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Article ; Online: Exploring novel perspectives on eosinophilic inflammation in severe asthma.

Candia, Claudio / Ambrosino, Pasquale / D'Anna, Silvestro E / Motta, Andrea / Maniscalco, Mauro

2024

Abstract: Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely ... ...

Abstract	Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62L
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2023-0801
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Article ; Online: Somatosensory Evoked Potentials following upper limb noninvasive electrical stimulation: a case study.

Artoni, Fiorenzo / Tanguenza, Arianna / D'Anna, Edoardo / Micera, Silvestro

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2020 Volume 2020, Page(s) 2881–2884

Abstract: Lack of sensory feedback is one of the main issues contributing to lack of control and embodiment for upper-limb prostheses. Noninvasive nerve stimulation may help amputees overcome such limitations by providing a degree of somatotopic feedback, however ... ...

Abstract	Lack of sensory feedback is one of the main issues contributing to lack of control and embodiment for upper-limb prostheses. Noninvasive nerve stimulation may help amputees overcome such limitations by providing a degree of somatotopic feedback, however its neural correlates have been only partly characterized so far. While the effects of median nerve stimulation have been studied, little attention has been given to ulnar nerve and bipolar stimulation, which might provide a finer modulation of the somatotopic sensation. Here, monopolar and bipolar transcutaneous electrical nerve stimulation (TENS) is repeatedly applied to the ulnar and median nerves and elicited Somatosensory Evoked Potentials (SEPs) are characterized by means of electroencephalography (EEG). Clear P50, P150 and P270 SEPs were outlined, with significantly different amplitudes between configurations. In each case scalp topographies showed a strong contralateral activation in the early phase after the stimulus onset (40-100 ms), compatible with generators in the somatosensory cortex and in accordance to previous literature on actual tactile stimuli, which gives way to a frontal-central distribution at long latencies (130-190 ms). These findings, although needing further validation with a larger pool of subjects, show that bipolar TENS could have potential applications in improving prosthesis control with tactile feedback.
MeSH term(s)	Electric Stimulation ; Evoked Potentials, Somatosensory ; Humans ; Median Nerve ; Somatosensory Cortex ; Upper Extremity
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC44109.2020.9176722
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Article ; Online: A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity.

Formento, Emanuele / D'Anna, Edoardo / Gribi, Sandra / Lacour, Stéphanie P / Micera, Silvestro

Journal of neural engineering

2020 Volume 17, Issue 4, Page(s) 46019

Abstract: Objective: Electrical stimulation is an effective method for artificially modulating the activity of the nervous system. However, current stimulation paradigms fail to reproduce the stochastic and asynchronous properties of natural neural activity. Here, ...

Abstract	Objective: Electrical stimulation is an effective method for artificially modulating the activity of the nervous system. However, current stimulation paradigms fail to reproduce the stochastic and asynchronous properties of natural neural activity. Here, we introduce a novel biomimetic stimulation (BioS) strategy that overcomes these limitations. Approach: We hypothesized that high-frequency amplitude-modulated bursts of stimulation could induce asynchronous neural firings by distributing recruitment over the duration of a burst, without sacrificing the ability to precisely control neural activity. We tested this hypothesis using computer simulations and ex vivo experiments. Main results: We found that BioS bursts induce asynchronous, stochastic, yet controllable, neural activity. We established that varying the amplitude, duration, and repetition frequency of a BioS burst enables graded modulation of the number of recruited fibers, their firing rate, and the synchronicity of their responses. Significance: These results demonstrate an unprecedented level of control over artificially induced neural activity, enabling the design of next-generation BioS paradigms with potentially profound consequences for the field of neurostimulation.
MeSH term(s)	Biomimetics ; Electric Stimulation ; Nervous System
Language	English
Publishing date	2020-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/aba4fc
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Article ; Online: Corrigendum: A Psychometric Platform to Collect Somatosensory Sensations for Neuroprosthetic Use.

Valle, Giacomo / Iberite, Francesco / Strauss, Ivo / D'Anna, Edoardo / Granata, Giuseppe / Di Iorio, Riccardo / Stieglitz, Thomas / Raspopovic, Stanisa / Petrini, Francesco M / Rossini, Paolo M / Micera, Silvestro

Frontiers in medical technology

2022 Volume 4, Page(s) 866538

Abstract: This corrects the article DOI: 10.3389/fmedt.2021.619280.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmedt.2021.619280.].
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Published Erratum
ISSN	2673-3129
ISSN (online)	2673-3129
DOI	10.3389/fmedt.2022.866538
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Article ; Online: A Psychometric Platform to Collect Somatosensory Sensations for Neuroprosthetic Use.

Frontiers in medical technology

2021 Volume 3, Page(s) 619280

Abstract: Somatosensory neuroprostheses exploit invasive and non-invasive feedback technologies to restore sensorimotor functions lost to disease or trauma. These devices use electrical stimulation to communicate sensory information to the brain. A sensation ... ...

Abstract	Somatosensory neuroprostheses exploit invasive and non-invasive feedback technologies to restore sensorimotor functions lost to disease or trauma. These devices use electrical stimulation to communicate sensory information to the brain. A sensation characterization procedure is thus necessary to determine the appropriate stimulation parameters and to establish a clear personalized map of the sensations that can be restored. Several questionnaires have been described in the literature to collect the quality, type, location, and intensity of the evoked sensations, but there is still no standard psychometric platform. Here, we propose a new psychometric system containing previously validated questionnaires on evoked sensations, which can be applied to any kind of somatosensory neuroprosthesis. The platform collects stimulation parameters used to elicit sensations and records subjects' percepts in terms of sensation location, type, quality, perceptual threshold, and intensity. It further collects data using standardized assessment questionnaires and scales, performs measurements over time, and collects phantom limb pain syndrome data. The psychometric platform is user-friendly and provides clinicians with all the information needed to assess the sensory feedback. The psychometric platform was validated with three trans-radial amputees. The platform was used to assess intraneural sensory feedback provided through implanted peripheral nerve interfaces. The proposed platform could act as a new standardized assessment toolbox to homogenize the reporting of results obtained with different technologies in the field of somatosensory neuroprosthetics.
Language	English
Publishing date	2021-03-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3129
ISSN (online)	2673-3129
DOI	10.3389/fmedt.2021.619280
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Article: Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.

D'Anna, Silvestro E / Maniscalco, Mauro / Carriero, Vitina / Gnemmi, Isabella / Caramori, Gaetano / Nucera, Francesco / Righi, Luisella / Brun, Paola / Balbi, Bruno / Adcock, Ian M / Stella, Maria Grazia / Ricciardolo, Fabio L M / Di Stefano, Antonino

Journal of clinical medicine

2020 Volume 9, Issue 6

Abstract: Background: ...

Abstract	Background:
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9061807
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Article ; Online: Sensitivity to temporal parameters of intraneural tactile sensory feedback.

Valle, Giacomo / Strauss, Ivo / D'Anna, Edoardo / Granata, Giuseppe / Di Iorio, Riccardo / Stieglitz, Thomas / Rossini, Paolo Maria / Raspopovic, Stanisa / Petrini, Francesco Maria / Micera, Silvestro

Journal of neuroengineering and rehabilitation

2020 Volume 17, Issue 1, Page(s) 110

Abstract: Background: Recent studies have shown that neural stimulation can be used to provide artificial sensory feedback to amputees eliciting sensations referred on the amputated hand. The temporal properties of the neural stimulation modulate aspects of ... ...

Abstract	Background: Recent studies have shown that neural stimulation can be used to provide artificial sensory feedback to amputees eliciting sensations referred on the amputated hand. The temporal properties of the neural stimulation modulate aspects of evoked sensations that can be exploited in a bidirectional hand prosthesis. Methods: We previously collected evidence that the derivative of the amplitude of the stimulation (intra-digit temporal dynamics) allows subjects to recognize object compliance and that the time delay among stimuli injected through electrodes implanted in different nerves (inter-digit temporal distance) allows to recognize object shapes. Nevertheless, a detailed characterization of the subjects' sensitivity to variations of intra-digit temporal dynamic and inter-digit temporal distance of the intraneural tactile feedback has not been executed. An exhaustive understanding of the overall potentials and limits of intraneural stimulation to deliver sensory feedback is of paramount importance to bring this approach closer and closer to the natural situation. To this aim, here we asked two trans-radial amputees to identify stimuli with different temporal characteristics delivered to the same active site (intra-digit temporal Dynamic Recognition (DR)) or between two active sites (inter-digit Temporal distance Recognition (TR)). Finally, we compared the results achieved for (simulated) TR with conceptually similar experiments with real objects with one subject. Results: We found that the subjects were able to identify stimuli with temporal differences (perceptual thresholds) larger than 0.25 s for DR and larger than 0.125 s for TR, respectively. Moreover, we also found no statistically significant differences when the subjects were asked to identify three objects during simulated 'open-loop' TR experiments or real 'closed-loop' tests while controlling robotic hand. Conclusions: This study is a new step towards a more detailed analysis of the overall potentials and limits of intraneural sensory feedback. A full characterization is necessary to develop more advanced prostheses capable of restoring all lost functions and of being perceived more as a natural limb by users.
MeSH term(s)	Adult ; Amputees/rehabilitation ; Artificial Limbs ; Electric Stimulation Therapy/methods ; Feedback, Sensory/physiology ; Female ; Hand/physiology ; Humans ; Middle Aged ; Robotics ; Touch/physiology
Language	English
Publishing date	2020-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-020-00737-8
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Article: Hand Control With Invasive Feedback Is Not Impaired by Increased Cognitive Load.

Valle, Giacomo / D'Anna, Edoardo / Strauss, Ivo / Clemente, Francesco / Granata, Giuseppe / Di Iorio, Riccardo / Controzzi, Marco / Stieglitz, Thomas / Rossini, Paolo M / Petrini, Francesco M / Micera, Silvestro

Frontiers in bioengineering and biotechnology

2020 Volume 8, Page(s) 287

Abstract: Recent experiments have shown that neural stimulation can successfully restore sensory feedback in upper-limb amputees improving their ability to control the prosthesis. However, the potential advantages of invasive sensory feedback with respect to non- ... ...

Abstract	Recent experiments have shown that neural stimulation can successfully restore sensory feedback in upper-limb amputees improving their ability to control the prosthesis. However, the potential advantages of invasive sensory feedback with respect to non-invasive solutions have not been yet identified. Our hypothesis was that a difference would appear when the subject cannot focus all the attention to the use of the prosthesis, but some additional activities require his/her cognitive attention, which is a quite common situation in real-life conditions. To verify this hypothesis, we asked a trans-radial amputee, equipped with a bidirectional hand prosthesis, to perform motor tasks also in combination with a cognitive task. Sensory feedback was provided via intraneural (invasive) or electro-tactile (non-invasive) stimulation. We collected also data related to self-confidence. While both approaches were able to significantly improve the motor performance of the subject when no additional cognitive effort was asked, the manual accuracy was not affected by the cognitive task only when intraneural feedback was provided. The highest self-confidence was obtained when intraneural sensory feedback was provided. Our findings show that intraneural sensory feedback is more robust to dual tasks than non-invasive feedback. This is the first direct comparison between invasive and non-invasive approaches for restoring sensory feedback and it could suggest an advantage of using invasive solutions.
Language	English
Publishing date	2020-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2020.00287
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Article ; Online: A somatotopic bidirectional hand prosthesis with transcutaneous electrical nerve stimulation based sensory feedback.

D'Anna, Edoardo / Petrini, Francesco M / Artoni, Fiorenzo / Popovic, Igor / Simanić, Igor / Raspopovic, Stanisa / Micera, Silvestro

Scientific reports

2017 Volume 7, Issue 1, Page(s) 10930

Abstract: According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, ...

Abstract	According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, and their long-term usability still needs to be fully investigated. Here, we developed a non-invasive alternative which maintains some of the advantages of invasive approaches, such as a somatotopic sensory restitution scheme. We used transcutaneous electrical nerve stimulation (TENS) to induce referred sensations to the phantom hand of amputees. These sensations were characterized in four amputees over two weeks. Although the induced sensation was often paresthesia, the location corresponded to parts of the innervation regions of the median and ulnar nerves, and electroencephalographic (EEG) recordings confirmed the presence of appropriate responses in relevant cortical areas. Using these sensations as feedback during bidirectional prosthesis control, the patients were able to perform several functional tasks that would not be possible otherwise, such as applying one of three levels of force on an external sensor. Performance during these tasks was high, suggesting that this approach could be a viable alternative to the more invasive solutions, offering a trade-off between the quality of the sensation, and the invasiveness of the intervention.
MeSH term(s)	Adult ; Amputees ; Feedback, Sensory ; Female ; Hand ; Humans ; Male ; Prostheses and Implants ; Transcutaneous Electric Nerve Stimulation
Language	English
Publishing date	2017-09-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-11306-w
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Article ; Online: Brain reactions to the use of sensorized hand prosthesis in amputees.

Granata, Giuseppe / Di Iorio, Riccardo / Miraglia, Francesca / Caulo, Massimo / Iodice, Francesco / Vecchio, Fabrizio / Valle, Giacomo / Strauss, Ivo / D'anna, Edoardo / Iberite, Francesco / Lauretti, Liverana / Fernandez, Eduardo / Romanello, Roberto / Petrini, Francesco M / Raspopovic, Stanisa / Micera, Silvestro / Rossini, Paolo M

Brain and behavior

2020 Volume 10, Issue 11, Page(s) e01734

Abstract: Objective: We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis.: Methods: A multimodal neurophysiological and ...

Abstract	Objective: We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis. Methods: A multimodal neurophysiological and neuroimaging evaluation of brain functional changes occurring during training in five consecutive amputees participating to experimental trials with robotic hands over a period of 10 years was carried out. In particular, modifications to the functional anatomy of sensorimotor brain areas under resting conditions were explored in order to check for eventual changes with respect to baseline. Results: Full evidence is provided to demonstrate brain functional changes, and some of them in both the hemispheres and others restricted to the hemisphere contralateral to the amputation/prosthetic hand. Conclusions: The study describes a unique experimental experience showing that brain reactions to the prolonged use of an artificial hand can be tracked for a tailored approach to a fully embedded artificial upper limb for future chronic uses in daily activities.
MeSH term(s)	Amputation ; Amputees ; Artificial Limbs ; Hand ; Humans ; Upper Extremity
Language	English
Publishing date	2020-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.1734
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