable diseases that result in adverse pregnancy outcomes such as spontaneous abortion, preterm births, and congenital fetal defects. For example, health care provider recommendation is correlated with maternal acceptance of influenza vaccination, however, up to 33 % of pregnant women remain unvaccinated irrespective of provider recommendation. Vaccine hesitancy is a multifactorial problem that both the medical and public health systems need to address synergistically. Vaccine education should incorporate balanced perspectives to deliver vaccine education. This narrative review addresses four questions: 1) what are the primary concerns of pregnant women that lead them to be hesitant about receiving vaccinations; 2) to what extent does the source (e.g. provider, friend, family) of vaccine advice and information influence a pregnant person's decision to accept a vaccine; 3) how does the delivery method of vaccine education influence their decision; 4) how can categorizing patients into four distinct groups based on their opinions and behavior regarding vaccines be used to improve provider-patient communication and increase vaccine acceptance. Results from the literature show that the three most common reasons for vaccine hesitancy include: i.) fear of side effects or adverse events; ii.) lack of confidence in vaccine safety; iii.) low perception of being at high risk of infection during pregnancy and/or not having previously received the vaccination when not pregnant. We conclude that vaccine hesitancy is dynamic therefore people do not always hold a static level of vaccine hesitancy. People may move between a continuum of vaccine hesitancy for a multifactorial reasons. A framework, characterized by levels of vaccine hesitancy before and during pregnancy, was constructed to help providers find balance between promoting individual health and public health while providing vaccine education.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Outcome ; Pregnant Women ; Vaccination ; Vaccination Hesitancy ; Vaccines/adverse effects
Chemical Substances	Vaccines
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.05.047
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Article ; Online: Evaluation and Comparison of the Hologic Aptima SARS-CoV-2 Assay and the CDC 2019-nCoV Real-Time Reverse Transcription-PCR Diagnostic Panel Using a Four-Sample Pooling Approach.

Mitchell, Stephanie L / Ventura, Samantha E

Journal of clinical microbiology

2020 Volume 58, Issue 12

MeSH term(s)	COVID-19/diagnosis ; COVID-19/virology ; Humans ; Real-Time Polymerase Chain Reaction/methods ; Real-Time Polymerase Chain Reaction/standards ; Reproducibility of Results ; SARS-CoV-2/genetics ; Sensitivity and Specificity
Keywords	covid19
Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Letter
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.02241-20
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Zs.A 1188: Show issues

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Article: Racial and Gender Diversity Among Students and Faculty in EHAC-Accredited Environmental Health Sciences Programs: Trend Analysis from 2009 to 2021.

Balanay, Jo Anne G / Mitchell, Leslie D / Richards, Stephanie L

Environmental health insights

2022 Volume 16, Page(s) 11786302221112917

Abstract: Diversity in the environmental health sciences (EHS) workforce is crucial in providing culturally sensitive services to diverse communities. This may be influenced by academic faculty training a diverse student body in the field of environmental health. ... ...

Abstract	Diversity in the environmental health sciences (EHS) workforce is crucial in providing culturally sensitive services to diverse communities. This may be influenced by academic faculty training a diverse student body in the field of environmental health. This study aimed to characterize the diversity of students and faculty in EHS programs accredited by the National Environmental Health Science and Protection Accreditation Council (EHAC). A retrospective analysis was conducted on secondary data obtained from annual surveys administered to program directors in EHAC-accredited academic programs that included both undergraduate and graduate EHS degrees. The database covered surveys on gender and race that were conducted by EHAC for 12 academic years spanning 2009-2010 to 2020-2021. Results show most students (undergraduate and graduate) were female (54.4% and 52.1%, respectively) and white (61.0% and 50.7%, respectively). Increasing trends were observed over the last 12 years (2009-2021) in female undergraduate (from 53.7% to 59.8%) and graduate (from 47.1% to 60.3%) students and in non-white undergraduate students (from 40.0% to 48.2%). Most faculty (teaching in undergraduate and graduate programs) were male (64.4% and 64.3%, respectively) and white (77.9% and 92.1%, respectively). Increasing trends were observed from 2009 to 2021 in female faculty teaching undergraduate (from 27.7% to 42.2%) and graduate (from 31.3% to 42.1%) students. Native American, Alaska Native, Native Hawaiian, and Pacific Islander are consistently the most underrepresented racial groups in both undergraduate and graduate students and faculty. This study provides baseline data on the diversity of students and faculty in EHAC-accredited programs, which is important in informing future research and efforts to increase such diversity. Gender and racial disparity in EHS students and faculty needs to be addressed to provide necessary support to women and non-White constituents by institutional change in culture through active recruitment and by stronger collaboration between professional organizations and minority groups.
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452946-1
ISSN	1178-6302
ISSN	1178-6302
DOI	10.1177/11786302221112917
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Article ; Online: Evaluation of the COVID19 ID NOW EUA assay.

Mitchell, Stephanie L / George, Kirsten St

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2020 Volume 128, Page(s) 104429

Abstract: Background: The SARS-CoV-2 pandemic caused a major surge in needed diagnostic capacity. In response, many EUA assays have become available for clinical laboratories, and more recently, the point of care device, Abbott ID NOW.: Objectives: To ... ...

Abstract	Background: The SARS-CoV-2 pandemic caused a major surge in needed diagnostic capacity. In response, many EUA assays have become available for clinical laboratories, and more recently, the point of care device, Abbott ID NOW. Objectives: To determine the analytical performance of the ID NOW assay for detecting SARS-CoV-2. Study design: Residual NP samples collected in viral transport media were tested by the ID NOW platform in two independent laboratories. Results were compared to either the CDC or New York EUA assays, which served as reference methods. Results: Overall agreement of ID NOW was 78.7%. Sensitivity was 71.7% and specificity was 100%. Notably, all false-negative results correlated to those samples that were weakly positive. Conclusions: ID NOW performs well for strong and moderately positive samples but has reduced sensitivity for weakly positive samples. This sensitivity, among other concerns, should be taken into consideration when using this test for patients with a low suspicion for COVID-19 disease.
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; False Negative Reactions ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Point-of-Care Testing ; SARS-CoV-2 ; Sensitivity and Specificity
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	Netherlands
Document type	Evaluation Study ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2020.104429
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Article ; Online: Erratum for Humphries et al., "CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests".

Humphries, Romney M / Ambler, Jane / Mitchell, Stephanie L / Castanheira, Mariana / Dingle, Tanis / Hindler, Janet A / Koeth, Laura / Sei, Katherine

Journal of clinical microbiology

2023 Volume 61, Issue 10, Page(s) e0073923

Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.00739-23
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Article ; Online: Pregnant Women's Concerns Regarding COVID-19 and Their Willingness to Be Vaccinated.

Mitchell, Stephanie L / Strassberg, Emmie / Rhoades, Courtney / Jones, Asia / Wagner, Jenna C P / Schulkin, Jay / Power, Michael L

Journal of women's health (2002)

2023 Volume 32, Issue 5, Page(s) 513–520

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Female ; Humans ; Pregnancy ; Influenza Vaccines/therapeutic use ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pregnant Women ; COVID-19 Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control
Chemical Substances	Influenza Vaccines ; COVID-19 Vaccines
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2022.0427
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Article ; Online: Next-Generation Sequencing in Clinical Microbiology: Are We There Yet?

Mitchell, Stephanie L / Simner, Patricia J

Clinics in laboratory medicine

2019 Volume 39, Issue 3, Page(s) 405–418

Abstract: Next-generation sequencing (NGS) applications have been transitioning from research tools to diagnostic methods and are becoming more commonplace in clinical microbiology laboratories. These applications include (1) whole-genome sequencing, (2) targeted ... ...

Abstract	Next-generation sequencing (NGS) applications have been transitioning from research tools to diagnostic methods and are becoming more commonplace in clinical microbiology laboratories. These applications include (1) whole-genome sequencing, (2) targeted next-generation sequencing methods, and (3) metagenomic next-generation sequencing. The introduction of these methods into the clinical microbiology laboratory has led to the theoretic question of "Will NGS-based methods supplant traditional methods for strain typing, identification, and antimicrobial susceptibility prediction?" The authors address this question and discuss where we are at now with clinical NGS applications for infectious diseases, what does the future hold, and at what cost?
MeSH term(s)	Bacteria/isolation & purification ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Microbiological Techniques
Language	English
Publishing date	2019-07-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2019.05.003
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