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  1. Article: Evaluation of neurological and cardiological findings in carbonmonoxide poisoning in children.

    Boztepe, Hatice / Yalaki, Zahide / Bilge, Yıldız Dallar

    Turk pediatri arsivi

    2014  Volume 49, Issue 4, Page(s) 314–322

    Abstract: Aim: The aim of our study was to investigate the relation of blood carboxyhemoglobin level with presentation finding and clinical properties and to demonstrate neurological and cardiological findings which are indicators of tissue hypoxia in patients ... ...

    Abstract Aim: The aim of our study was to investigate the relation of blood carboxyhemoglobin level with presentation finding and clinical properties and to demonstrate neurological and cardiological findings which are indicators of tissue hypoxia in patients followed up because of carbonmonoxide (CO) poisoning.
    Material and methods: Three hundred and twenty-five patients who were followed up because of carbonmonoxide poisoning between 2011 and 2013 in our pediatric emergency department were evaluated prospectively. Ethics committee approval was obtained for the study on 10.19.2011 (number: 0437). The carbonmonoxide levels, source of intoxication, neurological and cardiological findings and treatment methods were recorded. Blood gases and cardiac enzymes were studied and electrocardiography (ECG) was performed. The data were analysed using SPSS for windows 16.0 package program.
    Results: One hundred and sixty-eight (51.7%) of the patients were female and the median age was 9 years (11 days-17 years). Two hundred and twenty-eight (70.2%) of the patients were poisoned while using heater and 78.1% presented during winter months. The median carbonmonoxide level of the patients was found to be 24.8%. Cardiac enzymes were found to be increased in 10.5% of the patients, first degree A-V block was found in 0.6% and negative T wave was found in 0.3%. Glasgow coma score was found to be below 14 in 4.6% of the patients. A significant correlation was found between the carboxyhemoglobin levels and neurological findings, cardiological findings and lactate (p<0.05). Normobaric oxygen treatment was given to 76.3% of the patients and hyperbaric oxygen treatment was given to 23.7%.
    Conclusions: We think that neurological disorders and cardiac findings may be closely related, since systemic involvement may be easier in carbonmonoxide poisoning in children, Glasgow coma score should be assessed in the follow-up of the patients and cardiac enzymes and serum lactate levels should be monitored closely from the time of presentation.
    Language English
    Publishing date 2014-12-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 1306-0015
    ISSN 1306-0015
    DOI 10.5152/tpa.2014.201010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients.

    Ulusal Okyay, Gülay / Okyay, Kaan / Polattaş Solak, Evşen / Sahinarslan, Asife / Paşaoğlu, Özge / Ayerden Ebinç, Fatma / Paşaoğlu, Hatice / Boztepe Derici, Ülver / Sindel, Şükrü / Arınsoy, Turgay

    Hemodialysis international. International Symposium on Home Hemodialysis

    2015  Volume 19, Issue 3, Page(s) 452–462

    Abstract: Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk ... ...

    Abstract Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P < 0.001), waist circumference (β = 0.572, P < 0.001), body fat mass (β = 0.562, P < 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = -0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high-density lipoprotein cholesterol ratio (β = 0.529, P < 0.001), 1/HOMA-IR (β = -0.386, P = 0.006), and spKt/V (β = -0.311, P = 0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P > 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
    MeSH term(s) Adipose Tissue/abnormalities ; Adipose Tissue/physiopathology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cross-Sectional Studies ; Echocardiography/methods ; Female ; Humans ; Male ; Middle Aged ; Pericardium/abnormalities ; Pericardium/physiopathology ; Renal Dialysis/adverse effects ; Risk Factors
    Language English
    Publishing date 2015-02-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effects of iron on FGF23-mediated Ca-P metabolism in CKD patients.

    Deger, Serpil Muge / Erten, Yasemin / Pasaoglu, Ozge Tugce / Derici, Ulver Boztepe / Reis, Kadriye Altok / Onec, Kursad / Pasaoglu, Hatice

    Clinical and experimental nephrology

    2012  Volume 17, Issue 3, Page(s) 416–423

    Abstract: Background: Fibroblast growth factor 23 (FGF23) is an important counterregulatory hormone for phosphate homeostasis. Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized ...

    Abstract Background: Fibroblast growth factor 23 (FGF23) is an important counterregulatory hormone for phosphate homeostasis. Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.
    Methods: This cross-sectional study was performed in a single center, and involved 73 hemodialysis patients (47.7 ± 15.74 years old, 68.5% men), 29 peritoneal dialysis patients (44.55 ± 15.05 years old, 62.1% men), and 55 healthy (43.57 ± 14.36 years old, 55.6% men) subjects. The dialysis group was subcategorized according to iron therapy administration into users and nonusers.
    Results: The median iFGF23 level was significantly higher in the dialysis population than in the healthy controls [88.050 (25.2-1038.3) pg/ml versus 46.95 (2.4-356) pg/ml (p < 0.001)]. In the dialysis population, a significantly lower median iFGF23 level was observed in iron therapy users than in nonusers [87.6 (25.2-1038.3) versus 119 (51.6-1031); respectively, p = 0.045]. A significant negative association between iron administration and iFGF23 level was revealed by both univariate (r = -0.237, p = 0.016) and multivariate (β = -0.221, p = 0.032) analysis. No association was found between iFGF23 and serum ferritin and iron levels. Also, there was no association between iron therapy and serum phosphate level.
    Conclusion: In contrast to what is seen for the general population, this study showed that there was a negative relationship between iron administration and serum iFGF23 level in a dialysis population. We can therefore conclude that if high levels of FGF23 are harmful, iron therapy may have a beneficial effect on bone metabolism by reducing FGF23 levels in a dialysis population.
    MeSH term(s) Adult ; Aged ; Calcium/metabolism ; Cross-Sectional Studies ; Female ; Fibroblast Growth Factors/blood ; Humans ; Iron/therapeutic use ; Male ; Middle Aged ; Phosphates/metabolism ; Renal Dialysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/metabolism
    Chemical Substances Phosphates ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Iron (E1UOL152H7) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2012-11-20
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-012-0725-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Protective effect of beta-glucan on contrast induced-nephropathy and a comparison of beta-glucan with nebivolol and N-acetylcysteine in rats.

    Koc, Eyup / Reis, Kadriye Altok / Ebinc, Fatma Ayerden / Pasaoglu, Hatice / Demirtas, Canan / Omeroglu, Suna / Derici, Ulver Boztepe / Guz, Galip / Erten, Yasemin / Bali, Musa / Arinsoy, Turgay / Sindel, Sukru

    Clinical and experimental nephrology

    2011  Volume 15, Issue 5, Page(s) 658–665

    Abstract: Background: It has been shown that beta-glucan (BG), which has antioxidant and immunomodulatory effects, attenuats renal ischemia-reperfusion injury. We aimed to investigate whether BG might have a preventive role against the development of contrast- ... ...

    Abstract Background: It has been shown that beta-glucan (BG), which has antioxidant and immunomodulatory effects, attenuats renal ischemia-reperfusion injury. We aimed to investigate whether BG might have a preventive role against the development of contrast-induced nephropathy and to compare its effect with nebivolol (Nb) and N-acetylcysteine (NAC).
    Methods: Thirty-six Wistar albino female rats were randomly divided into six groups (n = 6 each): control, contrast media (CM), BG, BG + CM, Nb + CM, and NAC + CM. With the exception of control and CM groups, the others were given drugs orally once a day for 5 days. Kidney function parameters, inflammatory parameters, and serum and renal tissue oxidative stress markers were measured.
    Results: Increases of serum creatinine and blood urea nitrogen levels were significantly higher (p < 0.05) in the CM group only. Absolute changes of serum creatinine levels in BG, BG + CM and Nb + CM groups were significantly lower than those in the CM group (p < 0.05). Serum levels of advanced oxidation protein products and malondialdehyde were significantly less (p < 0.05) in the BG group compared to the CM group. Histopathological lesions in the CM group were more advanced (p < 0.05). No significant differences between the BG + CM, Nb + CM and NAC + CM groups were found with regard to histopathological findings.
    Conclusion: This study suggests that BG protects or ameliorates against contrast-induced nephropathy. Its beneficial effects may be similar to or greater than those of Nb or NAC.
    MeSH term(s) Acetylcysteine/therapeutic use ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/pathology ; Animals ; Benzopyrans/therapeutic use ; Blood Urea Nitrogen ; Contrast Media ; Creatinine/blood ; Ethanolamines/therapeutic use ; Female ; Nebivolol ; Protective Agents ; Rats ; beta-Glucans/therapeutic use
    Chemical Substances Benzopyrans ; Contrast Media ; Ethanolamines ; Protective Agents ; beta-Glucans ; Nebivolol (030Y90569U) ; Creatinine (AYI8EX34EU) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2011-04-26
    Publishing country Japan
    Document type Comparative Study ; Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-011-0451-z
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  5. Article ; Online: Effects of everolimus on cytokines, oxidative stress, and renal histology in ischemia-reperfusion injury of the kidney.

    Suyani, Elif / Derici, Ulver Boztepe / Sahin, Tolga / Ofluoglu, Ebru / Pasaoglu, Hatice / Erdem, Ozlem / Barit, Gonca / Reis, Kadriye Altok / Erten, Yasemin / Arinsoy, Turgay / Sindel, Sukru

    Renal failure

    2009  Volume 31, Issue 8, Page(s) 698–703

    Abstract: Background: To evaluate the effects of everolimus on renal ischemia-reperfusion injury (IRI).: Methods: Wistar albino rats were divided into control, ischemia-reperfusion (IR), and ischemia-reperfusion/everolimus (IR/eve) groups. Everolimus was ... ...

    Abstract Background: To evaluate the effects of everolimus on renal ischemia-reperfusion injury (IRI).
    Methods: Wistar albino rats were divided into control, ischemia-reperfusion (IR), and ischemia-reperfusion/everolimus (IR/eve) groups. Everolimus was administered for seven consecutive days to the IR/eve group prior to injury. IR and IR/eve groups underwent forty-five minutes ischemia followed by the application of reperfusion at 2 and 24 hours. Blood samples and kidneys were taken from all animals.
    Results: . Serum blood urea nitrogen and creatinine levels increased at two hours of reperfusion in the IR and IR/eve groups, and decreased at 24 hours of reperfusion in the IR group. In the IR/eve group, we detected significantly high interleukin-6 levels and low tumor necrosis factor-alpha and malondialdehyde levels at 24 hours. Myeloperoxidase levels increased at two hours of reperfusion in the IR/eve group, but decreased significantly at 24 hours. Everolimus did not improve renal tubular and interstitial injuries in renal IRI.
    Conclusions: It has been demonstrated that pretreatment with everolimus has beneficial effects on cytokines and oxidative stress in renal IRI. However, these effects are insufficient for the correction of histopathological changes and restoration of normal kidney function.
    MeSH term(s) Animals ; Cytokines/metabolism ; Everolimus ; Immunosuppressive Agents/administration & dosage ; Kidney/drug effects ; Kidney/pathology ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Reperfusion Injury/pathology ; Reperfusion Injury/therapy ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives
    Chemical Substances Cytokines ; Immunosuppressive Agents ; Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2009
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.3109/08860220903134555
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