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Article ; Online: Exploring the diverse role of pyruvate kinase M2 in cancer: Navigating beyond glycolysis and the Warburg effect.

Upadhyay, Saurabh / Khan, Shumayila / Hassan, Md Imtaiyaz

Biochimica et biophysica acta. Reviews on cancer

2024 Volume 1879, Issue 3, Page(s) 189089

Abstract: Pyruvate Kinase M2, a key enzyme in glycolysis, has garnered significant attention in cancer research due to its pivotal role in the metabolic reprogramming of cancer cells. Originally identified for its association with the Warburg effect, PKM2 has ... ...

Abstract	Pyruvate Kinase M2, a key enzyme in glycolysis, has garnered significant attention in cancer research due to its pivotal role in the metabolic reprogramming of cancer cells. Originally identified for its association with the Warburg effect, PKM2 has emerged as a multifaceted player in cancer biology. The functioning of PKM2 is intricately regulated at multiple levels, including controlling the gene expression via various transcription factors and non-coding RNAs, as well as adding post-translational modifications that confer distinct functions to the protein. Here, we explore the diverse functions of PKM2, encompassing newly emerging roles in non-glycolytic metabolic regulation, immunomodulation, inflammation, DNA repair and mRNA processing, beyond its canonical role in glycolysis. The ever-expanding list of its functions has recently grown to include roles in subcellular compartments such as the mitochondria and extracellular milieu as well, all of which make PKM2 an attractive drug target in the pursuit of therapeutics for cancer.
Language	English
Publishing date	2024-03-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2024.189089
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Article ; Online: Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase.

Khan, Shumayila / Upadhyay, Saurabh / Dave, Upma / Kumar, Ashwani / Gomes, James

International journal of biological macromolecules

2023 Volume 256, Issue Pt 2, Page(s) 128403

Abstract: The D-amino acid oxidase protein modulates neurotransmission by controlling the levels of D-serine, a co-agonist of N-methyl-D-aspartate receptors. Mutations in the DAO gene have been associated with ALS, with some studies reporting pathogenic mechanisms ...

Abstract	The D-amino acid oxidase protein modulates neurotransmission by controlling the levels of D-serine, a co-agonist of N-methyl-D-aspartate receptors. Mutations in the DAO gene have been associated with ALS, with some studies reporting pathogenic mechanisms of the R199W mutation. We have characterized two novel mutations R38H and Q201R found in ALS patients and report certain novel findings related to the R199W mutation. We report the first instance of crystal structure analysis of a patient-derived mutant of DAO, R38H, solved at 2.10 Å. The structure revealed significant perturbations and altered binding with the cofactor (FAD) and the inhibitor benzoate, supported by biochemical assays. Q201R-DAO also exhibited significantly lower ligand binding efficiency. Furthermore, kinetic analysis across all variants revealed reduced oxidase activity and substrate binding. Notably, R38H-DAO exhibited near-WT activity only at high substrate concentrations, while R199W-DAO and Q201R-DAO displayed drastic activity reduction. Additionally, structural perturbations were inferred for R199W-DAO and Q201R-DAO, evident by the higher oligomeric state in the holoenzyme form. We also observed thermal instability in case of R199W-DAO mutant. We hypothesize that the mutant enzymes may be rendered non-functional in a cellular context, potentially leading to NMDAR-associated excitotoxicity. The study provides novel insights into structural and functional aspects of DAO mutations in ALS.
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/genetics ; Kinetics ; Mutation ; Serine/genetics
Chemical Substances	Serine (452VLY9402)
Language	English
Publishing date	2023-11-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128403
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Article ; Online: ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency.

Kumar, Akhalesh / Sharma, Saurabh / Mishra, Sudhanshu / Ojha, Smriti / Upadhyay, Pawan

Anti-cancer agents in medicinal chemistry

2023 Volume 23, Issue 13, Page(s) 1499–1505

Abstract: Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of ... ...

Abstract	Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of these plants are primarily composed of polysaccharides, with the remaining amounts of resin (30-60%) and essential oils (5-10%) soluble in organic solvents. BA and its analogs are also reported to exhibit various in vivo and biological responses for example anti-inflammatory, anti-tumor, free radical scavenging activity, etc. Among all analogs, 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been demonstrated to be the most effective at reducing cytokine production and inhibiting the inflammatory responsecausing enzymes. In this review, we summarized the computational ADME prediction via the SwissADME computational tool and the structure-activity relationship of the Boswellic acid scaffold for the aspect of anticancer and antiinflammatory potency. In addition to these research findings which are associated with the therapy of acute inflammation and some cancers, the potential of boswellic acids against other disorders was also discussed.
MeSH term(s)	Humans ; Anti-Inflammatory Agents/pharmacology ; Structure-Activity Relationship ; Plant Extracts ; Triterpenes/pharmacology ; Triterpenes/metabolism ; Boswellia
Chemical Substances	boswellic acid (631-69-6) ; Anti-Inflammatory Agents ; Plant Extracts ; Triterpenes ; acetyl-11-ketoboswellic acid
Language	English
Publishing date	2023-04-18
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520623666230417080437
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Article ; Online: Black garlic particles as a natural pigment and emulsifier in a Pickering emulsion based low fat innovative mayonnaise: Improved rheology and bioactivity.

Vathsala, V / Saurabh, Vivek / Kumar Choupdar, Ganesh / Upadhyay, Neelam / Pal Singh, Sukhvinder / Dutta, Anirban / Kaur, Charanjit

Food research international (Ottawa, Ont.)

2023 Volume 173, Issue Pt 2, Page(s) 113484

Abstract: Black garlic is rich in brown pigments and Maillard reaction products are known for antioxidant activity and health promoting effects. In the present investigation, we report a facile strategy for fabricating low-fat innovative mayonnaise (IM) using ... ...

Abstract	Black garlic is rich in brown pigments and Maillard reaction products are known for antioxidant activity and health promoting effects. In the present investigation, we report a facile strategy for fabricating low-fat innovative mayonnaise (IM) using black garlic particles (BGP) as a natural pigment, and a functional ingredient. Whey protein concentrate and high methoxyl pectin at optimized concentrations were utilized for fabricating an IM which served as a control. IM
MeSH term(s)	Emulsions/chemistry ; Garlic ; Whey Proteins/chemistry ; Antioxidants ; Emulsifying Agents ; Pectins/chemistry ; Rheology
Chemical Substances	Emulsions ; Whey Proteins ; Antioxidants ; Emulsifying Agents ; Pectins (89NA02M4RX)
Language	English
Publishing date	2023-09-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113484
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Article ; Online: Haemophilus influenzae complicating chronic Cryptococcus meningoencephalitis in a newly diagnosed HIV patient at rural tertiary care centre in Northern India

Saurabh Pandey / Priyanka Rai / Babulal Kannaujiya / Vandana Upadhyay / Vinod Kumar Maurya

Journal of Medical Evidence, Vol 4, Iss 2, Pp 161-

An uncommon association

2023 Volume 162

Keywords	Medicine ; R
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ethylene scavenging film based on corn starch-gum acacia impregnated with sepiolite clay and its effect on quality of fresh broccoli florets

Upadhyay, Aakash / Kumar, Pardeep / Kardam, Saurabh Kumar / Gaikwad, Kirtiraj K.

Food bioscience. 2022 Apr., v. 46

2022

Abstract: Ethylene scavenging film based on corn starch (CS) and gum acacia (GA) nanocomposite film impregnated with sepiolite (SP) was fabricated by the casting method and characterized. FTIR, TGA, XRD, SEM, mechanical, water vapor barrier, and ethylene ... ...

Abstract	Ethylene scavenging film based on corn starch (CS) and gum acacia (GA) nanocomposite film impregnated with sepiolite (SP) was fabricated by the casting method and characterized. FTIR, TGA, XRD, SEM, mechanical, water vapor barrier, and ethylene scavenging properties of CS/GA films with and without SP were carried out. The addition of SP in the CS/GA films showed improved elongation and lowered water vapor permeability in comparison to the control film. Interfacial interaction between the CS/GA and SP was observed in FTIR. The SEM images showed that SP clay nanoparticles were evenly distributed in the CS/GA film matrix. Increasing the SP into CS/GA films improves tensile strength, water vapor permeability, crystallinity, and thermal stability. The CS/GA/SP film showed ethylene scavenging properties increasing with SP. Based on mechanical, water barrier permeability, and ethylene scavenging properties, CS/GA film impregnated with 20% SP was optimal and was selected for broccoli florets packaging. Broccoli packaged in a CS/GA/SP20 film and stored at 23 °C for 6 d showed a reduction in loss of weight, color, and total soluble solids of broccoli florets. CS/GA/SP nano biocomposites films show great potential in the area of active packaging due to their good mechanical, barrier, and ethylene scavenging properties.
Keywords	Acacia ; biocomposites ; broccoli ; clay ; color ; corn ; corn starch ; crystal structure ; ethylene ; florets ; gum arabic ; nanocomposites ; permeability ; sepiolite ; tensile strength ; thermal stability ; water vapor ; weight loss
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2212-4292
DOI	10.1016/j.fbio.2022.101556
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hydroxychloroquine: Adverse Drug Reaction Profile of an Old Drug in a New Situation.

Chopra, Deepti / Bhandari, Bharti / Rai, Jayant / Upadhyay, Rashmi / Sidhu, Jaspreet Kaur / Srivastava, Saurabh

Current drug safety

2022 Volume 17, Issue 4, Page(s) 370–374

Abstract: Background: Hydroxychloroquine (HCQ) has been extensively used during the COVID-19 pandemic both as a therapeutic and prophylactic drug. HCQ is generally well tolerated; however, adverse drug reactions (ADRs) in COVID-19 need further exploration. In ... ...

Abstract	Background: Hydroxychloroquine (HCQ) has been extensively used during the COVID-19 pandemic both as a therapeutic and prophylactic drug. HCQ is generally well tolerated; however, adverse drug reactions (ADRs) in COVID-19 need further exploration. In this study, we have determined the type and pattern of ADRs of HCQ as a prophylactic and therapeutic drug in COVID-19. Methods: All spontaneous suspected ADR reports due to HCQ in COVID-19 patients submitted to the ADR monitoring of a tertiary care hospital were included. Additionally, a survey was designed for active surveillance of ADRs among healthcare professionals (HCPs) who were on prophylaxis with HCQ. The ADRs were analyzed to determine severity, causality, and preventability using the Hartwig Scale, World Health Organisation-Uppasala Monitoring Centre (WHO-UMC) scale, and modified Schumock and Thornton criterion respectively. Results: Sixty-four ADR reports were received from COVID-19 patients. A total of 78 ADRs were reported by 49 HCPs who were on HCQ prophylaxis. The majority of the patients had ADRs related to skin and soft tissues (37.5%), whereas the HCPs on prophylaxis mostly had gastrointestinal complaints (42.3%). ADRs observed in HCPs on prophylaxis were mild, not requiring any intervention. However, 50% of ADRs in patients were of "moderate" category. Conclusion: Undiscerning and unsupervised use of HCQ can expose the general population as well as patients to serious adverse drug effects. Utmost care is necessary before using HCQ prophylactically or for treatment in COVID-19.
MeSH term(s)	COVID-19/drug therapy ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Humans ; Hydroxychloroquine/adverse effects ; Pandemics
Chemical Substances	Hydroxychloroquine (4QWG6N8QKH)
Language	English
Publishing date	2022-03-02
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/1574886317666220301111913
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Article ; Online: Contribution of zinc solubilizing bacterial isolates on enhanced zinc uptake and growth promotion of maize (Zea mays L.).

Upadhyay, Himantika / Gangola, Saurabh / Sharma, Anita / Singh, Arjun / Maithani, Damini / Joshi, Samiksha

Folia microbiologica

2021 Volume 66, Issue 4, Page(s) 543–553

Abstract: Zinc-solubilizing bacteria, namely Burkholderia cepacia and Acinetobacter baumannii (H1 and H3, respectively), able to grow in liquid basal medium supplemented with ZnO, ... ...

Abstract	Zinc-solubilizing bacteria, namely Burkholderia cepacia and Acinetobacter baumannii (H1 and H3, respectively), able to grow in liquid basal medium supplemented with ZnO, Zn
MeSH term(s)	Bacteria/metabolism ; Host Microbial Interactions/physiology ; Plant Development ; Plant Roots/microbiology ; Soil Microbiology ; Zea mays/growth & development ; Zea mays/metabolism ; Zea mays/microbiology ; Zinc/metabolism
Chemical Substances	Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-021-00863-3
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Article: Contribution of zinc solubilizing bacterial isolates on enhanced zinc uptake and growth promotion of maize (Zea mays L.)

Upadhyay, Himantika / Gangola, Saurabh / Sharma, Anita / Singh, Arjun / Maithani, Damini / Joshi, Samiksha

Folia microbiologica. 2021 Aug., v. 66, no. 4

2021

Abstract: Zinc-solubilizing bacteria, namely Burkholderia cepacia and Acinetobacter baumannii (H1 and H3, respectively), able to grow in liquid basal medium supplemented with ZnO, Zn₃ (PO₄)₂, and ZnSO₄·7H₂O (0.1%), showed plant growth promoting properties. The ... ...

Abstract	Zinc-solubilizing bacteria, namely Burkholderia cepacia and Acinetobacter baumannii (H1 and H3, respectively), able to grow in liquid basal medium supplemented with ZnO, Zn₃ (PO₄)₂, and ZnSO₄·7H₂O (0.1%), showed plant growth promoting properties. The treatment of Acinetobacter baumannii (H3) solubilizes the ZnO (1.42 ppm), Zn₃ (PO₄)₂ (1.15 ppm), and ZnSO₄·7H₂O (1.44 ppm).The maximum solubilization of ZnSO₄·7H₂O (1.42 ppm) was observed in Burkholderia cepacia (H1) after 15 days. Organic acids produced by the bacteria decreased the pH of the medium and helped in Zn solubilization. In pot experiment on maize, Burkholderia cepacia (H1) treatment significantly enhanced plant height and root length in the presence of ZnO (2%) added in 10 mL of inoculum in each pot. High-performance liquid chromatography (HPLC) analysis of maize root extract showed the presence of oxalic, maleic, tartaric, and fumaric acid after 60 days of the experiment. Bacterial treatments enhanced sugar and protein level in maize plants and were 55.2 and 42.55 µg/mL plant extract, respectively, under mixture of bacterial treatment. Hence, isolates H1 and H3 expressed highest potential throughout the experiments, as zinc solubilizers and plant growth-promoting strains. This study demonstrated that meticulous use of Zn-solubilizing bacterial strains could aid in enhanced plant growth and can be the potential bio-inoculants for biofortification of maize to overcome the problems of malnutrition.
Keywords	Acinetobacter baumannii ; Burkholderia cepacia ; Zea mays ; biofortification ; corn ; culture media ; fumaric acid ; growth promotion ; high performance liquid chromatography ; inoculum ; liquids ; malnutrition ; pH ; plant growth ; plant height ; protein content ; root extracts ; solubilization ; sugars ; zinc
Language	English
Dates of publication	2021-08
Size	p. 543-553.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-021-00863-3
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Article ; Online: An assessment of various potentially toxic elements and associated health risks in agricultural soil along the middle Gangetic basin, India.

Tyagi, Nidhi / Upadhyay, Munish Kumar / Majumdar, Arnab / Pathak, Saurabh Kumar / Giri, Biswajit / Jaiswal, Manoj Kumar / Srivastava, Sudhakar

Chemosphere

2022 Volume 300, Page(s) 134433

Abstract: The present study analysed the levels of potentially toxic elements along with physico-chemical properties of agricultural soil samples (n = 59) collected from fields situated along the path of river Ganga in the middle Gangetic floodplain in two ... ...

Abstract	The present study analysed the levels of potentially toxic elements along with physico-chemical properties of agricultural soil samples (n = 59) collected from fields situated along the path of river Ganga in the middle Gangetic floodplain in two districts, Ballia and Ghazipur. Arsenic (As), chromium (Cr), copper (Cu), nickel (Ni), zinc (Zn), lead (Pb), iron (Fe) and manganese (Mn) levels were analysed by Wavelength Dispersive-X-Ray Fluorescence Spectroscopy (WD-XRF) and the associated health risks along with diverse indices were calculated. The mean concentrations of As, Cu, Cr, Pb, Zn and Ni were found to be 15, 42, 85, 18, 87 and 47 mg kg
MeSH term(s)	Arsenic/analysis ; Environmental Monitoring/methods ; Humans ; India ; Lead/analysis ; Metals, Heavy/analysis ; Risk Assessment/methods ; Soil/chemistry ; Soil Pollutants/analysis
Chemical Substances	Metals, Heavy ; Soil ; Soil Pollutants ; Lead (2P299V784P) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2022-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.134433
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