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Article ; Online: Effects of a physiotherapeutic protocol in cardiorespiratory, muscle strength, aerobic capacity and quality of life after hematopoietic stem cell transplantation.

Morais, Natalia Igv / Palhares, Luciana Campanatti / Miranda, Eliana Cm / Lima, Carmen Sp / De Souza, Carmino A / Vigorito, Afonso C

Hematology, transfusion and cell therapy

2021 Volume 45, Issue 2, Page(s) 154–158

Abstract: Objective: To analyze the effects of hospital cardiorespiratory physical therapy protocol on the functional capacity and quality of life of patients submitted to hematopoietic stem cell transplantation (HSCT).: Methods: From January to December 2019, ...

Abstract	Objective: To analyze the effects of hospital cardiorespiratory physical therapy protocol on the functional capacity and quality of life of patients submitted to hematopoietic stem cell transplantation (HSCT). Methods: From January to December 2019, bilateral dynamometry, Manovacuometry and Ventilometry, peak expiratory flow "Peak Flow", 6-min walk test (6MWT), SF-36 Quality of Life Questionnaire and Visual Analog Scale (VAS) were applied in patients who have undergone an allogeneic or autologous hematopoietic stem cell transplantation (HSCT), pre-conditioning (initial evaluation) and pre-discharge (final evaluation). The patients were submitted to an intervention protocol, consisting of aerobic training, muscle strengthening and respiratory muscle training, between the two assessments. Results: 29 patients were enrolled in the study and 24 (83%) completed all procedure. Myeloablative and reduced intensity conditioning were performed in 89.6% and 10.4%, respectively; 17 (58%) patients have undergone an autologous HSCT; 10 (35%) identical related allogeneic HSCT, and 2 (7%) haploidentical allogeneic HSCT. The median number of interventions per patient was 3 (1-9). A decreasing in the right and left dynamometry (p ≤ 0.0001 and 0.002, respectively) and, also in the distance covered in the 6MWT (p = 0.004), was observed after HSCT. There was no significant difference in respiratory muscle strength, quality of life and fatigue sensation. Conclusion: Cardiorespiratory rehabilitation can preserve functional capacity and quality of life.
Language	English
Publishing date	2021-09-10
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2021.08.003
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Article ; Online: Oral shedding of CMV and HSV-1 in hematopoietic stem cell transplantation patients.

Costa, Andre L F / Santos, Bruna A / Torregrossa, Vinicius R / Miranda, Eliana C M / Vigorito, Afonso C / Palmieri, Michelle / Ricardo, Ana L F / Sarmento, Dmitry J S / Mamana, Ana C / Tozetto-Mendoza, Tania R / Correa, M Elvira P / Braz-Silva, Paulo H

Oral diseases

2020 Volume 27, Issue 6, Page(s) 1572–1579

Abstract: Objectives: To evaluate the oral shedding of herpesviruses in patients undergoing hematopoietic stem cell transplantation (HSCT) and correlate it with oral mucositis (OM).: Methods: Saliva samples were collected before the HSCT and on day D + 8. ... ...

Abstract	Objectives: To evaluate the oral shedding of herpesviruses in patients undergoing hematopoietic stem cell transplantation (HSCT) and correlate it with oral mucositis (OM). Methods: Saliva samples were collected before the HSCT and on day D + 8. Multiplex Polymerse Chain Reaction (PCR) was performed to detect herpes simplex virus (HSV)-1 and HSV-2, Epstein-Barr virus (EBV), Cytomegalovirus (CMV), Variella-zoster virus (VZV), and human herpesvirus (HHV)-6, HHV-7, and HHV-8. OM was assessed according to WHO criteria. Results: Thirty one patients were enrolled, in which 20 of 31 (64.5%) were males; median age was 50 (21-70) years; 16 of 31 (51.6%) underwent allo-HSCT; and 15 of 31 (48.4%) underwent auto-HSCT. On D + 8, OM grades III and IV were observed in 8 of 31 (25.8%) patients. In the first salivary collection, EBV was found in 24 of 31 (77.4%), followed by HHV-6 (7/31, 22.6%) and HHV-7 (8/31 25.8%). In the second collection, EBV was found in 24 of 27(89%), followed by HSV-1 (8/27, 30%) and CMV, HHV-6, and HHV-7 (5/27, 18.5%, each one). On D + 8, OM grades II and IV were associated with the presence of HSV-1. HSV-1 was also associated with worsening degrees of OM on D + 15. Conclusion: The presence of HSV-1 and CMV in oral samples was more frequent on day D + 8 after HSCT. HSV-1 detection was associated with severity and worsening of OM. HSV-1 and CMV seem to be associated with oral dysbiosis due to HSCT.
MeSH term(s)	Cytomegalovirus/genetics ; Cytomegalovirus Infections ; DNA, Viral ; Epstein-Barr Virus Infections/complications ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 1, Human/genetics ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Middle Aged
Chemical Substances	DNA, Viral
Language	English
Publishing date	2020-11-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.13690
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Article ; Online: Sinonasal disorders in hematopoietic stem cell transplantation.

Bento, Lucas Ricci / Ortiz, Erica / Nicola, Ester Maria Danieli / Vigorito, Afonso C / Sakano, Eulalia

Brazilian journal of otorhinolaryngology

2014 Volume 80, Issue 4, Page(s) 285–289

Abstract: Introduction: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression.: Objective: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between ... ...

Abstract	Introduction: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. Objective: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. Methods: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. Results: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. Conclusion: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment.
MeSH term(s)	Chronic Disease ; Graft vs Host Disease ; Hematologic Diseases/surgery ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Retrospective Studies ; Rhinitis/diagnosis ; Rhinitis/etiology ; Sinusitis/diagnosis ; Sinusitis/etiology
Language	English
Publishing date	2014-06-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2014.05.009
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Article ; Online: Sinonasal disorders in hematopoietic stem cell transplantation

Lucas Ricci Bento / Erica Ortiz / Ester Maria Danieli Nicola / Afonso C. Vigorito / Eulalia Sakano

Brazilian Journal of Otorhinolaryngology , Vol 80, Iss 4, Pp 285-

2014 Volume 289

Abstract: INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between ... ...

Abstract	INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. METHODS: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. RESULTS: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. CONCLUSION: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment.
Keywords	Sinusite ; Transplante de células-tronco hematopoéticas ; Condutas terapêuticas ; Doença enxerto-hospedeiro ; Otorhinolaryngology ; RF1-547 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transplante de células-tronco hematopoéticas e a regeneração da hematopoese Hematopoietic stem cell transplant and recovery of hematopoiesis

Afonso C. Vigorito / Cármino A. de Souza

Revista Brasileira de Hematologia e Hemoterapia, Vol 31, Iss 4, Pp 280-

2009 Volume 284

Abstract: As células-tronco hematopoéticas periféricas (CTP) praticamente substituíram a medula óssea (MO) como fonte de células-tronco hematopoéticas nos transplantes autólogos e nos últimos anos é usada com maior frequência nos alogênicos, particularmente no ... ...

Abstract	As células-tronco hematopoéticas periféricas (CTP) praticamente substituíram a medula óssea (MO) como fonte de células-tronco hematopoéticas nos transplantes autólogos e nos últimos anos é usada com maior frequência nos alogênicos, particularmente no tratamento de doenças avançadas. A recuperação hematopoética, utilizando esta fonte de células, é mais rápida após a utilização de CTP comparada com a MO. O sangue de cordão umbilical surgiu como uma outra fonte de células-tronco hematopoéticas para a realização de transplantes. O risco mínimo para o doador e a rápida disponibilidade estão entre as vantagens desta fonte de células. A recuperação mais lenta de neutrófilos e plaquetas é a maior preocupação do ponto de vista clínico. A biópsia de MO pode ser uma importante ferramenta para a obtenção de informações em relação à recuperação hematopoética após os transplantes de células-tronco hematopoéticas (TCTH). A histopatologia da reconstituição hematopoética da MO, após um transplante de sangue de cordão umbilical, demonstra um atraso quando comparada com os transplantes de MO. Entretanto, ocorre uma recuperação hematopoética gradual e, tardiamente, não são observadas diferenças entre os transplantes com MO e sangue de cordão umbilical. A histologia da MO, por sua vez, não esclarece a origem genotípica da hematopoese pós-transplante. Assim, a análise do quimerismo tornou-se um instrumento importante para o acompanhamento da enxertia e é a base da intervenção terapêutica para evitar a rejeição do enxerto, manter a enxertia e tratar uma recidiva clínica iminente através da imunoterapia. Esta revisão destacará a recuperação hematopoética após a realização de um TCTH. Mobilized peripheral blood has replaced the use of bone marrow as a source of hematopoietic stem cells in most autologous transplants and is increasingly used in allogeneic transplants. The hematopoietic reconstitution after using mobilized peripheral blood is faster compared to bone marrow. Umbilical cord blood has emerged as another rich source of hematopoietic stem cells for transplantation. The minimal risk to the donor and the rapid availability are among the great advantages of this stem cell source. The slow recovery of neutrophil and platelet counts is the major clinical concern. Bone marrow biopsy is an important tool for obtaining information regarding the hematopoietic recovery after hematopoietic stem cell transplantation. The histopathological hematopoietic reconstitution of the bone marrow after umbilical cord blood transplantation is delayed compared to bone marrow transplantation. However, gradual hematopoietic recovery is seen, and afterwards no other differences comparing bone marrow and umbilical cord transplants are observed. Bone marrow histology does not elucidate the genotypic origin of post-transplant hematopoiesis. Hence, chimerism analysis has become an important instrument for engraftment surveillance, and is the basis for treatment intervention to avoid graft rejection, to maintain engraftment, and to treat clinical imminent relapse by immunotherapy. This review focuses on the hematopoietic recovery after hematopoietic stem cell transplantation.
Keywords	Transplante de células-tronco hematopoéticas ; regeneração ; hemopoiese ; Hematopoietic stem cell transplant ; recovery ; hematopoiesis ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-08-01T00:00:00Z
Publisher	Sociedade Brasileira de Hematologia e Hemoterapia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chronic graft-versus-host-disease treatment in Brazil: analyses of failure-free survival.

Vigorito, Afonso Celso / Miranda, Eliana Cristina Martins / Colturato, Vergilio Antonio Rensi / Funke, Vaneuza Araujo Moreira / Fatobene, Giancarlo / Mariano, Livia / Macedo, Maria Cristina Martins de Almeida / Ribeiro, Lorena Bedotti / Daudt, Liane Esteves / Moreira, Maria Cláudia Rodrigues / Bonfim, Carmem / Colella, Marcos Paulo / Seber, Adriana / Rodrigues, Morgani / Duarte, Fernando Barroso / Martin, Paul J / Flowers, Mary E D

Transplantation and cellular therapy

2023 Volume 29, Issue 4, Page(s) 276.e1–276.e7

Abstract: Failure-free survival (FFS), defined as the absence of new systemic treatment, recurrence of original malignancy and mortality not associated with recurrence after allogeneic hematopoietic stem cell transplantation (HCT), is a robust clinical measure to ... ...

Abstract	Failure-free survival (FFS), defined as the absence of new systemic treatment, recurrence of original malignancy and mortality not associated with recurrence after allogeneic hematopoietic stem cell transplantation (HCT), is a robust clinical measure to interpret results of initial systemic treatment of chronic graft-versus-host disease (cGVHD). We evaluate FFS after initial treatment of cGVHD in a mixed-race cohort from a resource-constrained country. This retrospective study included 354 consecutive patients after their first HCT between January 2014 and August 2020, who received initial systemic treatment for moderate or severe cGVHD at 13 Brazilian centers. Cox regression models were used to identify risk factors for treatment failure. The overall median follow-up among survivors was 28 months (range 1-71) after initial treatment. FFS was 89% at 6 months, 71% at 1 year and 52% at 2 years. New systemic treatment was the major cause of failure. In multivariable models, prior grades II-IV acute GVHD, a National Institutes of Health severity score of 3 in liver, gastrointestinal tract or lung involvement, and onset of initial treatment of cGVHD within 12 months after transplantation were all associated with an increased risk of treatment failure. Our results could serve as a benchmark for the design of future clinical trials evaluating initial treatment of cGVHD in resource-constrained locations.
MeSH term(s)	United States ; Humans ; Brazil/epidemiology ; Retrospective Studies ; Bronchiolitis Obliterans Syndrome ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease/drug therapy
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2023.01.007
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Article ; Online: Adherence to tyrosine kinase inhibitor therapy for chronic myeloid leukemia: a Brazilian single-center cohort.

de Almeida, Maria H / Pagnano, Katia B B / Vigorito, Afonso C / Lorand-Metze, Irene / de Souza, Carmino A

Acta haematologica

2013 Volume 130, Issue 1, Page(s) 16–22

Abstract: The introduction of oral tyrosine kinase inhibitors (TKIs) has dramatically improved outcomes in chronic myeloid leukemia (CML) patients. However, treatment success is directly related to good long-term adherence. Adherence to TKI therapy was evaluated ... ...

Abstract	The introduction of oral tyrosine kinase inhibitors (TKIs) has dramatically improved outcomes in chronic myeloid leukemia (CML) patients. However, treatment success is directly related to good long-term adherence. Adherence to TKI therapy was evaluated in 137 CML patients over a period of 1 year. Three different methods were used to evaluate adherence: the Morisky questionnaire, a medication diary and the medication possession ratio (MPR). MPR was the most effective method of assessing adherence (median adherence 96.5%; p = 0.0001), duration of TKI treatment was the variable that most impacted adherence (p = 0.03), and the MPR was inversely correlated to the duration of therapy. Additionally, participation in clinical trials, better quality of life as reported by patients and higher socioeconomic status were all related to better compliance (p = 0.02, 0.007 and 0.01, respectively). For patients treated with imatinib for 24-48 months (n = 22), individuals with major molecular response (MMR) had a significantly better MPR than those who failed to achieve MMR (p = 0.04). In this group, the mean MPR was 87% for the population without apparent molecular response and 96% for those achieving MMR; however, only 24% of the patients were completely adherent to TKI treatment.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Benzamides/therapeutic use ; Brazil ; Child ; Cohort Studies ; Female ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Piperazines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyrimidines/therapeutic use ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
Chemical Substances	Benzamides ; Piperazines ; Protein Kinase Inhibitors ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2013-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000345722
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Article ; Online: Histological features of the nasal mucosa in hematopoietic stem cell transplantation.

Ortiz, Érica / Sakano, Eulália / Meirelles, Luciana R / Vigorito, Afonso C / Cintra, Maria L / Paschoal, Ilma A / Chone, Carlos T

American journal of rhinology & allergy

2011 Volume 25, Issue 5, Page(s) 191–195

Abstract: Background: Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD). Histological descriptions ... ...

Abstract	Background: Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD). Histological descriptions of the oral mucosa, lung ciliary epithelium, and intestinal mucosa related to HSCT have been described. However, few have described the nasal mucosa. We, therefore, sought to elucidate the histological and ultrastructural features of the nasal mucosa in patients after HSCT to better understand the pathophysiology of the immune response. Methods: Uncinate processes from 24 HSCT patients and 12 immunocompetent patients were subjected to histological analyses via light and transmission electron microscopy (TEM). Results: TEM revealed aberrant cilia structure, altered mitochondria quantity, microvilli, and cytoplasm vacuolization. All HSCT patients with rhinosinusitis had significant loss or absence of cilia (p = 0.018). Apoptotic bodies were increased and Goblet cells decreased in nasal epithelium from patients with chronic GVHD (p = 0.04). Conclusion: This tissue destruction likely enhances pathogen penetration resulting in recurrent infection.
Language	English
Publishing date	2011-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.2500/ajra.2011.25.3644
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Article ; Online: Histological features of the nasal mucosa in hematopoietic stem cell transplantation.

Ortiz, Erica / Sakano, Eulália / Meirelles, Luciana R / Vigorito, Afonso C / Cintra, Maria L / Paschoal, Ilma A / Chone, Carlos T

American journal of rhinology & allergy

2011 Volume 25, Issue 5, Page(s) e191–5

Abstract	Background: Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD). Histological descriptions of the oral mucosa, lung ciliary epithelium, and intestinal mucosa related to HSCT have been described. However, few have described the nasal mucosa. We, therefore, sought to elucidate the histological and ultrastructural features of the nasal mucosa in patients after HSCT to better understand the pathophysiology of the immune response. Methods: Uncinate processes from 24 HSCT patients and 12 immunocompetent patients were subjected to histological analyses via light and transmission electron microscopy (TEM). Results: TEM revealed aberrant cilia structure, altered mitochondria quantity, microvilli, and cytoplasm vacuolization. All HSCT patients with rhinosinusitis had significant loss or absence of cilia (p = 0.018). Apoptotic bodies were increased and Goblet cells decreased in nasal epithelium from patients with chronic GVHD (p = 0.04). Conclusion: This tissue destruction likely enhances pathogen penetration resulting in recurrent infection.
MeSH term(s)	Adult ; Aged ; Apoptosis ; Cilia/ultrastructure ; Goblet Cells/pathology ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppression ; Microscopy, Electron, Transmission ; Middle Aged ; Mitochondria/ultrastructure ; Nasal Mucosa/immunology ; Nasal Mucosa/ultrastructure ; Rhinitis/immunology ; Rhinitis/pathology ; Rhinitis/therapy ; Sinusitis/immunology ; Sinusitis/pathology ; Sinusitis/therapy ; Vacuoles/ultrastructure ; Young Adult
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.2500/ajra.2011.25.3644
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Article: Quantifying loss of CD34+ cells collected by apheresis after processing for freezing and post-thaw.

Castelhano, Mariana V / Reis-Alves, Suiellen C / Vigorito, Afonso C / Rocha, Felipe F / Pereira-Cunha, Fernanda G / De Souza, Carmino A / Lorand-Metze, Irene

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2013 Volume 48, Issue 2, Page(s) 241–246

Abstract: Introduction: CD34(+) cells collected for autologous bone marrow transplantation (BMT) are usually quantified in the apheresis product after collection, but the necessity to repeat these measures post-thaw is controversial.: Methods: We examined the ... ...

Abstract	Introduction: CD34(+) cells collected for autologous bone marrow transplantation (BMT) are usually quantified in the apheresis product after collection, but the necessity to repeat these measures post-thaw is controversial. Methods: We examined the loss of CD34(+) cells after collection, preparation for freezing and post-thaw in apheresis products collected for BMT. Results: Median number of CD34(+) cells collected per unit was 1.61×10(6)/kg, viability: 97-100%. This number decreased to 1.38×10(6)/kg, viability: 96-100% before freezing and was 1.17×10(6)/kg post-thaw. Viability decreased to 86-98%. The relative loss of viable PBHPC showed an inverse correlation with the ratio "CD34(+) cells/total nucleated cells" (r=-0.45; p=<0.0005). This relative loss was largest in patients with Hodgkin's lymphoma. Conclusion: Cryopreservation and thawing of PBHPCs in leukapheresis products provokes a small but significant stem cell loss. So, quantification of viable CD34(+) cells post-thaw is important, especially in poorly mobilizing patients. Besides, the ratio "CD34(+) cells/total nucleated cells" after leukapheresis is an important parameter for prediction of neutrophil recovery after BMT.
MeSH term(s)	Antigens, CD34/metabolism ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Bone Marrow Transplantation ; Cell Survival ; Cryopreservation ; Female ; Humans ; Leukapheresis ; Lymphoma, Non-Hodgkin/metabolism ; Lymphoma, Non-Hodgkin/pathology ; Lymphoma, Non-Hodgkin/therapy ; Male ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Multiple Myeloma/therapy ; Time Factors ; Transplantation, Autologous
Chemical Substances	Antigens, CD34
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2013.01.017
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In stock of ZB MED Cologne/Königswinter

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