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  1. Article ; Online: Monitoring of optic sheath diameter during acute migraine attack: an objective criteria for the severity of disease.

    Şimşek, Sadullah / Gültekin, Edip / İşlek, Akif

    Acta neurologica Belgica

    2024  

    Abstract: Background: The etiology of migraine can be complex and multifactorial but not clear, also, intracranial pressure has been already associated with migraine attacks. This study aimed to monitor intracranial pressure during migraine attack to understand ... ...

    Abstract Background: The etiology of migraine can be complex and multifactorial but not clear, also, intracranial pressure has been already associated with migraine attacks. This study aimed to monitor intracranial pressure during migraine attack to understand the possible relations with disease and severity.
    Methods: A prospective randomized study was designed. Patients with a definitive diagnosis of migraine underwent ultrasonography for optic nerve sheath diameter (ONSD) measurement before treatment and were re-measured after the attack was resolved. The severity of the migraine was assessed with Headache Impact Test-6 (HIT-6) and Migraine Disability Assessment (MIDAS) questionnaire before the treatment and after the symptoms regressed. ONSD values and scores from the questionnaires were compared before and after the migraine attack.
    Results: The study included 11 (52.4%) women and 10 (47.6%) men, and 42 eyes were evaluated. ONSD was detected as 4.23 ± 0.26 mm in the right eye and 4.10 ± 0.32 mm in the left eye during the migraine attack and decreased to 3.65 ± 0.41 mm in the right eye and 3.50 ± 0.33 mm in the left eye after the attack was treated (p < 0.001, both). A similar statistical improvement was found in HIT-6 and MIDAS scores with ONSD after treatment (p < 0.001). A significant positive correlation was found between the ONSD value in both eyes and HIT-6/MIDAS scores during the migraine attack, and also, after the migraine attack.
    Conclusion: A subjective increase of ONSD values during the migraine attack decreased after the disease resolved, also changes in ONSD values were significantly correlated with the severity of symptoms.
    Language English
    Publishing date 2024-01-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-023-02454-0
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  2. Article ; Online: A fatal rhino-orbit-cerebral mucormycosis infection aggravated by coronavirus disease-2019.

    İşlek, Akif / Şimşek, Sadullah

    Revista da Sociedade Brasileira de Medicina Tropical

    2022  Volume 55, Page(s) e06662021

    MeSH term(s) COVID-19/complications ; Coronavirus ; Humans ; Mucormycosis/complications ; Mucormycosis/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0666-2021
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  3. Article ; Online: Diagnostic and predictive value of resistive / pulsatility indices of ophthalmic artery and common carotid artery for the development of diabetic retinopathy.

    Şimşek, Sadullah / İşlek, Akif

    Acta radiologica (Stockholm, Sweden : 1987)

    2022  Volume 64, Issue 5, Page(s) 1966–1973

    Abstract: Background: Ophthalmic artery resistive index (OA RI) was a controversial parameter to show hemodynamic changes due to diabetic retinopathy (DRP).: Purpose: To investigate the diagnostic and predictive value of resistive and pulsatility index (RI and ...

    Abstract Background: Ophthalmic artery resistive index (OA RI) was a controversial parameter to show hemodynamic changes due to diabetic retinopathy (DRP).
    Purpose: To investigate the diagnostic and predictive value of resistive and pulsatility index (RI and PI, respectively) of OA and common carotid artery (CCA) for the development of DRP.
    Material and methods: A total of 60 patients with diabetes mellitus (DM) type 2 (study group) and 30 healthy participants (control group) were evaluated between January and June 2021 by Doppler ultrasonography (DUS). RI and PI values were compared between groups with a Student's
    Results: In total, there were 20 (22.2%) patients with DM without DRP (DMwoRP), 20 (22.2%) patients in the non-proliferative diabetic retinopathy group (NPDRP), and 20 (22.2%) patients in the proliferative diabetic retinopathy group (PDRP). The mean of CCA RI and OA RI in the PDRP group was significantly higher than in the other three groups (
    Conclusion: The OA RI accurately reflects DRP-induced orbital blood flow changes and is a predictive index for DRP prognosis.
    MeSH term(s) Humans ; Ophthalmic Artery/diagnostic imaging ; Diabetic Retinopathy/diagnostic imaging ; Hemodynamics ; Carotid Artery, Common ; ROC Curve ; Blood Flow Velocity/physiology ; Ultrasonography, Doppler, Color ; Diabetes Mellitus
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851221137766
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  4. Article ; Online: A fatal rhino-orbit-cerebral mucormycosis infection aggravated by coronavirus disease-2019

    Akif İşlek / Sadullah Şimşek

    Revista da Sociedade Brasileira de Medicina Tropical, Vol

    2022  Volume 55

    Keywords Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Medicina Tropical (SBMT)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Lacrimal Sac Anterior Border-Maxillary Line Distance: Effect on Endoscopic Dacryocystorhinostomy (EDCR) Surgery Results and NLDO-SS Questionnaire.

    Ciğer, Ejder / İşlek, Akif

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2021  Volume 74, Issue Suppl 2, Page(s) 1382–1387

    Abstract: This study aimed to investigate the effect of the maxillary line (ML)-lacrimal sac anterior border (LSA) distance on the results of endoscopic dacryocystorhinostomy (EDCR) operation. The study was designed retrospectively. The distance between LSA and ML ...

    Abstract This study aimed to investigate the effect of the maxillary line (ML)-lacrimal sac anterior border (LSA) distance on the results of endoscopic dacryocystorhinostomy (EDCR) operation. The study was designed retrospectively. The distance between LSA and ML was measured from preoperative paranasal sinus computed tomography (PNSCT) images. Nasolacrimal duct obstruction symptom score (NLDO-SS) was calculated before and after surgery. The endoscopically proven of the transition of the 2% fluorescein drop instilled into the eye to the nasal passage accepted as a surgical success. 47 patients included in the study and eight of them underwent bilateral EDCR. The average age of the patients was 50.3 ± 14.8. The LSA-ML distance was 4.2 ± 1.0 mm in all patients. The duration of surgery was found as 38.1 ± 6.1 min for each side. The preoperative NLDO-SS mean was 54.9 ± 11.7 and 22.2 ± 12.1 postoperatively (
    Language English
    Publishing date 2021-03-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-021-02524-w
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  6. Article: Inferior Turbinate Bone Graft for Dorsal Augmentation in Rhinoplasty.

    Ciğer, Ejder / İşlek, Akif

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2021  Volume 74, Issue Suppl 2, Page(s) 1302–1304

    Abstract: The most serious form of nasal dorsum pathologies is saddle nose deformity. Vary of nasal dorsal augmentation grafts were reported in the literature but inferior bone graft (ITBG) alone has not attracted attention. The ITBG has advantages such as easy ... ...

    Abstract The most serious form of nasal dorsum pathologies is saddle nose deformity. Vary of nasal dorsal augmentation grafts were reported in the literature but inferior bone graft (ITBG) alone has not attracted attention. The ITBG has advantages such as easy and fast harvesting, easy to shape due to cancellous bone tissue. The graft technique is similar to the inferior turbinoplasty with the medial mucosal flap technique and can be performed without bioabsorbable hemostatic material (e.g. Turkish Delight), suture fixation, or without tissue adhesives. Major complications of the ITBG technique are injury of the posterior lateral nasal branch of the sphenopalatine artery and subdermal mucous cyst that developing on nasal dorsum. Since easy application, fast harvesting, and similar permanence to cartilage grafts as augmentation material, ITBG can also been used successfully in minor dorsal deficits in addition to saddle nose deformities.
    Language English
    Publishing date 2021-02-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-021-02422-1
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  7. Article: Phantosmia with COVID-19 Related Olfactory Dysfunction: Report of Nine Case.

    İşlek, Akif / Balcı, Mustafa Koray

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2021  Volume 74, Issue Suppl 2, Page(s) 2891–2893

    Abstract: Phantosmia has been described as a sense of smell without a true stimulating odor and not been reported with COVID-19 disease. Nine patients admitted to Ear Nose Throat (ENT) Clinic with complaints of a phantom smell sense after an average of 33.5 ± 9.5 ... ...

    Abstract Phantosmia has been described as a sense of smell without a true stimulating odor and not been reported with COVID-19 disease. Nine patients admitted to Ear Nose Throat (ENT) Clinic with complaints of a phantom smell sense after an average of 33.5 ± 9.5 days after the initial PCR diagnosis. According to the Sniffin 'Sticks test, phantosmia was associated with objective hyposmia in three patients with the persistent phantom smell, and other six patients were detected normosmic. Phantosmia or olfactory hallucinations have not been previously associated with COVID-19 disease. Additionally, COVID-19 related phantosmia showed different characteristics according to described in the literature.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12070-021-02505-z.
    Language English
    Publishing date 2021-03-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-021-02505-z
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  8. Article: Diagnostic Value of Butanol Threshold Test in COVID-19 Related Olfactory Dysfunction.

    İşlek, Akif / Balcı, Mustafa Koray

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2021  Volume 74, Issue Suppl 2, Page(s) 2873–2877

    Abstract: Olfactory and taste dysfunction has been reported as a specific, preliminary symptom in COVID-19, but a few comparative studies with quantitative tests are reported. In this study, we aimed to compare the butanol olfactory threshold values between COVID- ... ...

    Abstract Olfactory and taste dysfunction has been reported as a specific, preliminary symptom in COVID-19, but a few comparative studies with quantitative tests are reported. In this study, we aimed to compare the butanol olfactory threshold values between COVID-19 patients and healthy volunteers.A cross-sectional study was designed. A total of 53 patients were included in the COVID-19 group and the control group. The definitive diagnosis of COVID-19 was made with reverse-transcription polymerase chain reaction (RT-PCR) test. Frequency of odor and taste dysfunction and other head and neck system-specific and other symptoms were recorded. Afterward, olfactory threshold values determined according to Connecticut Chemosensory Clinical Research Center (CCCRC) test principle for study groups. 21 patients included in the COVID-19 group and 32 patients in the control group. Symptom onset time was 7.1 ± 3.1 (min: 3, max: 14) days for COVID-19 patients. The most common symptom in the otolaryngology system was olfactory dysfunction (n = 15, 71.4%). The butanol olfactory threshold value was determined as an average of 4.4 ± 1.9 in the COVID-19 group and 6.4 ± 0.8 in the control group (
    Language English
    Publishing date 2021-02-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-021-02420-3
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  9. Article ; Online: Anterior Palatoplasty With Expansion Sphincter Pharyngoplasty for All Type of Pharyngeal Collapse.

    Ciğer, Ejder / İşlek, Akif

    The Laryngoscope

    2021  Volume 132, Issue 6, Page(s) 1313–1319

    Abstract: Objectives/hypothesis: This study was aimed to compare the efficiency of the anterior palatoplasty and expansion sphincter pharyngoplasty (APwESP) technique for all patterns of velopharyngeal obstruction (anterior-posterior [APPC], lateral [LPC], or ... ...

    Abstract Objectives/hypothesis: This study was aimed to compare the efficiency of the anterior palatoplasty and expansion sphincter pharyngoplasty (APwESP) technique for all patterns of velopharyngeal obstruction (anterior-posterior [APPC], lateral [LPC], or combined circular pharyngeal collapse [CPC]).
    Study design: The study was designed as a randomized prospective trial at Kâtip Çelebi University, Atatürk Training, and Research Hospital.
    Methods: Patients only with velopharyngeal obstruction were included. Three groups were created according to the obstruction pattern (APPC, LPC, and CPC) for the study. Outcome parameters included patient's demographics, apnea-hypopnea index (AHI), lowest oxygen saturation (LOS), Stanford subjective scale of snoring (SSSS), and Epworth sleepiness scale (ESS).
    Results: Thirty-one (34.1%) patients were in APPC group, while 30 (33.0%) patients were in LPC, and 30 (33.0%) were in CPC group. Preoperatively for all patients, on average, AHI was 33.4 ± 13.6, SSSS was 8.3 ± 1.0, ESS was 16.5 ± 2.6, and LOS was determined as 85.5 ± 3.6. There was a significant postoperative improvement in all parameters for all patients. There was no significant difference in outcome parameters between the groups according to obstruction pattern postoperatively. After APwESP surgery, obstruction pattern was not a significant factor for AHI (P = .234), SSSS (P = .180), and LOS (P = .280) (repeated measure analysis of variance test). The rate of surgical success was detected similarly for both of the study groups (P = .435). The rate of successful surgery for severe obstructive sleep apnea in the APPC group was 72.2%, 88.2% in the LPC group, and 75.0% in the CPC group (P = .472).
    Conclusion: A combination of APwESP surgery can manage all types of pharyngeal obstruction confidently.
    Level of evidence: 3 Laryngoscope, 132:1313-1319, 2022.
    MeSH term(s) Cleft Palate ; Humans ; Pharyngeal Diseases ; Pharynx/surgery ; Prospective Studies ; Sleep Apnea, Obstructive/surgery ; Snoring ; Treatment Outcome
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29999
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  10. Article: Evaluation of effects of chronic nasal steroid use on rhinological symptoms of COVID-19 with SNOT-22 questionnaire.

    İşlek, Akif / Balcı, Mustafa Koray

    Pharmacological reports : PR

    2021  Volume 73, Issue 3, Page(s) 781–785

    Abstract: Background: The benefits of corticosteroids for the treatment of COVID-19 infection are documented in the literature. The goal of the study is to compare the severity of rhinological symptoms of COVID-19 between patients with nasal steroid use (NSU) and ...

    Abstract Background: The benefits of corticosteroids for the treatment of COVID-19 infection are documented in the literature. The goal of the study is to compare the severity of rhinological symptoms of COVID-19 between patients with nasal steroid use (NSU) and the control group (CG) using the sino-nasal outcome test (SNOT-22) questionnaire.
    Methods: A face-to-face survey was conducted at a second referral state hospital between. Patients with a complete recovery from COVID-19 were included in NSU and CG groups. Two subscales of the SNOT-22 were filled by the patients. The frequency and duration of smell and taste loss and SNOT-22 scores were compared between the two groups.
    Results: Forty-seven patients were included in the study. Thirty-one patients were in CG and 16 patients in the NSU group. Twenty-four (51.1%) patients were females and 23 (48.9%) were males. The mean age was 41.4 ± 8.6 years. Olfactory dysfunction was detected in 12 (75%) patients in the NSU group, and 31 (93.3%) patients in the control group (CG). Gustatory dysfunction was seen in 10 (62.5%) patients in the NSU group and 24 (77.4%) patients NSU group. (p = 0.071, 0.279, respectively). The duration of the olfactory (6.6 ± 2.5 days) and gustatory dysfunction (6.1 ± 2.6 days) and the mean SNOT-22 total score (11.9 ± 1.6) was significantly lower in the NSU group (p < 0.001, CI 11.1-5.1, CI 9.9-4.6, CI 9.3-5.9, respectively).
    Conclusions: Although nasal steroid use does not prevent olfactory and gustatory dysfunction in COVID-19 patients, it may reduce the severity and duration of these symptoms.
    MeSH term(s) Adult ; COVID-19/drug therapy ; Female ; Humans ; Male ; Olfaction Disorders/drug therapy ; Olfaction Disorders/virology ; SARS-CoV-2 ; Sino-Nasal Outcome Test ; Smell/drug effects ; Steroids/therapeutic use ; Surveys and Questionnaires ; Taste Disorders/drug therapy
    Chemical Substances Steroids
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1007/s43440-021-00235-1
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