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Article: Incidence, Pattern, Causes, and Outcome of Acute Chest Pain Among Patients Presenting in the Emergency Department of a Tertiary Care Hospital in North India.

Mateen, Saboor / Masakputra, Vasim / Siddiqi, Zeba / Fatima, Jalees

2024 Volume 16, Issue 3, Page(s) e56115

Abstract: Background: Acute chest pain is a common presentation in emergency departments worldwide. Differentiating between cardiac and non-cardiac chest pain is crucial for patient management and resource allocation.: Methods: This study analyzed 714 patients ...

Abstract	Background: Acute chest pain is a common presentation in emergency departments worldwide. Differentiating between cardiac and non-cardiac chest pain is crucial for patient management and resource allocation. Methods: This study analyzed 714 patients presenting with acute chest pain in a tertiary care hospital in North India. We investigated demographic characteristics, chief complaints, risk factors, ECG findings, and final diagnoses to identify patterns associated with cardiac (CCP) and non-cardiac chest pain (NCCP). Results: CCP was diagnosed in 53.7% (n=383) and NCCP in 46.3% (n=331). Significant predictors of CCP included age (OR=1.05, p<0.001), smoking (OR=2.22, p<0.001), diabetes (OR=1.57, p=0.003), hypertension (OR=1.82, p<0.001), and family history of ischemic heart disease (IHD) (OR=1.42, p=0.01). Central chest pain was more common in CCP (60% vs. 40%, p<0.001), as were abnormal ECG findings such as ST-segment depression (35% vs. 10%, p<0.001) and elevation (29% vs. 6%, p<0.001). Normal ECG was more prevalent in NCCP (60%, p<0.001). Conclusion: Traditional cardiovascular risk factors remain strongly associated with CCP. Smoking has a particularly high odds ratio, suggesting the need for targeted interventions. ECG findings significantly aid in differentiating CCP from NCCP. This study underscores the importance of a comprehensive approach in evaluating acute chest pain to ensure accurate diagnosis and effective treatment.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56115
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Article ; Online: Interactions between diabetic and hypertensive drugs: a pharmacogenetics approach.

Ansari, Asma Imran / Rizvi, Aliya Abbas / Verma, Shrikant / Abbas, Mohammad / Siddiqi, Zeba / Mishra, Divakar / Verma, Sushma / Raza, Syed Tasleem / Mahdi, Farzana

Molecular genetics and genomics : MGG

2023 Volume 298, Issue 4, Page(s) 803–812

Abstract: Diabetes is known to increase susceptibility to hypertension due to increase in inflammation, oxidative stress, and endothelial dysfunction, leading to vascular stiffness. The polytherapy might lead to several drug-drug interactions (DDIs), which cause ... ...

Abstract	Diabetes is known to increase susceptibility to hypertension due to increase in inflammation, oxidative stress, and endothelial dysfunction, leading to vascular stiffness. The polytherapy might lead to several drug-drug interactions (DDIs), which cause certain life-threatening complications such as diabetic nephropathy and hypoglycaemia. So, in this review we focused on drug-drug interactions and impact of genetic factors on drug responses for better disease management. Drug-drug interactions (DDIs) may act either synergistically or antagonistically. For instance, a combination of metformin with angiotensin II receptor antagonist or angiotensin-converting enzyme inhibitors (ACEIs) synergistically improves glucose absorption, whereas the same hypertensive drug combination with sulphonylurea might cause severe hypoglycaemia sometimes. Thiazolidinediones (TDZs) can cause fluid retention and heart failure when taken alone, but a combination of angiotensin II receptor antagonist with TZDs prevents these side effects. Interindividual genetic variation affects the DDI response. We found two prominent genes, GLUT4 and PPAR-γ, which are common targets for most of the drug. So, all of these findings established a connection between drug-drug interaction and genetics, which might be used for effective disease management.
MeSH term(s)	Humans ; Pharmacogenetics ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/genetics ; Hypertension/drug therapy ; Hypertension/genetics ; Angiotensin Receptor Antagonists/adverse effects ; Hypoglycemia
Chemical Substances	Angiotensin Receptor Antagonists
Language	English
Publishing date	2023-05-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2044817-X
ISSN	1617-4623 ; 1617-4615
ISSN (online)	1617-4623
ISSN	1617-4615
DOI	10.1007/s00438-023-02011-7
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Article ; Online: Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases

Syed Tasleem Raza / Saliha Rizvi / Sheeba Afreen / Sanchita Srivastava / Zainab Siddiqui / Naseem Fatima / Zeba Siddiqi / Farzana Mahdi

Advances in Biomarker Sciences and Technology, Vol 5, Iss , Pp 57-

2023 Volume 67

Abstract: Background: Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels of blood sugar associated with long-term damage, organs failure, especially the ... ...

Abstract	Background: Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels of blood sugar associated with long-term damage, organs failure, especially the eyes, heart, kidneys, blood vessels and nerves whose frequency has increased progressively worldwide. Objectives: The aims of this study were to evaluate the plasma levels of miRNA-126, miRNA-486, miRNA-223 and miRNA-375 in newly diagnosed T2DM susceptible and healthy control individuals. Methods: In this study, we evaluated the T2DM-related miRNAs miRNA-126, miRNA-486, miRNA-223 and miRNA-375 in plasma of three study groups comprising healthy control (N = 36), newly diagnosed T2DM (N = 29) and T2DM susceptible individuals (N = 30) using Real Time polymerase chain reaction (RT-PCR) (Taqman®). All the statistical analysis were done using SPSS version 21software. Results: Significant associations were found between these parameters. The expression levels of miR-126, miR-486, miR-223, and miR-375 were downregulated in T2DM patients and further reduced in T2DM-susceptible individuals compared to healthy controls. Additionally, miR-223 and miR-375 showed an inverse correlation with HbA1c levels, while all four miRs displayed an inverse correlation with FBS levels in the combined group analysis. Conclusion: These observed associations further suggest that miR-126, miR-223, and miR-375 may be involved in the regulation of glucose metabolism and glycemic control. Their down regulation could potentially contribute to impaired insulin signaling, beta-cell dysfunction, inflammation, and disrupted glucose homeostasis, all of which are characteristics of diabetes.
Keywords	miR-126 ; miR-486 ; miR-223 and miR-375 ; Type 2 diabetes mellitus ; Gene regulation ; miRNA ; Toxicology. Poisons ; RA1190-1270 ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	KeAi Communications Co. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prevalence of Comorbidities in Survivors and Non-Survivors of Severe COVID-19 at a Dedicated COVID Care Centre.

Siddiqi, Zeba / Fatima, Jalees / Bhatt, Divyansh / Shukla, Vaibhav / Malik, Mustahsin / Ashfaq, Aquib / Masakputra, Vasim / Barbhuyan, Aditya

The Journal of the Association of Physicians of India

2022 Volume 70, Issue 1, Page(s) 11–12

Abstract: Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. Diseases such as diabetes, hypertension, cardiovascular and pulmonary diseases are common comorbidities in COVID-19 patients and have ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. Diseases such as diabetes, hypertension, cardiovascular and pulmonary diseases are common comorbidities in COVID-19 patients and have been correlated with increased disease severity. Comorbidities lead the COVID-19 patient into a vicious infectious circle and are substantially associated with significant morbidity and mortality. This study was aimed to estimate prevalence of comorbidities in severe category of COVID survivors and non survivors. More than 90% patients with multiple comorbidities admitted to ICU did not survive compared to those with one or two comorbidities. Diabetes followed by hypertension was the most common comorbidity in these patients. Thus comorbid individuals must adopt vigilant preventive measures including vaccination and they require intensive management for better outcome.
MeSH term(s)	COVID-19 ; Comorbidity ; Humans ; Intensive Care Units ; Prevalence ; SARS-CoV-2 ; Survivors
Language	English
Publishing date	2022-01-17
Publishing country	India
Document type	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
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Article ; Online: Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity.

Verma, Shrikant / Verma, Sushma / Khan, Faizan Haider / Siddiqi, Zeba / Raza, Syed Tasleem / Abbas, Mohammad / Mahdi, Farzana

International journal of immunogenetics

2022 Volume 50, Issue 1, Page(s) 5–11

Abstract: Coronavirus disease-2019 (COVID-19) is pro-inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin-6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and associated with ...

Abstract	Coronavirus disease-2019 (COVID-19) is pro-inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin-6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and associated with the severity in COVID-19 patients. The differential expression of IL6 cytokine in COVID-19 patients may be associated with the presence of single nucleotide polymorphisms (SNPs) in regulatory region of cytokine genes. The aim of this study is to investigate the role of two promoter polymorphisms of the IL6 gene (-597G > A and -174G > C) with the severity of COVID-19. The study included 242 patients, out of which 97 patients with severe symptoms and 145 patients with mild symptoms of COVID-19. Genotyping of two selected SNPs, rs1800795 (-174G > C) and rs1800797 (-597G > A) of promoter region of IL6 gene, was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In our study, individuals with GC genotypes of IL6 (-174G > C) polymorphism showed significantly higher risk of severity [adjusted odds (OR) 3.86, p <.001] but we did not observe any association of COVID-19 severity with rs1800797 (-597G > A) polymorphism. The COVID-19 severity was significantly higher in individuals having 'C' allele of IL6 (-174G > C) polymorphism (p = .014). Linkage disequilibrium between rs1800795 (-174G > C) and rs1800797 (-597G > A) showed that individuals having AC* haplotype significantly association with COVID-19 severity (p = .034). Our results suggest that 'C' allele of rs1800795 (-174G > C) polymorphism of IL6 may be the risk allele for severity of COVID-19 in North Indian population.
MeSH term(s)	Humans ; Interleukin-6/genetics ; Genetic Predisposition to Disease ; COVID-19/genetics ; Genotype ; Polymorphism, Single Nucleotide ; Gene Frequency
Chemical Substances	Interleukin-6
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2177883-8
ISSN	1744-313X ; 1744-3121
ISSN (online)	1744-313X
ISSN	1744-3121
DOI	10.1111/iji.12605
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Zs.A 994: Show issues

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Article ; Online: Comparative study between WIDAL and DOT ELISA in the diagnosis of Typhoid fever

Sarah Hassan / Vineeta Khare / Shadma Yaqool / Syed Abid Asghar / Mastan Singh / Zeba Siddiqi

Asian Journal of Medical Sciences, Vol 12, Iss 4, Pp 81-

2021 Volume 85

Abstract: Background: Typhoid fever, also known as enteric fever, is a communicable disease, found only in man and occurs due to systemic infection mainly by Salmonella typhi organisms. Blood culture is regarded as the gold standard for diagnosis and carry 70-75% ... ...

Abstract	Background: Typhoid fever, also known as enteric fever, is a communicable disease, found only in man and occurs due to systemic infection mainly by Salmonella typhi organisms. Blood culture is regarded as the gold standard for diagnosis and carry 70-75% diagnostic yield in the first week of illness. Aims and Objective: To compare the sensitivity and specificity of Widal test and dot ELISA with blood culture in the early diagnosis of Typhoid fever. Materials and Methods: A Cross-Sectional study was carried out in the Department of Microbiology, Era’s Lucknow Medical College and Hospital for a period of 18 months. Patients presenting with acute febrile illness suspicious of typhoid fever accompanied by clinical signs and symptoms of typhoid fever in the absence of any other known febrile illnesses, were included in the study. Widal and Dot ELISA was performed using serum samples and for blood culture aseptically collected blood was used. Results: Sensitivity, Specificity, PPV, NPV of DOT ELISA as compared to Blood culture for typhoid positivity was found to be 92.6%, 83.7%, 55.6% and 98.1% respectively. Diagnostic accuracy of DOT ELISA as compared to Blood culture was found to be 85.3%. Conclusion: For both early and late diagnosis of typhoid fever with high sensitivity as well as accuracy for identification of typhoid fever, the rapid diagnostic test (Dot Elisa) is better than the Widal test. However, it may be an increased burden to healthcare owing to a low positive predictive value in a low prevalence scenario.
Keywords	dot elisa ; salmonella typhi ; widal test ; blood culture ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
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Article: Study of Association of Metabolic Syndrome and Risk Factors of Nephrolithiasis.

Karoli, Ritu / Fatima, Jalees / Karoli, Yogesh / Singh, Prem Shanker / Siddiqi, Zeba / Shukla, Vaibhav / Khan, Faraz Ahmad

The Journal of the Association of Physicians of India

2021 Volume 69, Issue 1, Page(s) 32–35

Abstract: Background and aim: The increasing incidence of nephrolithiasis in recent decades is coinciding with rising epidemic of obesity, metabolic syndrome, and type 2 diabetes. This temporal concordance suggests that a link might exist between these metabolic ... ...

Abstract	Background and aim: The increasing incidence of nephrolithiasis in recent decades is coinciding with rising epidemic of obesity, metabolic syndrome, and type 2 diabetes. This temporal concordance suggests that a link might exist between these metabolic abnormalities and urinary stone disease. Therefore, the present study was aimed to investigate the association between presence of risk factors of nephrolithiasis and metabolic syndrome. Methods: In a hospital-based, case control study, hundred patients of metabolic syndrome diagnosed according to IDF criteria and hundred age and matched controls were studied for presence of risk factors of nephrolithiasis. Results: Patients with metabolic syndrome had significantly higher uricosuri a,hypercalciuria,oxaluria and hypocitraturia. The prevalence of risk factors of nephrolithiasis was also higher in patients with metabolic syndrome. The most prevalent was low urinary pH in 40% patients with mean pH of 5.8±1.6. Amongst other factors, 33% had hyperuricemia, 29% had hypercalciuria, 15% had oxaluria 13% had hypocitraturia and 10% had hyperuricosuria. Significant correlation was observed between risk factors of nephrolithiasis and components of metabolic syndrome. Conclusion: The present study provides an evidence of association between risk factors of nephrolithiasis and metabolic syndrome and suggests that nephrolithiasis may be a systemic disorder representing the interaction of multiple metabolic derangements. Determining common modifiable risk factors for the development of kidney stones might uncover new preventive strategies.
MeSH term(s)	Case-Control Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Kidney Calculi ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Risk Factors
Language	English
Publishing date	2021-07-06
Publishing country	India
Document type	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
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Article: A Clinical Study to Evaluate the Association Between Metabolic Syndrome and Sensorineural Hearing Loss.

Bhargava, Anuja / Faiz, Syed Mohd / Srivastava, Saurabh / Gupta, Rajeev Krishna / Siddiqi, Zeba / Agarwal, Ekta / Gupta, Sneha

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2021 Volume 73, Issue 3, Page(s) 346–350

Abstract: Metabolic syndrome is considered to be a triggering factor for deterioration of health related quality of life. In present study we assessed hearing loss consequent to metabolic syndrome. A total of 100 patients diagnosed for metabolic syndrome (IDF ... ...

Abstract	Metabolic syndrome is considered to be a triggering factor for deterioration of health related quality of life. In present study we assessed hearing loss consequent to metabolic syndrome. A total of 100 patients diagnosed for metabolic syndrome (IDF criteria) were included in the study. All the patients underwent pure tone audiometry and impedance audiometry. All the patients underwent anthropometric measurements, lipid profile, blood sugar and blood pressure assessments. Data was analyzed using SPSS 21.0 software. A total of 62% patients had sensorineural hearing loss. Maximum (35%) had mild hearing loss, followed by moderate hearing loss (23%). Only 4 (4%) cases had severe hearing loss. Older age, wider waist circumference, higher fasting blood glucose levels and lower blood pressure were found to be significantly associated with sensorineural hearing loss and its severity on univariate analysis. However, on multivariate assessment only age and waist circumference showed a significant association with hearing loss.
Language	English
Publishing date	2021-05-05
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-021-02539-3
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Zs.A 5300: Show issues

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Article ; Online: Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.

Abbas, Mohammad / Verma, Sushma / Verma, Shrikant / Siddiqui, Sahabjada / Khan, Faizan H / Raza, Syed T / Siddiqi, Zeba / Eba, Ale / Mahdi, Farzana

Journal of medical virology

2021 Volume 93, Issue 9, Page(s) 5446–5451

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global health issue and develops into a broad range of illnesses from asymptomatic to fatal respiratory diseases. SARS-CoV-2 ...

Abstract	Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global health issue and develops into a broad range of illnesses from asymptomatic to fatal respiratory diseases. SARS-CoV-2 infection is associated with oxidative stress that triggers cytokine production, inflammation, and other pathophysiological processes. Glutathione-S-transferase (GST) is an important enzyme that catalyzes the conjugation of glutathione (GSH) with electrophiles to protect the cell from oxidative damage and participates in the antioxidant defense mechanism in the lungs. Thus, in this study, we investigated the role of GSTM1 and GSTT1 gene polymorphism with COVID-19 susceptibility, as well as its outcome. The study included 269 RT-PCR confirmed COVID-19 patients with mild (n = 149) and severe (n = 120) conditions. All subjects were genotyped for GSTM1 and GSTT1 by multiplex polymerase chain reaction (mPCR) followed by statistical analysis. The frequency of GSTM1
MeSH term(s)	Adult ; Aged ; Alleles ; COVID-19/genetics ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Female ; Follow-Up Studies ; Gene Expression ; Gene Frequency ; Genetic Predisposition to Disease ; Glutathione/metabolism ; Glutathione Transferase/genetics ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Polymorphism, Genetic ; Proportional Hazards Models ; SARS-CoV-2/pathogenicity ; Severity of Illness Index
Chemical Substances	glutathione S-transferase T1 (EC 2.5.1.-) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2021-06-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27076
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Zs.A 1320: Show issues

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Article: Association between

Raza, Syed Tasleem / Abbas, Shania / Siddiqi, Zeba / Mahdi, Farzana

International journal of molecular and cellular medicine

2017 Volume 6, Issue 2, Page(s) 121–130

Abstract: Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to ... ...

Abstract	Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of
Language	English
Publishing date	2017-07-04
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2697015-6
ISSN	2251-9645 ; 2251-9637
ISSN (online)	2251-9645
ISSN	2251-9637
DOI	10.22088/acadpub.BUMS.6.2.6
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