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Article ; Online: Oncostatin M: A mysterious cytokine in cancers.

Masjedi, Ali / Hajizadeh, Farnaz / Beigi Dargani, Farzaneh / Beyzai, Behzad / Aksoun, Mohsen / Hojjat-Farsangi, Mohammad / Zekiy, Angelina / Jadidi-Niaragh, Farhad

International immunopharmacology

2020 Volume 90, Page(s) 107158

Abstract: Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role ...

Abstract	Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor has been detected in various cancers including colon cancer, breast cancer, pancreatic cancer, myeloma, brain tumors, chronic lymphocytic leukemia, and hepatoblastoma. STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and all other hallmarks of cancer cells. However, due to the presence of multiple signaling pathways, it can act contradictory in some cancers. In this review, we will discuss the emerging roles of OSM in cancer and elucidate its function in tumor control or progression and finally discuss therapeutic approaches designed to manipulate this cytokine in cancer.
MeSH term(s)	Animals ; Cytokines/metabolism ; Cytokines/therapeutic use ; Humans ; Mice ; Neoplasms/immunology ; Neoplasms/metabolism ; Oncostatin M/metabolism ; Oncostatin M/therapeutic use ; STAT3 Transcription Factor ; Signal Transduction
Chemical Substances	Cytokines ; STAT3 Transcription Factor ; STAT3 protein, human ; Oncostatin M (106956-32-5)
Language	English
Publishing date	2020-11-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2020.107158
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Zs.A 5408: Show issues

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Article: Mapping Substrate Types and Compositions in Shallow Streams

Niroumand-Jadidi, Milad / Pahlevan, Nima / Vitti, Alfonso

Remote sensing, 11(3):262

2019

Abstract: ... for substrate mapping in shallow fluvial systems (depth < 1 m). To do so, we performed three different ... reflectance in NIR bands, when the water column is relatively thick (>0.5 m) and/or when the water is turbid ...

Institution	Leibniz-Institut für Gewässerökologie und Binnenfischerei
Abstract	Remote sensing of riverbed compositions could enable advances in hydro-morphological and habitat modeling. Substrate mapping in fluvial systems has not received as much attention as in nearshore, optically shallow inland, and coastal waters. As finer spatial-resolution image data become more available, a need emerges to expand research on the remote sensing of riverbed composition. For instance, research to date has primarily been based on spectral reflectance data from above the water surface without accounting for attenuation by the water-column. This study analyzes the impacts of water-column correction for substrate mapping in shallow fluvial systems (depth < 1 m). To do so, we performed three different experiments: (a) analyzing spectroscopic measurements in a hydraulic laboratory setting, (b) simulating water-leaving radiances under various optical scenarios, and (c) evaluating the potential to map bottom composition from a WorldView-3 (WV3) image of a river in Northern Italy. Following the retrieval of depth and diffuse attenuation coefficient ( Kd ), bottom reflectances were estimated using a water-column correction method. The results indicated significant enhancements in streambed maps based on bottom reflectances relative to maps produced from above-water spectra. Accounting for deep-water reflectance, embedded in the water-column correction, was demonstrated to have the greatest impact on the retrieval of bottom reflectance in NIR bands, when the water column is relatively thick (>0.5 m) and/or when the water is turbid. We also found that the WV3’s red-edge band (i.e., 724 nm) considerably improved the characterization of submerged aquatic vegetation (SAV) densities from either above-water or retrieved bottom spectra. This study further demonstrated the feasibility of mapping SAV density classes from a WV3 image of the Sarca River in Italy by retrieving the bottom reflectances.
Keywords	bottom reflectance ; river ; substrate ; WorldView-3 ; aquatic vegetation ; spectroscopy ; radiative transfer ; water-column correction
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Histology Image Viewer and Converter (HIVC): A High-Speed Freeware Software to View and Convert Whole Slide Histology Images.

Razian, Sayed Ahmadreza / Jadidi, Majid

Computer methods in biomechanics and biomedical engineering. Imaging & visualization

2023 Volume 11, Issue 5, Page(s) 1652–1660

Abstract: Histology images are widely used to assess the microstructure of biological tissues, but scanners often save images in bulky SVS and multi-layered TIFF formats. These formats were designed to archive image blocks and high-resolution textual information ... ...

Abstract	Histology images are widely used to assess the microstructure of biological tissues, but scanners often save images in bulky SVS and multi-layered TIFF formats. These formats were designed to archive image blocks and high-resolution textual information and are not compatible with conventional image analysis software. Our goal was to create a freeware Histology Image Viewer and Converter (HIVC) with a graphical user interface that allows viewing and converting whole-slide images in batch. HIVC was developed using C# Language for Windows x64 operating system. HIVC's performance was assessed by converting 20 whole-slide images to a JPG format at 20x and 40x resolution and comparing the results to ImageJ, Cell Profiler, QuPath, Nanoborb, and Aperio ImageScope. HIVC was more than 8-times faster in converting images than other software packages. This software allows high-speed batch conversion of histology images to traditional formats, permitting platform-independent secondary analyses.
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Journal Article
ISSN	2168-1163
ISSN	2168-1163
DOI	10.1080/21681163.2023.2174776
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Article: Endodontic management of type IIIb dens invaginatus in central incisor: A case report.

Ghandi, Mostafa / Jadidi, Soheila

Clinical case reports

2023 Volume 11, Issue 7, Page(s) e7679

Abstract: We described a type IIIb dens invaginatus, its root canal treatment, and results on 3- and 12-month visits. Despite its significant challenges, proper endodontic therapy in such cases can cause positive prognosis and successful outcome. ...

Abstract	We described a type IIIb dens invaginatus, its root canal treatment, and results on 3- and 12-month visits. Despite its significant challenges, proper endodontic therapy in such cases can cause positive prognosis and successful outcome.
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7679
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Article: Accidental finding prior to rhinoplasty: Rhinolith-A rare case report.

Heidarizadeh, Mehdi / Sarrafzadeh, Arash / Mohebiniya, Maryam / Jadidi, Soheila

Clinical case reports

2024 Volume 12, Issue 3, Page(s) e8679

Abstract: Through this case report, we review a rare radiographic finding within the nasal cavity and its histopathological findings in order to emphasize the importance of familiarizing oneself with all radiographic findings, regardless of their rarity. ...

Abstract	Through this case report, we review a rare radiographic finding within the nasal cavity and its histopathological findings in order to emphasize the importance of familiarizing oneself with all radiographic findings, regardless of their rarity.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8679
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Article ; Online: Healthcare-associated infections in Iranian pediatric and adult intensive care units: A comprehensive review of risk factors, etiology, molecular epidemiology, antimicrobial sensitivity, and prevention strategies during the COVID-19 pandemic.

Safarabadi, Mehdi / Motallebirad, Tahereh / Azadi, Davood / Jadidi, Ali

Journal of intensive care medicine

2024 , Page(s) 8850666241249162

Abstract: The current review article provides a comprehensive analysis of nosocomial infections in pediatric and adult intensive care units (ICUs) in Iran. We examine the risk factors and etiology of nosocomial infections, with a particular focus on molecular ... ...

Abstract	The current review article provides a comprehensive analysis of nosocomial infections in pediatric and adult intensive care units (ICUs) in Iran. We examine the risk factors and etiology of nosocomial infections, with a particular focus on molecular epidemiology and antimicrobial sensitivity. In this article, we explore a range of prevention strategies, including hand hygiene, personal protective equipment, environmental cleaning, antibiotic stewardship, education, and training. Moreover, we discuss the impact of the COVID-19 pandemic on infection control measures in ICUs and provide valuable insights for healthcare professionals and policymakers seeking to address this critical public health issue. In conclusion, this review article can serve as a valuable resource for those interested in understanding and improving infection control in ICUs and beyond.
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666241249162
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Article ; Online: EMF promote BMSCs differentiation and functional recovery in hemiparkinsonian rats.

Jadidi, Taha / Asadian, Nader / Jadidi, Majid / Ali Vafaei, Abbas

Neuroscience letters

2022 Volume 784, Page(s) 136765

Abstract: Bone marrow mesenchymal stem cells (BMSCs) have self-renewal ability while maintaining the proliferation facility. The BMSCs reproducing ability could affect by electromagnetic fields (EMFs) as a physical inducing factor. We focused on the EMF (400 µT, ... ...

Abstract	Bone marrow mesenchymal stem cells (BMSCs) have self-renewal ability while maintaining the proliferation facility. The BMSCs reproducing ability could affect by electromagnetic fields (EMFs) as a physical inducing factor. We focused on the EMF (400 µT, 75 Hz) exposed multi-potential BMSCs which differentiated and successfully implanted in the substantia nigra pars compacta (SNpc) of Parkinson's disease rat model. The purified BMSCs are exposed to sinusoidal and square waveform EMF (1 h/1 week or 7 h/1 day) then injected into the left SNpc of Parkinson's rats. To evaluate the morphology of EMF exposed BMSCs, the cresyl violet staining labeled the Nissl bodies. After evaluation of the rat's activity by behavioral tests (open-field and rotarod tests), the brains were obtained for the preparation of SNpc blocks and carry out the cresyl violet staining. Cell morphology proved most cell differentiation to neurons in the sinusoidal EMF groups. In the sinusoidal EMF exposure groups, large and small neurons were seen with apparent synapses. Although in the square EMF exposed groups some neurons were seen, most of the differentiated cells were astrocytes, microglia, and oligodendrocyte. The results confirmed an improvement in locomotors' activity of BMSC alone and sinusoidal EMF exposed groups. We presented a low-frequency EMF (75 Hz) to promote the capability of BMSC proliferation, differentiation to neurons and glial cells, and motor coordination activity in the treatment of hemiparkinsonian rats.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; Electromagnetic Fields ; Mesenchymal Stem Cells ; Neurons ; Rats
Language	English
Publishing date	2022-06-28
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2022.136765
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Zs.A 1166: Show issues

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Article ; Online: Evaluation of cost-effectiveness of single-credit traffic safety course based on Kirkpatrick model: a case study of Iran.

Golestani, Mina / Sadeghi-Bazargani, Homayoun / Harzand-Jadidi, Sepideh / Soori, Hamid

BMC medical education

2024 Volume 24, Issue 1, Page(s) 128

Abstract: Background: Training plays a role in reducing traffic accidents, and evaluating the effectiveness of training programs in managers' decision-making for training continuation is important. Thus, the present study aimed to evaluate the cost-effectiveness ... ...

Abstract	Background: Training plays a role in reducing traffic accidents, and evaluating the effectiveness of training programs in managers' decision-making for training continuation is important. Thus, the present study aimed to evaluate the cost-effectiveness of a single-credit traffic safety course based on the four levels of the Kirkpatrick model in all Iranian universities. Methods: This interventional study aimed to evaluate the cost-effectiveness of a single-credit traffic safety course based on the Kirkpatrick model from 2016 to 2020 in Iran. The data were collected in three stages: (1) calculating the costs of offering traffic safety courses, (2) determining the effectiveness of providing such courses based on the levels of the Kirkpatrick model, and (3) evaluating the cost-effectiveness of administering traffic safety courses. Data were collected through researcher-made and standardized questionnaires. The research population included traffic safety course instructors and university students who could take this course. Finally, the data were analyzed with SPSS v. 23 and also calculations related to ICER, which shows the cost effectiveness of providing single credit course. Results: Scores of the students' reaction level to the traffic safety course was 41.8% before the course; this score was estimated at 67% after the course. At the level of learning, students' knowledge was 43.6% before the training course, which reached 73% after the course. At the level of behavior, the state of students' desirable traffic behaviors was 54% before the course, which reached 66.1% after the course. The educational effectiveness of the course presentation at the level of results was 58.2% before and 74.8% after the course. While assuming that the weights of all model levels were constant, the cost of a 1% increase in the overall educational effectiveness by using the Kirkpatrick model, compared to not providing the course (not administering the intervention) was 486.46 USD. Conclusion: The results showcased the effectiveness of the traffic safety course in all four levels of The Kirkpatrick model. Therefore, policy-makers and officials in charge of delivering this program should strengthen it and resolve its deficiencies to realize all its educational goals at the highest level.
MeSH term(s)	Humans ; Iran ; Cost-Effectiveness Analysis ; Cost-Benefit Analysis ; Students ; Learning
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05122-w
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Article ; Online: Effect of stachys lavandulifolia on occupational stress in emergency medical technicians.

Jadidi, Ali / Irannejad, Behrooz / Salehi, Mehdi / Safarabadi, Mehdi

Explore (New York, N.Y.)

2023 Volume 19, Issue 6, Page(s) 803–805

Abstract: Objective: According to studies, occupational stress is quite prevalent among Emergency Medical Technicians (EMTs). On the other hand, it has been shown that Stachys lavandulifolia, also known as the Mountain Tea in Iran, has anxiolytic properties. ... ...

Abstract	Objective: According to studies, occupational stress is quite prevalent among Emergency Medical Technicians (EMTs). On the other hand, it has been shown that Stachys lavandulifolia, also known as the Mountain Tea in Iran, has anxiolytic properties. Considering the current increasing trend of using remedies based on alternative medicine for stress management, the present clinical trial intended to investigate the effect of Stachys lavandulifolia on occupational stress in EMTs METHODS: The present study included 60 EMTs working in Arak, Markazi province, Iran, who were randomly divided into study and control groups. The study group was treated with tea made of Stachys lavandulifolia (2 g daily) for 2 months, while the control group was treated with black tea. Moreover, the level of occupational stress in the study participants was assessed using the Hospital Stress Scale (HSS-35) before and after the intervention. Data analysis was performed using the SPSS software version 22. Results: According to our results, the mean occupational stress score was significantly decreased in the study group after the intervention (p < 0.05). Moreover, the post-intervention scores were significantly lower in the study group compared to the control group (p < 0.05). However, there was no significant change in occupational stress in the control group after the intervention (p > 0.05). Conclusion: In combination with other stress-relieving options, the tea made of Stachys lavandulifolia can be used as a complementary therapy for alleviating occupational stress in EMTs.
MeSH term(s)	Humans ; Iran ; Stachys ; Tea ; Occupational Stress/prevention & control ; Emergency Medical Technicians/psychology
Chemical Substances	Tea
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2023.04.003
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Article ; Online: Substrate-Controlled Diastereo- and Enantiodivergent Synthesis of Bis-Spirocyclopropyloxindoles from Available Isatin as a Single Starting Material.

Eskandari, Mehdi / Jadidi, Khosrow / Notash, Behrouz

The Journal of organic chemistry

2023 Volume 88, Issue 9, Page(s) 5254–5274

Abstract: The first diastereo- and enantiodivergent asymmetric synthesis of new bis-spirocyclopropyloxindole scaffolds has been accomplished from the readily available isatin as a single starting material. ... ...

Abstract	The first diastereo- and enantiodivergent asymmetric synthesis of new bis-spirocyclopropyloxindole scaffolds has been accomplished from the readily available isatin as a single starting material. Four
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c02452
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