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  1. Article ; Online: Gastric emptying study before gastric peroral endoscopic myotomy (G-POEM): can intragastric meal distribution be a predictor of success?

    Mandarino, Francesco Vito / Testoni, Sabrina Gloria Giulia / Barchi, Alberto / Pepe, Gino / Esposito, Dario / Fanti, Lorella / Viale, Edi / Biamonte, Paolo / Azzolini, Francesco / Danese, Silvio

    Gut

    2022  Volume 72, Issue 5, Page(s) 1019–1020

    MeSH term(s) Humans ; Gastric Emptying ; Pyloromyotomy ; Esophageal Achalasia ; Esophageal Sphincter, Lower/surgery ; Stomach ; Gastroparesis/surgery ; Treatment Outcome ; Natural Orifice Endoscopic Surgery
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-327701
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  2. Article ; Online: Self-oriented anisotropic structure of G-hydrogels as a delicate balance between attractive and repulsive forces.

    Pepe, Alessia / Moretti, Paolo / Yoneda, Juliana S / Carducci, Federica / Itri, Rosangela / Mariani, Paolo

    Nanoscale

    2023  Volume 15, Issue 37, Page(s) 15196–15205

    Abstract: Guanine (G) hydrogels are very attractive materials made by the supramolecular organization of G ... that make long, flexible and knotted G-quadruplexes, were investigated by small- and wide-angle X-ray ...

    Abstract Guanine (G) hydrogels are very attractive materials made by the supramolecular organization of G-derivatives in water. In this paper, hydrogels composed of guanosine 5'-monophosphate (GMP) and guanosine (Gua), that make long, flexible and knotted G-quadruplexes, were investigated by small- and wide-angle X-ray scattering (SAXS and WAXS) to comprehend the origin of their unique orientational properties. The SAXS intensity, analysed at a fixed scattering vector modulus
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr01348k
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  3. Article ; Online: Dose assessment intercomparisons within the RENEB network using G

    Terzoudi, Georgia I / Pantelias, Gabriel / Darroudi, Firouz / Barszczewska, Katarzyna / Buraczewska, Iwona / Depuydt, Julie / Georgieva, Dimka / Hadjidekova, Valeria / Hatzi, Vasiliki I / Karachristou, Ioanna / Karakosta, Maria / Meschini, Roberta / M'Kacher, Radhia / Montoro, Alegria / Palitti, Fabrizio / Pantelias, Antonio / Pepe, Gaetano / Ricoul, Michelle / Sabatier, Laure /
    Sebastià, Natividad / Sommer, Sylwester / Vral, Anne / Zafiropoulos, Demetre / Wojcik, Andrzej

    International journal of radiation biology

    2017  Volume 93, Issue 1, Page(s) 48–57

    Abstract: ... biodosimetry analyzing G: Materials and methods: Comparative analysis among different partners for dose ... or partial-body triage biodosimetry by scoring excess-fragments or dicentrics in G ...

    Abstract Purpose: Dose assessment intercomparisons within the RENEB network were performed for triage biodosimetry analyzing G
    Materials and methods: Comparative analysis among different partners for dose assessment included shipment of PCC-slides and captured images to construct dose-response curves for up to 6 Gy γ-rays. Accident simulation exercises were performed to assess the suitability of the PCC assay by detecting speed of analysis and minimum number of cells required for categorization of potentially exposed individuals.
    Results: Calibration data based on Giemsa-stained fragments in excess of 46 PCC were obtained by different partners using galleries of PCC images for each dose-point. Mean values derived from all scores yielded a linear dose-response with approximately 4 excess-fragments/cell/Gy. To unify scoring criteria, exercises were carried out using coded PCC-slides and/or coded irradiated blood samples. Analysis of samples received 24 h post-exposure was successfully performed using Giemsa staining (1 excess-fragment/cell/Gy) or centromere/telomere FISH-staining for dicentrics.
    Conclusions: Dose assessments by RENEB partners using appropriate calibration curves were mostly in good agreement. The PCC assay is quick and reliable for whole- or partial-body triage biodosimetry by scoring excess-fragments or dicentrics in G
    MeSH term(s) Biological Assay/methods ; Biological Assay/standards ; Chromosome Aberrations/radiation effects ; Europe ; Humans ; Lymphocytes/cytology ; Lymphocytes/radiation effects ; Micronucleus Tests/methods ; Quality Assurance, Health Care ; Radiation Exposure/analysis ; Radiation Monitoring/methods ; Radiation Monitoring/standards ; Reproducibility of Results ; Resting Phase, Cell Cycle/genetics ; Resting Phase, Cell Cycle/radiation effects ; Sensitivity and Specificity
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Validation Studies
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2016.1234725
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  4. Article ; Online: Gastric peroral endoscopic myotomy (G-POEM) for refractory gastroparesis: 3-month follow-up results.

    Azzolini, Francesco / Testoni, Sabrina Gloria / Esposito, Dario / Bonura, Giuliano Francesco / Pepe, Gino / Testoni, Pier Alberto

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 52, Issue 10, Page(s) 1215–1218

    MeSH term(s) Aged ; Female ; Follow-Up Studies ; Gastric Emptying ; Gastroparesis/surgery ; Humans ; Male ; Middle Aged ; Prospective Studies ; Pyloromyotomy/methods ; Treatment Outcome
    Language English
    Publishing date 2020-08-17
    Publishing country Netherlands
    Document type Letter ; Observational Study
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.07.023
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  5. Article: Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity.

    Pepe, Dionissia A / Toumpa, Dimitra / André-Barrès, Christiane / Menendez, Christophe / Mouray, Elisabeth / Baltas, Michel / Grellier, Philippe / Papaioannou, Dionissios / Athanassopoulos, Constantinos M

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 5, Page(s) 921–927

    Abstract: A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor ...

    Abstract A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analogue (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial activity was evaluated using the CQ-resistant
    Language English
    Publishing date 2020-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.9b00669
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  6. Article ; Online: Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923.

    Esposito, Veronica / Esposito, Francesca / Pepe, Antonietta / Gomez Monterrey, Isabel / Tramontano, Enzo / Mayol, Luciano / Virgilio, Antonella / Galeone, Aldo

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV ... deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex grooves ... molecular modeling data suggest that all of them preserve the ability to fold in a stable dimeric parallel G ...

    Abstract In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV-integrase aptamer T30923, in which specific 2'-deoxyguanosines have been singly replaced by 8-methyl-2'-deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex grooves as a steric probe to investigate the interaction aptamer/target. Although, the various modified aptamers differ in the localization of the methyl group, NMR, circular dichroism (CD), electrophoretic and molecular modeling data suggest that all of them preserve the ability to fold in a stable dimeric parallel G-quadruplex complex resembling that of their natural counterpart T30923. However, the biological data have shown that the T30923 variants are characterized by different efficiencies in inhibiting the HIV-integrase, thus suggesting the involvement of the G-quadruplex grooves in the aptamer/target interaction.
    MeSH term(s) Aptamers, Nucleotide/pharmacology ; Circular Dichroism ; Dimerization ; G-Quadruplexes ; HIV Integrase/metabolism ; HIV Integrase Inhibitors/pharmacology ; Humans ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Oligonucleotides/pharmacology ; Transition Temperature
    Chemical Substances Aptamers, Nucleotide ; HIV Integrase Inhibitors ; Intercellular Signaling Peptides and Proteins ; Oligonucleotides ; T30923 ; lens epithelium-derived growth factor ; HIV Integrase (EC 2.7.7.-)
    Language English
    Publishing date 2020-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165637
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  7. Article ; Online: A novel pyrimidine tetrad contributing to stabilize tetramolecular G-quadruplex structures.

    Esposito, V / Pepe, A / Filosa, R / Mayol, L / Virgilio, A / Galeone, A

    Organic & biomolecular chemistry

    2016  Volume 14, Issue 10, Page(s) 2938–2943

    Abstract: G-quadruplex structures formed by oligodeoxyribonucleotides TGGU(NH2)GGT (AM, U(NH2) = 5-amino-2' ... indicate that all 7-mer oligonucleotides form tetramolecular parallel G-quadruplex structures ... tetrad characterized by eight hydrogen bonds that stabilizes the G-quadruplex structure more efficiently ...

    Abstract G-quadruplex structures formed by oligodeoxyribonucleotides TGGU(NH2)GGT (AM, U(NH2) = 5-amino-2'-deoxyuridine), TGGU(Br)GGT (BR, U(Br) = 5-bromo-2'-deoxyuridine) and TGGTGGT (TH) have been investigated through circular dichroism, nuclear magnetic resonance, gel electrophoresis and molecular modeling techniques. Collected data indicate that all 7-mer oligonucleotides form tetramolecular parallel G-quadruplex structures with all residues adopting anti glycosidic bonds. In the case of AM, data suggest the occurrence of a novel U(NH2)-tetrad characterized by eight hydrogen bonds that stabilizes the G-quadruplex structure more efficiently than U(Br)- and T-tetrads.
    MeSH term(s) Circular Dichroism ; G-Quadruplexes ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Nucleic Acid Conformation ; Pyrimidines/chemistry
    Chemical Substances Pyrimidines
    Language English
    Publishing date 2016-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c5ob02358k
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  8. Article ; Online: Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

    Veronica Esposito / Francesca Esposito / Antonietta Pepe / Isabel Gomez Monterrey / Enzo Tramontano / Luciano Mayol / Antonella Virgilio / Aldo Galeone

    International Journal of Molecular Sciences, Vol 21, Iss 5637, p

    2020  Volume 5637

    Abstract: In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV ... deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex grooves ... molecular modeling data suggest that all of them preserve the ability to fold in a stable dimeric parallel G ...

    Abstract In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV-integrase aptamer T30923, in which specific 2′-deoxyguanosines have been singly replaced by 8-methyl-2′-deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex grooves as a steric probe to investigate the interaction aptamer/target. Although, the various modified aptamers differ in the localization of the methyl group, NMR, circular dichroism (CD), electrophoretic and molecular modeling data suggest that all of them preserve the ability to fold in a stable dimeric parallel G-quadruplex complex resembling that of their natural counterpart T30923. However, the biological data have shown that the T30923 variants are characterized by different efficiencies in inhibiting the HIV-integrase, thus suggesting the involvement of the G-quadruplex grooves in the aptamer/target interaction.
    Keywords G-quadruplex ; 8-methyl-2′-deoxyguanosine ; aptamers ; integrase ; HIV ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article ; Online: Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.

    Hampel, Sonja M / Pepe, Antonella / Greulich-Bode, Karin M / Malhotra, Sanjay V / Reszka, Anthony P / Veith, Sebastian / Boukamp, Petra / Neidle, Stephen

    Molecular pharmacology

    2012  Volume 83, Issue 2, Page(s) 470–480

    Abstract: G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and ...

    Abstract G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to deregulation of mitosis, followed by apoptosis and downregulation of oncogene expression. We report here on investigations into the mechanism of action of tetra-substituted naphthalene diimide ligands on the basis of cell biologic data together with a National Cancer Institute COMPARE study. We conclude that four principal mechanisms of action are implicated for these compounds: 1) telomere uncapping with subsequent DNA damage response and senescence; 2) inhibition of transcription/translation of oncogenes; 3) genomic instability through telomeric DNA end fusions, resulting in mitotic catastrophe and apoptosis; and 4) induction of chromosomal instability by telomere aggregate formation.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA/drug effects ; DNA/metabolism ; DNA Damage ; G-Quadruplexes ; Humans ; Imides/pharmacology ; Ligands ; MCF-7 Cells ; Mitosis/drug effects ; Naphthalenes/pharmacology ; Oncogenes/drug effects ; Telomere/drug effects ; Telomere/metabolism
    Chemical Substances Antineoplastic Agents ; Imides ; Ligands ; Naphthalenes ; naphthalenediimide (22291-04-9) ; DNA (9007-49-2)
    Language English
    Publishing date 2012-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/mol.112.081075
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    Zs.A 525: Show issues Location:
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  10. Article: Factor II 20210 G-->A polymorphism associated to factor V Leiden: a report of two thrombophilic families.

    Prisco, D / Gori, A M / Pepe, G / Marcucci, R / Brunelli, T / Giusti, B / Gensini, G F / Abbate, R

    Thrombosis research

    1998  Volume 89, Issue 5, Page(s) 249–252

    MeSH term(s) Adult ; Factor V/genetics ; Female ; Humans ; Italy ; Male ; Middle Aged ; Pedigree ; Point Mutation ; Polymorphism, Genetic ; Prothrombin/genetics ; Thrombophlebitis/genetics
    Chemical Substances factor V Leiden ; Factor V (9001-24-5) ; Prothrombin (9001-26-7)
    Language English
    Publishing date 1998-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/s0049-3848(98)00013-9
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