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  1. Article ; Online: Cutaneous disorders of adolescence among Nigerian secondary school students.

    Oyedepo, Jadesola Tryphena / Katibi, Oludolapo Sherifat / Adedoyin, Olanrewaju Timothy

    The Pan African medical journal

    2020  Volume 36, Page(s) 36

    Abstract: Introduction: A community-based, age-specific survey of skin disorders is usually necessary to characterize the true burden of skin disease among a given population and help to tailor health care personnel training and delivery towards the prevalent ... ...

    Abstract Introduction: A community-based, age-specific survey of skin disorders is usually necessary to characterize the true burden of skin disease among a given population and help to tailor health care personnel training and delivery towards the prevalent disorders in resource poor settings.
    Methods: This was a descriptive cross-sectional study among adolescents attending secondary schools in Ilorin, Kwara State, Nigeria. A thousand and three hundred students were recruited from public and private secondary schools through a multi-staged stratified random sampling method. Information was obtained via a semi-structured questionnaire and all students underwent a physical examination. Data was analysed using SPSS version 20. Information generated was presented with tables and figures.
    Results: The prevalence of skin disease in the study was 66.5%. More females, mid-adolescents, students in senior class and those attending public schools had skin disorders. The most prevalent skin disease were: acne vulgaris, pityriasis versicolor, tinea capitis, pityriasis capitis and traction alopecia.
    Conclusion: Skin conditions are highly prevalent among the adolescent population. Infective and inflammatory skin conditions appear to be more prevalent than other classes. Most times, only a few skin disorders account for the bulk of dermatoses affecting this age group. Adolescent skin healthcare should be subsidized because of the high prevalence of skin disorders in this age group.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nigeria/epidemiology ; Prevalence ; Schools ; Skin Diseases/epidemiology ; Skin Diseases/physiopathology ; Students/statistics & numerical data ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-05-27
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2020.36.36.21089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics and Clinical Outcomes of Children With Wilms' Tumour: A 15-year Experience in a Single Centre in Nigeria.

    Nasir, Abdulrasheed A / Abdur-Raheem, Nurudeen T / Abdur-Rahman, Lukman O / Ibiyeye, Taibat T / Sayomi, Tolulope O / Adedoyin, Olanrewaju T / Adeniran, James O

    Journal of pediatric surgery

    2023  Volume 59, Issue 5, Page(s) 1009–1014

    Abstract: Background: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment ... ...

    Abstract Background: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment abandonment and infrastructure deficit. The purpose of this study was to analyze the clinical outcome of children with Wilms tumour managed in a Nigerian referral centre over a 15-year period.
    Methods: This is a retrospective study of children with WT (nephroblastoma) who were treated at our institution between January 2006 and December 2020. Clinical characteristics, treatments, and outcomes were analyzed.
    Results: Thirty-five patients were identified. The median age at diagnosis was 36 months including 22 (62.9 %) females. Twenty-six (74.3 %) had advanced (stage III & IV) disease. Confirmatory histology was available for 16 patients ((45.7 %) among which 10 (62.5 %) were mixed type. The right kidney was affected in 18 patients (51.4 %), left in 15 (42.9 %) and 2 were not documented. Preoperative chemotherapy was given in 22 (62.9 %) patients and 13 (37.1) patients had primary nephrectomy. Eight (22.9 %) patients died during treatment (from disease or treatment related causes), and one abandoned treatment. A total of 26 patients completed treatment. Out of these, 8 (30.8 %) were lost to follow up, four patients died and 14 (53.8 %) patients survived at a median follow-up period of 18 months. The survival decreased with advancing stages of the disease, p = 0.002.
    Conclusions: Majority of children with Wilms tumour in our practice presented with advanced disease. Death during treatment, treatment abandonment and lost to follow up were common.
    Level of evidence: Level II.
    Type of study: Retrospective Study.
    MeSH term(s) Child ; Female ; Humans ; Infant ; Child, Preschool ; Male ; Retrospective Studies ; Nigeria/epidemiology ; Wilms Tumor/pathology ; Kidney Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Treatment Outcome
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2023.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The anatomy of crises in Sub- Saharan Africa economic underdevelopment

    Samuel Oluwapelumi Olofinlade / Cecelia Oluwakemi Aina Ogunwole / James Ishola Aransiola / Favour Ayobami Olanrewaju / Isaac Salami Adedoyin / Daniel Olawole Olofinlade

    Expresión Económica, Iss

    A literature review

    2023  Volume 52

    Abstract: Political upheaval, economic crisis, corruption and food insecurity are the bane for economic underdevelopment in sub–Saharan Africa; these have caused many lives to face some difficulties and to witness unpalatable experiences. This paper looked into ... ...

    Abstract Political upheaval, economic crisis, corruption and food insecurity are the bane for economic underdevelopment in sub–Saharan Africa; these have caused many lives to face some difficulties and to witness unpalatable experiences. This paper looked into this issue and brought out some factors that likely aggravate the difficulties, crises and insecurity in sub–Saharan Africa especially. A few internal factors that contribute to food insecurity include poor leadership, conflict and subconscious of political administration. It is believed that outside factors contributed in a subtle, occasionally overt manner to the solution of the issue. This paper explained how political crisis, economic crisis, insecurity and food insecurity as a bane of economic underdevelopment of the sub-Saharan African country. The political crisis ranges from an underdeveloped political system, frequent changes in government, political instability, frequent change in government policies, abandonment of economic programs, and banditry and pirate activities at sea. Economic crises such as inflation, debt servicing, bogus foreign exchange regime, infrastructural decay, wrong economic policies are part of the bane of underdevelopment in sub-Saharan Africa. While on Food insecurity, drought, pest and diseases, pandemic outbreak (COVID19), Ukraine crisis/war, storage inadequacy, and seasonality of produce was part of the predicament that hinders development in sub-Saharan Africa. Also, suggestions were made to improve both the political and economic issues regarding food security and the development of sub-Saharan Africa.
    Keywords Political ; Economic ; Corruption ; Food insecurity ; Underdevelopment ; Sub-Sahara ; Economic history and conditions ; HC10-1085 ; Finance ; HG1-9999 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Universidad de Guadalajara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A Prospective Cohort Study of the Clinical Predictors of Bacteremia in Under-Five Children With Acute Undifferentiated Fever Attending a Secondary Health Facility in Northwestern Nigeria.

    Ogunkunle, Taofik Oluwaseun / Adedoyin, Timothy Olanrewaju / Ernest, Samuel Kolade / Hassan-Hanga, Fatimah / Imam, Abdulazeez / Olaosebikan, Rasaq / Obaro, Stephen K

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 730082

    Abstract: Background: Children with acute febrile illness with no localizing signs often receive antibiotics empirically in most resource-poor settings. However, little is known about the burden of bacteremia in this category of patients, and an appraisal is thus ...

    Abstract Background: Children with acute febrile illness with no localizing signs often receive antibiotics empirically in most resource-poor settings. However, little is known about the burden of bacteremia in this category of patients, and an appraisal is thus warranted. This will guide clinical practice and promote rational antibiotics use.
    Methods: We prospectively followed up 140 under-five children who presented with acute undifferentiated fever at the emergency/outpatient pediatric unit of a secondary healthcare facility. Baseline clinical and laboratory information was obtained and documented in a structured questionnaire. We compared baseline characteristics between participants with bacteremia and those without bacteremia. We further fitted a multivariable logistic regression model to identify factors predictive of bacteremia among the cohort.
    Result: The prevalence of bacteremia was 17.1%, and
    Conclusion: Among under-five children with acute undifferentiated fever, longer duration of fever, lethargy, inpatient care, tachypnea, and lymphopenia were the significant predictors of bacteremia.
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.730082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinicopathological Features and Treatment Outcome of Patients with Gastric Cancer in Lagos: Is the Outlook Getting Better?

    Osinowo, Adedapo Olumide / Olajide, Thomas Olagboyega / Balogun, Olanrewaju Samuel / Makanjuola, Ayomide / Adesanya, Adedoyin Adekunle / Atoyebi, Oluwole A

    Journal of the West African College of Surgeons

    2023  Volume 13, Issue 1, Page(s) 67–73

    Abstract: Background: Gastric cancer (GC) is an important cause of morbidity and mortality in Nigeria. Significant advances in the management of GC in South-West Nigeria occurred in the last three decades.: Patients and methods: This was a retrospective ... ...

    Abstract Background: Gastric cancer (GC) is an important cause of morbidity and mortality in Nigeria. Significant advances in the management of GC in South-West Nigeria occurred in the last three decades.
    Patients and methods: This was a retrospective comparative study of patients with GC that presented at our tertiary hospital in the last three decades. Information on clinicopathological features and treatment outcome were analysed. Data of two consecutive periods; 1991-2004 (Group I) and 2005-2018 (Group II) were compared.
    Results: Ninety-one patients were studied; Group I (47 patients), Group II (44 patients). The mean age was 56.4 ± 12.7 years and male-to-female ratio was 1.8 to 1.0. The predominant symptoms were epigastric pain in 81(89.0%) (43 vs. 38) and weight loss in 63(69.2%) (32 vs. 31), whereas the signs were epigastric tenderness in 44(46.1%) (24 vs. 20) and epigastric mass in 42(46.1%) (26 vs. 16). The overall mean duration of symptom was 12.3 ± 16.9 months. Barium meal diagnosed GC in 29(61.7%) patients in Group I vs. 4(9.1%) patients in Group II. Conversely, endoscopy diagnosed GC in 23(48.9%) patients in Group I vs. 37(84.1%) patients in Group II. Operations undertaken included palliative subtotal gastrectomy 26(28.6%), potentially curative subtotal gastrectomy 15(16.5%) and non-resectional surgeries in 27(29.7%) patients. The overall incidence of major post-operative complications was 33%. Thirty-nine (42.8%) of the studied patients were lost to follow up. The median postoperative survival for Groups I and II patients was 22 weeks and 58 weeks, P = 0.012, respectively.
    Conclusion: The outcome of management of patients with GC at our tertiary hospital has improved modestly in the past three decades. Patients are still presenting late with very advanced disease.
    Language English
    Publishing date 2023-01-18
    Publishing country India
    Document type Journal Article
    ISSN 2276-6944
    ISSN 2276-6944
    DOI 10.4103/jwas.jwas_219_22
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  6. Article ; Online: Cutaneous disorders of adolescence among Nigerian secondary school students

    Jadesola Tryphena Oyedepo / Oludolapo Sherifat Katibi / Olanrewaju Timothy Adedoyin

    The Pan African Medical Journal, Vol 36, Iss

    2020  Volume 36

    Abstract: INTRODUCTION: a community-based, age-specific survey of skin disorders is usually necessary to characterize the true burden of skin disease among a given population and help to tailor health care personnel training and delivery towards the prevalent ... ...

    Abstract INTRODUCTION: a community-based, age-specific survey of skin disorders is usually necessary to characterize the true burden of skin disease among a given population and help to tailor health care personnel training and delivery towards the prevalent disorders in resource poor settings. METHODS: this was a descriptive cross-sectional study among adolescents attending secondary schools in Ilorin, Kwara State, Nigeria. A thousand and three hundred students were recruited from public and private secondary schools through a multi-staged stratified random sampling method. Information was obtained via a semi-structured questionnaire and all students underwent a physical examination. Data was analysed using SPSS version 20. Information generated was presented with tables and figures. RESULTS: the prevalence of skin disease in the study was 66.5%. More females, mid-adolescents, students in senior class and those attending public schools had skin disorders. The most prevalent skin disease were Acne vulgaris, Pityriasis versicolor, Tinea capitis, Pityriasis capitis and Traction alopecia. CONCLUSION: skin conditions are highly prevalent among the adolescent population. Infective and inflammatory skin conditions appear to be more prevalent than other classes. Most times, only a few skin disorders account for the bulk of dermatoses affecting this age group. Adolescent skin healthcare should be subsidized because of the high prevalence of skin disorders in this age group.
    Keywords skin ; adolescence ; community ; Medicine ; R
    Subject code 571
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Incidence and predictors of acute kidney injury in children with severe malaria

    Folake Moriliat Afolayan / Olanrewaju Timothy Adedoyin / Mohammed Baba Abdulkadir / Olayinka Rasheed Ibrahim / Sikiru Abayomi Biliaminu / Olugbenga Ayodeji Mokuolu / Ayodele Ojuawo

    Paediatrica Indonesiana, Vol 62, Iss 1, Pp 44-

    2022  Volume 50

    Abstract: Background Acute kidney injury (AKI) is an underrecognized complication of severe malaria and an independent risk factor for mortality among children. Objective To determine the incidence and factors predictive of AKI as defined by the pediatric risk, ... ...

    Abstract Background Acute kidney injury (AKI) is an underrecognized complication of severe malaria and an independent risk factor for mortality among children. Objective To determine the incidence and factors predictive of AKI as defined by the pediatric risk, injury, failure, loss, and end-stage (pRIFLE) criteria in children with severe malaria and to assess in-hospital mortality rates in malarial AKI (MAKI). Methods This was a prospective cohort study in 170 children aged 0.5 to 14 years with confirmed Plasmodium falciparum on peripheral blood smears and clinical and/or laboratory features of severe malaria. Serum creatinine was determined using the Jaffe method and glomerular filtration rate (eGFR) was estimated using the Schwartz equation. The primary outcome was the incidence of AKI as defined by the pRIFLE criteria. Secondary outcomes included in-hospital mortality comparison between AKI and non-AKI groups, as well as factors predictive of AKI. Results The incidence of MAKI was 61.2% (104/170) and was comparable between males (66.7%) and females (70.6%). Mean eGFR was lower among children with AKI than those without [42.00 (SD 22) vs. 98.7 (SD 3.9) mL/min/1.73m2, respectively; P=0.005]. Children with MAKI were categorized as having risk (47/104; 45.2%), injury (33/104; 31.7%), or failure (24/104; 23.1%). Mortality rates in AKI and non-AKI subjects were comparable (4.8% vs. 4.6%; P=0.888). Predictors of MAKI were hemoglobinuria [adjusted OR (aOR) 3.948; 95%CI 1.138 to 8.030], deep acidotic breathing (aOR 2.991; 95%CI 3.549 to 66.898), and longer hospital stay (aOR 2.042; 95%CI 3.617 to 12.156). Children with MAKI were more likely to have a longer hospital stay by a mean of 2.5 days. Conclusion AKI is a common complication in children with severe malaria. MAKI has a low mortality rate comparable to those with severe malaria but without AKI. Hemoglobinuria, deep acidotic breathing, and longer hospital stay were predictive of MAKI.
    Keywords acute kidney injury ; prifle ; severe malaria ; children ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 360
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Indonesian Pediatric Society Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria.

    Olanrewaju, Timothy O / Osafo, Charlotte / Raji, Yemi R / Mamven, Manmak / Ajayi, Samuel / Ilori, Titilayo O / Arogundade, Fatiu A / Ulasi, Ifeoma I / Gbadegesin, Rasheed / Parekh, Rulan S / Tayo, Bamidele / Adeyemo, Adebowale A / Adedoyin, Olanrewaju T / Chijioke, Adindu A / Bewaji, Clement / Grobbee, Diederick E / Blankestijn, Peter J / Klipstein-Grobusch, Kerstin / Salako, Babatunde L /
    Adu, Dwomoa / Ojo, Akinlolu O

    Kidney international reports

    2022  Volume 8, Issue 3, Page(s) 658–666

    Abstract: Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD); however, the burden of cardiovascular risk factors in patients with CKD in Africa is not well characterized. We ... ...

    Abstract Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD); however, the burden of cardiovascular risk factors in patients with CKD in Africa is not well characterized. We determined the prevalence of selected cardiovascular risk factors, and association with CKD in the Human Heredity for Health in Africa Kidney Disease Research Network study.
    Methods: We recruited patients with and without CKD in Ghana and Nigeria. CKD was defined as estimated glomerular filtration rate of <60 ml/min per 1.73 m
    Results: We enrolled 8396 participants (cases with CKD, 3956), with 56% females. The mean age (45.5 ± 15.1 years) did not differ between patients and control group. The prevalence of hypertension (59%), diabetes (20%), and elevated cholesterol (9.9%), was higher in CKD patients than in the control participants (
    Conclusion: Cardiovascular risk factors are prevalent in middle-aged adult patients with CKD in Ghana and Nigeria, with higher proportions in Ghana than in Nigeria. Hypertension, elevated cholesterol, and underweight were independently associated with CKD.
    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.11.021
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  9. Article ; Online: Prevalence of chronic kidney disease and risk factors in North-Central Nigeria: a population-based survey.

    Olanrewaju, Timothy Olusegun / Aderibigbe, Ademola / Popoola, Ademola Alabi / Braimoh, Kolawole Thomas / Buhari, Mikhail Olayinka / Adedoyin, Olanrewaju Timothy / Kuranga, Sulyman Alege / Biliaminu, Sikiru Abayomi / Chijioke, Adindu / Ajape, Abdulwahab Akanbi / Grobbee, Diederick E / Blankestijn, Peter J / Klipstein-Grobusch, Kerstin

    BMC nephrology

    2020  Volume 21, Issue 1, Page(s) 467

    Abstract: Background: Chronic kidney disease (CKD) is a growing challenge in low- and middle-income countries, particularly in sub-Saharan Africa. There is insufficient population-based data on CKD in Nigeria that is required to estimate its true burden, and to ... ...

    Abstract Background: Chronic kidney disease (CKD) is a growing challenge in low- and middle-income countries, particularly in sub-Saharan Africa. There is insufficient population-based data on CKD in Nigeria that is required to estimate its true burden, and to design prevention and management strategies. The study aims to determine the prevalence of CKD and its risk factors in Nigeria.
    Methods: We studied 8 urban communities in Kwara State, North-Central zone of Nigeria. Blood pressure, fasting blood sugar, urinalysis, weight, height, waist circumference and hip circumference were obtained. Albuminuria and kidney length were measured by ultrasound while estimated glomerular filtration rate (eGFR) was derived from serum creatinine, using chronic disease epidemiology collaboration (CKD-EPI) equation. Associations of risk factors with CKD were determined by multivariate logistic regression and expressed as adjusted odds ratio (aOR) with corresponding 95% confidence intervals.
    Results: One thousand three hundred and fifty-three adults ≥18 years (44% males) with mean age of 44.3 ± 14.4 years, were screened. Mean kidney lengths were: right, 93.5 ± 7.0 cm and left, 93.4 ± 7.5 cm. The age-adjusted prevalence of hypertension was 24%; diabetes 4%; obesity 8.7%; albuminuria of > 30 mg/L 7%; and dipstick proteinuria 13%. The age-adjusted prevalence of CKD by estimated GFR < 60 ml/min/1.73m
    Conclusions: CKD and its risk factors are prevalent among middle-aged urban populations in North-Central Nigeria. It is common among women, fueled by diabetes, ageing, obesity, and albuminuria. These data add to existing regional studies of burden of CKD that may serve as template for a national prevention framework for CKD in Nigeria. One of the limitations of the study is that the participants were voluntary community dwellers and as such not representative for the community. The sample may thus have been subjected to selection bias possibly resulting in overestimation of CKD risk factors.
    MeSH term(s) Adult ; Albuminuria/epidemiology ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Nigeria/epidemiology ; Obesity/epidemiology ; Pregnancy ; Pregnancy Complications/epidemiology ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-020-02126-8
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  10. Article: Prevalence and risk factors for hypertension among school children in Ilorin, Northcentral Nigeria.

    Ibrahim, Olayinka R / Afolabi, Joseph K / Adedoyin, Olanrewaju T / Ojuawo, Ayodele I

    Journal of family & community medicine

    2018  Volume 26, Issue 3, Page(s) 181–186

    Abstract: Background: The global prevalence of childhood hypertension has increased from 1% to 2% to 4%-5%, with a value as high as 9.8% reported in Nigeria. However, the various risk factors associated with childhood hypertension in Nigeria are less explored. ... ...

    Abstract Background: The global prevalence of childhood hypertension has increased from 1% to 2% to 4%-5%, with a value as high as 9.8% reported in Nigeria. However, the various risk factors associated with childhood hypertension in Nigeria are less explored. The aim of this study was to determine the prevalence of hypertension and related risk factors (sociodemographic, family history of hypertension, history of snoring, birth order, and anthropometric indices) in primary school children in Nigeria.
    Materials and methods: A total of 1745 school children aged 6-12 years were selected using systematic random sampling method. Blood pressure (BP) was measured using the fourth report guideline. Those with BP higher than 90
    Results: Prevalence of systolic and or diastolic hypertension at the third visit was 3.0%. Prevalence of systolic hypertension (3
    Conclusions: Prevalence of hypertension is low (3.0%), and only obesity (BMI ≥ 95
    Language English
    Publishing date 2018-02-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 2580509-5
    ISSN 2229-340X ; 1319-1683
    ISSN (online) 2229-340X
    ISSN 1319-1683
    DOI 10.4103/jfcm.JFCM_42_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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