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Article: Saving Brain and Vein: Administering Hypertonic Saline Through a Peripheral IV Catheter.

Herrmann, Jeremy R / Au, Alicia K

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2022 Volume 23, Issue 4, Page(s) 327–329

MeSH term(s)	Brain ; Catheters ; Head ; Humans ; Saline Solution, Hypertonic ; Veins
Chemical Substances	Saline Solution, Hypertonic
Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002924
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Harnessing the Promise of the Cold Stress Response for Acute Brain Injury and Critical Illness in Infants and Children.

Jackson, Travis C / Herrmann, Jeremy R / Fink, Ericka L / Au, Alicia K / Kochanek, Patrick M

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 25, Issue 3, Page(s) 259–270

MeSH term(s)	Infant ; Child ; Humans ; Cold-Shock Response ; Critical Illness/therapy ; Brain Injuries/therapy
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003424
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Retrospective Validation of a Computerized Physiologic Equation to Predict Minute Ventilation Needs in Critically Ill Children.

Pelletier, Jonathan H / Rakkar, Jaskaran / Au, Alicia K / Fuhrman, Dana Y / Clark, Robert S B / Kochanek, Patrick M / Horvat, Christopher M

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2024

Abstract: Objectives: Mechanical ventilation (MV) is pervasive among critically ill children. We sought to validate a computerized physiologic equation to predict minute ventilation requirements in children and test its performance against clinician actions in an ...

Abstract	Objectives: Mechanical ventilation (MV) is pervasive among critically ill children. We sought to validate a computerized physiologic equation to predict minute ventilation requirements in children and test its performance against clinician actions in an in silico trial. Design: Retrospective, electronic medical record linkage, cohort study. Setting: Quaternary PICU. Patients: Patients undergoing invasive MV, serial arterial blood gas (ABG) analysis within 1-6 hours, and pharmacologic neuromuscular blockade (NMB). Measurements and main results: ABG values were filtered to those occurring during periods of NMB. Simultaneous ABG and minute ventilation data were linked to predict serial Paco2 and pH values using previously published physiologic equations. There were 15,121 included ABGs across 500 encounters among 484 patients, with a median (interquartile range [IQR]) of 20 (10-43) ABGs per encounter at a duration of 3.6 (2.1-4.2) hours. The median (IQR) Paco2 prediction error was 0.00 (-3.07 to 3.00) mm Hg. In Bland-Altman analysis, the mean error was -0.10 mm Hg (95% CI, -0.21 to 0.01 mm Hg). A nested, in silico trial of ABGs meeting criteria for weaning (respiratory alkalosis) or escalation (respiratory acidosis), compared the performance of recommended ventilator changes versus clinician decisions. There were 1,499 of 15,121 ABGs (9.9%) among 278 of 644 (43.2%) encounters included in the trial. Calculated predictions were favorable to clinician actions in 1124 of 1499 ABGs (75.0%), equivalent to clinician choices in 26 of 1499 ABGs (1.7%), and worse than clinician decisions in 349 of 1499 ABGs (23.3%). Calculated recommendations were favorable to clinician decisions in sensitivity analyses limiting respiratory rate, analyzing only when clinicians made changes, excluding asthma, and excluding acute respiratory distress syndrome. Conclusions: A computerized equation to predict minute ventilation requirements outperformed clinicians' ventilator adjustments in 75% of ABGs from critically ill children in this retrospective analysis. Prospective validation studies are needed.
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003462
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Maximum Pao

Pelletier, Jonathan H / Ramgopal, Sriram / Au, Alicia K / Clark, Robert S B / Horvat, Christopher M

Critical care explorations

2020 Volume 2, Issue 9, Page(s) e0186

Abstract: A relationship between ... ...

Abstract	A relationship between Pao
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000186
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Article ; Online: Trends in Bronchiolitis ICU Admissions and Ventilation Practices: 2010-2019.

Pelletier, Jonathan H / Au, Alicia K / Fuhrman, Dana / Clark, Robert S B / Horvat, Christopher

Pediatrics

2021 Volume 147, Issue 6

Abstract: Objectives: To determine the changes in ICU admissions, ventilatory support, length of stay, and cost for patients with bronchiolitis in the United States.: Methods: Retrospective cross-sectional study of the Pediatric Health Information Systems ... ...

Abstract	Objectives: To determine the changes in ICU admissions, ventilatory support, length of stay, and cost for patients with bronchiolitis in the United States. Methods: Retrospective cross-sectional study of the Pediatric Health Information Systems database. All patients age <2 years admitted with bronchiolitis and discharged between January 1, 2010 and December 31, 2019, were included. Outcomes included proportions of annual ICU admissions, invasive mechanical ventilation (IMV), noninvasive ventilation (NIV), and cost. Results: Of 203 859 admissions for bronchiolitis, 39 442 (19.3%) were admitted to an ICU, 6751 (3.3%) received IMV, and 9983 (4.9%) received NIV. ICU admissions for bronchiolitis doubled from 11.7% in 2010 to 24.5% in 2019 ( Conclusions: The proportions of children with bronchiolitis admitted to an ICU and receiving NIV have substantially increased, whereas the proportion receiving IMV is unchanged over the past decade. Further study is needed to better understand the factors underlying these temporal patterns.
MeSH term(s)	Bronchiolitis/epidemiology ; Bronchiolitis/therapy ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Hospitalization/statistics & numerical data ; Hospitalization/trends ; Humans ; Intensive Care Units, Pediatric/statistics & numerical data ; Male ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; United States
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2020-039115
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Um IV Zs.131: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 357: Show issues

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Article ; Online: Examination of Sex-Specific Participant Inclusion in Exercise Physiology Endothelial Function Research: A Systematic Review.

Lew, Lindsay A / Williams, Jennifer S / Stone, Jenna C / Au, Alicia K W / Pyke, Kyra E / MacDonald, Maureen J

Frontiers in sports and active living

2022 Volume 4, Page(s) 860356

Abstract: Background: To combat historical underrepresentation of female participants in research, guidelines have been established to motivate equal participation by both sexes. However, the pervasiveness of female exclusion has not been examined in vascular ... ...

Abstract	Background: To combat historical underrepresentation of female participants in research, guidelines have been established to motivate equal participation by both sexes. However, the pervasiveness of female exclusion has not been examined in vascular exercise physiology research. The purpose of this study was to systematically quantify the sex-specific prevalence of human participants and identify the rationales for sex-specific inclusion/exclusion in research examining the impact of exercise on vascular endothelial function. Methods: A systematic search was conducted examining exercise/physical activity and vascular endothelial function, assessed via flow mediated dilation. Studies were categorized by sex: male-only, female-only, or mixed sex, including examination of the sample size of males and females. Analysis was performed examining sex-inclusion criteria in study design and reporting and rationale for inclusion/exclusion of participants on the basis of sex. Changes in proportion of female participants included in studies were examined over time in 5 year cohorts. Results: A total of 514 studies were identified, spanning 26 years (1996-2021). Of the total participants, 64% were male and 36% were female, and a male bias was identified (32% male-only vs. 12% female-only studies). Proportions of female participants in studies remained relatively constant in the last 20 years. Male-only studies were less likely to report sex in the title compared to female-only studies (27 vs. 78%, Conclusions: This systematic review provides the first analysis of sex-based inclusion/exclusion and rationale for sex-based decisions in human vascular exercise physiology research. These findings contribute to identifying the impact of research guidelines regarding inclusion of males and females and the perceived barriers to designing studies with equal sex participation, in an effort to increase female representation in vascular exercise physiology research. Systematic review registration: CRD42022300388.
Language	English
Publishing date	2022-03-25
Publishing country	Switzerland
Document type	Systematic Review
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2022.860356
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Article ; Online: Association between pediatric TBI mortality and median family income in the United States: A retrospective cohort study.

Pelletier, Jonathan H / Rakkar, Jaskaran / Simon, Dennis / Au, Alicia K / Fuhrman, Dana Y / Clark, Robert S B / Kochanek, Patrick M / Horvat, Christopher M

Lancet Regional Health. Americas

2022 Volume 5

Abstract: Background: There are regional disparities in pediatric traumatic brain injury (TBI) mortality across the United States, but the factors underlying these differences are unclear.: Methods: We performed a retrospective cross-sectional analysis of the ... ...

Abstract	Background: There are regional disparities in pediatric traumatic brain injury (TBI) mortality across the United States, but the factors underlying these differences are unclear. Methods: We performed a retrospective cross-sectional analysis of the Pediatric Health Information System database including inpatient hospital encounters for children less than 18 years old with a primary diagnosis of TBI between 2010-2019. Findings: Lower median family income was associated with pediatric TBI mortality. Encounters from zip-codes with a median family income of <$20,000 had a 3.1% (29/950) mortality, as opposed to 1.3% (29/2,267) mortality for zip-codes with a median family income of >$80,000 (p = 0.00096). In multivariable logistic regression, every $10,000 of income was associated with an odds ratio of mortality of 0.94 (95% confidence interval 0.90 - 0.98). 82.5% (397/481) of ballistic TBI injuries were caused by a firearm. Lower income was associated with a higher proportion of ballistic TBI injuries (2.5% [24/950] for <$20,000 versus 0.3% [7/2,267] for >$80,000, p < 0.0001). In multivariable logistic regression, ballistic TBI injuries were associated with an odds ratio of mortality of 5.19 (95% confidence interval 4.00 - 6.73). United States regional variation in pediatric TBI mortality was linearly associated with the percentage of ballistic TBI (adjusted r-squared 0.59, p = 0.0097). Interpretation: Children from lower income zip-codes are more likely to sustain a ballistic TBI, and more likely to die. Further work is necessary to determine causal factors underlying these associations and to design interventions that prevent these injuries and/or improve outcomes.
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2021.100164
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Article ; Online: Healthcare Use in the Year Following Bronchiolitis Hospitalization.

Pelletier, Jonathan H / Au, Alicia K / Fuhrman, Dana Y / Marroquin, Oscar C / Suresh, Srinivasan / Clark, Robert S B / Kochanek, Patrick M / Horvat, Christopher M

Hospital pediatrics

2022 Volume 12, Issue 11, Page(s) 937–949

Abstract: Objectives: Healthcare utilization after bronchiolitis hospitalization is incompletely understood. We aimed to characterize readmissions and outpatient visits within 1 year after hospital discharge.: Methods: Retrospective multicenter observational ... ...

Abstract	Objectives: Healthcare utilization after bronchiolitis hospitalization is incompletely understood. We aimed to characterize readmissions and outpatient visits within 1 year after hospital discharge. Methods: Retrospective multicenter observational cohort study of children under 24-months old admitted with bronchiolitis between January 1, 2010 and December 12, 2019 to the Pediatric Health Information Systems database. A single-center nested subset using linked electronic health records allowed analysis of outpatient visits. Results: There were 308 306 admissions for bronchiolitis among 271 115 patients across 47 hospitals between 2010-2019. The percent of patients readmitted within 30 days after discharge was 6.0% (16 167 of 271 115), and 17.8% (48 332 of 271 115) of patients were readmitted within 1 year. 22.9% (16 919 of 74 001) of patients admitted to an ICU and 26.8% (7865 of 29 378) of patients undergoing mechanical ventilation were readmitted within 1 year. There were 1438 patients with outpatient healthcare data available. There were a median (interquartile range) of 9 (6-13) outpatient visits per patient within 1 year after discharge. Outpatient healthcare use increased for 4 months following bronchiolitis hospitalization compared with previously reported age-matched controls. Higher income, white race, commercial insurance, complex chronic conditions, ICU admission, and mechanical ventilation were associated with higher outpatient utilization. Higher quartiles of outpatient use were associated with readmission for bronchiolitis and all-cause readmissions. Conclusions: Readmissions in the year after bronchiolitis hospitalization are common, and outpatient healthcare use is increased for 4 months following discharge. Prospective study is needed to track long-term outcomes of infants with bronchiolitis.
MeSH term(s)	Infant ; Humans ; Child ; Child, Preschool ; Patient Readmission ; Retrospective Studies ; Hospitalization ; Bronchiolitis/epidemiology ; Bronchiolitis/therapy ; Delivery of Health Care
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2022-006657
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Article ; Online: Strategies to address structural and institutional barriers to success among students of color in nursing programs.

Matthews, Alicia K / Abboud, Sarah / Smith, Ariel U / Smith, Charese / Jeremiah, Rohan / Hart, Alysha / Weaver, Terri

Journal of professional nursing : official journal of the American Association of Colleges of Nursing

2022 Volume 40, Page(s) 96–104

Abstract: The COVID-19 pandemic and the significant disparities experienced by Black, Indigenous, and people of color (BIPOC) in infections, hospitalizations, and deaths associated with the Coronavirus have underscored the imperative to increase the size and ... ...

Abstract	The COVID-19 pandemic and the significant disparities experienced by Black, Indigenous, and people of color (BIPOC) in infections, hospitalizations, and deaths associated with the Coronavirus have underscored the imperative to increase the size and diversity of the healthcare workforce, including nursing. Academically focused pipeline development programs have led to some advances in minority recruitment and retention; however, emerging research highlights the importance of extra-academic factors that reduce the sense of belonging and persistence among underrepresented and minority students. The purpose of this manuscript is to describe the diversity, equity, and inclusion goals and activities of a college of nursing located in a minority-serving institution. Here, we emphasize the description of a range of activities aimed at meeting our diversity goals. Further, we highlight the actions initiated in response to emergent "extra-academic" student needs over the past year related to the COVID-19 pandemic and police brutality. The strategies described have implications for improving diversity, equity, and inclusion among higher education institutions in nursing.
MeSH term(s)	COVID-19/epidemiology ; Cultural Diversity ; Humans ; Minority Groups/education ; Pandemics ; Pilot Projects ; Students, Nursing
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632951-2
ISSN	1532-8481 ; 8755-7223
ISSN (online)	1532-8481
ISSN	8755-7223
DOI	10.1016/j.profnurs.2022.03.005
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Article: Severe postoperative hyponatremia after pediatric intracranial tumor surgery--is this preventable?*.

Au, Alicia K / Bell, Michael J

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2014 Volume 15, Issue 5, Page(s) 497–498

MeSH term(s)	Brain Neoplasms/blood ; Brain Neoplasms/surgery ; Female ; Humans ; Hyponatremia/blood ; Male ; Postoperative Complications/blood
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000000175
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