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Article ; Online: Prostate Cancer Radioligand Therapy: Beta-labeled Radiopharmaceuticals.

Yechiel, Yaniv / Chicheportiche, Alexandre / Keidar, Zohar / Ben-Haim, Simona

2024

Abstract: Prostate cancer is the most common malignancy in men worldwide, with an estimated 174,650 new cases per year in the United States, and the second cancer-related cause of death, after lung cancer, with 31,620 deaths per year. While the 5 year survival ... ...

Abstract	Prostate cancer is the most common malignancy in men worldwide, with an estimated 174,650 new cases per year in the United States, and the second cancer-related cause of death, after lung cancer, with 31,620 deaths per year. While the 5 year survival rate for prostate cancer in patients without metastatic spread is nearly 100%, those with distant metastases have 5 year survival rates of approximately 30%. Initial diagnosis and assessment are based on PSA levels, Gleason score (derived from prostate biopsy), and advanced imaging modalities, including prostate MR imaging and PSMA-PET/computed tomography in patients with high-risk features.
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2764575-7
ISSN	1879-9809 ; 1556-8598
ISSN (online)	1879-9809
ISSN	1556-8598
DOI	10.1016/j.cpet.2024.03.011
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Article ; Online: Delayed levodopa-responsive parkinsonism following acute midbrain injury.

Friedman-Korn, Tali / Weill, Caroline / Ben-Haim, Simona / Arkadir, David

Journal of the neurological sciences

2024 Volume 459, Page(s) 122983

Abstract: Acute midbrain injury may cause both hyperkinetic movement disorders and parkinsonism. The temporal interval between the insult and the emergence of hyperkinetic disorders can last years. A delayed appearance of parkinsonism, on the other hand, was ... ...

Abstract	Acute midbrain injury may cause both hyperkinetic movement disorders and parkinsonism. The temporal interval between the insult and the emergence of hyperkinetic disorders can last years. A delayed appearance of parkinsonism, on the other hand, was rarely described. We present three cases of male patients (50-, 58- and 28-year-old) who developed levodopa-responsive parkinsonism 20, 8 and two years, respectively, after acute brain insult involving the midbrain. Insults included subcortical intracerebral hemorrhage dissecting into the midbrain, embolic basilar occlusion and trauma. A fluorodopa scan, performed in two cases, revealed reduced striatal uptake. All individuals improved on low doses of levodopa and developed motor fluctuations shortly after levodopa was introduced. We conclude that delayed, levodopa-responsive parkinsonism following midbrain injury should be recognized in the relevant clinical setup. Possible mechanisms include age-related loss of dopaminergic neurons superimposed on acute injury and secondary neurodegeneration.
MeSH term(s)	Humans ; Male ; Levodopa/adverse effects ; Parkinsonian Disorders/complications ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/drug therapy ; Brain ; Mesencephalon/diagnostic imaging ; Corpus Striatum
Chemical Substances	Levodopa (46627O600J)
Language	English
Publishing date	2024-04-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2024.122983
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Article ; Online: Carried away with the flow to maintain the reserve.

Massalha, Samia / Ben-Haim, Simona

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2021 Volume 29, Issue 4, Page(s) 1679–1682

MeSH term(s)	Blood Flow Velocity ; Coronary Circulation ; Coronary Vessels ; Humans
Language	English
Publishing date	2021-07-06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-021-02717-4
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Article ; Online: 99m

Itzkovich, Dror / Ben-Haim, Simona / Godefroy, Jeremy / Stokar, Joshua

JCEM case reports

2022 Volume 1, Issue 1, Page(s) luac011

Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luac011
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Article ; Online: Impact of Single-Time-Point Estimates of

Chicheportiche, Alexandre / Sason, Moshe / Zidan, Mahmoud / Godefroy, Jeremy / Krausz, Yodphat / Gross, David J / Grozinsky-Glasberg, Simona / Ben-Haim, Simona

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 10, Page(s) 1610–1616

Abstract: Dosimetry ... ...

Abstract	Dosimetry after
MeSH term(s)	Humans ; Retrospective Studies ; Octreotide/adverse effects ; Radiometry ; Kidney ; Single Photon Emission Computed Tomography Computed Tomography ; Neuroendocrine Tumors/radiotherapy ; Neuroendocrine Tumors/drug therapy ; Organometallic Compounds/therapeutic use
Chemical Substances	Octreotide (RWM8CCW8GP) ; Organometallic Compounds
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264923
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Article: Towards accurate

Raskin, Stanislav / Gamliel, Dan / Abookasis, David / Ben-Haim, Simona / Chicheportiche, Alexandre

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 5

Abstract: Background: Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). However, such method shows ... ...

Abstract	Background: Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). However, such method shows inconsistent results when the background activity varies. The aim of the present study was to propose a new calibration method by considering the sphere-to-background counts/voxel ratio (SBVR) in addition to the VOI for CFs calculation. A PET cylindrical flood phantom, a NEMA IQ body phantom, a Data spectrum Torso Phantom (ECT/TOR/P) and a LK-S Kyoto Liver/Kidney phantom were used. The NEMA IQ phantom was used to calibrate the camera and to produce CFs for the different spheres volumes and for varying sphere-to-background activity ratios. The spheres were filled with a uniform activity concentration of Results: The relative errors in quantification using the NEMA IQ phantom with the new calibration method were 0.16%, 5.77%, 9.34% for the large, medium and small sphere, respectively, for a time per view of 30-s. The conventional calibration method gave errors of 3.65%, 6.65%, 30.28% for 30-s. The LK-S Kyoto Liver/Kidney Phantom resulted in quantification errors of 3.40%, 2.14%, 11.18% for the large, medium and small spheres, respectively, for 30-s; compared to 11.31%, 17.54%, 14.43% for 30-s, respectively, for the conventional method. Similar results were obtained for shorter acquisitions times with 20-s and 10-s time per view. Conclusion: These results suggest that SBVR allows to improve quantification accuracy. The shorter time-per-view acquisitions had similar relative differences compared to the full-time acquisition which allows shorter imaging times with
Language	English
Publishing date	2023-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00526-x
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Article ; Online: Variability in bone-seeking tracers and imaging protocols for the diagnosis of cardiac amyloidosis: The more the merrier?

Weiler-Sagie, Michal / Ben-Haim, Simona

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2020 Volume 29, Issue 1, Page(s) 319–322

MeSH term(s)	Amyloidosis/diagnostic imaging ; Cardiomyopathies/diagnostic imaging ; Humans ; Radionuclide Imaging
Language	English
Publishing date	2020-09-07
Publishing country	United States
Document type	Editorial
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-020-02330-x
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Article ; Online: Towards accurate 177Lu SPECT activity quantification and standardization using lesion-to-background voxel ratio

Stanislav Raskin / Dan Gamliel / David Abookasis / Simona Ben-Haim / Alexandre Chicheportiche

EJNMMI Physics, Vol 10, Iss 1, Pp 1-

2023 Volume 17

Abstract: Abstract Background Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). However, such method shows ... ...

Abstract	Abstract Background Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). However, such method shows inconsistent results when the background activity varies. The aim of the present study was to propose a new calibration method by considering the sphere-to-background counts/voxel ratio (SBVR) in addition to the VOI for CFs calculation. A PET cylindrical flood phantom, a NEMA IQ body phantom, a Data spectrum Torso Phantom (ECT/TOR/P) and a LK-S Kyoto Liver/Kidney phantom were used. The NEMA IQ phantom was used to calibrate the camera and to produce CFs for the different spheres volumes and for varying sphere-to-background activity ratios. The spheres were filled with a uniform activity concentration of 177Lu, while the background was first filled with cold water and activity was added between each SPECT scan. SPECT imaging was performed for 30-s, 20-s, and 10-s exposure per view. The calculated CFs were expressed as function of the sphere volume and SBVR. The obtained CFs were validated for an additional NEMA IQ acquisition with different activities in spheres and background and for the Torso and Liver/Kidney phantoms with inserted NEMA IQ spheres. The quantification accuracy was compared with the conventional method not taking SBVR into consideration. Results The relative errors in quantification using the NEMA IQ phantom with the new calibration method were 0.16%, 5.77%, 9.34% for the large, medium and small sphere, respectively, for a time per view of 30-s. The conventional calibration method gave errors of 3.65%, 6.65%, 30.28% for 30-s. The LK-S Kyoto Liver/Kidney Phantom resulted in quantification errors of 3.40%, 2.14%, 11.18% for the large, medium and small spheres, respectively, for 30-s; compared to 11.31%, 17.54%, 14.43% for 30-s, respectively, for the conventional method. Similar results were obtained for shorter acquisitions times with 20-s and 10-s time ...
Keywords	177Lu activity quantification ; Gamma camera calibration ; SPECT ; Calibration factors ; Sphere-to-background counts/voxel ratio ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sentinel Lymph Node Identification in Cutaneous Head & Neck Cancer - Lymphoscintigraphy Late Phase.

Hirshoren, Nir / Abd El Qadir, Narmeen / Weinberger, Jeffrey M / Eliashar, Ron / Ben-Haim, Simona

The Laryngoscope

2022 Volume 132, Issue 11, Page(s) 2164–2168

Abstract: Objective: Sentinel node (SN) biopsy following lymphoscintography is recommended for high-risk cutaneous malignancies. Herein, we investigate different lymphoscintography phases, focusing on the importance of the late static phase and the resultant ... ...

Abstract	Objective: Sentinel node (SN) biopsy following lymphoscintography is recommended for high-risk cutaneous malignancies. Herein, we investigate different lymphoscintography phases, focusing on the importance of the late static phase and the resultant discovery of distal echelon solitary positive sentinel nodes that would otherwise have been overlooked. Methods: In this retrospective cohort study, conducted in a tertiary referral medical center, we assessed SN localization and time from tracer injection to SN identification on lymphoscintigraphy. Findings on scan were compared with SN found in the surgical field, and with the final pathological investigation. Results: Seventy-three patients, undergoing SN biopsy for head and neck skin malignancies, were investigated. Most patients were male (n = 50). The average age was 65.7 (±15.7) years and the average follow-up time was 29.1 (±22.4) months. Overall, 101 SNs were histologically investigated, demonstrating 7 positive SN. Eleven patients (15%) benefited from the late lymphoscintigraphy phase. In four studies, an SN was identified only in the late static phase, one of which was positive for the disease. In seven patients, SN was identified in the early phase with additional, different, SN on the late phase, one of which was positive for the disease. Comparing the yield (positive SNs) of early versus late phases, demonstrated the same importance (p = 0.275). Conclusions: The late lymphoscintigraphy phase has a crucial role in high-risk HN cutaneous cancer. Level of evidence: 3 Laryngoscope, 132:2164-2168, 2022.
MeSH term(s)	Aged ; Female ; Head and Neck Neoplasms/surgery ; Humans ; Lymph Nodes/pathology ; Lymphadenopathy ; Lymphoscintigraphy ; Male ; Melanoma/pathology ; Retrospective Studies ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/pathology
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30076
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Article: The Meaning of a Group Facilitation Training to Creative Arts Therapists Working in the Public Education System.

Roginsky, Efrat / Ben-Haim, Atara / Cooper, Talya / Ben-Simon, Shoval / Regev, Dafna / Snir, Sharon

Children (Basel, Switzerland)

2023 Volume 10, Issue 6

Abstract: Many creative arts therapists who provide group therapy to children and adolescents in the Israeli education system do not feel they were sufficiently trained as group facilitators. Group facilitation training was provided over the course of two ... ...

Abstract	Many creative arts therapists who provide group therapy to children and adolescents in the Israeli education system do not feel they were sufficiently trained as group facilitators. Group facilitation training was provided over the course of two consecutive years by a regional support center to over 40 creative arts therapists and their clinical supervisors working in the Israel Ministry of Education. A two-stage qualitative research project examined the participants' experiences during this training. Interviews were conducted regarding the therapists' first-year experiences. A questionnaire was administered at the end of the second year. Both were analyzed according to the Consensual Qualitative Research method. The research findings pertain to the participants' perceptions of group arts therapy in the Israeli education system and included the development of unique group models, the advantages and power of group therapy at school, and the intimidating and disruptive experiences of school settings. The participants also provided their impressions of the training course: their growing confidence and skills, and the many changes required in group arts therapy at public schools to provide more professional and efficient service. The discussion centers on the value of group arts therapy in the education system and the steps needed to enhance therapists' confidence and efficiency in this field.
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10060933
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