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  1. Article ; Online: Cerebrospinal fluid metagenomics has greatest added value as a test for Powassan virus among patients in New England with suspected central nervous system infection.

    Klontz, Erik H / Solomon, Isaac H / Turbett, Sarah E / Lemieux, Jacob E / Branda, John A

    Diagnostic microbiology and infectious disease

    2024  Volume 108, Issue 4, Page(s) 116169

    Abstract: Cerebrospinal fluid (CSF) metagenomic next generation sequencing (mNGS) can detect diverse pathogens in patients with central nervous system infection. Due to its high cost and unclear clinical utility, it is typically reserved for patients with ... ...

    Abstract Cerebrospinal fluid (CSF) metagenomic next generation sequencing (mNGS) can detect diverse pathogens in patients with central nervous system infection. Due to its high cost and unclear clinical utility, it is typically reserved for patients with unrevealing routine workups. A multi-center retrospective analysis of real-world CSF mNGS was performed involving orders between 2017 and 2022 at a large New England healthcare system. CSF mNGS was performed 64 times with 17 positive results (27 %). In 11/17 positive samples (65 %), the infectious agent had not been previously detected using routine methods. Arboviruses (n = 8) were the most frequently detected agents, particularly Powassan virus (n = 6). Results changed therapy in 3/64 cases (5 %). Positive results were associated with immunodeficiency (p = 0.06), especially anti-B-cell therapy (p = 0.02), and earlier sample collection (p = 0.06). The association with compromised humoral immunity was stronger in the arbovirus and Powassan virus subgroups (p = 0.001), whose constituents were older than the overall cohort and had higher mortality rates.
    MeSH term(s) Humans ; Central Nervous System Infections ; Encephalitis Viruses, Tick-Borne ; High-Throughput Nucleotide Sequencing ; Metagenomics/methods ; New England ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2023.116169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Laboratory Diagnosis for SARS-CoV-2 Infection.

    Christensen, Bianca B / Azar, Marwan M / Turbett, Sarah E

    Infectious disease clinics of North America

    2022  Volume 36, Issue 2, Page(s) 327–347

    Abstract: The optimal diagnostic test for SARS-CoV-2 infection should be selected based on a patient's clinical syndrome and presentation in relation to symptom onset. Molecular testing, most often reverse-transcriptase polymerase chain reaction, offers the ... ...

    Abstract The optimal diagnostic test for SARS-CoV-2 infection should be selected based on a patient's clinical syndrome and presentation in relation to symptom onset. Molecular testing, most often reverse-transcriptase polymerase chain reaction, offers the highest sensitivity and specificity during acute infection, whereas antigen testing can also be useful for acute diagnosis when rapid turnaround of results is necessary or if molecular testing is unavailable. Serologic testing is often reserved for identifying individuals with prior or late COVID-19 infection.
    MeSH term(s) COVID-19/diagnosis ; Humans ; Molecular Diagnostic Techniques ; SARS-CoV-2
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2022.02.002
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  3. Article ; Online: Severe antigen excess confounding the detection of

    Grewal, Eric P / Russo, Anthony R / Roth, Maxwell T / Rogaishio, Eunice L / Turbett, Sarah E / Rosenberg, Eric S / Branda, John A / Nussbaum, Eliezer Zachary

    Journal of clinical pathology

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Letter
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2024-209438
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  4. Article ; Online: Case 9-2022: A 56-Year-Old Woman with Fever, Myalgias, Diarrhea, and Cough.

    Vyas, Jatin M / Castle, Alison C / Bourgouin, Patrick P / Turbett, Sarah E

    The New England journal of medicine

    2022  Volume 386, Issue 12, Page(s) 1166–1174

    MeSH term(s) Anaplasma phagocytophilum/isolation & purification ; Anaplasmosis/complications ; Anaplasmosis/diagnosis ; Bias ; COVID-19/diagnosis ; Cough/etiology ; Decision Making ; Diagnosis, Differential ; Diarrhea/etiology ; Female ; Fever/etiology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Middle Aged ; Myalgia/etiology ; Symptom Assessment
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2115846
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  5. Article ; Online: Evaluation of the rapid Quidel Sofia Lyme fluorescent immunoassay as a first-tier test in a modified 2-tier testing algorithm for Lyme disease: A comparison with the Zeus ELISA Borrelia VlsE1/pepC10 lgG/IgM assay followed by the Zeus monovalent IgM/IgG confirmatory assay.

    Lee-Lewandrowski, Elizabeth / Turbett, Sarah / Branda, John A / Lewandrowski, Kent

    American journal of clinical pathology

    2023  Volume 160, Issue 6, Page(s) 599–602

    Abstract: Objectives: Recently modified 2-tier testing (MTTT) algorithms using 2 enzyme immunoassays (EIAs) as opposed to an EIA followed by immunoblot have been approved by the US Food and Drug Administration (FDA) for the screening and confirmation of Lyme ... ...

    Abstract Objectives: Recently modified 2-tier testing (MTTT) algorithms using 2 enzyme immunoassays (EIAs) as opposed to an EIA followed by immunoblot have been approved by the US Food and Drug Administration (FDA) for the screening and confirmation of Lyme disease. The Quidel Sofia Lyme fluorescent immunoassay is a rapid lateral-flow method that can be performed in real time, permitting on-demand testing. We evaluated the performance of the Sofia assay as a first-tier test in an MTTT algorithm.
    Methods: We compared the Sofia Lyme test with the Zeus ELISA Borrelia VlsE1/pepC10 lgG/IgM test, followed by the Zeus monovalent IgM/IgG EIA as the confirmatory test.
    Results: When used as a first-tier test compared with a standard Zeus MTTT assay, the positive percentage agreement was 91.4%% (95% CI, 77.6%-97.0%). The negative percentage agreement was 100% (95% CI, 94.0%-100%). The overall agreement was 98.3% (95% CI, 94.2%-99.4%). κ = 0.945, indicating "almost perfect agreement."
    Conclusions: The Sofia Lyme test performs well compared with an FDA-approved MTTT.
    MeSH term(s) Humans ; Borrelia ; Sensitivity and Specificity ; Antibodies, Bacterial ; Serologic Tests/methods ; Immunoglobulin G ; Lyme Disease/diagnosis ; Enzyme-Linked Immunosorbent Assay ; Algorithms ; Coloring Agents ; Immunoglobulin M
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin G ; Coloring Agents ; Immunoglobulin M
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad094
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  6. Article ; Online: Rapid antimicrobial resistance detection methods for bloodstream infection in solid organ transplantation: Proposed clinical guidance, unmet needs, and future directions.

    Turbett, Sarah E / Banach, David B / Bard, Jennifer Dien / Gandhi, Ronak G / Letourneau, Alyssa R / Azar, Marwan M

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 6, Page(s) e14113

    Abstract: Recent advances in antimicrobial resistance detection have spurred the development of multiple assays that can accurately detect the presence of bacterial resistance from positive blood cultures, resulting in faster institution of effective antimicrobial ...

    Abstract Recent advances in antimicrobial resistance detection have spurred the development of multiple assays that can accurately detect the presence of bacterial resistance from positive blood cultures, resulting in faster institution of effective antimicrobial therapy. Despite these advances, there are limited data regarding the use of these assays in solid organ transplant (SOT) recipients and there is little guidance on how to select, implement, and interpret them in clinical practice. We describe a practical approach to the implementation and interpretation of these assays in SOT recipients using the best available data and expert opinion. These findings were part of a consensus conference sponsored by the American Society of Transplantation held on December 7, 2021 and represent the collaboration between experts in transplant infectious diseases, pharmacy, antimicrobial and diagnostic stewardship, and clinical microbiology. Areas of unmet need and recommendations for future investigation are also presented.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Drug Resistance, Bacterial ; Anti-Infective Agents/therapeutic use ; Transplant Recipients ; Communicable Diseases ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-08-18
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14113
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  7. Article ; Online: Implementation of a SARS-CoV-2 Genotyping Panel for Prompt Omicron Variant Identification: A Pragmatic Tool for Clinical Laboratories.

    Nussbaum, Eliezer Zachary / Thiriveedhi, Vamsi / Uddin, Rockib / Cho, Ha Eun / Carroll, Seamus / Rosenberg, Eric S / Lemieux, Jacob E / Turbett, Sarah E

    Annals of internal medicine

    2022  Volume 175, Issue 6, Page(s) 906–908

    MeSH term(s) COVID-19 ; Genotype ; Humans ; Laboratories, Clinical ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Research Support, U.S. Gov't, P.H.S. ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-0023
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  8. Article ; Online: Editorial Commentary: Fecal ESBL Screening: Are We Ready for This Information?

    Turbett, Sarah E / Mansour, Michael K

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2016  Volume 63, Issue 3, Page(s) 319–321

    MeSH term(s) Enterobacteriaceae ; Enterobacteriaceae Infections ; Feces ; Humans ; beta-Lactamases
    Chemical Substances beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciw288
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  9. Article ; Online: Case 12-2020: A 24-Year-Old Man with Fever, Cough, and Dyspnea.

    Barros, Nicolas / McDermott, Shaunagh / Wong, Alexandra K / Turbett, Sarah E

    The New England journal of medicine

    2020  Volume 382, Issue 16, Page(s) 1544–1553

    MeSH term(s) Animals ; Antibodies, Viral/blood ; Bites and Stings/complications ; Bronchoscopy ; Cough/etiology ; Diagnosis, Differential ; Dyspnea/etiology ; Fever/etiology ; Hantavirus Pulmonary Syndrome/complications ; Hantavirus Pulmonary Syndrome/diagnosis ; Hantavirus Pulmonary Syndrome/transmission ; Humans ; Leukocyte Count ; Leukocytosis/diagnosis ; Leukocytosis/etiology ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Mice ; Peromyscus ; Pneumonia/diagnosis ; Sin Nombre virus/immunology ; Sin Nombre virus/isolation & purification ; Thrombocytopenia/diagnosis ; Thrombocytopenia/etiology ; Tomography, X-Ray Computed ; Vaping/adverse effects ; Young Adult
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc1916256
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  10. Article ; Online: Case 2-2020: A 64-Year-Old Man with Fever and Respiratory Failure.

    Azar, Marwan M / Muse, Victorine V / Villalba, Julian A / Turbett, Sarah E

    The New England journal of medicine

    2020  Volume 382, Issue 3, Page(s) 276–285

    MeSH term(s) Acute Kidney Injury/etiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Bronchoalveolar Lavage Fluid/microbiology ; Coccidioidomycosis/complications ; Coccidioidomycosis/diagnosis ; Diagnosis, Differential ; Fatal Outcome ; Fever/etiology ; Glomerulonephritis/complications ; Glomerulonephritis/diagnosis ; Heart Failure/etiology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases, Fungal/complications ; Lung Diseases, Fungal/diagnosis ; Male ; Middle Aged ; Myocardium/pathology ; Pneumonia/diagnosis ; Radiography, Thoracic ; Respiratory Insufficiency/etiology
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc1913468
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