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Article: The effects of heliox non-saturation diving on the cardiovascular system and cognitive functions.

Lee, Dal-Woo / Jung, Su-Jeen / Ju, Jeong-Sun

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

2020 Volume 47, Issue 1, Page(s) 93–100

Abstract: The purpose of this study was to investigate the effects of a single bout of heliox non-saturation diving on the cardiovascular system and cognitive function. Ten recreational scuba divers (10 males, ∼35 years old) participated in this study. These ... ...

Abstract	The purpose of this study was to investigate the effects of a single bout of heliox non-saturation diving on the cardiovascular system and cognitive function. Ten recreational scuba divers (10 males, ∼35 years old) participated in this study. These subjects made two pool dives within a one-week interval, alternating gases with compressed air (21% O2, 79% N2) and with heliox (21% O2 and 79% He). The depth was to 26 meters over a 20-minute duration. The results showed that heliox diving significantly increased blood O2 saturation by 1.15% and significantly decreased blood lactate levels by ∼57% when compared with air diving (P ≺ 0.05). However, there were no significant differences in resting heart rate, systolic or diastolic pressure, core body blood pressure, and pulse wave velocity between the heliox and air dives. The Stroop test showed that the heliox dive significantly increased cognitive function compared with the air dive in both the simple test (Offtime) and interference test (Ontime) (P ≺ 0.05). It was concluded that the heliox dive increases blood O2 saturation and decreases blood lactate concentration when compared with air dives. These conditions are likely to help divers reduce hypoxia in the water, reduce the risk of loss of consciousness, reduce fatigue and allow them to dive for longer. Heliox diving may also help judgment and risk coping skills in the water due to the improvement of cognitive ability as compared to air breathing dives.
MeSH term(s)	Adult ; Air ; Blood Pressure/drug effects ; Cardiovascular System/drug effects ; Cell Hypoxia ; Cognition/drug effects ; Diving/physiology ; Heart Rate/drug effects ; Helium/pharmacology ; Humans ; Hypoxia/blood ; Hypoxia/prevention & control ; Lactic Acid/blood ; Male ; Oxygen/blood ; Oxygen/pharmacology ; Pulse Wave Analysis ; Recreation ; Time Factors ; Vascular Stiffness
Chemical Substances	Helium (206GF3GB41) ; Lactic Acid (33X04XA5AT) ; heliox (58933-55-4) ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154414-4
ISSN	1066-2936
ISSN	1066-2936
DOI	10.22462/01.03.2020.10
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Article: Immunogenicity and Safety of a Newly Developed Live Attenuated Varicella Vaccine in Healthy Children: A Multi-National, Randomized, Double-Blinded, Active-Controlled, Phase 3 Study.

Choi, Ui Yoon / Kim, Ki Hwan / Cho, Hye-Kyung / Kim, Dong Ho / Ma, Sang Hyuk / Choi, Young Youn / Kim, Chun Soo / Capeding, Maria Rosario / Kobashi, Ilya Angelica Rochin / Kim, Hun / Ryu, Ji Hwa / Lee, Su Jeen / Park, Ho Keun / Kim, Jong-Hyun

Vaccines

2023 Volume 11, Issue 9

Abstract: Korean manufacturers have developed a new varicella vaccine, NBP608. This phase 3, randomized, double-blind, multicenter study aimed to compare the immunogenicity and safety of NBP608 in healthy children to those of ... ...

Abstract	Korean manufacturers have developed a new varicella vaccine, NBP608. This phase 3, randomized, double-blind, multicenter study aimed to compare the immunogenicity and safety of NBP608 in healthy children to those of Varivax
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11091416
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Article ; Online: Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques.

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 23

Abstract: Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine ... ...

Abstract	Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine adjuvanted with AS03, which has recently been authorized for marketing in South Korea under the trade name SKYCovione
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00622-0
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Article ; Online: Corrigendum to "Recombinant measles virus encoding the spike protein of SARS-CoV-2 efficiently induces Th1 responses and neutralizing antibodies that block SARS-CoV-2 variants" [Vaccine 41(11) (2023) 1892-1901].

Kwak, Hye Won / Park, Hyo-Jung / Jung, Seo-Yeon / Oh, Eun Young / Park, Sang-In / Kim, Yeonhwa / Park, Hyeong-Jun / Park, Sohyun / Kim, You-Jin / Ko, Hae Li / Lee, Jung-Ah / Won, Hyeran / Hwang, Yun-Ho / Kim, Seo Yeon / Kim, Se Eun / Bae, Seong Eun / Yoon, Minhyuk / Kim, Jae-Ouk / Song, Manki /

Lee, Su Jeen / Seo, Ki-Weon / Lee, Kunse / Kim, Dokeun / Kim, Hun / Lee, Sang-Myeong / Hong, So-Hee / Nam, Jae-Hwan

Vaccine

2023 Volume 41, Issue 47, Page(s) 7033

Language	English
Publishing date	2023-10-19
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.10.033
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Zs.MO 458: Show issues

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Article ; Online: Amelioration of late-onset hepatic steatosis in IDH2-deficient mice.

Lee, Su Jeong / Cha, Hanvit / Kim, Hyunjin / Lee, Jin Hyup / Park, Jeen-Woo

Free radical research

2017 Volume 51, Issue 4, Page(s) 368–374

Abstract: Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population and can evolve into nonalcoholic steatohepatosis (NASH), cirrhosis, and complications such as liver failure and hepatocellular carcinoma. Recently, we reported that ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population and can evolve into nonalcoholic steatohepatosis (NASH), cirrhosis, and complications such as liver failure and hepatocellular carcinoma. Recently, we reported that mitochondrial NADP
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2017.1320554
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Zs.A 2236: Show issues

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Article ; Online: Intranasal immunization with the recombinant measles virus encoding the spike protein of SARS-CoV-2 confers protective immunity against COVID-19 in hamsters.

Vaccine

2023 Volume 42, Issue 2, Page(s) 69–74

Abstract: Background: As the nasal mucosa is the initial site of infection for COVID-19, intranasal vaccines are more favorable than conventional vaccines. In recent clinical studies, intranasal immunization has been shown to generate higher neutralizing ... ...

Abstract	Background: As the nasal mucosa is the initial site of infection for COVID-19, intranasal vaccines are more favorable than conventional vaccines. In recent clinical studies, intranasal immunization has been shown to generate higher neutralizing antibodies; however, there is a lack of evidence on sterilizing immunity in the upper airway. Previously, we developed a recombinant measles virus encoding the spike protein of SARS-CoV-2 (rMeV-S), eliciting humoral and cellular immune responses against SARS-CoV-2. Objectives: In this study, we aim to provide an experiment on nasal vaccines focusing on a measles virus platform as well as injection routes. Study design: Recombinant measles viruses expressing rMeV-S were prepared, and 5 × 10 Results: The intranasal immunization of rMeV-S elicits protective immune responses and alleviates virus-induced pathophysiology, such as body weight reduction and lung weight increase in hamsters. Furthermore, lung immunohistochemistry demonstrated that intranasal rMeV-S immunization induces effective SARS-CoV-2 clearance that correlates with viral RNA content, as determined by qRT-PCR, in the lung and nasal wash samples, SARS-CoV-2 viral titers in lung, nasal wash, BALF samples, serum RBD-specific IgG concentration, and RBD-specific IgA concentration in the BALF. Conclusion: An intranasal vaccine based on the measles virus platform is a promising strategy owing to the typical route of infection of the virus, the ease of administration of the vaccine, and the strong immune response it elicits.
MeSH term(s)	Animals ; Cricetinae ; SARS-CoV-2 ; Measles virus/genetics ; COVID-19/prevention & control ; Spike Glycoprotein, Coronavirus ; Immunization ; Measles ; Orthopoxvirus ; Nasal Mucosa ; Antibodies, Neutralizing ; Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Antibodies, Viral ; Administration, Intranasal
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-12-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.12.011
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP+-dependent isocitrate dehydrogenase in HaCaT cells.

Lee, Su Jeong / Park, Jeen-Woo

BMB reports

2013 Volume 47, Issue 4, Page(s) 209–214

Abstract: Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox ... ...

Abstract	Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for antioxidant systems. In this study, we demonstrated that knockdown of IDPc expression by RNA interference enhances UVB-induced apoptosis of immortalized human HaCaT keratinocytes. This effect manifested as DNA fragmentation, changes in cellular redox status, mitochondrial dysfunction, and modulation of apoptotic marker expression. Based on our findings, we suggest that attenuation of IDPc expression may protect skin from UVB-mediated damage, by inducing the apoptosis of UV-damaged cells.
MeSH term(s)	Apoptosis/genetics ; Apoptosis/radiation effects ; Cell Line ; Cytosol/enzymology ; Humans ; Isocitrate Dehydrogenase/deficiency ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; RNA Interference ; Ultraviolet Rays
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41) ; isocitrate dehydrogenase (NADP+) (EC 1.1.1.42)
Language	English
Publishing date	2013-11-28
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
DOI	10.5483/bmbrep.2014.47.4.137
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Article ; Online: Evaluation of glycoprotein E subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand RNA-based adjuvant.

Lee, Su Jeen / Park, Hyo-Jung / Ko, Hae Li / Lee, Jung Eun / Lee, Hyun Joo / Kim, Hun / Nam, Jae-Hwan

Immunity, inflammation and disease

2020 Volume 8, Issue 2, Page(s) 216–227

Abstract: Introduction: Varicella-zoster virus (VZV), a human alphaherpesvirus 3, elicits both chickenpox and shingles and/or postherpetic neuralgia. A live attenuated vaccine (LAV) and glycoprotein E (gE) subunit vaccine were developed to prevent VZV-induced ... ...

Abstract	Introduction: Varicella-zoster virus (VZV), a human alphaherpesvirus 3, elicits both chickenpox and shingles and/or postherpetic neuralgia. A live attenuated vaccine (LAV) and glycoprotein E (gE) subunit vaccine were developed to prevent VZV-induced diseases. We recently reported that single-strand RNA (ssRNA) based on the intergenic region of the internal ribosome entry site of cricket paralysis virus (CrPV) is an effective adjuvant for protein-based and virus-like particle-based vaccines. Here, Chinese hamster ovary expression system and an LAV from Oka/SK strains. Methods: We appraised the adjuvant effect of the same CrPV ssRNA encoding the gE gene formulated in the two vaccines using VZV-primed C57BL/6 mice and guinea pigs. Humoral immunity and cell-mediated immunity were assessed by enzyme-linked immunosorbent assay (ELISA) and ELISPOT in gE subunit vaccine and by ELISA and fluorescent antibody to membrane antigen in LAV. Results: The gE subunit vaccine-induced gE-specific antibodies and CD4 Conclusions: Taken together, these results highlight that the gE subunit vaccine and LAV developed in this study can be functional VZV vaccines, and ssRNAs appear to function better as adjuvants in a subunit vaccine than in an LAV.
MeSH term(s)	A549 Cells ; Adjuvants, Immunologic/administration & dosage ; Animals ; Antibodies, Viral/blood ; CD4-Positive T-Lymphocytes/immunology ; CHO Cells ; Cricetinae ; Cricetulus ; Guinea Pigs ; Herpes Zoster/immunology ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine/administration & dosage ; Herpes Zoster Vaccine/immunology ; Herpesvirus 3, Human ; Humans ; Immunity, Cellular ; Mice ; Mice, Inbred C57BL ; RNA, Messenger ; Vaccines, Attenuated ; Vaccines, Subunit ; Viral Envelope Proteins/administration & dosage ; Viral Envelope Proteins/immunology
Chemical Substances	Adjuvants, Immunologic ; Antibodies, Viral ; Herpes Zoster Vaccine ; RNA, Messenger ; Vaccines, Attenuated ; Vaccines, Subunit ; Viral Envelope Proteins ; glycoprotein E, varicella-zoster virus
Keywords	covid19
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2050-4527
ISSN (online)	2050-4527
DOI	10.1002/iid3.297
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Article ; Online: Immunogenicity and Safety of a Newly Developed Live Attenuated Varicella Vaccine in Healthy Children

Ui Yoon Choi / Ki Hwan Kim / Hye-Kyung Cho / Dong Ho Kim / Sang Hyuk Ma / Young Youn Choi / Chun Soo Kim / Maria Rosario Capeding / Ilya Angelica Rochin Kobashi / Hun Kim / Ji Hwa Ryu / Su Jeen Lee / Ho Keun Park / Jong-Hyun Kim

Vaccines, Vol 11, Iss 1416, p

A Multi-National, Randomized, Double-Blinded, Active-Controlled, Phase 3 Study

2023 Volume 1416

Abstract	Korean manufacturers have developed a new varicella vaccine, NBP608. This phase 3, randomized, double-blind, multicenter study aimed to compare the immunogenicity and safety of NBP608 in healthy children to those of Varivax TM (control). Children aged 12 months to 12 years were randomized in a ratio of 1:1 to receive either NBP608 or the control vaccine. Serum samples were obtained before vaccination and within six to eight weeks after vaccination. In total, 499 participants (NBP608, n = 251; control, n = 248) were enrolled. The seroconversion rate (SCR) measured using a FAMA assay was 99.53% in the NBP608 group, and the lower limit of the 95% confidence interval (95% LCL) for the SCR difference (NBP608 minus the control) was 0.52%. This 95% LCL for the difference was higher than the specified non-inferiority margin of −15%. In an assessment using gpELISA, the SCR was 99.53% in the NBP608 group, and the 95% LCL for the SCR difference was 6.5%, which was higher than the specified non-inferiority margin of −15%. There were no significant differences between the NBP608 and control group with respect to the proportions of participants who demonstrated local and systemic solicited AEs. This study indicated that NBP608 had a clinically acceptable safety profile and was not immunologically inferior to Varivax TM .
Keywords	varicella ; vaccine ; immunogenicity ; safety ; children ; clinical trial ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene.

Lee, Su Jeong / Kim, Sung Hwan / Park, Kwon Moo / Lee, Jin Hyup / Park, Jeen-Woo

Free radical biology & medicine

2016 Volume 99, Page(s) 179–188

Abstract: Reactive oxygen species (ROS) are a byproduct of normal metabolism and play important roles in cell signaling and homeostasis. Mitochondria, the main organelles involved in intracellular ROS production, play central roles in modulating redox-dependent ... ...

Abstract	Reactive oxygen species (ROS) are a byproduct of normal metabolism and play important roles in cell signaling and homeostasis. Mitochondria, the main organelles involved in intracellular ROS production, play central roles in modulating redox-dependent cellular processes such as metabolism and apoptosis. We recently reported an important role for mitochondrial NADP
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2016.08.011
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