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  1. Article: The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential.

    Shin, Yeo Jin / Kwon, Ki-Sun / Suh, Yousin / Lee, Kwang-Pyo

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1308274

    Abstract: Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly ...

    Abstract Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1308274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of non-coding RNAs in muscle aging

    Yeo Jin Shin / Ki-Sun Kwon / Yousin Suh / Kwang-Pyo Lee

    Frontiers in Molecular Biosciences, Vol

    regulatory mechanisms and therapeutic potential

    2024  Volume 10

    Abstract: Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly ...

    Abstract Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.
    Keywords ncRNA ; miRNA ; lncRNA ; circRNA ; skeletal muscle ; aging ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New

    Lee, Kang-In / Jo, Yousang / Yuk, Heung Joo / Kim, Sun-Young / Kim, Hyungjun / Kim, Hye Jin / Hwang, Soo-Keol / Park, Ki-Sun

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety ... ...

    Abstract Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13030340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Combined Hurdle Technologies Using UVC Waterproof LED for Inactivating Foodborne Pathogens on Fresh-Cut Fruits.

    Kim, Geun-Hyang / Lee, Chae-Lim / Yoon, Ki-Sun

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: This study investigated the combined bactericidal efficacy of slightly acidic electrolyzed water (SAEW), fumaric acid (FA), and ultravioletC waterproof light-emitting diodes (UVC W-LED) for the control ... ...

    Abstract This study investigated the combined bactericidal efficacy of slightly acidic electrolyzed water (SAEW), fumaric acid (FA), and ultravioletC waterproof light-emitting diodes (UVC W-LED) for the control of
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10081712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effects of Combined Aerosolization with Ultraviolet C Light-Emitting Diode on Enterohemorrhagic

    Lee, Chae-Lim / Kim, Geun-Hyang / Yoon, Ki-Sun

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: Washing soft fresh produce such as strawberries, baby leaves, and sliced onions with sanitizing agents is challenging due to their fragile texture. Thus, treatments like aerosolization using slightly acidic electrolyzed water (SAEW) and ultraviolet C ... ...

    Abstract Washing soft fresh produce such as strawberries, baby leaves, and sliced onions with sanitizing agents is challenging due to their fragile texture. Thus, treatments like aerosolization using slightly acidic electrolyzed water (SAEW) and ultraviolet C light-emitting diode (UVC LED) irradiation may be good alternatives. In the present study, the reduction effects of a combined treatment of aerosolization using SAEW and UVC LED irradiation on enterohemorrhagic
    Language English
    Publishing date 2021-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10081834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Automatic Pharyngeal Phase Recognition in Untrimmed Videofluoroscopic Swallowing Study Using Transfer Learning with Deep Convolutional Neural Networks

    Ki-Sun Lee / Eunyoung Lee / Bareun Choi / Sung-Bom Pyun

    Diagnostics, Vol 11, Iss 2, p

    2021  Volume 300

    Abstract: Background: Video fluoroscopic swallowing study (VFSS) is considered as the gold standard diagnostic tool for evaluating dysphagia. However, it is time consuming and labor intensive for the clinician to manually search the recorded long video image frame ...

    Abstract Background: Video fluoroscopic swallowing study (VFSS) is considered as the gold standard diagnostic tool for evaluating dysphagia. However, it is time consuming and labor intensive for the clinician to manually search the recorded long video image frame by frame to identify the instantaneous swallowing abnormality in VFSS images. Therefore, this study aims to present a deep leaning-based approach using transfer learning with a convolutional neural network (CNN) that automatically annotates pharyngeal phase frames in untrimmed VFSS videos such that frames need not be searched manually. Methods: To determine whether the image frame in the VFSS video is in the pharyngeal phase, a single-frame baseline architecture based the deep CNN framework is used and a transfer learning technique with fine-tuning is applied. Results: Compared with all experimental CNN models, that fine-tuned with two blocks of the VGG-16 (VGG16-FT5) model achieved the highest performance in terms of recognizing the frame of pharyngeal phase, that is, the accuracy of 93.20 (±1.25)%, sensitivity of 84.57 (±5.19)%, specificity of 94.36 (±1.21)%, AUC of 0.8947 (±0.0269) and Kappa of 0.7093 (±0.0488). Conclusions: Using appropriate and fine-tuning techniques and explainable deep learning techniques such as grad CAM, this study shows that the proposed single-frame-baseline-architecture-based deep CNN framework can yield high performances in the full automation of VFSS video analysis.
    Keywords videofluoroscopic swallowing study ; action recognition ; deep learning ; convolutional neural network ; transfer learning ; Medicine (General) ; R5-920
    Subject code 006
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Paeoniflorin Alleviates Skeletal Muscle Atrophy in Ovariectomized Mice through the ERα/NRF1 Mitochondrial Biogenesis Pathway.

    Park, Ki-Sun / Kim, Hyungjun / Kim, Hye Jin / Lee, Kang-In / Lee, Seo-Young / Kim, Jieun

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 4

    Abstract: Muscle atrophy in postmenopausal women is caused by estrogen deficiency and a variety of inflammatory factors, including tumor necrosis factor alpha (TNFα). Paeoniflorin (PNF), a natural compound with anti-inflammatory properties, improves estradiol ... ...

    Abstract Muscle atrophy in postmenopausal women is caused by estrogen deficiency and a variety of inflammatory factors, including tumor necrosis factor alpha (TNFα). Paeoniflorin (PNF), a natural compound with anti-inflammatory properties, improves estradiol synthesis. Here, we demonstrate that PNF inhibits the progression of TNFα-induced skeletal muscle atrophy after menopause by restoring mitochondrial biosynthesis. Differentiated myoblasts damaged by TNFα were restored by PNF, as evident by the increase in the expression of myogenin (MyoG) and myosin heavy chain 3 (Myh3)-the markers of muscle differentiation. Moreover, diameter of atrophied myotubes was restored by PNF treatment. TNFα-repressed nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) (a major regulator of mitochondrial biosynthesis) were restored by PNF, via regulation by estrogen receptor alpha (ERα), an upregulator of NRF1. This mechanism was confirmed in ovariectomized (OVX) mice with a ~40% reduction in the cross-sectional area of the anterior tibialis muscle. OVX mice administered PNF (100, 300 mg/kg/day) for 12 weeks recovered more than ~20%. Behavioral, rotarod, and inverted screen tests showed that PNF enhances reduced muscle function in OVX mice. ERα restored expression of mitofusin 1 (MFN1) and mitofusin 2 (MFN2) (mitochondrial fusion markers) and dynamin-related protein (DRP1) and fission 1 (FIS1) (mitochondrial fission markers). Therefore, PNF can prevent muscle atrophy in postmenopausal women by inhibiting dysfunctional mitochondrial biogenesis.
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15040390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Automatic Pharyngeal Phase Recognition in Untrimmed Videofluoroscopic Swallowing Study Using Transfer Learning with Deep Convolutional Neural Networks.

    Lee, Ki-Sun / Lee, Eunyoung / Choi, Bareun / Pyun, Sung-Bom

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 2

    Abstract: Background: Video fluoroscopic swallowing study (VFSS) is considered as the gold standard diagnostic tool for evaluating dysphagia. However, it is time consuming and labor intensive for the clinician to manually search the recorded long video image ... ...

    Abstract Background: Video fluoroscopic swallowing study (VFSS) is considered as the gold standard diagnostic tool for evaluating dysphagia. However, it is time consuming and labor intensive for the clinician to manually search the recorded long video image frame by frame to identify the instantaneous swallowing abnormality in VFSS images. Therefore, this study aims to present a deep leaning-based approach using transfer learning with a convolutional neural network (CNN) that automatically annotates pharyngeal phase frames in untrimmed VFSS videos such that frames need not be searched manually.
    Methods: To determine whether the image frame in the VFSS video is in the pharyngeal phase, a single-frame baseline architecture based the deep CNN framework is used and a transfer learning technique with fine-tuning is applied.
    Results: Compared with all experimental CNN models, that fine-tuned with two blocks of the VGG-16 (VGG16-FT5) model achieved the highest performance in terms of recognizing the frame of pharyngeal phase, that is, the accuracy of 93.20 (±1.25)%, sensitivity of 84.57 (±5.19)%, specificity of 94.36 (±1.21)%, AUC of 0.8947 (±0.0269) and Kappa of 0.7093 (±0.0488).
    Conclusions: Using appropriate and fine-tuning techniques and explainable deep learning techniques such as grad CAM, this study shows that the proposed single-frame-baseline-architecture-based deep CNN framework can yield high performances in the full automation of VFSS video analysis.
    Language English
    Publishing date 2021-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11020300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identification of novel genes associated with exercise and calorie restriction effects in skeletal muscle.

    Kang, Jae Sook / Kim, Min Ju / Kwon, Eun-Soo / Lee, Kwang-Pyo / Kim, Chuna / Kwon, Ki-Sun / Yang, Yong Ryoul

    Aging

    2023  Volume 15, Issue 11, Page(s) 4667–4684

    Abstract: Exercise and caloric restriction (CR) significantly increase longevity across a range of species and delay aging-related losses in organ function. Although both interventions enhance skeletal muscle function, the molecular mechanisms underlying these ... ...

    Abstract Exercise and caloric restriction (CR) significantly increase longevity across a range of species and delay aging-related losses in organ function. Although both interventions enhance skeletal muscle function, the molecular mechanisms underlying these associations are unknown. We sought to identify genes regulated by CR and exercise in muscle, and investigate their relationship with muscle function. To do this, expression profiles of Gene Expression Omnibus datasets obtained from the muscle tissue of calorie-restricted male primates and young men post-exercise were analyzed. There were seven transcripts (
    MeSH term(s) Male ; Mice ; Animals ; Caloric Restriction ; Muscle, Skeletal/metabolism ; Aging/metabolism ; Longevity ; Physical Conditioning, Animal/physiology ; Adaptor Proteins, Signal Transducing/metabolism
    Chemical Substances Pygo1 protein, mouse ; Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Synergistic effect of UV-C LED irradiation and PLA/PBAT-based antimicrobial packaging film on fresh-cut vegetables

    Kim, Hyun-Ji / Lee, Chae-Lim / Yoon, Ki-Sun / Rhim, Jong-Whan

    Food control. 2022 Aug., v. 138

    2022  

    Abstract: The combined use of ultraviolet-C light-emitting diodes (UV–C LED) irradiation and antimicrobial packaging film was used to secure the safety of fresh-cut vegetables. The antimicrobial packaging film was prepared by adding grapefruit seed extract (GSE) ... ...

    Abstract The combined use of ultraviolet-C light-emitting diodes (UV–C LED) irradiation and antimicrobial packaging film was used to secure the safety of fresh-cut vegetables. The antimicrobial packaging film was prepared by adding grapefruit seed extract (GSE) and zinc oxide nanoparticles (ZnO) to a blend film of poly(lactide) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT). The GSE and ZnO added film (PLA/PBAT/GSE/ZnO film) showed moderate antioxidant activity of about 36.3% and 21.9% in the ABTS and DPPH methods, respectively, and exhibited strong antibacterial activity against Enterohemorrhagic Escherichia coli (EHEC) and Staphylococcus aureus. The UV-C LED treatment reduced EHEC by 0.47, 0.55, and 0.61 Log CFU/g and S. aureus by 0.46, 0.39, and 0.33 Log CFU/g of fresh-cut onion, cabbage, and carrot, respectively. The combined UV-C LED irradiation and antimicrobial packaging showed a significant synergistic effect in reducing the bacteria during storage. After 7 days of storage at 10 °C, it showed 2.02, 2.82, and 2.06 log CFU/g lower E. coli, and 1.59, 1.77, and 1.47 log CFU/g lower S. aureus in onion, cabbage, and carrot, respectively, than the control group. The combined use of UV-C LED and antimicrobial packaging has a high potential to extend the shelf life of fresh-cut vegetables without heat treatment or the addition of chemical preservatives.
    Keywords Staphylococcus aureus ; antibacterial properties ; antioxidant activity ; cabbage ; carrots ; enterohemorrhagic Escherichia coli ; food safety ; grapefruits ; heat treatment ; irradiation ; onions ; seed extracts ; shelf life ; synergism ; ultraviolet radiation ; zinc oxide
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1027805-9
    ISSN 0956-7135
    ISSN 0956-7135
    DOI 10.1016/j.foodcont.2022.109027
    Database NAL-Catalogue (AGRICOLA)

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