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Article ; Online: Author Correction: Model-based assessment of Chikungunya and O'nyong-nyong virus circulation in Mali in a serological cross-reactivity context.

Hozé, Nathanaël / Diarra, Issa / Sangaré, Abdoul Karim / Pastorino, Boris / Pezzi, Laura / Kouriba, Bourèma / Sagara, Issaka / Dabo, Abdoulaye / Djimdé, Abdoulaye / Thera, Mahamadou Ali / Doumbo, Ogobara K / de Lamballerie, Xavier / Cauchemez, Simon

Nature communications

2023 Volume 14, Issue 1, Page(s) 2549

Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36821-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5.

Touret, Franck / Baronti, Cécile / Pastorino, Boris / Villarroel, Paola Mariela Saba / Ninove, Laetitia / Nougairède, Antoine / de Lamballerie, Xavier

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12609

Abstract: The replacement of the Omicron BA.1 variant of SARS-CoV-2 by the BA.2 and the rapid growth of the BA.5 sub lineage, which have both different sets of mutations in the spike glycoprotein, alters the spectrum of activity of therapeutic antibodies currently ...

Abstract	The replacement of the Omicron BA.1 variant of SARS-CoV-2 by the BA.2 and the rapid growth of the BA.5 sub lineage, which have both different sets of mutations in the spike glycoprotein, alters the spectrum of activity of therapeutic antibodies currently licensed in the European Union. Using clinical strains of the Omicron BA.2 and BA.5 variants, we compared the neutralising power of monoclonal antibodies against the Omicron BA.1, BA.2 and BA.5 variants, using an ancestral strain (lineage B.1, D614G) and a Delta variant strain as reference. Sotrovimab/Vir-7831 is less active against BA.2 than against BA.1 (fold change reduction ~ 1,4) and even less active against BA.5 (fold change reduction ~ 2.7). Within the Evusheld /AZD7442 cocktail, Cilgavimab/AZD1061 is more active against BA.2 and BA.5 than against BA.1 (fold change increase ~ 32), whilst the very low activity of Tixagevimab/AZD8895 against BA.1 is not enhanced against BA.2 nor BA.5. In total, compared to BA.1, the activity of the Evusheld/AZD7442 is significantly improved against BA.2 while BA.5 is intermediate but closer to BA.2.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/drug therapy ; Drug Combinations ; Humans ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; Drug Combinations ; Spike Glycoprotein, Coronavirus ; cilgavimab and tixagevimab drug combination ; spike protein, SARS-CoV-2 ; tixagevimab ; cilgavimab (1KUR4BN70F) ; sotrovimab (1MTK0BPN8V)
Language	English
Publishing date	2022-07-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16964-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prolonged Infectivity of SARS-CoV-2 in Fomites.

Pastorino, Boris / Touret, Franck / Gilles, Magali / de Lamballerie, Xavier / Charrel, Rémi N

Emerging infectious diseases

2020 Volume 26, Issue 9

Abstract: We spotted severe acute respiratory syndrome coronavirus 2 on polystyrene plastic, aluminum, and glass for 96 hours with and without bovine serum albumin (3 g/L). We observed a steady infectivity (<1 ... ...

Abstract	We spotted severe acute respiratory syndrome coronavirus 2 on polystyrene plastic, aluminum, and glass for 96 hours with and without bovine serum albumin (3 g/L). We observed a steady infectivity (<1 log
MeSH term(s)	Aluminum/analysis ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Transmission, Infectious ; Fomites/virology ; Glass/analysis ; Humans ; Pandemics ; Plastics/analysis ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Time Factors
Chemical Substances	Plastics ; Aluminum (CPD4NFA903)
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Letter
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2609.201788
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Article ; Online: SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021.

Gallian, Pierre / Hozé, Nathanaël / Brisbarre, Nadège / Saba Villarroel, Paola Mariela / Nurtop, Elif / Isnard, Christine / Pastorino, Boris / Richard, Pascale / Morel, Pascal / Cauchemez, Simon / de Lamballerie, Xavier

iScience

2023 Volume 26, Issue 4, Page(s) 106222

Abstract: We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n = 32605), from March-2020 to January-2021. A mathematical model combined seroprevalence with a daily number of hospital admissions to estimate the ... ...

Abstract	We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n = 32605), from March-2020 to January-2021. A mathematical model combined seroprevalence with a daily number of hospital admissions to estimate the probability of hospitalization upon infection and determine the number of infections while correcting for antibody decay. There was an overall seroprevalence increase over the study period and we estimate that ∼15% of the French population had been infected by SARS-CoV-2 by January-2021. The infection/hospitalization ratio increased with age, from 0.31% (18-30yo) to 4.5% (61-70yo). Half of the IgG-S1 positive individuals had no detectable antibodies 4 to 5 months after infection. The seroprevalence in group O donors (7.43%) was lower (p = 0.003) than in A, B, and AB donors (8.90%). We conclude, based on seroprevalence data and mathematical modeling, that a large proportion of the French population was unprotected against severe disease prior to the vaccination campaign.
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106222
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Biosafety and Biosecurity in European Containment Level 3 Laboratories: Focus on French Recent Progress and Essential Requirements.

Pastorino, Boris / de Lamballerie, Xavier / Charrel, Rémi

Frontiers in public health

2017 Volume 5, Page(s) 121

Abstract: Even if European Union (EU) Member States are obliged to implement EU Directives 2000/54/ ... ...

Abstract	Even if European Union (EU) Member States are obliged to implement EU Directives 2000/54/EC
Keywords	covid19
Language	English
Publishing date	2017-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2017.00121
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples

Pastorino, Boris / Touret, Franck / Gilles, Magali / Luciani, Lea / de Lamballerie, Xavier / Charrel, Remi N

Viruses. 2020 June 08, v. 12, no. 6

2020

Abstract: Clinical samples collected in coronavirus disease 19 (COVID-19), patients are commonly manipulated in biosafety level 2 laboratories for molecular diagnostic purposes. Here, we tested French norm NF-EN-14476+A2 derived from European standard EN-14885 to ... ...

Abstract	Clinical samples collected in coronavirus disease 19 (COVID-19), patients are commonly manipulated in biosafety level 2 laboratories for molecular diagnostic purposes. Here, we tested French norm NF-EN-14476+A2 derived from European standard EN-14885 to assess the risk of manipulating infectious viruses prior to RNA extraction. SARS-CoV-2 cell-culture supernatant and nasopharyngeal samples (virus-spiked samples and clinical samples collected in COVID-19 patients) were used to measure the reduction of infectivity after 10 min contact with lysis buffer containing various detergents and chaotropic agents. A total of thirteen protocols were evaluated. Two commercially available formulations showed the ability to reduce infectivity by at least 6 log 10, whereas others proved less effective.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; biosafety ; cell culture ; chemical treatment ; detergents ; pathogenicity ; patients ; risk assessment ; viruses
Language	English
Dates of publication	2020-0608
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v12060624
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?

Pastorino, Boris / Touret, Franck / Gilles, Magali / de Lamballerie, Xavier / Charrel, Remi N

Viruses

2020 Volume 12, Issue 7

Abstract: Standard precautions to minimize the risk of SARS-CoV-2 transmission implies that infected cell cultures and clinical specimens may undergo some sort of inactivation to reduce or abolish infectivity. We evaluated three heat inactivation protocols (56 °C- ... ...

Abstract	Standard precautions to minimize the risk of SARS-CoV-2 transmission implies that infected cell cultures and clinical specimens may undergo some sort of inactivation to reduce or abolish infectivity. We evaluated three heat inactivation protocols (56 °C-30 min, 60 °C-60 min and 92 °C-15 min) on SARS-CoV-2 using (i) infected cell culture supernatant, (ii) virus-spiked human sera (iii) and nasopharyngeal samples according to the recommendations of the European norm NF EN 14476-A2. Regardless of the protocol and the type of samples, a 4 Log
MeSH term(s)	Antibodies, Neutralizing/immunology ; Betacoronavirus/immunology ; COVID-19 ; Containment of Biohazards/methods ; Containment of Biohazards/standards ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Enzyme-Linked Immunosorbent Assay ; Hot Temperature ; Humans ; Neutralization Tests ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Serologic Tests/methods ; Serologic Tests/standards ; Virus Inactivation
Chemical Substances	Antibodies, Neutralizing
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12070735
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples.

Pastorino, Boris / Touret, Franck / Gilles, Magali / Luciani, Lea / de Lamballerie, Xavier / Charrel, Remi N

Viruses

2020 Volume 12, Issue 6

Abstract	Clinical samples collected in coronavirus disease 19 (COVID-19), patients are commonly manipulated in biosafety level 2 laboratories for molecular diagnostic purposes. Here, we tested French norm NF-EN-14476+A2 derived from European standard EN-14885 to assess the risk of manipulating infectious viruses prior to RNA extraction. SARS-CoV-2 cell-culture supernatant and nasopharyngeal samples (virus-spiked samples and clinical samples collected in COVID-19 patients) were used to measure the reduction of infectivity after 10 minute contact with lysis buffer containing various detergents and chaotropic agents. A total of thirteen protocols were evaluated. Two commercially available formulations showed the ability to reduce infectivity by at least 6 log 10, whereas others proved less effective.
MeSH term(s)	Animals ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; Betacoronavirus/physiology ; COVID-19 ; Cell Culture Techniques/methods ; Chlorocebus aethiops ; Containment of Biohazards/methods ; Containment of Biohazards/standards ; Coronavirus Infections/virology ; Humans ; Nasopharynx/virology ; Pandemics ; Pneumonia, Viral/virology ; RNA, Viral/isolation & purification ; SARS-CoV-2 ; Specimen Handling/methods ; Vero Cells ; Viral Load/methods ; Virus Inactivation/drug effects
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12060624
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors.

Gallian, Pierre / Pastorino, Boris / Morel, Pascal / Chiaroni, Jacques / Ninove, Laetitia / de Lamballerie, Xavier

Antiviral research

2020 Volume 181, Page(s) 104880

Abstract: We investigated the distribution of antibodies neutralizing SARS-CoV-2 according to age, sex or blood group in French blood donors. In 464 samples collected before the emergence of SARS-CoV-2 (2017 and 2018), our virus neutralization assay had a 100% ... ...

Abstract	We investigated the distribution of antibodies neutralizing SARS-CoV-2 according to age, sex or blood group in French blood donors. In 464 samples collected before the emergence of SARS-CoV-2 (2017 and 2018), our virus neutralization assay had a 100% specificity. It was used to test 998 samples collected from blood donors during the last week of March or the first week of April 2020. As expected at this stage of the outbreak, the prevalence was low (2.7%) and, importantly, criteria for blood donation imply that the vast majority of seropositives had asymptomatic or pauci-symptomatic SARS-CoV-2 infections. Seroprevalence values did not differ significantly among age groups (but were slightly higher in donors <30yo and ≥60yo), and between males and females (2.82% vs 2.69%), unlike what has been observed regarding hospitalizations admission to ICU and death rates in France. By contrast, we observed that the proportion of seropositives was significantly lower in group O donors (1.32% vs 3.86% in other donors, p = 0.014). We conclude that virus infection seems to occur with a similar incidence in men and women among French blood donors, but that blood group O persons are less at risk of being infected and not only of suffering from severe clinical presentations, as previously suggested.
MeSH term(s)	Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; Blood Donors ; Blood Group Antigens ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Female ; France/epidemiology ; Hospitalization ; Humans ; Incidence ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Risk ; SARS-CoV-2 ; Sensitivity and Specificity ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Blood Group Antigens
Keywords	covid19
Language	English
Publishing date	2020-07-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104880
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prolonged Infectivity of SARS-CoV-2 in Fomites

Boris Pastorino / Franck Touret / Magali Gilles / Xavier de Lamballerie / Rémi N. Charrel

Emerging Infectious Diseases, Vol 26, Iss 9, Pp 2256-

2020 Volume 2257

Abstract	We spotted severe acute respiratory syndrome coronavirus 2 on polystyrene plastic, aluminum, and glass for 96 hours with and without bovine serum albumin (3 g/L). We observed a steady infectivity (<1 log10 drop) on plastic, a 3.5 log10 decrease on glass, and a 6 log10 drop on aluminum. The presence of proteins noticeably prolonged infectivity.
Keywords	COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; SARS ; 2019 coronavirus disease ; zoonoses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216 ; covid19
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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