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  1. Article ; Online: Analysing monkeypox epidemic drivers: Policy simulation and multi-index modelling across 39 nations.

    Lin, Mengxuan / Xin, Yingrong / Wang, Jiaojiao / Nie, Pengyuan / Yan, Qunjiao / Wang, Ligui / Wang, Lei

    Journal of global health

    2024  Volume 14, Page(s) 4037

    Abstract: Background: This study aimed to analyse the drivers of the monkeypox (Mpox) epidemic and policy simulation to support health care policies against the Mpox epidemic.: Methods: We established a three-round selection mechanism for 164 factors using ... ...

    Abstract Background: This study aimed to analyse the drivers of the monkeypox (Mpox) epidemic and policy simulation to support health care policies against the Mpox epidemic.
    Methods: We established a three-round selection mechanism for 164 factors using Lasso and negative binomial regression to investigate the correlation between significant drivers and the cumulative confirmed cases of Mpox. Policy simulation for each driver was evaluated, and the varying effects of implementation at different times were examined.
    Results: HIV/AIDS prevalence and air transport passengers carried were significant determinants of the risk of the Mpox epidemic across various countries, with regression coefficients of 1.417 and 0.766, respectively. A decrease in HIV/AIDS prevalence by 10, 20, 30, and 40% corresponded to reductions in the number of Mpox cases by 6.28, 6.55, 6.87, and 7.26%, respectively. Similarly, 20, 40, 60, and 80% travel restrictions led to reductions in Mpox cases by 7.16, 15.63, 26.28%, and 41.46%, respectively. Controlling air transport passengers carried in the first month could postpone outbreak onset by 0.5-2.0 months.
    Conclusions: Mpox prevention and control policies should primarily focus on travel restrictions during high disease-risk periods and flight suspensions from high-risk nations in combination with regular HIV/AIDS prevention and treatment strategies.
    MeSH term(s) Humans ; Mpox (monkeypox)/epidemiology ; Acquired Immunodeficiency Syndrome ; Epidemics/prevention & control ; Disease Outbreaks ; Health Policy
    Language English
    Publishing date 2024-02-09
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.14.04037
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  2. Article ; Online: Intestinal obstruction in pregnancy-a rare presentation of uterine perforation.

    Shen, Jiayu / Teng, Xinyuan / Chen, Jing / Jin, Ligui / Wang, Liquan

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 507

    Abstract: Background: Intestinal obstruction is an uncommon non-obstetric condition during pregnancy which may cause maternal and fetal mortality. Clinicians are confronted with challenges in diagnosis and treatment of intestinal obstruction due to the ... ...

    Abstract Background: Intestinal obstruction is an uncommon non-obstetric condition during pregnancy which may cause maternal and fetal mortality. Clinicians are confronted with challenges in diagnosis and treatment of intestinal obstruction due to the overlapping symptoms, concerns over radiological evaluation, and surgical risks.
    Case presentation: We reported a 39-year old, gravida 7, para 2, woman who suffered from acute intestinal obstruction at 34 weeks of gestation. Ultrasonography and abdominal computed tomography were applied for intestinal obstruction diagnose. Conservative treatment was initially attempted. But following ultrasound found the absence of fluid in the amniotic sac and the patient showed no improvement in clinical symptoms. An emergency caesarean section was then performed. Intra-operative assessment showed dense adhesion between the left wall of uterus and omentum, descending colon, and sigmoid colon. After adhesion dialysis, uterine rupture with complete opening of the uterine wall at the site of left uterine cornua was found without active bleeding. The uterine rupture was then repaired.
    Conclusions: Although uncommon during pregnancy, clinical suspicion of bowel obstruction is necessary especially in women with a history of abdominal surgery. Surgical intervention is indicated when conservative therapy fails and when there are signs of abnormal fetal conditions and worsened symptoms.
    MeSH term(s) Pregnancy ; Female ; Humans ; Adult ; Uterine Perforation/complications ; Uterine Rupture/etiology ; Uterine Rupture/surgery ; Cesarean Section ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Uterus
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-05827-8
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  3. Article ; Online: Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

    Wu, Ligui / Wang, Mingyu / Rong, Lingling / Wang, Wenbiao / Chen, Linwei / Wu, Qiaofeng / Sun, Haoyu / Huang, Xiangfeng / Zou, Xiaoming

    Journal of Environmental Sciences. 2024 Jan., v. 135 p.161-173

    2024  

    Abstract: Antibiotic resistance genes (ARGs) can be easily promoted by antibiotics, however, the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in, especially, activated sludge sequencing batch ... ...

    Abstract Antibiotic resistance genes (ARGs) can be easily promoted by antibiotics, however, the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in, especially, activated sludge sequencing batch reactors. In the present study, the effects of 9 sulfonamides (SAs) with different structures on the proliferation dynamic of sulfonamide resistance genes (Suls) in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined (30 days), and the results showed that the largest proliferation value (∆Aᴿ) of Suls dynamic for SAs (sulfachloropyridazine) was approximately 2.9 times than that of the smallest one (sulfadiazine). The proliferation of Suls was significantly related to the structural features (minHBint6, SssNH, SHBd and SpMax2_Bhm) that represent the biological activity of SAs. To interpret the phenomenon, a mechanistic model was developed and the results indicated that the biodegradation of SAs (T₁/₂) rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation. T₁/₂ was proved to be dependent on the interactions between SAs and receptors (Ebᵢₙdᵢₙg), the cleavage mode (bond dissociation energy), and the site of nucleophilic assault. Besides, the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of Suls. Overall, our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.
    Keywords Lewis bases ; activated sludge ; antibiotic resistance ; antibiotic resistance genes ; antibiotics ; bioactive properties ; biodegradation ; dissociation ; energy ; mechanistic models ; metagenomics ; mutation rate ; sulfadiazine ; Sulfonamides ; Suls ; Proliferation ; Mechanism
    Language English
    Dates of publication 2024-01
    Size p. 161-173.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1092300-7
    ISSN 1878-7320 ; 1001-0742
    ISSN (online) 1878-7320
    ISSN 1001-0742
    DOI 10.1016/j.jes.2022.11.014
    Database NAL-Catalogue (AGRICOLA)

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    Z 7630: Show issues

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  4. Article ; Online: Evaluation of control measures for COVID-19 in Wuhan, China.

    Wang, Ligui / Chen, Hui / Qiu, Shaofu / Song, Hongbin

    The Journal of infection

    2020  Volume 81, Issue 2, Page(s) 318–356

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Bearing Fault Diagnosis Using Piecewise Aggregate Approximation and Complete Ensemble Empirical Mode Decomposition with Adaptive Noise.

    Hu, Lei / Wang, Ligui / Chen, Yanlu / Hu, Niaoqing / Jiang, Yu

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 17

    Abstract: Complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) effectively separates the fault vibration signals of rolling bearings and improves the diagnosis of rolling bearing faults. However, CEEMDAN has high memory requirements and low ...

    Abstract Complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) effectively separates the fault vibration signals of rolling bearings and improves the diagnosis of rolling bearing faults. However, CEEMDAN has high memory requirements and low computational efficiency. In each iteration of CEEMDAN, fault vibration signals are added with noises, both the vibration signals added with noises and the added noises are decomposed with classical empirical mode decomposition (EMD). This paper proposes a rolling bearing fault diagnosis method that combines piecewise aggregate approximation (PAA) with CEEMDAN. PAA enables CEEMDAN to decompose long signals and to achieve enhanced diagnosis. In particular, the method first yields the vibration envelope using bandpass filtering and demodulation, then compresses the envelope using PAA, and finally decomposes the compressed signal with CEEMDAN. Test data verification results show that the proposed method is more effective and more efficient than CEEMDAN.
    MeSH term(s) Algorithms ; Noise ; Signal-To-Noise Ratio ; Vibration
    Language English
    Publishing date 2022-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22176599
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  6. Article ; Online: A model study on predicting new COVID-19 cases in China based on social and news media.

    Lin, Mengxuan / Chen, Hui / Wang, Yuqi / Qiu, Shaofu / Yang, Mingjuan / Du, Xinying / Zheng, Tao / Song, Hongbin / Wang, Ligui

    The Journal of infection

    2022  Volume 84, Issue 4, Page(s) e1–e3

    MeSH term(s) COVID-19 ; China/epidemiology ; Humans ; Mass Media ; Social Media
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.01.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
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  8. Article ; Online: Verification of PEMS measurement accuracy based on light vehicle emission test system

    Wang Gang / Qian Chao / Yang Guoliang / Nan Ligui / Yu Haige

    E3S Web of Conferences, Vol 268, p

    2021  Volume 01003

    Abstract: For the requirements of the portable emission measurement system (PEMS) measurement accuracy for limits and measurement methods for emissions from light-duty vehicles(CHINA 6), based on the light-duty vehicle emission test system in steady-state ... ...

    Abstract For the requirements of the portable emission measurement system (PEMS) measurement accuracy for limits and measurement methods for emissions from light-duty vehicles(CHINA 6), based on the light-duty vehicle emission test system in steady-state conditions and WLTC conditions for PEMS gaseous pollutants, mass flow rate , particle number (PN) verify accuracy of measurement. The results showed that the relative measurement errors of CO, CO2, NOx, fuel consumption and mass flow rate were −5.49%, 2.53%, 10.55%, 2.09% and −2.79%. The relative measurement errors of CO, CO2, NOx, fuel consumption and PN under WLTC condition were 6.67%, 2.54%, 12.96%, 2.37% and −16.08%, which meeting the requirements of the regulations.
    Keywords light vehicle ; portable ; emission testing ; accuracy of measurement ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A novel humanized tri-receptor transgenic mouse model of HAdV infection and pathogenesis.

    Wang, Yawei / Wang, Min / Bao, Renlong / Wang, Ligui / Du, Xinying / Qiu, Shaofu / Yang, Chaojie / Song, Hongbin

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e29026

    Abstract: Human adenovirus (HAdV) is a highly virulent respiratory pathogen that poses clinical challenges in terms of diagnostics and treatment. Currently, no effective therapeutic drugs or prophylactic vaccines are available for HAdV infections. One factor ... ...

    Abstract Human adenovirus (HAdV) is a highly virulent respiratory pathogen that poses clinical challenges in terms of diagnostics and treatment. Currently, no effective therapeutic drugs or prophylactic vaccines are available for HAdV infections. One factor contributing to this deficiency is that existing animal models, including wild-type and single-receptor transgenic mice, are unsuitable for HAdV proliferation and pathology testing. In this study, a tri-receptor transgenic mouse model expressing the three best-characterized human cellular receptors for HAdV (hCAR, hCD46, and hDSG2) was generated and validated via analysis of transgene insertion, receptor mRNA expression, and protein abundance distribution. Following HAdV-7 infection, the tri-receptor mice exhibited high transcription levels at the early and late stages of the HAdV gene, as well as viral protein expression. Furthermore, the tri-receptor mice infected with HAdV exhibited dysregulated cytokine responses and multiple tissue lesions. This transgenic mouse model represents human HAdV infection and pathogenesis with more accuracy than any other reported animal model. As such, this model facilitates the comprehensive investigation of HAdV pathogenesis as well as the evaluation of potential vaccines and therapeutic modalities for HAdV.
    MeSH term(s) Mice ; Animals ; Humans ; Mice, Transgenic ; Adenovirus Infections, Human ; Adenoviridae Infections ; Protein Processing, Post-Translational ; Gene Expression ; Disease Models, Animal ; Adenoviruses, Human/physiology
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29026
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    Zs.A 1320: Show issues Location:
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  10. Article ; Online: Hydrogen bonding-induced high-performance stretchable organic semiconductors

    Jinhan Chen / Zheng Wang / Zhifeng Deng / Ligui Chen / Xuhui Wu / Yihan Gao / Yumeng Hu / Mei Li / Hongzhen Wang

    Frontiers in Chemistry, Vol

    a Review

    2023  Volume 11

    Abstract: Semiconductors are widely used in electron devices. With the development of wearable soft-electron devices, conventional inorganic semiconductors are unable to meet the demand because of their high rigidity and high cost. Thus, scientists construct ... ...

    Abstract Semiconductors are widely used in electron devices. With the development of wearable soft-electron devices, conventional inorganic semiconductors are unable to meet the demand because of their high rigidity and high cost. Thus, scientists construct organic semiconductors with high charge mobility, low cost, eco-friendly, stretchable, etc. Due to the excellent performance of stretchable organic semiconductors, they can be widely used as wearable soft-electron devices, such as stretchable organic field-effect transistors (OFETs), organic solar cells (OSCs), etc. Contains flexible display devices and flexible power sources, which are of great interest for applications of future electron devices. However, there are still some challenges that need to be solved. Commonly, enhancing the stretchability may cause the degradation of charge mobility, because of the destruction of the conjugated system. Currently, scientists find that hydrogen bonding can enhance the stretchability of organic semiconductors with high charge mobility. Thus in this review, based on the structure and design strategies of hydrogen bonding, various hydrogen bonding induced stretchable organic semiconductors are introduced. In addition, the applications of the hydrogen bonding induced stretchable organic semiconductors are reviewed. Finally, the stretchable organic semiconductors design concept and potential evolution trends are discussed. The final goal is to outline a theoretical scaffold for the design of high-performance wearable soft-electron devices, which can also further advance the development of stretchable organic semiconductors for applications.
    Keywords hydrogen bonding ; stretchable organic semiconductors ; charge mobility ; softelectron devices ; OSCs ; OFETs ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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