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  1. Book: Chronic kidney disease, dialysis, and transplantation

    Himmelfarb, Jonathan / Ikizler, T. Alp

    companion to Brenner & Rector's the kidney

    2019  

    Author's details Jonathan Himmelfarb, MD; T. Alp Ikizler, MD
    Keywords Renal Dialysis ; Kidney Transplantation ; Kidney Failure, Chronic / therapy ; Kidney Failure, Chronic / complications
    Language English
    Size xii, 779 Seiten, Illustrationen, Diagramme
    Edition Fourth edition
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT019617408
    ISBN 978-0-323-52978-5 ; 0-323-52978-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 71 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: An Innovation Ecosystem.

    Himmelfarb, Jonathan / Ratner, Buddy D

    Journal of the American Society of Nephrology : JASN

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: From Home to Wearable Hemodialysis: Barriers, Progress, and Opportunities.

    Rivara, Matthew B / Himmelfarb, Jonathan

    Clinical journal of the American Society of Nephrology : CJASN

    2024  

    Abstract: Although the past two decades have seen substantial proportional growth of home hemodialysis in the United States, the absolute number of patients treated with home hemodialysis remains small. Currently available stationary hemodialysis devices for use ... ...

    Abstract Although the past two decades have seen substantial proportional growth of home hemodialysis in the United States, the absolute number of patients treated with home hemodialysis remains small. Currently available stationary hemodialysis devices for use in the home have inherent limitations that represent barriers for more widespread adoption by a larger proportion of individuals with kidney failure. These limitations include device weight and bulk, ergonomics considerations, technical complexity, vascular access challenges, and limited remote patient monitoring. Recent years have witnessed a resurgence in research and development of prototype wearable kidney replacement devices incorporating innovations in miniaturization, new biomaterials, and new methods for toxin clearance and dialysate regeneration. Recent work has built on five decades of incremental innovation in wearable dialysis concepts and prototypes, starting from the work by Kolff in the 1970s. Wearable dialysis devices that successfully overcome key persistent barriers to successful development and adoption of these technologies will radically reshape the landscape of kidney replacement therapies and have the potential to dramatically improve the lives of individuals living with kidney failure.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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  4. Article ; Online: Resolved: Targeting a Higher Hemoglobin Is Associated with Greater Risk in Patients with CKD Anemia: Con.

    Himmelfarb, Jonathan / Szczech, Lynda Anne

    Journal of the American Society of Nephrology : JASN

    2023  Volume 20, Issue 7, Page(s) 1436–1443

    Language English
    Publishing date 2023-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/01.asn.0000926908.25661.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Kidney Disease Modeling with Organoids and Organs-on-Chips.

    Musah, Samira / Bhattacharya, Rohan / Himmelfarb, Jonathan

    Annual review of biomedical engineering

    2024  

    Abstract: Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics are limited by ...

    Abstract Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics are limited by a poor understanding of the molecular mechanisms underlying human kidney disease onset and progression. Additionally, 90% of drug candidates fail in human clinical trials, often due to toxicity and efficacy not accurately predicted in animal models. The advent of ex vivo kidney models, such as those engineered from induced pluripotent stem (iPS) cells and organ-on-a-chip (organ-chip) systems have garnered considerable interest owing to their ability to more accurately model tissue development and patient-specific responses and drug toxicity. This review describes recent advances in developing kidney organoids and organ-chips by harnessing iPS cell biology to model human-specific kidney functions and disease states. We also discuss challenges that must be overcome to realize the potential of organoids and organ-chips as dynamic and functional conduits of the human kidney. Achieving these technological advances could revolutionize personalized medicine applications and therapeutic discovery for kidney disease. Expected final online publication date for the
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1448425-0
    ISSN 1545-4274 ; 1523-9829
    ISSN (online) 1545-4274
    ISSN 1523-9829
    DOI 10.1146/annurev-bioeng-072623-044010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Chronic kidney disease, dialysis, and transplantation

    Himmelfarb, Jonathan / Sayegh, Mohamed H.

    companion to Brenner & Rector's the kidney

    (Expert consult)

    2010  

    Title variant Brenner & Rector's the kidney
    Author's details Jonathan Himmelfarb and Mohamed Sayegh
    Series title Expert consult
    Keywords Renal Dialysis ; Kidney Transplantation ; Kidney Failure, Chronic / therapy ; Kidney Failure, Chronic / complications
    Language English
    Size XIX, 737 S. : Ill., graph. Darst., 28 cm
    Edition 3. ed.
    Publisher Saunders Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Accompanying material Zugang über Code zu Internetausgabe
    HBZ-ID HT016727269
    ISBN 978-1-437-70987-2 ; 1-437-70987-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 1357 order for loan Magazin
    Zugang zu Internetausgabe aus lizenzrechtlichen Gründen nicht verfügbar

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  7. Article ; Online: Modeling Shiga toxin-induced human renal-specific microvascular injury.

    Whelan, Russell / Lih, Daniel / Xue, Jun / Himmelfarb, Jonathan / Zheng, Ying

    Integrative biology : quantitative biosciences from nano to macro

    2024  Volume 16

    Abstract: Shiga toxin (Stx) causes significant renal microvascular injury and kidney failure in the pediatric population, and an effective targeted therapy has yet to be demonstrated. Here we established a human kidney microvascular endothelial cell line for the ... ...

    Abstract Shiga toxin (Stx) causes significant renal microvascular injury and kidney failure in the pediatric population, and an effective targeted therapy has yet to be demonstrated. Here we established a human kidney microvascular endothelial cell line for the study of Stx mediated injuries with respect to their morphologic, phenotypic, and transcriptional changes, and modeled Stx induced thrombotic microangiopathy (TMA) in flow-mediated 3D microvessels. Distinct from other endothelial cell lines, both isolated primary and immortalized human kidney microvascular endothelial cells demonstrate robust cell-surface expression of the Stx receptor Gb3, and concomitant dose-dependent toxicity to Stx, with significant contributions from caspase-dependent cell death. Use of a glucosylceramide synthase inhibitor (GCSi) to target disruption of the synthetic pathway of Gb3 resulted in remarkable protection of kidney microvascular cells from Stx injury, shown in both cellular morphologies, caspase activation and transcriptional analysis from RNA sequencing. Importantly, these findings are recapitulated in 3D engineered kidney microvessels under flow. Moreover, whole blood perfusion through Stx-treated microvessels led to marked platelet binding on the vessel wall, which was significantly reduced with the treatment of GCSi. These results validate the feasibility and utility of a bioengineered ex vivo human microvascular model under flow to recapitulate relevant blood-endothelial interactions in STEC-HUS. The profound protection afforded by GCSi demonstrates a preclinical opportunity for investigation in human tissue approximating physiologic conditions. Moreover, this work provides a broad foundation for novel investigation into TMA injury pathogenesis and treatment. Insight Box: Shiga toxin (Stx) causes endothelial injury that results in significant morbidity and mortality in the pediatric population, with no effective targeted therapy. This paper utilizes human kidney microvascular cells to examine Stx mediated cell death in both 2D culture and flow-mediated 3D microvessels, with injured microvessels also developing marked platelet binding and thrombi formation when perfused with blood, consistent with the clinical picture of HUS. This injury is abrogated with a small molecule inhibitor targeting the synthetic pathway of the Shiga toxin receptor. Our findings shed light onto Stx-induced vascular injuries and pave a way for broad investigation into thrombotic microangiopathies.
    MeSH term(s) Child ; Humans ; Endothelial Cells ; Kidney ; Biomedical Engineering ; Caspases ; Shiga Toxins
    Chemical Substances Caspases (EC 3.4.22.-) ; Shiga Toxins
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2480063-6
    ISSN 1757-9708 ; 1757-9694
    ISSN (online) 1757-9708
    ISSN 1757-9694
    DOI 10.1093/intbio/zyae001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rescuing kidney patients from early demise: role of anti-cytokine therapies.

    Ikizler, T Alp / Himmelfarb, Jonathan

    Kidney international

    2021  Volume 100, Issue 6, Page(s) 1152–1154

    MeSH term(s) Cytokines ; Humans ; Kidney
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Authors' Reply: Serum Protein-induced Tubular Injury.

    Lidberg, Kevin / Himmelfarb, Jonathan / Kelly, Edward / Akilesh, Shreeram

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 8, Page(s) 1627–1628

    MeSH term(s) Albuminuria ; Blood Proteins ; Humans ; Kidney Tubules, Proximal ; Nephrotic Syndrome ; Proteinuria/chemically induced
    Chemical Substances Blood Proteins
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022060657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Conference proceedings: Acute renal failure

    Himmelfarb, Jonathan

    from bench to bedside ; [papers that were prepared for a symposium held at the Sixth Annual Spring Clinical Nephrology Meetings]

    (Advances in renal replacement therapy ; 4, Suppl. 1)

    1997  

    Institution Spring Clinical Nephrology Meeting
    Author's details Jonathan Himmelfarb ..., guest ed
    Series title Advances in renal replacement therapy ; 4, Suppl. 1
    Collection
    Keywords Kidney Failure, Acute / congresses
    Language English
    Size 101 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Orlando, Fla
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007562433
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4627 -4,Suppl.1- not available for loan Zeitschriften-Lesesaal

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